RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples.

abstract：BACKGROUND:The freshwater snail Lymnaea stagnalis (L. stagnalis) has served as a successful model for studies in the field of Neuroscience. However, a serious drawback in the molecular analysis of the nervous system of L. stagnalis has been the lack of large-scale genomic or neuronal transcriptome information, thereby ...

journal_title：BMC genomics

authors： Feng ZP,Zhang Z,van Kesteren RE,Straub VA,van Nierop P,Jin K,Nejatbakhsh N,Goldberg JI,Spencer GE,Yeoman MS,Wildering W,Coorssen JR,Croll RP,Buck LT,Syed NI,Smit AB

更新日期：2009-09-23 00:00:00

abstract：BACKGROUND:Adjuvant Radiotherapy (RT) after surgical removal of tumors proved beneficial in long-term tumor control and treatment planning. For many years, it has been well concluded that radio-sensitivities of tumors upon radiotherapy decrease according to the sizes of tumors and RT models based on Poisson statistics ...

journal_title：BMC genomics

authors： Yang JY,Niemierko A,Yang MQ,Deng Y

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:The completion of the Plasmodium falciparum genome represents a milestone in malaria research. The genome sequence allows for the development of genome-wide approaches such as microarray and proteomics that will greatly facilitate our understanding of the parasite biology and accelerate new drug and vaccine ...

journal_title：BMC genomics

authors： Lu F,Jiang H,Ding J,Mu J,Valenzuela JG,Ribeiro JM,Su XZ

更新日期：2007-07-27 00:00:00

abstract：BACKGROUND:Eucalyptus is one of the most important sources of industrial cellulose. Three species of this botanical group are intensively used in breeding programs: E. globulus, E. grandis and E. urophylla. E. globulus is adapted to subtropical/temperate areas and is considered a source of high-quality cellulose; E. gr...

journal_title：BMC genomics

authors： Salazar MM,Nascimento LC,Camargo EL,Gonçalves DC,Lepikson Neto J,Marques WL,Teixeira PJ,Mieczkowski P,Mondego JM,Carazzolle MF,Deckmann AC,Pereira GA

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:Ultrasound imaging technology has wide applications in cattle reproduction and has been used to monitor individual follicles and determine the patterns of follicular development. However, the speckles in ultrasound images affect the post-processing, such as follicle segmentation and finally affect the measur...

journal_title：BMC genomics

authors： Tang J,Guo S,Sun Q,Deng Y,Zhou D

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:Horses have been strongly selected for speed, strength, and endurance-exercise traits since the onset of domestication. As a result, highly specialized horse breeds have developed with many modern horse breeds often representing closed populations with high phenotypic and genetic uniformity. However, a great...

journal_title：BMC genomics

authors： Velie BD,Lillie M,Fegraeus KJ,Rosengren MK,Solé M,Wiklund M,Ihler CF,Strand E,Lindgren G

更新日期：2019-02-04 00:00:00

abstract：BACKGROUND:Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in germ line cells it causes a condition called inherited chromosomall...

journal_title：BMC genomics

authors： Greninger AL,Knudsen GM,Roychoudhury P,Hanson DJ,Sedlak RH,Xie H,Guan J,Nguyen T,Peddu V,Boeckh M,Huang ML,Cook L,Depledge DP,Zerr DM,Koelle DM,Gantt S,Yoshikawa T,Caserta M,Hill JA,Jerome KR

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Nitrogen (N) is a key macronutrient required for plant growth and development. In this study, watermelon plants were grown under hydroponic conditions at 0.2 mM N, 4.5 mM N, and 9 mM N for 14 days. RESULTS:Dry weight and photosynthetic assimilation at low N (0.2 mM) was reduced by 29 and 74% compared with h...

journal_title：BMC genomics

authors： Nawaz MA,Chen C,Shireen F,Zheng Z,Sohail H,Afzal M,Ali MA,Bie Z,Huang Y

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:Gene duplication is prevalent in many species and can result in coding and regulatory divergence. Gene duplications can be classified as whole genome duplication (WGD), tandem and inserted (non-syntenic). In maize, WGD resulted in the subgenomes maize1 and maize2, of which maize1 is considered the dominant s...

journal_title：BMC genomics

authors： Li L,Briskine R,Schaefer R,Schnable PS,Myers CL,Flagel LE,Springer NM,Muehlbauer GJ

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and memory, and cognition. While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen ...

journal_title：BMC genomics

authors： Hixson KM,Cogswell M,Brooks-Kayal AR,Russek SJ

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infection with Aeromonas salmonicida, the causative agent of furunculosis. The vertebrate liver has multifaceted f...

journal_title：BMC genomics

authors： Causey DR,Pohl MAN,Stead DA,Martin SAM,Secombes CJ,Macqueen DJ

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The σ(54) subunit controls a unique class of promoters in bacteria. Such promoters, without exception, require enhancer binding proteins (EBPs) for transcription initiation. Desulfovibrio vulgaris Hildenborough, a model bacterium for sulfate reduction studies, has a high number of EBPs, more than most sequen...

journal_title：BMC genomics

authors： Kazakov AE,Rajeev L,Chen A,Luning EG,Dubchak I,Mukhopadhyay A,Novichkov PS

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Finger millet (Eleusine coracana (L.) Gaertn.) is an important staple food crop widely grown in Africa and South Asia. Among the millets, finger millet has high amount of calcium, methionine, tryptophan, fiber, and sulphur containing amino acids. In addition, it has C4 photosynthetic carbon assimilation mech...

journal_title：BMC genomics

authors： Hittalmani S,Mahesh HB,Shirke MD,Biradar H,Uday G,Aruna YR,Lohithaswa HC,Mohanrao A

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:Bulbs of the ornamental flower Lilium pumilum enter a period of dormancy after flowering in spring, and require exposure to cold for a period of time in order to release dormancy. Previous studies focused mainly on anatomical, physiological and biochemical changes during dormancy release. There are no dorman...

journal_title：BMC genomics

authors： Wang W,Su X,Tian Z,Liu Y,Zhou Y,He M

更新日期：2018-03-14 00:00:00

abstract：BACKGROUND:Cryptosporidium hominis is a dominant species for human cryptosporidiosis. Within the species, IbA10G2 is the most virulent subtype responsible for all C. hominis-associated outbreaks in Europe and Australia, and is a dominant outbreak subtype in the United States. In recent yearsIaA28R4 is becoming a major ...

journal_title：BMC genomics

authors： Guo Y,Tang K,Rowe LA,Li N,Roellig DM,Knipe K,Frace M,Yang C,Feng Y,Xiao L

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Second generation sequencing has permitted detailed sequence characterisation at the whole genome level of a growing number of non-model organisms, but the data produced have short read-lengths and biased genome coverage leading to fragmented genome assemblies. The PacBio RS long-read sequencing platform off...

journal_title：BMC genomics

authors： Ferrarini M,Moretto M,Ward JA,Šurbanovski N,Stevanović V,Giongo L,Viola R,Cavalieri D,Velasco R,Cestaro A,Sargent DJ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Sorghum belongs to the tribe of the Andropogoneae that includes potential biofuel crops like switchgrass, Miscanthus and successful biofuel crops like corn and sugarcane. However, from a genomics point of view sorghum has compared to these other species a simpler genome because it lacks the additional rounds...

journal_title：BMC genomics

authors： Calviño M,Bruggmann R,Messing J

更新日期：2011-07-08 00:00:00

abstract：:ᅟ: Upon publication of the original article [1], the authors had flagged that there was an error in Fig. 1c, as the key in this figure was displaying incorrectly. The colours had not displayed in the key in the final published article, and instead appear as plain white. ...

journal_title：BMC genomics

authors： Hohmann N,Koch MA

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Transposable Elements (TEs) are key components that shape the organization and evolution of genomes. Fungi have developed defense mechanisms against TE invasion such as RIP (Repeat-Induced Point mutation), MIP (Methylation Induced Premeiotically) and Quelling (RNA interference). RIP inactivates repeated sequ...

journal_title：BMC genomics

authors： Amselem J,Lebrun MH,Quesneville H

更新日期：2015-02-28 00:00:00

abstract：BACKGROUND:The complete sequences of chloroplast genomes provide wealthy information regarding the evolutionary history of species. With the advance of next-generation sequencing technology, the number of completely sequenced chloroplast genomes is expected to increase exponentially, powerful computational tools annota...

journal_title：BMC genomics

authors： Liu C,Shi L,Zhu Y,Chen H,Zhang J,Lin X,Guan X

更新日期：2012-12-20 00:00:00

abstract：BACKGROUND:Genome rearrangement describes gross changes of chromosomal regions, plays an important role in evolutionary biology and has profound impacts on phenotype in organisms ranging from microbes to humans. With more and more complete genomes accomplished, lots of genomic comparisons have been conducted in order t...

journal_title：BMC genomics

authors： Wang D,Li S,Guo F,Ning K,Wang L

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Fusion genes are known to be drivers of many common cancers, so they are potential markers for diagnosis, prognosis or therapy response. The advent of paired-end RNA sequencing enhances our ability to discover fusion genes. While there are available methods, routine analyses of large number of samples are st...

journal_title：BMC genomics

authors： Vu TN,Deng W,Trac QT,Calza S,Hwang W,Pawitan Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus performed full genome analyses on four Listeria monocytogenes, including human and food isolates from both a 1988 case of sporadic...

journal_title：BMC genomics

authors： Orsi RH,Borowsky ML,Lauer P,Young SK,Nusbaum C,Galagan JE,Birren BW,Ivy RA,Sun Q,Graves LM,Swaminathan B,Wiedmann M

更新日期：2008-11-13 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNA molecules that downregulate gene expression by base pairing to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). Up to now, rare information for the miRNAs is available in decapod crustaceans. Our previous studies showed that many miRNA-binding sit...

journal_title：BMC genomics

authors： Song YN,Shi LL,Liu ZQ,Qiu GF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Many gram-negative bacteria use type III secretion systems (T3SSs) to translocate effector proteins into host cells. T3SS effectors can give some bacteria a competitive edge over others within the same environment and can help bacteria to invade the host cells and allow them to multiply rapidly within the ho...

journal_title：BMC genomics

authors： Hobbs CK,Porter VL,Stow ML,Siame BA,Tsang HH,Leung KY

更新日期：2016-12-19 00:00:00

abstract：BACKGROUND:High-throughput omics technologies such as microarrays and next-generation sequencing (NGS) have become indispensable tools in biological research. Computational analysis and biological interpretation of omics data can pose significant challenges due to a number of factors, in particular the systems integrat...

journal_title：BMC genomics

authors： Hermida L,Poussin C,Stadler MB,Gubian S,Sewer A,Gaidatzis D,Hotz HR,Martin F,Belcastro V,Cano S,Peitsch MC,Hoeng J

更新日期：2013-07-29 00:00:00

abstract：BACKGROUND:Interactions among transcription factors (TFs) and histone modifications (HMs) play an important role in the precise regulation of gene expression. The context specificity of those interactions and further its dynamics in normal and disease remains largely unknown. Recent development in genomics technology e...

journal_title：BMC genomics

authors： Zhang L,Xue G,Liu J,Li Q,Wang Y

更新日期：2018-12-31 00:00:00

abstract：BACKGROUND:Cotton, one of the world's leading crops, is important to the world's textile and energy industries, and is a model species for studies of plant polyploidization, cellulose biosynthesis and cell wall biogenesis. Here, we report the construction of a plant-transformation-competent binary bacterial artificial ...

journal_title：BMC genomics

authors： Lee MK,Zhang Y,Zhang M,Goebel M,Kim HJ,Triplett BA,Stelly DM,Zhang HB

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:The Andean cultivar Paloma is resistant to Mesoamerican and Andean races of Colletotrichum lindemuthianum, the fungal pathogen that causes the destructive anthracnose disease in common bean. Remarkably, Paloma is resistant to Mesoamerican races 2047 and 3481, which are among the most virulent races of the an...

journal_title：BMC genomics

authors： de Lima Castro SA,Gonçalves-Vidigal MC,Gilio TAS,Lacanallo GF,Valentini G,da Silva Ramos Martins V,Song Q,Galván MZ,Hurtado-Gonzales OP,Pastor-Corrales MA

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:Understanding how and why genetic variation is partitioned across geographic space is of fundamental importance to understanding the nature of biological species. How geographical isolation and local adaptation contribute to the formation of ecotypically differentiated groups of plants is just beginning to b...

journal_title：BMC genomics

authors： Gould BA,Palacio-Mejia JD,Jenkins J,Mamidi S,Barry K,Schmutz J,Juenger TE,Lowry DB

更新日期：2018-11-01 00:00:00