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The Concave Shape of the Forced Expiratory Flow-Volume Curve in 3 Seconds Is a Practical Surrogate of FEV1/FVC for the Diagnosis of Airway Limitation in Inadequate Spirometry.

Abstract：

BACKGROUND:Spirometry is important for the differential diagnosis of dyspnea. However, some patients cannot exhale for ≥6 s to achieve the American Thoracic Society/European Respiratory Society criteria. The aim of this study was to demonstrate the reliability of a new parameter that quantifies the degree of concavity in the first 3 s to define airway limitation as a surrogate for the FEV1/FVC. METHODS:Four hundred spirometry test results were selected through complete random sampling. The new parameter, termed the AUC3/AT3, was calculated as the area under the descending limb of the expiratory flow-volume curve before the end of the first 3 s (AUC3) divided by the area of the triangle before the end of the first 3 s (AT3). The AUC3/AT3 was compared with the FEV1/FVC using Pearson's correlation analysis. The level of agreement between the AUC3/AT3 and the FEV1/FVC in the detection of airway obstruction was analyzed using the kappa statistic. We also compared the diagnostic accuracy of the new index with that of the FEV1/forced expiratory volume in the first 3 s (FEV3). RESULTS:There was a strong correlation (r = 0.88, P < .001) between the AUC3/AT3 and the FEV1/FVC. There was also strong agreement between the AUC3/AT3 and the FEV1/FVC in the detection of obstruction with kappa indices of 0.72 (Global Initiative for Chronic Obstructive Lung Disease [GOLD] criterion) and 0.67 (lower limit of normal criterion), and these values were greater than those obtained for the FEV1/FEV3. The AUC3/AT3 also exhibited acceptable sensitivity, specificity, positive predictive value, and negative predictive value. The diagnostic accuracies of the AUC3/AT3 were 86.3% (GOLD criterion) and 83.8% (lower limit of normal criterion), which were greater than the 76.0 and 74.0% obtained for the FEV1/FEV3, respectively. CONCLUSIONS:The AUC3/AT3 can be utilized as a surrogate parameter for the FEV1/FVC when patients cannot complete a 6-s expiratory effort. Additionally, the performance of this index is better than that of the FEV1/FEV3 in the identification of airway limitations.

journal_name

Respir Care

journal_title

Respiratory care

authors

Li H,Liu C,Zhang Y,Xiao W

doi

10.4187/respcare.05016

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

363-369

issue

eissn

0020-1324

issn

1943-3654

pii

respcare.05016

journal_volume

pub_type

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The Concave Shape of the Forced Expiratory Flow-Volume Curve in 3 Seconds Is a Practical Surrogate of FEV1/FVC for the Diagnosis of Airway Limitation in Inadequate Spirometry.