Abstract:
:AIDS-associated Kaposi's sarcoma (AIDS-KS) caused by human herpes virus 8 (HHV-8) is the most severe and resistant form of KS tumor. Our aim was to verify whether there is an association between HHV-8 variability and development of AIDS-KS in Brazil by comparing the HHV-8 variability between individuals without and with KS. Saliva samples and blood, when available, were analyzed by polymerase chain reaction (PCR) techniques for detection of the fragments of ORF K1 of HHV-8, which were then genotyped and analyzed regarding the genetic variability. Our study described 106 positive cases for HHV-8 in the saliva from 751 AIDS patients without previous KS. In addition, we performed a phylogenetic analysis of HHV-8 in 34 of the 106 AIDS patients without KS and in 33 of the 37 patients with active KS. The distribution of HHV-8 genotypes A, B, C, and F in AIDS individuals was indistinguishable by comparing non-KS and KS groups, as well as regarding ethnicity. Considering the KS group, genotype B was associated with better prognosis of KS tumor. Interestingly, we found a particular profile of diversity within clade C and 2 recombinant patterns of HHV-8 in the saliva of AIDS individuals without KS. We emphasize the need to achieve standard genotyping protocol for ORF K1 amplification, thus allowing for substantial detection of HHV-8 variants. Our findings can shed light on the role of HHV-8 variability in the pathogenesis of AIDS-KS.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Tozetto-Mendoza TR,Ibrahim KY,Tateno AF,de Oliveira CM,Sumita LM,Sanchez MCA,Luna EJ,Pierrotti LC,Drexler JF,Braz-Silva PH,Pannuti CS,Romano CMdoi
10.1097/MD.0000000000005291subject
Has Abstractpub_date
2016-11-01 00:00:00pages
e5291issue
48eissn
0025-7974issn
1536-5964pii
00005792-201611290-00009journal_volume
95pub_type
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