Abstract:
INTRODUCTION:Currently, the options are limited for the treatment of patients who have failed 2 lines of chemotherapy for advanced lung squamous cell carcinoma (SCC). Recently, nivolumab, a fully human IgG4 programmed death 1 immune checkpoint inhibitor antibody, was approved to treat patients with advanced stage, relapsed/refractory lung SCC. Although nivolumab has demonstrated antitumor activity with survival benefit in Caucasian patients, its efficacy in Asian patients is unknown. CASE REPORT:In this report, we describe a Chinese patient with relapsed advanced stage lung SCC who had an excellent response to nivolumab after only 2 doses without any adverse effects. Immunohistochemical analysis indicated the tumor was stained positive for programmed death-ligand 1. CONCLUSION:To our knowledge, this is the first report of satisfactory efficacy of short-term nivolumab treatment in a Chinese patient with relapsed advanced-stage lung SCC. Further clinical trials in Asian countries are needed to test whether nivolumab immunotherapy is a safe and effective treatment for Asian patients with lung SCC.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Pi G,He H,Bi J,Li Y,Li Y,Zhang Y,Wang M,Han G,Lin Cdoi
10.1097/MD.0000000000005077subject
Has Abstractpub_date
2016-10-01 00:00:00pages
e5077issue
40eissn
0025-7974issn
1536-5964pii
00005792-201610040-00062journal_volume
95pub_type
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