Abstract:
RATIONALE:Regorafenib is the new standard third-line therapy in metastatic colorectal cancer (mCRC). However, the reported 1-year overall survival rate does not exceed 25%. PATIENT CONCERNS:A 55-year-old man affected by mCRC, treated with regorafenib combined with stereotactic body radiotherapy (SBRT), showing a durable response. INTERVENTIONS:After 6 months of regorafenib, a PET/CT scan revealed a focal uptake in a solid lung nodule which was treated with SBRT, whereas continuing regorafenib administration. Fourteen months later, the patient had further progression in a parasternal lymph node, but treatment with regorafenib was continued. The regorafenib-associated side effects, such us the hand-foot syndrome, were favorable managed by reducing the dose from 160 to 120 mg/day. OUTCOMES:Patient-reported outcome was characterized by a progression-free survival of approximately 3 years. LESSONS:in presence of oligometastatic progression, a local SBRT while retaining the same systemic therapy may be a better multidisciplinary approach. Moreover, disease progression is no longer an absolute contraindication for continuing the regorafenib treatment.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Roberto M,Falcone R,Mazzuca F,Archibugi L,Castaldi N,Botticelli A,Osti MF,Marchetti Pdoi
10.1097/MD.0000000000009023subject
Has Abstractpub_date
2017-12-01 00:00:00pages
e9023issue
48eissn
0025-7974issn
1536-5964pii
00005792-201712010-00100journal_volume
96pub_type
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