The role of stereotactic body radiation therapy in oligometastatic colorectal cancer: Clinical case report of a long-responder patient treated with regorafenib beyond progression.

Abstract:

RATIONALE:Regorafenib is the new standard third-line therapy in metastatic colorectal cancer (mCRC). However, the reported 1-year overall survival rate does not exceed 25%. PATIENT CONCERNS:A 55-year-old man affected by mCRC, treated with regorafenib combined with stereotactic body radiotherapy (SBRT), showing a durable response. INTERVENTIONS:After 6 months of regorafenib, a PET/CT scan revealed a focal uptake in a solid lung nodule which was treated with SBRT, whereas continuing regorafenib administration. Fourteen months later, the patient had further progression in a parasternal lymph node, but treatment with regorafenib was continued. The regorafenib-associated side effects, such us the hand-foot syndrome, were favorable managed by reducing the dose from 160 to 120 mg/day. OUTCOMES:Patient-reported outcome was characterized by a progression-free survival of approximately 3 years. LESSONS:in presence of oligometastatic progression, a local SBRT while retaining the same systemic therapy may be a better multidisciplinary approach. Moreover, disease progression is no longer an absolute contraindication for continuing the regorafenib treatment.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Roberto M,Falcone R,Mazzuca F,Archibugi L,Castaldi N,Botticelli A,Osti MF,Marchetti P

doi

10.1097/MD.0000000000009023

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

e9023

issue

48

eissn

0025-7974

issn

1536-5964

pii

00005792-201712010-00100

journal_volume

96

pub_type

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