Transcatheter aortic valve implantation in the patients with chronic liver disease: A mini-review and meta-analysis.

Abstract:

BACKGROUND:Chronic liver disease is traditionally conceived as a risk factor for cardiovascular surgery. Transcatheter aortic valve implantation (TAVI) has recently burgeoned to precede surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis at intermediate to high surgical risk. The evidence regarding TAVI in the patients with chronic liver disease is currently scarce. METHODS:This article aims to assess the application of TAVI technique in the patients with chronic liver disease. RESULTS:TAVI in the patients with chronic liver disease produced acceptable postoperative results. The post-TAVI outcomes were comparable between the patients with or without chronic liver disease, except for a lower rate of pacemaker implantation in the patients with chronic liver disease (OR, 0.49[0.27-0.87], P = .02). In the patients with chronic liver disease, compared to SAVR, TAVI led to a decrease in the in-hospital mortality (OR, 0.43[0.22-0.86], P = .02) and need for transfusion (OR, 0.39[0.25-0.62], P < .0001). The rest outcomes were similar between the 2 groups. CONCLUSIONS:This systematic review and meta-analysis supported that TAVI is a reliable therapeutic option for treating severe aortic stenosis in the patients with chronic liver disease. Future large-scale randomized controlled trials investigating the mid-term and long-term prognosis are needed to further verify these results.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Ma X,Zhao D,Li J,Wei D,Zhang J,Yuan P,Kong X,Ma J,Ma H,Sun L,Zhang Y,Jiao Q,Wang Z,Zhang H

doi

10.1097/MD.0000000000019766

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

e19766

issue

16

eissn

0025-7974

issn

1536-5964

pii

00005792-202004170-00064

journal_volume

99

pub_type

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