Abstract:
BACKGROUND:Chronic liver disease is traditionally conceived as a risk factor for cardiovascular surgery. Transcatheter aortic valve implantation (TAVI) has recently burgeoned to precede surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis at intermediate to high surgical risk. The evidence regarding TAVI in the patients with chronic liver disease is currently scarce. METHODS:This article aims to assess the application of TAVI technique in the patients with chronic liver disease. RESULTS:TAVI in the patients with chronic liver disease produced acceptable postoperative results. The post-TAVI outcomes were comparable between the patients with or without chronic liver disease, except for a lower rate of pacemaker implantation in the patients with chronic liver disease (OR, 0.49[0.27-0.87], P = .02). In the patients with chronic liver disease, compared to SAVR, TAVI led to a decrease in the in-hospital mortality (OR, 0.43[0.22-0.86], P = .02) and need for transfusion (OR, 0.39[0.25-0.62], P < .0001). The rest outcomes were similar between the 2 groups. CONCLUSIONS:This systematic review and meta-analysis supported that TAVI is a reliable therapeutic option for treating severe aortic stenosis in the patients with chronic liver disease. Future large-scale randomized controlled trials investigating the mid-term and long-term prognosis are needed to further verify these results.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Ma X,Zhao D,Li J,Wei D,Zhang J,Yuan P,Kong X,Ma J,Ma H,Sun L,Zhang Y,Jiao Q,Wang Z,Zhang Hdoi
10.1097/MD.0000000000019766subject
Has Abstractpub_date
2020-04-01 00:00:00pages
e19766issue
16eissn
0025-7974issn
1536-5964pii
00005792-202004170-00064journal_volume
99pub_type
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