Intra-arterial chemotherapy for unilateral advanced intraocular retinoblastoma: Results and short-term complications.

Abstract:

:Intra-arterial chemotherapy (IAC) has become an essential technique for the management of advanced intraocular retinoblastoma (RB). In this study, the aim of this article is to describe the clinical results and the short-term complications of IAC performed in our hospital.We retrospectively analyzed patients with newly diagnosed unilateral advanced intraocular (group D or E) RB undergoing IAC from October 2016 to December 2017 in our hospital. We recorded the data including age, gender, cycles of IAC, pathway of arteries approached (ophthalmic artery or middle meningeal artery), ocular and systematic complications, globe salvage.Sixty-one patients underwent IAC performing 189 procedures with a median of 3.1 sessions per eye (range, 1-5 sessions). The overall globe salvage rate is 78.7% (Group D (84.2%), and Group E (69.6%) and followed-up. Short-term ocular complications include eyelid edema (15 cases), ptosis (5 cases), forehead congestion (3 cases), retina hemorrhage (5 cases), choroid atrophy (2 cases), phthisis bulbi (1 case), bradycardia and hypotension during the procedure (7cases), myelosuppressions (6 cases), and nausea and vomiting (5cases).IAC is safe and effective for the treatment of unilateral advanced intraocular RB with a very low complication rate.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wang L,Han M,Zhao J,Wu C,Wang Z,Li J,Song D,Wang C,Yang Y,Guo L

doi

10.1097/MD.0000000000012676

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

e12676

issue

42

eissn

0025-7974

issn

1536-5964

pii

00005792-201810190-00013

journal_volume

97

pub_type

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