Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children.

Abstract:

BACKGROUND:The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. METHODS:In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression. RESULTS:The prevalence of undervaccination was 60.6% (median 16 days) and decreasing (p < 0.0001). Among 145 cases and 2,900 controls, 58 (40.0%) and 721 (24.9%) were undervaccinated (OR 2.28, 95% CI 1.57-3.31). The attributable risk percent was 22.5% (95% CI 14.5-27.9). CONCLUSIONS:Undervaccination was decreasing. Approximately up to one-fifth pertussis cases in children aged 3-35 months could have been prevented with on-time vaccination.

journal_name

Hum Vaccin Immunother

authors

Huang WT,Lin HC,Yang CH

doi

10.1080/21645515.2016.1249552

subject

Has Abstract

pub_date

2017-04-03 00:00:00

pages

757-761

issue

4

eissn

2164-5515

issn

2164-554X

journal_volume

13

pub_type

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