Abstract:
:Uveitis, the pathologic condition of inflammation of the uvea, frequently leads to severe vision loss and blindness. S100A8 is a calcium-binding protein which mainly expresses in granulocytes and monocytes and plays a prominent role in the regulation of inflammatory processes and immune response. Here, we determined the role of S100A8-positive cells in acute anterior uveitis (AAU) and keratitis. In rat models of endotoxin (lipopolisaccharide, LPS) -induced uveitis (EIU) and keratitis, S100A8-positive granulocytes and monocytes increased significantly in the iris-ciliary body and cornea as well as in the blood. Interestingly, Glucocorticoids slightly increased S100A8 levels in leukocytes, but reduced its presence significantly in the iris-ciliary body after LPS injection. Moreover, inhibition of NF-kB activation remarkably suppressed both progression of AAU and total S100A8 levels in leukocytes and the iris-ciliary body after LPS administration. Additionally, S100A8 protein level was also found to be elevated in the serum of AAU patients parallel with the progression of AAU through the designated clinical stages. Thus, S100A8 plays a pivotal role in the processes of AAU through involvement in migration and infiltration of S100A8-positive cells. Our findings suggest that serum levels of S100A8 protein can be used to monitor inflammatory activity in AAU.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang Y,Zhang Z,Zhang L,Li X,Lu R,Xu P,Zhang X,Dai M,Dai X,Qu J,Lu F,Chi Zdoi
10.1038/srep36140subject
Has Abstractpub_date
2016-10-27 00:00:00pages
36140issn
2045-2322pii
srep36140journal_volume
6pub_type
杂志文章abstract::The endogenous circadian clock drives oscillations that are completely synchronized with the environmental day-night rhythms with a period of approximately 24 hours. Temporal misalignment between one's internal circadian clock and the external solar time often occurs in shift workers and long-distance travelers; such ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46702
更新日期:2017-04-26 00:00:00
abstract::Melanoma patients' plasma contains exosomes produced by malignant and normal cells. Plasma exosomes were isolated and separated by immunocapture into two fractions: melanoma cell-derived exosomes (MTEX) and normal cell-derived exosomes (non-MTEX). Immunosuppressive effects of MTEX on primary human immune cells were ev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56542-4
更新日期:2020-01-09 00:00:00
abstract::An increased breast cancer risk during adulthood has been linked to estrogen exposure during fetal life. However, the impossibility of removing estrogens from the feto-maternal unit has hindered the testing of estrogen's direct effect on mammary gland organogenesis. To overcome this limitation, we developed an ex vivo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40806
更新日期:2017-01-19 00:00:00
abstract::Hybrid samples based on ZnO colloidal nanocrystals (NCs) deposited on AlGaN/GaN quantum well (QW) structures with different top barrier thickness d = 3, 6 and 9 nm are studied by time-resolved photoluminescence. Thermal behavior of the QW exciton lifetime in the hybrids and in the bare QW structures has been compared ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07889
更新日期:2015-01-20 00:00:00
abstract::Recently, magnetic nanoparticles (MNPs), which can be manipulated in the magnetic field, have received much attention in tumor therapy. Extremely low frequency magnetic field (ELMF) system can initiate MNPs vibrating and the movement of MNPs inside of cells can be controlled by adjusting the frequency and intensity of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46287
更新日期:2017-04-11 00:00:00
abstract::Efficient presentation of alien antigens triggers activation of T lymphocytes and robust host defense against invading pathogens. This pathophysiological process relies on the expression of major histocompatibility complex (MHC) molecules in antigen presenting cells such as macrophages. Aberrant MHC II transactivation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40531
更新日期:2017-01-17 00:00:00
abstract::Exolysin (ExlA) is a recently-identified pore-forming toxin secreted by a subset of Pseudomonas aeruginosa strains identified worldwide and devoid of Type III secretion system (T3SS), a major virulence factor. Here, we characterized at the ultrastructural level the lesions caused by an ExlA-secreting strain, CLJ1, in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02349-0
更新日期:2017-05-18 00:00:00
abstract::We evaluate the track segment yield G' of typical water radiolysis products (eaq-, ·OH and H2O2) under heavy ions (He, C and Fe ions) using a Monte Carlo simulation code in the Geant4-DNA. Furthermore, we reproduce experimental results of ·OH of He and C ions around the Bragg peak energies (< 6 MeV/u). In the relative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81215-6
更新日期:2021-01-15 00:00:00
abstract::Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22322
更新日期:2016-02-29 00:00:00
abstract::The studies on the increasing incidence of thyroid abnormalities are scarce. The aim of this current study was to ascertain the effects of geographical region on thyroid abnormalities under the context of universal salt iodization (USI). We randomly selected 1255 participants residing in inland and 1248 in coast, with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80248-7
更新日期:2021-01-13 00:00:00
abstract::The rapid urbanization in China has been associated with a growing hunger for energy consumption and steadily-increasing CO2 emissions. In this paper, an integrated system dynamics model composed of four sub-models is developed to simulate the urbanization and energy consumption in China from 1998 to 2050. Three scena...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66125-3
更新日期:2020-06-19 00:00:00
abstract::The Na+/H+ exchanger-1 (NHE1) supports tumour growth, making NHE1 inhibitors of interest in anticancer therapy, yet their molecular effects are incompletely characterized. Here, we demonstrate that widely used pyrazinoylguanidine-type NHE1 inhibitors potently inhibit growth and survival of cancer cell spheroids, in a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62430-z
更新日期:2020-04-02 00:00:00
abstract::Self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N(9)-(2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18891
更新日期:2016-01-04 00:00:00
abstract::We aimed to develop and validate a multiparametric MR radiomics model using conventional, diffusion-, and perfusion-weighted MR imaging for better prognostication in patients with newly diagnosed glioblastoma. A total of 216 patients with newly diagnosed glioblastoma were enrolled from two tertiary medical centers and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61178-w
更新日期:2020-03-06 00:00:00
abstract::Using classical molecular dynamics with a more reliable reactive LCBOPII potential, we have performed a detailed study on the direct graphite-to-diamond phase transition. Our results reveal a new so-called "wave-like buckling and slipping" mechanism, which controls the transformation from hexagonal graphite to cubic d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05930
更新日期:2014-08-04 00:00:00
abstract::Extravillous trophoblasts (EVTs) have the potential to provide the entire fetal genome for prenatal testing. Previous studies have demonstrated the presence of EVTs in the cervical canal and the ability to retrieve a small quantity of these cells by cervical sampling. However, these small quantities of trophoblasts ar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48346-3
更新日期:2019-08-20 00:00:00
abstract::Detailed structural analyses of the mushroom body which plays critical roles in olfactory learning and memory revealed that it is directly connected with multiple primary sensory centers in Drosophila. Connectivity patterns between the mushroom body and primary sensory centers suggest that each mushroom body lobe proc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29481
更新日期:2016-07-11 00:00:00
abstract::Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. The purpose of this open-label, one arm, dose-escalation, exploratory study is to evaluate the ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-12371-x
更新日期:2017-09-22 00:00:00
abstract:UNLABELLED:To fabricate high-performance metal-halide perovskite solar cells, a thermal annealing process is indispensable in preparing high quality perovskite film. And usually such annealing is performed on hot plate. However hot-plate annealing could cause problems such as inhomogeneous heating (induced by non-tight...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21257
更新日期:2016-02-16 00:00:00
abstract::The complement system is the first line of defense against foreign intruders, and deregulation of this system has been described in multiple diseases. In age-related macular degeneration (AMD), patients have higher complement activation levels compared to controls. Recently, a combination of three single nucleotide po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26568
更新日期:2016-05-31 00:00:00
abstract::This is the first study to investigate the impact of a second fibula flap or a soft tissue flap combined with bridging plate for a repeated segmental mandibulectomy reconstruction on flap outcomes in head and neck cancer patients. A retrospective comparative analysis (2007-2016) of 61 patients who underwent a second s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44467-x
更新日期:2019-05-28 00:00:00
abstract::Sorafenib is a RAF inhibitor approved for several cancers, including hepatocellular carcinoma (HCC). Inhibition of RAF kinases can induce a dose-dependent "paradoxical" upregulation of the downstream mitogen-activated protein kinase (MAPK) pathway in cancer cells. It is unknown whether "paradoxical" ERK activation occ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44123
更新日期:2017-03-09 00:00:00
abstract::Neutron energy is directly correlated with the energy of the incident ions in experiments involving laser-driven nuclear reactions. Using high-energy incident ions reduces the energy concentration of the generated neutrons. A novel "laser-collider" method was used at the Shenguang II laser facility to produce monoener...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27363
更新日期:2016-06-02 00:00:00
abstract::The Mont-Blanc massif, being iconic with its large glaciers and peaks of over 4,000 m, will experience a sharp increase in summer temperatures during the twenty-first century. By 2100, the impact of climate change on the cryosphere and hydrosphere in the Alps is expected to lead to a decrease in annual river discharge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67379-7
更新日期:2020-06-26 00:00:00
abstract::We study the capillary retraction of a Newtonian semi-infinite liquid filament through analytical methods. We derive a long-time asymptotic-state expansion for the filament profile using a one-dimensional free-surface slender cylindrical flow model based on the three-dimensional axisymmetric Navier-Stokes equations. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51824-3
更新日期:2019-10-29 00:00:00
abstract::A novel fungal species, Aspergillus labruscus sp. nov., has been found in Brazil during an investigation of the fungal species present on the surface of grape berries (Vitis labrusca L.) for use in the production of concentrated grape juice. It seems to be associated to V. labrusca, and has never been recovered from V...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06589-y
更新日期:2017-07-24 00:00:00
abstract::The correlations between early responses and the variations in physical density and primary tumor volume (TV) according to cone-beam computed tomography (CBCT) during chemoradiotherapy for non-small cell lung cancer (NSCLC) patients were investigated. 54 patients with inoperable and locally advanced NSCLC were include...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14548-w
更新日期:2017-11-07 00:00:00
abstract::The cortisol stress response and the molecular programming of the corticoid axis were characterized for the first time during early ontogeny in a Mediterranean marine teleost, the European sea bass (Dicentrarchus labrax). Sea bass embryos, pre-larvae and larvae at specific points of development were exposed to acute s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05525
更新日期:2014-07-02 00:00:00
abstract::In this study, the improved Aesop's fable paradigm-a series of experiments originally used to test whether some animals understand the causality associated with water replacement-was used to explore the cognitive ability of Azure-winged magpies (Cyanopica cyanus). Experimental results on causal cue tasks showed that t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80452-5
更新日期:2021-01-12 00:00:00
abstract::Coupling between dynamical heterogeneity of ionic liquids and their structural periodicity on different length-scales can be directly probed by quasielastic neutron scattering with polarization analysis. The technique provides the tools to investigate single-particle and cooperative ion motions separately and, thus, d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34481-w
更新日期:2018-11-06 00:00:00