LIMK1/2 inhibitor LIMKi 3 suppresses porcine oocyte maturation.

abstract：:In this study, we demonstrated the successful transformation of two pea (Pisum sativum L.) cultivars using Agrobacterium rhizogenes, whereby transgenic roots in the resulting composite plants showed expression of the gene encoding the green fluorescent protein. Subsequent to infection with A. rhizogenes, approximately...

journal_title：PeerJ

authors： Leppyanen IV,Kirienko AN,Dolgikh EA

更新日期：2019-03-06 00:00:00

abstract：BACKGROUND:Preterm birth is a main determinant of neonatal mortality and morbidity and a major contributor to the overall mortality and burden of disease. However, research of the preterm birth is hindered by the imprecise definition of the clinical phenotype and complexity of the molecular phenotype due to multiple pr...

journal_title：PeerJ

authors： Bukowski R,Sadovsky Y,Goodarzi H,Zhang H,Biggio JR,Varner M,Parry S,Xiao F,Esplin SM,Andrews W,Saade GR,Ilekis JV,Reddy UM,Baldwin DA

更新日期：2017-09-01 00:00:00

abstract：Background:Parkinson's disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which may characterize a prodromal phase of PD. A potential pharmacological strategy is to introduce neu...

journal_title：PeerJ

authors： Benvenutti R,Marcon M,Reis CG,Nery LR,Miguel C,Herrmann AP,Vianna MRM,Piato A

更新日期：2018-06-01 00:00:00

abstract：:Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance to inactivation by angiotensin converting enzyme (A...

journal_title：PeerJ

authors： Charest-Morin X,Bachelard H,Jean M,Marceau F

更新日期：2017-01-18 00:00:00

abstract：:Marine sponges host complex microbial consortia that vary in their abundance, diversity and stability amongst host species. While our understanding of sponge-microbe interactions has dramatically increased over the past decade, little is known about how sponges and their microbial symbionts interact with viruses, the ...

journal_title：PeerJ

authors： Pascelli C,Laffy PW,Kupresanin M,Ravasi T,Webster NS

更新日期：2018-10-17 00:00:00

abstract：:Researchers often need to consider the practical significance of a relationship. For example, interpreting the magnitude of an effect size or establishing bounds in equivalence testing requires knowledge of the meaningfulness of a relationship. However, there has been little research exploring the degree of relationsh...

journal_title：PeerJ

authors： Beribisky N,Davidson H,Cribbie RA

更新日期：2019-05-14 00:00:00

abstract：:Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We p...

journal_title：PeerJ

authors： McCann A,Ryan FJ,Stockdale SR,Dalmasso M,Blake T,Ryan CA,Stanton C,Mills S,Ross PR,Hill C

更新日期：2018-05-07 00:00:00

abstract：:Transmissible gastroenteritis virus (TGEV), belonging to the coronaviridae family, is the key cause of the fatal diarrhea of piglets and results in many pathological processes. microRNAs (miRNAs) play a key role in the regulation of virus-induced apoptosis. During the process of apoptosis induced by TGEV infection in ...

journal_title：PeerJ

authors： Zhao X,Song X,Bai X,Fei N,Huang Y,Zhao Z,Du Q,Zhang H,Zhang L,Tong D

更新日期：2016-02-04 00:00:00

abstract：:Solanum lycopersicum, belonging to Solanaceae, is one of the commonly used model plants. The GRAS genes are transcriptional regulators, which play a significant role in plant growth and development, and the functions of several GRAS genes have been recognized, such as, axillary shoot meristem formation, radial root pa...

journal_title：PeerJ

authors： Niu Y,Zhao T,Xu X,Li J

更新日期：2017-11-08 00:00:00

abstract：Background:In the absence of highly effective antiviral therapies against SARS-CoV-2, it is crucial to counter the known pathophysiological causes of severe COVID-19. Evaluating the efficacy existing drugs may expedite the development of such therapeutics. Severe COVID-19 is largely the result of a dysregulated immune ...

journal_title：PeerJ

authors： Kaye AG,Siegel R

更新日期：2020-11-02 00:00:00

abstract：Background:The Chinese Natural Forest Protection program has been conducted nationwide and has achieved resounding success. However, timber importation has increased; therefore, producing more domestic timber is critical to meet the demand for raw materials. Fertilization is one of the most effective silviculture pract...

journal_title：PeerJ

authors： Hou L,Dong Z,Yang Y,Zhang D,Zhang S,Zhang S

更新日期：2018-04-13 00:00:00

abstract：:Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Therapeutic options are still scarce. We hypothesized that cachexia-induced muscle oxidative stress may be attenuated in response to treatment with beta2-adrenoceptor-selective agonist formoterol in rats. In ...

journal_title：PeerJ

authors： Salazar-Degracia A,Busquets S,Argilés JM,López-Soriano FJ,Barreiro E

更新日期：2017-12-13 00:00:00

abstract：:Atoposaurid crocodyliforms represent an important faunal component of Late Jurassic to Early Cretaceous Laurasian semi-aquatic to terrestrial ecosystems, with numerous spatiotemporally contemporaneous atoposaurids known from western Europe. In particular, the Late Jurassic of France and Germany records evidence for hi...

journal_title：PeerJ

authors： Tennant JP,Mannion PD

更新日期：2014-09-25 00:00:00

abstract：:We explored the genetic background of social interactions in two breeding metapopulations of the pied flycatcher (Ficedula hypoleuca) in Western Siberia. In 2005, we sampled blood from birds breeding in study areas located in the city of Tomsk and in a natural forest 13 km southward of Tomsk (Western Siberia, Russia)....

journal_title：PeerJ

authors： Grinkov VG,Bauer A,Gashkov SI,Sternberg H,Wink M

更新日期：2018-12-06 00:00:00

abstract：:Turbidity currents are the main drivers behind the transportation of terrestrial sediments to the deep sea, and turbidite deposits from such currents have been widely used in geological studies. Nevertheless, the contribution of turbidity currents to vertical displacement of seawater has rarely been discussed. This is...

journal_title：PeerJ

authors： Kawagucci S,Miwa T,Lindsay DJ,Ogura E,Yamamoto H,Nishibayashi K,Yokooka H,Nishi S,Takahashi A,Lee S

更新日期：2020-12-09 00:00:00

abstract：:Genome sequencing is rapidly being adopted in reference labs and hospitals for bacterial outbreak investigation and diagnostics where time is critical. Seven gene multi-locus sequence typing is a standard tool for broadly classifying samples into sequence types (STs), allowing, in many cases, to rule a sample out of a...

journal_title：PeerJ

authors： Page AJ,Keane JA

更新日期：2018-07-31 00:00:00

abstract：:Forest soils sequester a large amount of carbon (C) and have a significant effect on the global C balance. Forests are commonly managed to maintain certain age structures but the effects of this management on soil C pools (kg C m-2) is still uncertain. We compared 40-year-old (1GF) and 24-year-old (2GF) plantations of...

journal_title：PeerJ

authors： Ma J,Han H,Cheng X

更新日期：2020-01-21 00:00:00

abstract：:Palythoa caribaeorum is a zoanthid often dominant in shallow rocky environments along the west coast of the Atlantic Ocean, from the tropics to the subtropics. This species has high environmental tolerance and is a good space competitor in reef environments. Considering current and future scenarios in the global clima...

journal_title：PeerJ

authors： Durante LM,Cruz ICS,Lotufo TMC

更新日期：2018-05-17 00:00:00

abstract：:Dendritic spines are described as neuronal protrusions. The morphology of dendritic spines and dendrites has a strong relationship to its function, as well as playing an important role in understanding brain function. Quantitative analysis of dendrites and dendritic spines is essential to an understanding of the forma...

journal_title：PeerJ

authors： Wang S,Chen M,Li Y,Shao Y,Zhang Y,Du S,Wu J

更新日期：2016-07-20 00:00:00

abstract：:Although liver cirrhosis and hepatocellular carcinoma are major consequences of hepatitis C (HCV), there has been an increasing number of studies examining extrahepatic manifestations, especially those caused by systemic chronic inflammation and metabolic complications that might predispose HCV patients to atheroscler...

journal_title：PeerJ

authors： Pavicic Ivelja M,Dolic K,Tandara L,Perkovic N,Mestrovic A,Ivic I

更新日期：2021-01-14 00:00:00

abstract：:Acontia, located in the gastrovascular cavity of anemone, are thread-like tissue containing numerous stinging cells which serve as a unique defense tissue against predators of the immobile acontiarian sea anemone. Although its morphology and biological functions, such as defense and digestion, have been studied, the d...

journal_title：PeerJ

authors： Lam J,Cheng YW,Chen WU,Li HH,Chen CS,Peng SE

更新日期：2017-02-21 00:00:00

abstract：:Background. Physical, visual, chemical, and auditory cues signalling fighting ability have independently evolved in many animal taxa as a means to resolve conflicts without escalating to physical aggression. Facial width-to-height ratio (fWHR, i.e., the relative width to height of the face) has been associated with do...

journal_title：PeerJ

authors： Borgi M,Majolo B

更新日期：2016-03-21 00:00:00

abstract：:Plasma membrane NADPH oxidases, also named respiratory burst oxidase homologues (Rbohs), play pivotal roles in many aspects of growth and development, as well as in responses to hormone signalings and various biotic and abiotic stresses. Although Rbohs family members have been identified in several plants, little is k...

journal_title：PeerJ

authors： Zhang G,Yue C,Lu T,Sun L,Hao F

更新日期：2020-01-17 00:00:00

abstract：Background:Electrochemical signals play an important role in cell communication and behavior. Electrically charged ions transported across cell membranes maintain an electrochemical imbalance that gives rise to bioelectric signaling, called membrane potential or Vmem. Vmem plays a key role in numerous inter- and intrac...

journal_title：PeerJ

authors： Bhavsar MB,Cato G,Hauschild A,Leppik L,Costa Oliveira KM,Eischen-Loges MJ,Barker JH

更新日期：2019-02-08 00:00:00

abstract：:Melanoma is a global concern and accounts for the major mortality of skin cancers. Herpes simplex virus thymidine kinase gene with ganciclovir (HSV-TK/GCV) is a promising gene therapy for melanoma. Despite its low efficiency, it is well known for its bystander effect which is mainly mediated by gap junction. In this s...

journal_title：PeerJ

authors： Li H,Du H,Zhang G,Wu Y,Qiu P,Liu J,Guo J,Liu X,Sun L,Du B,Tan Y

更新日期：2019-09-20 00:00:00

abstract：:Metoposaurids are representatives of the extinct amphibian clade Temnospondyli, found on almost every continent exclusively in the Late Triassic deposits. Osteohistologically, it is one of the best-known temnospondyl groups, analyzed with a wide spectrum of methods, such as morphology, morphometry, bone histology or c...

journal_title：PeerJ

authors： Teschner EM,Chakravorti S,Sengupta DP,Konietzko-Meier D

更新日期：2020-09-08 00:00:00

abstract：:Introduction. Adolescent interpersonal violence is a global public health problem, yet gaps remain in the epidemiologic literature on adolescent violence in low- and middle-income countries (LMIC). Prevalence rates and risk and protective factors reported in high-income countries may be different from those reported i...

journal_title：PeerJ

authors： Celedonia KL,Wilson ML,El Gammal HA,Hagras AM

更新日期：2013-08-13 00:00:00

abstract：Background:Self-efficacy and enjoyment are two main constructs proposed within many motivational theories in any human endeavor, sport and physical activity included. Methods:The purpose of this study was to examine the factor structure of two pictorial scales measuring self-efficacy and enjoyment levels in a sample o...

journal_title：PeerJ

authors： Morano M,Bortoli L,Ruiz MC,Vitali F,Robazza C

更新日期：2019-07-29 00:00:00

abstract：:The recent publication of a number of high resolution bacterial voltage-gated sodium channel structures has opened the door for the mechanisms employed by these channels to distinguish between ions to be elucidated. The way these channels select between Na(+) and K(+) has been investigated in computational studies, bu...

journal_title：PeerJ

authors： Corry B

更新日期：2013-02-12 00:00:00

abstract：:Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment of diuresis, bacterial infections and cancer, as well as a...

journal_title：PeerJ

authors： Zhou L,Fu X,Jiang L,Wang L,Bai S,Jiao Y,Xing S,Li W,Ma J

更新日期：2017-12-20 00:00:00