Abstract：
:Phosphatases play key roles in normal physiology and diseases. Studying phosphatases has been both essential and challenging, and the application of conventional genetic and biochemical methods has led to crucial but still limited understanding of their mechanisms, substrates, and exclusive functions within highly intricate networks. With the advances in technologies such as cellular imaging and molecular and chemical biology in terms of sensitive tools and methods, the phosphatase field has thrived in the past years and has set new insights for cell signaling studies and for therapeutic development. In this review, we give an overview of the existing interdisciplinary tools for phosphatases, give examples on how they have been applied to increase our understanding of these enzymes, and suggest how they-and other tools yet barely used in the phosphatase field-might be adapted to address future questions and challenges.
journal_name
ACS Chem Bioljournal_title
ACS chemical biologyauthors
Fahs S,Lujan P,Köhn Mdoi
10.1021/acschembio.6b00570subject
Has Abstractpub_date
2016-11-18 00:00:00pages
2944-2961issue
11eissn
1554-8929issn
1554-8937journal_volume
11pub_type
杂志文章,评审abstract：:The LpxC enzyme in the lipid A biosynthetic pathway is one of the most promising and clinically unexploited antibiotic targets for treatment of multidrug-resistant Gram-negative infections. Progress in medicinal chemistry has led to the discovery of potent LpxC inhibitors with a variety of chemical scaffolds and disti...
journal_title：ACS chemical biology
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abstract：:The publication of the first high-resolution crystal structure of a eukaryotic Cys-loop receptor, GluClα, has provided valuable structural information on this important class of ligand-gated ion channels (LGIC). However, limited functional data exist for the GluCl receptors. Before applying the structural insights fro...
journal_title：ACS chemical biology
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journal_title：ACS chemical biology
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journal_title：ACS chemical biology
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journal_title：ACS chemical biology
pub_type： 评论,杂志文章,评审
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更新日期：2013-02-15 00:00:00
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更新日期：2018-09-21 00:00:00
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更新日期：2018-11-16 00:00:00
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更新日期：2019-04-19 00:00:00
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更新日期：2015-01-16 00:00:00
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更新日期：2019-09-20 00:00:00
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更新日期：2008-03-20 00:00:00
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更新日期：2011-01-21 00:00:00
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