Abstract:
:The goal of incorporating renewable carbon into the fuel and chemical enterprise will most likely be successful when combined systems of biocatalysts and chemical catalysts are exploited. Significant efforts in the biocatalytic release of sugars from biomass are being pursued for subsequent use in fermentation. Two recent papers demonstrate an alternative approach to converting these sugars to a liquid fuel by using chemical catalysts.
journal_name
ACS Chem Bioljournal_title
ACS chemical biologyauthors
Shanks BHdoi
10.1021/cb7001522subject
Has Abstractpub_date
2007-08-17 00:00:00pages
533-5issue
8eissn
1554-8929issn
1554-8937journal_volume
2pub_type
杂志文章abstract::Benzodiazepines are clinically relevant drugs that bind to GABAA neurotransmitter receptors at the α+/γ2- interfaces and thereby enhance GABA-induced chloride ion flux leading to neuronal hyperpolarization. However, the structural basis of benzodiazepine interactions with their high-affinity site at GABAA receptors is...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.8b00144
更新日期:2018-08-17 00:00:00
abstract::Aldehydes are key intermediates in many cellular processes, from endogenous metabolic pathways like glycolysis to undesired exogenously induced processes such as lipid peroxidation and DNA interstrand cross-linking. Alkyl aldehydes are well documented to be cytotoxic, affecting the functions of DNA and protein, and th...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.6b00269
更新日期:2016-08-19 00:00:00
abstract::Enzymatic transfer of the AMP portion of ATP to substrate proteins has recently been described as an essential mechanism of bacterial infection for several pathogens. The first AMPylator to be discovered, VopS from Vibrio parahemolyticus, catalyzes the transfer of AMP onto the host GTPases Cdc42 and Rac1. Modification...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb4006886
更新日期:2014-02-21 00:00:00
abstract::Epitranscriptomic modifications play an important role in RNA function and can impact gene expression. Here, we apply a chemical proteomics approach to investigate readers of N1-methyladenosine (m1A), a poorly characterized modification on mammalian mRNA. We find that YTHDF proteins, known m6A readers, recognize m1A-m...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.9b00655
更新日期:2020-01-17 00:00:00
abstract::The remodeling of active sites to generate novel biocatalysts is an attractive and challenging task. We developed a stepwise loop insertion strategy (StLois), in which randomized residue pairs are inserted into active site loops. The phosphotriesterase-like lactonase from Geobacillus kaustophilus (GkaP-PLL) was used t...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.7b00018
更新日期:2017-05-19 00:00:00
abstract::The ever-growing drug resistance problem worldwide highlights the urgency to discover and develop new drugs. Microbial natural products are a prolific source of drugs. Genome sequencing has revealed a tremendous amount of uncharacterized natural product biosynthetic gene clusters (BGCs) encoded within microbial genome...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.0c00581
更新日期:2020-09-18 00:00:00
abstract::Though phenotypic and target-based high-throughput screening approaches have been employed to discover new antibiotics, the identification of promising therapeutic candidates remains challenging. Each approach provides different information, and understanding their results can provide hypotheses for a mechanism of act...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.7b00468
更新日期:2017-09-15 00:00:00
abstract::We have developed a chemically controlled very long-acting delivery system to support once-monthly administration of a peptidic GLP-1R agonist. Initially, the prototypical GLP-1R agonist exenatide was covalently attached to hydrogel microspheres by a self-cleaving β-eliminative linker; after subcutaneous injection in ...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.7b00218
更新日期:2017-08-18 00:00:00
abstract::Despite the stereospecificity of translation for l-amino acids (l-AAs) in vivo, synthetic biologists have enabled ribosomal incorporation of d-AAs in vitro toward encoding polypeptides with pharmacologically desirable properties. However, the steps in translation limiting d-AA incorporation need clarification. In this...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.8b00952
更新日期:2019-02-15 00:00:00
abstract::The human ClpP proteolytic complex (HsClpP) is a serine protease located in the mitochondrial matrix and participates in the maintenance of the mitochondrial proteome among other cellular functions. HsClpP typically forms a multimeric complex with the AAA+ protein unfoldase HsClpX. Notably, compared to that of normal,...
journal_title:ACS chemical biology
pub_type: 杂志文章,评审
doi:10.1021/acschembio.9b00347
更新日期:2019-11-15 00:00:00
abstract::As part of the central core domain of the ribosome, helix 69 of 23S rRNA participates in an important intersubunit bridge and contacts several protein translation factors. Helix 69 is believed to play key roles in protein synthesis. Even though high-resolution crystal structures of the ribosome exist, the solution dyn...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb200497q
更新日期:2012-05-18 00:00:00
abstract::Chromophore-assisted light inactivation (CALI) is a potentially powerful tool for the acute disruption of a target protein inside living cells with high spatiotemporal resolution. This technology, however, has not been widely utilized, mainly because of the lack of an efficient chromophore as the photosensitizing agen...
journal_title:ACS chemical biology
pub_type: 信件
doi:10.1021/cb100431e
更新日期:2011-05-20 00:00:00
abstract::Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene, which produces an essential protein known as SMN. The severity of SMA is modified by variable copy number of a second gene,SMN2, which produces an mRNA that is incorrectly spliced with deletion of the last exon. We describ...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb800120t
更新日期:2008-11-21 00:00:00
abstract::mRNA-based therapies and vaccines constitute a disruptive technology with the potential to revolutionize modern medicine. Chemically modified 5' cap structures have provided access to mRNAs with superior translational properties that could benefit the currently flourishing mRNA field. Prime examples of compounds that ...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.0c00864
更新日期:2021-01-13 00:00:00
abstract::A major risk for patients having estrogen receptor α (ERα)-positive breast cancer is the recurrence of drug-resistant metastases after initial successful treatment with endocrine therapies. Recent studies have implicated a number of activating mutations in the ligand-binding domain of ERα that stabilize the agonist co...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.8b00877
更新日期:2018-12-21 00:00:00
abstract::The endoplasmic reticulum (ER) is the initial site of biogenesis of secretory pathway proteins, including proteins localized to the ER, Golgi, lysosomes, intracellular vesicles, plasma membrane, and extracellular compartments. Proteins within the secretory pathway contain a high abundance of disulfide bonds to protect...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.9b01014
更新日期:2020-02-21 00:00:00
abstract::HIV infection is pandemic in humans and is responsible for millions of deaths every year. The discovery of new cellular targets that can be used to prevent the infection process represents a new opportunity for developing more effective antiviral drugs. In this context, dendritic cell-specific ICAM-3 grabbing non-inte...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb900216e
更新日期:2010-03-19 00:00:00
abstract::Human alkyladenine DNA glycosylase (AAG) initiates the base excision repair pathway by excising alkylated and deaminated purine lesions. In vitro biochemical experiments demonstrate that AAG uses facilitated diffusion to efficiently search DNA to find rare sites of damage and suggest that electrostatic interactions ar...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.5b00409
更新日期:2015-11-20 00:00:00
abstract::Reactive oxygen species (ROS) play an important role in the onset of Parkinson's disease (PD), and deciphering protective mechanisms is a major goal for therapeutic development. Here, DJ-1 (PARK7) gained major attention when a conserved cysteine residue with a putative role in oxidative stress sensing/protection was l...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.8b00633
更新日期:2018-08-17 00:00:00
abstract::Hydrogen sulfide (H2S) is an important gasotransmitter and biomolecule, and many synthetic small-molecule H2S donors have been developed for H2S-related research. One important class of triggerable H2S donors is self-immolative thiocarbamates, which function by releasing carbonyl sulfide (COS), which is rapidly conver...
journal_title:ACS chemical biology
pub_type: 信件
doi:10.1021/acschembio.8b00981
更新日期:2019-02-15 00:00:00
abstract::Microbes are essential to the global ecosystem, but undesirable microbial growth causes issues ranging from food spoilage and infectious diseases to harmful cyanobacterial blooms. The use of chemicals to control microbial growth has achieved significant success, while specific roles for a majority of essential genes i...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.0c00507
更新日期:2020-08-21 00:00:00
abstract::Seasonal and pandemic influenza viruses continue to be a leading global health concern. Emerging resistance to the current drugs and the variable efficacy of vaccines underscore the need for developing new flu drugs that will be broadly effective against wild-type and drug-resistant influenza strains. Here, we report ...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb400400j
更新日期:2013-11-15 00:00:00
abstract::Polyhalogenated dibenzo-p-dioxins are arguably among the most toxic molecules known to man. In addition to anthropogenic sources, marine invertebrates also harbor polybrominated dibenzo-p-dioxins of as yet unknown biogenic origin. Here, we report that the bmp gene locus in marine bacteria, a recently characterized sou...
journal_title:ACS chemical biology
pub_type: 信件
doi:10.1021/cb5004338
更新日期:2014-09-19 00:00:00
abstract::Lysine specific demethylase 1 (LSD1, also known as KDM1) is a histone modifying enzyme that regulates the expression of many genes important in cancer progression and proliferation. It is present in various transcriptional complexes including those containing the estrogen receptor (ER). Indeed, inhibition of LSD1 acti...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb300108c
更新日期:2012-07-20 00:00:00
abstract::The T cell receptor (TCR)-cluster of differentiation 3 (CD3) signaling complex plays an important role in initiation of adaptive immune responses, but weak interactions have obstructed delineation of the individual TCR-CD3 subunit interactions during T cell signaling. Here, we demonstrate that unnatural amino acids (U...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb500351s
更新日期:2014-09-19 00:00:00
abstract::Light-activated protein domains provide a convenient, modular, and genetically encodable sensor for optogenetics and optobiology. Although these domains have now been deployed in numerous systems, the precise mechanism of photoactivation and the accompanying structural dynamics that modulate output domain activity rem...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.0c00543
更新日期:2020-10-16 00:00:00
abstract::Various potential G-quadruplex forming sequences present in the genome offer a platform to modulate their function by means of stabilizing molecules. Though G-quadruplex structures exhibit diverse structural topologies, the presence of G-quartets as a common structural element makes the design of topology specific lig...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb5008597
更新日期:2015-03-20 00:00:00
abstract::Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of Ubc13 with two inhibitors, NSC697923 and BAY 11-7082, which inhibit DNA damage and NF-κB signaling in human cells. NSC697923 and BAY 11-7082 both i...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.5b00222
更新日期:2015-07-17 00:00:00
abstract::Sugar aminotransferases (SATs) are an important class of tailoring enzymes that catalyze the 5'-pyridoxal phosphate (PLP)-dependent stereo- and regiospecific installation of an amino group from an amino acid donor (typically L-Glu or L-Gln) to a corresponding ketosugar nucleotide acceptor. Herein we report the strateg...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/acschembio.5b00244
更新日期:2015-09-18 00:00:00
abstract::Platinum-based drugs have been used to successfully treat diverse cancers for several decades. Cisplatin, the original compound of this class, cross-links DNA, resulting in cell cycle arrest and cell death via apoptosis. Cisplatin is effective against several tumor types, yet it exhibits toxic side effects and tumors ...
journal_title:ACS chemical biology
pub_type: 杂志文章
doi:10.1021/cb300320d
更新日期:2012-11-16 00:00:00