当前位置： SCI文献检索 > JOURNAL OF ENDODONTICS期刊下所有文献 > Effects of a Bioactive Scaffold Containing a Sustained Transforming Growth Factor-β1-releasing Nanoparticle System on the Migration and Differentiation of Stem Cells from the Apical Papilla.

Effects of a Bioactive Scaffold Containing a Sustained Transforming Growth Factor-β1-releasing Nanoparticle System on the Migration and Differentiation of Stem Cells from the Apical Papilla.

Abstract：

INTRODUCTION:This 2-part study hypothesized that a bioactive scaffold containing a sustained transforming growth factor (TGF)-β1-releasing nanoparticle system will promote migration and enhance differentiation of stem cells from the apical papilla (SCAP). The study aimed to develop and characterize a novel modified chitosan-based scaffold containing TGF-β1-releasing chitosan nanoparticles (TGF-β1-CSnp) to enhance migration and differentiation of SCAP. METHODS:Part I concerns the synthesis and characterization of a carboxymethyl chitosan-based scaffold and TGF-β1-CSnp. Part II examines the effect of sustained TGF-β1 release from scaffold containing TGF-β1-CSnp on odontogenic differentiation of SCAP. RESULTS:The scaffold demonstrated properties conducive to cellular activities. The incorporation of TGF-β1 in CSnp allowed sustained release of TGF-β1, facilitating delivery of a critical concentration of TGF-β1 at the opportune time. TGF-β1 bioactivity was maintained for up to 4 weeks. SCAP showed greater viability, migration, and biomineralization in the presence of TGF-β1-CSnp than in the presence of free TGF-β1. SCAP cultured in TGF-β1-CSnp + scaffold showed significantly higher dentin matrix protein-1 and dentin sialophosphoprotein signals compared with free TGF-β1 + scaffold or CSnp + scaffold. CONCLUSIONS:These experiments highlighted the potential of a carboxymethyl chitosan-based scaffold with growth factor releasing nanoparticles to promote migration and differentiation of SCAP. The results of this study may have direct application to improve current endodontic regenerative protocols.

journal_name

J Endod

journal_title

Journal of endodontics

authors

Bellamy C,Shrestha S,Torneck C,Kishen A

doi

10.1016/j.joen.2016.06.017

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1385-92

issue

9

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(16)30372-7

journal_volume

42

pub_type

杂志文章

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