Abstract:
:A new model of subacute compression of the spinal cord is described. Using an expanding epidural mass, a gradual, progressive, and highly reproducible neurological deficit was induced in rats over a 7-day period, resulting in paraplegia. Studies of spinal cord edema, disruption of the blood-spinal cord barrier, and somatosensory evoked responses, as well as histopathological and microangiographical studies, revealed a marked similarity to changes produced in other spinal compression models and in humans. The model may serve to answer some fundamental questions regarding the pathophysiology and efficacy of various treatment modalities of spinal cord compression.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Arbit E,Galicich W,Galicich JH,Lau Ndoi
10.1227/00006123-198906000-00011subject
Has Abstractpub_date
1989-06-01 00:00:00pages
860-3issue
6eissn
0148-396Xissn
1524-4040journal_volume
24pub_type
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