Abstract:
OBJECTIVE:Vestibular schwannomas present significant management challenges in patients with neurofibromatosis Type 2 (NF2). We evaluated the results of gamma knife radiosurgery for the management of these tumors, focusing on tumor response, hearing preservation, and other factors affecting outcomes. METHODS:Stereotactic radiosurgery was performed to manage 74 schwannomas in 62 patients. Ipsilateral serviceable hearing was present in 35% of tumors before the procedure. The mean tumor volume was 5.7 cm3. The mean margin and maximum dose used were 14 and 27.5 Gy, respectively. Cox regression analyses were performed to identify factors affecting outcomes. RESULTS:The median follow-up period was 53 months, and two patients were lost to follow-up. Actuarial local control rates at were 85, 81, and 81% at 5, 10, and 15 years, respectively. Tumor volume was significant as a predictor of local control. Since 1992, using current radiosurgery techniques (magnetic resonance imaging scan targeting and reduced margin dose to 14 Gy or less), the actuarial serviceable hearing preservation rate is 73% at 1 year, 59% at 2 years, and 48% at 5 years after radiosurgery. Facial neuropathy occurred in 8% of tumors, trigeminal neuropathy occurred in 4%, and vestibular dysfunction occurred in 4%. Radiation dose and tumor volume were predictive of development of new deficits. No radiosurgery-associated secondary tumors or atypical or malignant changes were noted. CONCLUSION:Stereotactic radiosurgery is a safe and effective management modality for neurofibromatosis Type 2 vestibular schwannomas. Although results do not seem to be as good as for patients with sporadic unilateral tumors, gamma knife radiosurgery results seem favorable and indicate that radiosurgery should be strongly considered for primary tumor management in selected patients.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Mathieu D,Kondziolka D,Flickinger JC,Niranjan A,Williamson R,Martin JJ,Lunsford LDdoi
10.1227/01.NEU.0000255340.26027.53subject
Has Abstractpub_date
2007-03-01 00:00:00pages
460-8; discussion 468-70issue
3eissn
0148-396Xissn
1524-4040pii
00006123-200703000-00005journal_volume
60pub_type
临床试验,杂志文章相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:Cerebral autoregulation maintains a relatively stable cerebral blood flow over a range of perfusion pressures. During exercise, regional cerebral blood flow may be elevated in particular areas of the brain. This case report presents the impact of aerobic exercise on intracranially measured pressure and brain ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000371976.21043.C8
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Infection is a significant cause of morbidity with cranioplasty procedures. However, few studies have investigated the effect of specific surgical practices on cranioplasty infection. OBJECTIVE:To analyze the literature on the effect of early surgery (within 3 months of craniectomy), implant material, and m...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/NEU.0b013e31820a5470
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Treatment of one side in cases of dissecting aneurysms of the bilateral vertebral arteries (VAs) with subarachnoid hemorrhage may result in dissection or rupture on the contralateral side. CLINICAL PRESENTATION:Three patients presented with dissecting aneurysms of the bilateral VAs with subara...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200206000-00033
更新日期:2002-06-01 00:00:00
abstract::Anterior cervical instrumentation is used as an adjunct to bone fusion; however, definitive biomechanical data to support some applications and techniques are lacking. In the absence of supportive experimental data, posterior cortical penetration has been recommended with the Caspar system. Previously, we compared the...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199312000-00013
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Identifying which factors influence treatment costs of transsphenoidal surgery for removal of sellar lesions can be complex. OBJECTIVE:To identify which patient-level factors are associated with higher costs and evaluate the relationship between expenditures and short-term patient-reported outcomes. METHOD...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx471
更新日期:2018-10-01 00:00:00
abstract::A case of cerebellopontine angle petrous bone osteoma manifesting as homolateral trigeminal neuralgia and causing a mild brain stem compression is presented. The literature concerning osteomas and particularly those affecting the temporal bone is reviewed. This is the second report of an osteoma located on the inner s...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199412000-00018
更新日期:1994-12-01 00:00:00
abstract:INTRODUCTION:Isolated spinal aneurysms are rare; only a few have been reported. To the best of our knowledge, this series represents the largest experience with four ruptured spinal aneurysms, all of which were treated surgically. METHODS:Clinical information from the hospital charts and diagnostic images of four pati...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000186010.34779.10
更新日期:2005-12-01 00:00:00
abstract:UNLABELLED:BAC1KGROUND: AG1478 is an epithelial growth factor receptor tyrosine kinase inhibitor. Epithelial growth factor receptor regulates the expression of cadherin in cells via its action on β-catenin, and N-cadherin downregulation promotes infiltration and cerebrospinal fluid (CSF) dissemination of glioma cells. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318215a3d0
更新日期:2011-08-01 00:00:00
abstract::A stab wound to the right flank of a 24-year-old man produced immediate paralysis of both legs but spared sensation. Recovery was slow but sufficient to allow walking with a cane. Radicular artery interruption, in combination with systemic hypotension, is presumed to have caused selective watershed infarction of the s...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199308000-00014
更新日期:1993-08-01 00:00:00
abstract::In this study, we reevaluate the results of radiofrequency rhizotomy and review the effectiveness of other surgical procedures for the treatment of trigeminal neuralgia. Five hundred patients with trigeminal neuralgia underwent radiofrequency rhizotomy at the University of Cincinnati Medical Center, Cincinnati, OH, be...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199605000-00001
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:We compared long-term seizure outcome and health-related quality of life (HRQoL) of patients who underwent epilepsy surgery and matched medically treated nonsurgical controls with intractable epilepsy. METHODS:Medically treated controls were identified for patients operated on for epilepsy between January 1,...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000315999.58022.1c
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Trigeminal neuralgia is often caused by compression, demyelination, and injury of the trigeminal nerve root entry zone by an adjacent artery and/or vein. Previously described variations of the nerve-vessel relationship note external nerve compression. We offer a detailed classification of intraneural vessels ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000351757.29658.C0
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:The prognosis of giant aneurysms remains poor despite recent advances in microneurosurgery. Thick-walled and partially calcified giant aneurysms with an atheromatic base are difficult to clip safely. Special techniques allowing reshaping of the base and ensuring the stability of clips are often needed. We pre...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000330400.68015.88
更新日期:2009-03-01 00:00:00
abstract::Infusion of 25% mannitol into the internal carotid artery of the dog results in a reversible disruption of the blood-brain barrier (BBB). This osmotic BBB disruption enhances the penetratin of systemically administered methotrexate (MTX) into the ipsilateral cerebral hemisphere. Brain methotexate levels were maximized...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198007000-00006
更新日期:1980-07-01 00:00:00
abstract::A large meningioma in the cerebellopontine angle manifested itself as a contralateral hemifacial spasm. On computed tomographic and magnetic resonance imaging scans, the brain stem was markedly displaced and distorted by the tumor. After total removal of the meningioma, the hemifacial spasm completely disappeared. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199502000-00021
更新日期:1995-02-01 00:00:00
abstract::Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the tr...
journal_title:Neurosurgery
pub_type: 传,历史文章,杂志文章
doi:10.1097/00006123-200203000-00032
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:Cognitive decline occurs in 25% of patients after carotid endarterectomy (CEA). Elevated serum concentrations of S-100B and neuron-specific enolase (NSE) occur after stroke, and serum S-100B levels at 24 hours are associated with clinical outcome after both stroke and CEA. We hypothesized that we could detect...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000093493.16850.11
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To describe a procedure for Leksell gamma knife (LGK) radiosurgery in a lateral position, for treatment of far-lateral intracranial lesions. METHODS:Positioning of the patient in the lateral decubitus position during LGK treatment switches the x and y axis coordinates. This increases the range of the x axis ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Cerebral vasospasm is an independent predictor of poor outcome after subarachnoid hemorrhage (SAH). The nitric oxide-cyclic guanosine monophosphate (NO-cGMP) vasodilatory pathway is strongly implicated in its pathophysiology. Preliminary studies suggest that phosphodiesterase 5 (PDE5), an enzyme that degrade...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31822ec2b0
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Aneurysmal subarachnoid hemorrhage (aSAH) is associated with disproportionally high mortality and long-term neurological sequelae. Management of patients with aSAH has changed markedly over the years, leading to improvements in outcome. OBJECTIVE:To describe trends in aSAH care and outcome in a high-volume ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa465
更新日期:2020-12-11 00:00:00
abstract:OBJECTIVE:Subarachnoid hemorrhage (SAH) predisposes patients to excessive natriuresis and volume contraction. We studied the effects of postoperative administration of 5% albumin solution on sodium balance and blood volume after SAH. We also sought to identify physiological variables that influence renal sodium excreti...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006123-199804000-00048
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To determine the usefulness of endovascular embolization for treatment of dural arteriovenous fistulae of the superior petrosal sinus. METHODS:We performed a retrospective review of 18 patients treated during a 16-year period. Transarterial and/or transvenous embolizations were performed as a preoperative ad...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000068790.37318.24
更新日期:2003-07-01 00:00:00
abstract::Metastatic lesions to the midbrain are rare. They are found in 1 to 3% of autopsy series of solitary brain metastases. The consensus of opinion in the current literature is that they are inoperable lesions and should be treated by radiation therapy alone. This is the first case report of a completely excised metastati...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198606000-00022
更新日期:1986-06-01 00:00:00
abstract:OBJECTIVE:To determine whether low-grade gliomas contain functional cortical activity more often than high-grade gliomas within radiologically defined abnormal tissue. METHODS:Patients with intra-axial cerebral lesions located in the vicinity of eloquent brain cortex preoperatively underwent magnetic source imaging. A...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200112000-00005
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:Hemifacial spasm caused by a cerebellopontine angle lipoma is extremely rare. We describe a patient with left-sided hemifacial spasm caused by vascular compression of the facial and vestibulocochlear cranial nerves by the anteroinferior cerebellar artery embedded within a cerebellopontine angle lipoma. CLINI...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000325734.30302.97
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Immunostaining for p53 commonly is considered a marker of neoplasia. Previous studies of nonneoplastic processes have yielded conflicting results. METHODS:To test the assumption that p53 immunoreactivity indicates neoplasia, we examined 60 formalin-fixed, paraffin-embedded biopsies of nonneoplastic central n...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200211000-00021
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:Iron catalyzed generation of injurious free radicals has been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). The present study assessed the effects of the iron chelator deferiprone on cerebral vasospasm in an in vivo rabbit model of SAH. METHODS:Twenty-four rabbits ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199712000-00028
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Magnetic resonance with diffusion tensor image (DTI) may be able to estimate trajectories compatible with subcortical tracts close to brain lesions. A limit of DTI is brain shifting (movement of the brain after dural opening and tumor resection). OBJECTIVE:To calculate the brain shift of trajectories compat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31821a8555
更新日期:2011-09-01 00:00:00
abstract::This experiment was designed to study the effects of intravascular volume expansion with crystalloid and colloid agents on intracranial pressure (ICP) and computerized electroencephalographic (EEG) data in dogs with cerebral vasogenic edema. A liquid nitrogen cold lesion was produced in the right parietal lobes of 30 ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198908000-00004
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:The contralateral approach to internal carotid-ophthalmic artery aneurysms has been used in selected cases but has rarely been described for a giant internal carotid artery aneurysm. We report a case of giant aneurysm that was successfully clipped via the contralateral pterional approach. CLIN...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200104000-00059
更新日期:2001-04-01 00:00:00