Abstract:
OBJECTIVE:The aim of the study was to assess the diagnostic value of computed tomography perfusion (CTp) of prostate in distinguishing between normal tissue and malignant lesion by using quantitative threshold values of CTp parameters. MATERIALS AND METHODS:Sixty-one consecutive men with indication for radical prostatectomy were prospectively enrolled. All patients were intravenously injected with 80-mL bolus of nonionic iodinated contrast medium during cine-mode acquisition protocol. Perfusion data sets were analyzed by a dedicated software system and values for each of the 4 CTp parameters (blood volume, blood flow, mean transit time, and permeability surface-area product measurements) were recorded. Receiver operating characteristic curves were calculated to find which CTp parameter and which cutoff value might reveal the best diagnostic accuracy. Histopathology was used as reference standard. RESULTS:Statistical correlation between radiological and pathological results was performed on 48 patients using 3456 segmented squares. Blood volume and permeability surface revealed the best diagnostic accuracy for differentiating between malignant and benign squares, with cutoff values of 6.1 and 16.5, respectively, and a sensitivity of 84.8% and 81.8%, respectively. All parameters showed also a high negative predictive value: 97.1% for blood volume and 95.4% for permeability surface. CONCLUSIONS:Blood volume and permeability surface are the 2 CTp parameters with the highest diagnostic accuracy in differentiating between normal tissue and prostatic neoplasia. Due to the extremely high negative predictive value, they are particularly valuable in excluding the presence of cancer and thus resulting potentially useful in assessing cancer response to adjuvant therapy.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Osimani M,Bellini D,Pastore A,Palleschi G,Di Cristofano C,Rengo M,Porta N,Boboc GI,Della Rocca C,Carbone A,Petrozza V,Laghi Adoi
10.1097/RCT.0000000000000432subject
Has Abstractpub_date
2016-09-01 00:00:00pages
740-5issue
5eissn
0363-8715issn
1532-3145journal_volume
40pub_type
杂志文章abstract:OBJECTIVE:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disorder, characterized by hemosiderin deposition in the proximal renal tubules. MATERIALS AND METHODS:We examined six cases of PNH with MRI including gradient echo imaging. RESULTS:On T2- and T2*-weighted imaging a characteristic hypointens...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199309000-00016
更新日期:1993-09-01 00:00:00
abstract::Uterine cirsoid aneurysm is uncommon. It is important to make a diagnosis of this disease preoperatively, because repeated curettages may induce life-threatening massive genital bleeding. We present a case of a 51-year-old woman with uterine cirsoid aneurysm in whom MRI and MRA were very useful for the preoperative di...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199603000-00023
更新日期:1996-03-01 00:00:00
abstract::Acute infarction of an appendix epiploica resulted in an inflammatory process involving the caudal aspect of the transverse colon and the adjacent greater omentum. Computed tomography demonstrated prominent linear soft tissue densities, an increase in CT number of the involved greater omentum, and posterior displaceme...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198601000-00032
更新日期:1986-01-01 00:00:00
abstract::We report imaging findings in five patients who had sudden cardiac arrest during contrast-enhanced computed tomography (CT). We observed strikingly dense abdominal veins, variable degrees of arterial enhancement, and poor abdominal visceral enhancement. Comparison with a control group of 30 patients revealed a statist...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200301000-00017
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:The Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Trial phase III is a multicenter, randomized clinical trial in the management and treatment of subjects with small intracerebral hemorrhage and large intraventricular hemorrhage. Accurate localization, segmentation, and quantific...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/RCT.0b013e318245c1fa
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To investigate the magnetic resonance imaging (MRI) features of well-differentiated hepatocellular carcinoma (HCC). METHODS:We reviewed the MRI of 32 patients with 33 pathologically confirmed well-differentiated HCC. The MRI protocol included T2-weighted imaging with and without fat saturation, dual-phase T1...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200607000-00008
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Among the various organs that may be affected by hereditary hemorrhagic telangiectasia (HHT), the liver can show various degrees of vascular and parenchymal involvement. The purpose of this prospective study comprising a large series of patients was to reassess the computed tomography (CT) features of hepatic...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200407000-00009
更新日期:2004-07-01 00:00:00
abstract::A case of a 26-year-old woman with decreasing vision in her right eye, diplopia, headache, and galactorrhea is presented. Both CT and MR studies showed a large sphenoid fibroosseous lesion that had a ground glass appearance on CT and low-to-intermediate proton density and low T2-weighted and low T1-weighted signal int...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199305000-00032
更新日期:1993-05-01 00:00:00
abstract::We aim to review the imaging appearance of peripheral nerve sheath tumors (PNSTs) of head and neck according to updated fourth edition of World Health Organization classification. Peripheral nerve sheath tumor can be sporadic or associated with neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. S...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0000000000001109
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the prevention of liver ischemic injury by preoperative coil embolization in patients with a replaced hepatic artery scheduled for pancreatectomy with splanchnic artery resection. METHODS:Between July 2009 and May 2012, 4 patients with replaced hepatic artery underwent p...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000325
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence of azygos arch valves and assess azygos valve insufficiency at computed tomography angiography (CTA) of the chest or body with high rate contrast material injection. METHODS:Three hundred twenty-one CTAs using high intravenous injection rates (3-5 mL/second) of 300 mgI/mL contrast ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31819679ae
更新日期:2009-09-01 00:00:00
abstract::Fifteen of 605 examinations of patients aged 60 to 85 years showed symmetrical white matter hypodensity on computed tomography (CT). Six of these showed severe white matter hypodensity, low grade atrophy, and dilated ventricles. A diagnosis of encephalopathia subcorticalis chronica progressiva, or Binswanger disease, ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198002000-00003
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to define the range of abnormalities and to assess the contribution of high-resolution CT (HRCT) in the evaluation of miliary tuberculosis involving the lung parenchyma. MATERIALS AND METHODS:The authors retrospectively reviewed HRCT scans of 11 patients with microbiologically o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199411000-00003
更新日期:1994-11-01 00:00:00
abstract::Differences in signal intensity involving lobes of the liver were noted in seven cases of liver tumor. The clinical significance and possible cause of these differences in lobar intensity are discussed. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198603000-00013
更新日期:1986-03-01 00:00:00
abstract::Seventy selected cases were reviewed retrospectively to assess the normal Gd-DTPA enhanced MR appearance of the cervical anterior epidural venous plexus. This structure can enhance quite markedly and has a somewhat variable appearance on MR imaging but we believe that it can be differentiated from pathological enhance...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199209000-00017
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:The purpose of this work was to determine the accuracy of predicting arterial enhancement from peripheral versus central venous test bolus injections at CT angiography (CTA). METHOD:In 40 patients with abdominal aortic aneurysms, aortoiliac enhancement profiles were predicted by mathematical deconvolution of t...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200103000-00024
更新日期:2001-03-01 00:00:00
abstract::We present a case of a clinically suspected cerebral infarction that was diagnosed as a seizure focus on pulsed arterial spin labeling. The finding of hyperperfusion with perfusion imaging significantly impacted clinical management of the patient. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31814cf81f
更新日期:2008-03-01 00:00:00
abstract::Fifty-two computed tomography examinations through the region of the pancreas were retrospectively analyzed to determine if marked stomach distension influenced the visualization of the pancreatic tail. Of the 29 patients who had marked stomach distension, 25 (86%) had displacement of small bowel loops away from the v...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198108000-00008
更新日期:1981-08-01 00:00:00
abstract::Prenatal diagnosis of monoamnionicity is necessary for optimal care of a twin gestation. When the fetuses are discordant for a lethal anomaly, unequivocal confirmation is imperative. Ultrasound evaluation of our patient revealed a twin gestation discordant for anencephaly and with possible monoamnionicity. When sonogr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199401000-00034
更新日期:1994-01-01 00:00:00
abstract::The objective of this study was to assess the efficacy of MR mammography (MRM) in evaluating breast cancer extent in women with fatty or dense breasts, and its contribution to the therapeutic approach. The authors reviewed 97 carcinomas detected in 93 women (both symptomatic and from screening) that were classified in...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000191684.51215.9c
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Differentiation of invasive thymoma from thymic carcinoma is important because of their different clinical behaviors. Retrospectively, we evaluated the CT findings of invasive thymomas and thymic carcinomas to determine the differential points between them. MATERIALS AND METHODS:We reviewed the CT scans of 1...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199503000-00005
更新日期:1995-03-01 00:00:00
abstract::Computed tomography has had an increasing role in the evaluation of patients after blunt trauma. Important findings in thoracic trauma include acute traumatic aortic injury, pneumothorax, hemothorax, pulmonary contusions and lacerations, mediastinal hematoma, and diaphragmatic rupture. The solid abdominal viscera may ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/01.rct.0000120858.80935.59
更新日期:2004-07-01 00:00:00
abstract::An assessment of the role of marrow fat as a source of error in single energy quantitative CT (SEQCT) measurements of the spine is presented. Fat-induced shifts and spreads in SEQCT findings are discriminated and quantified. Studies using chemical analysis have reported an average vertebral bone mineral (MIN) loss of ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198911000-00015
更新日期:1989-11-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether liver extracellular volume (ECV) measured using equilibrium computed tomography (EQ-CT) can be used to quantitatively assess doxorubicin-induced liver injury (DILI). METHODS:The ethical approval was obtained from the Institutional Animal Care and Use Committee...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000968
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:The purpose of this work was to determine the optimal delay times in two-phase helical CT for nodular hepatocellular carcinoma (HCC). METHOD:Twenty-four patients with nodular HCC (size 2.1-6.7 cm, mean 4.2 cm) were divided into three groups to undergo single-level dynamic CT with 150 ml of contrast material (i...
journal_title:Journal of computer assisted tomography
pub_type: 临床试验,杂志文章
doi:10.1097/00004728-200003000-00005
更新日期:2000-03-01 00:00:00
abstract::Hepatocellular carcinoma and cholangiocarcinoma are the most common primary liver malignancies in adults (comprising >85%); however, liver is also host to some unusual primary malignant tumors. Some of these tumors show distinct demographic, clinicopathologic, and imaging features. Imaging features of these uncommon p...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0000000000000382
更新日期:2016-05-01 00:00:00
abstract::We present a unique case of aggressive osteoblastoma arising from thyroid cartilage. A 52-year-old man presented with a 10 month history of neck discomfort but without frank pain. CT and MR examinations disclosed a well defined mass arising from the thyroid cartilage. This lesion had areas of coarse calcifications and...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199601000-00021
更新日期:1996-01-01 00:00:00
abstract::Diffuse low attenuation lesions on CT scans are caused by various pathologic conditions, especially differences of the intratumoral matrix. Low attenuation on CT scans was more defined than fat density and less than muscle density, the so-called near water density. We present representative cases of low attenuation le...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-200009000-00018
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to optimize chest port contrast injections using stepwise improvements. METHODS:Ex vivo injections were tested. Two hundred scans using power port injections were then evaluated. RESULTS:The highest flow rate was achieved using a 19G access needle, larger diameter tubing, and warme...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000001048
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To capture 3D shape variation of the levator ani during straining with open access MR imaging. METHODS:Optimal scan-planning based on statistical shape modeling is developed for recovering the entire 3D structure of the levator ani from a limited number of 2D imaging planes. Statistical shape modeling ensure...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000155076.42784.ed
更新日期:2005-03-01 00:00:00