Abstract:
PURPOSE:The purpose of this study was to determine whether liver extracellular volume (ECV) measured using equilibrium computed tomography (EQ-CT) can be used to quantitatively assess doxorubicin-induced liver injury (DILI). METHODS:The ethical approval was obtained from the Institutional Animal Care and Use Committee regulations. Thirteen dogs administered with doxorubicin for 0 to 24 weeks were imaged by contrast-enhanced EQ-CT. The dogs were divided into 3 groups: the baseline (13 dogs), 16-week (10 dogs), and 24-week (7 dogs) groups. Pathological analysis of the liver was performed using hematoxylin-eosin and Masson staining. Liver ECV uptake was calculated for each group and correlated with the histopathological and serological findings of hepatic fibrosis (hyaluronic acid and procollagen type III). RESULTS:In the baseline group, the median ECVs of the right and left liver lobes were 21.78% (interquartile range [IQR], 16.78%-26.68%) and 20.91% (IQR, 16.39%-24.07%), respectively. In the 16- and 24-week groups, the median ECVs of these 2 liver lobes were 28.18% (IQR, 20.56%-34.61%) and 25.96% (IQR, 14.07%-41.38%) and 29.71% (IQR, 27.19%-35.25%) and 29.22% (IQR, 22.62%-38.67%), respectively. There were no significant differences in ECV between the left and right lobes in the 3 groups (P < 0.05). Both the 16- and 24-week groups showed significantly higher ECV than did the primary group (P = 0.001-0.0006). However, there were no significant differences in ECV between the 16-week group and 24-week group (P = 0.412). There was a positive correlation between the serum index and edema due to the inflammation and necrosis associated with DILI (R = 0.6534, R = 0.7129). CONCLUSIONS:Extracellular volume measured by EQ-CT imaging can accurately predict the potential DILI through the quantification of ECV changes.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Han P,Zhou Z,Wang R,Wang H,Sun Z,Wang X,Xu Ldoi
10.1097/RCT.0000000000000968subject
Has Abstractpub_date
2020-03-01 00:00:00pages
204-208issue
2eissn
0363-8715issn
1532-3145journal_volume
44pub_type
杂志文章abstract::Transorbital penetration of the cranial cavity by a small wooden object can pass unnoticed, while producing severe, life-threatening consequences. The occurrence of a traumatic intracranial aneurysm secondary to a wooden foreign body has not been reported previously in the English literature, to our knowledge. Familia...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198705000-00030
更新日期:1987-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was twofold: (a) to determine the significance of high signal intensity surrounding the gallbladder as seen on T2-weighted HASTE (half-Fourier acquisition single shot turbo SE) MR images in patients with acute cholecystitis and (b) to determine the sensitivity of T2-weighted HASTE MR i...
journal_title:Journal of computer assisted tomography
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004728-199807000-00025
更新日期:1998-07-01 00:00:00
abstract::We present a case of a child with acute bacterial leptomeningeal infection caused by Streptococcus pneumoniae. There was an extension of infection along multiple Virchow-Robin spaces into the brain parenchyma, resulting in multiple microabscesses. These abscesses showed restricted diffusion on the diffusion-weighted i...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318187ff15
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to evaluate the effect of heart rate on exposure window, best phase, and image quality for stress computed tomography perfusion (CTP) in the CORE320 study. METHODS:The CTP data sets were analyzed to determine the best phase for perfusion analysis. A predefined exposure window coveri...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,多中心研究
doi:10.1097/RCT.0000000000000514
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to establish the reference window settings for display of virtual monoenergetic images (VMIs) from spectral detector computed tomography when assessing hypodense liver lesions. METHODS:In patients with cysts (n = 24) or metastases (n = 26), objective (HU, signal-to-noise ratio [SNR])...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000794
更新日期:2018-11-01 00:00:00
abstract::A psoas mass in a patient with a history of penetrating trauma to the area was demonstrated by computed tomography (CT) to represent a lumbar artery pseudoaneurysm surrounded by hematoma. This report emphasizes the importance of recognizing the anatomic position of the lumbar arteries on CT images and considering the ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198406000-00044
更新日期:1984-06-01 00:00:00
abstract::The authors present findings from a scientific study in a 36-year-old male patient who was transferred for the evaluation of a restenosis in aortic coarctation that was initially treated by surgical repair. Contrast-enhanced magnetic resonance angiography and comprehensive flow-sensitive 4-dimensional magnetic resonan...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181906766
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:: The aim of this study was to achieve the quantitative analysis of the characteristic computed tomography (CT) findings and course of interstitial pneumonia using the volume histogram method. METHODS:: Contrast (CNT), variance (VAR), and entropy (EPY) values from whole-lung volume data were compared betwee...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200603000-00014
更新日期:2006-03-01 00:00:00
abstract::The transfer of magnetization between a free and a bound pool of spins is described in terms of the respective longitudinal relaxation times and the life times of spins in each pool. The effect of an off resonance radiofrequency (RF) pulse in producing saturation in the bound pool and a consequent decrease in both the...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199201000-00003
更新日期:1992-01-01 00:00:00
abstract::The purpose of this report is to describe a further distinctive cause of crazy-paving pattern on thin-section computed tomography in a patient affected by pulmonary granulomatous mycosis fungoides. It was possible to reconcile the crazy-paving appearance on thin-section computed tomography scan with the histopathologi...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000214269.72180.64
更新日期:2006-09-01 00:00:00
abstract::Elevation of the anterior part of the right diaphragm results in the spurious radiological appearance of a mass at the right lung base. Standard chest views are usually sufficient to show the true nature of the "mass." Occasionally, however, a true mass lesion cannot be entirely excluded, and further studies are then ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198110000-00023
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE:The objectives of this study were to develop a software program that calculates bone cross-sectional area (CSA) and moments of inertia from digital images, test the computations for accuracy, and implement the software in a study of longitudinal changes in bone properties in a large group of postmenopausal wo...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199407000-00021
更新日期:1994-07-01 00:00:00
abstract::The inhalation of small quantities of carbon-11 labeled carbon monoxide results in a useful red cell label to identify vascular structures in the body and quantitate red cell concentration in tissues. Transverse section images are obtained using PC-II, the Massachusetts General Hospital (MGH) Positron Camera. Attenuat...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-197811000-00001
更新日期:1978-11-01 00:00:00
abstract::Nephrogenic systemic fibrosis (NSF) is a rare, idiopathic systemic fibrosing disorder that is predominantly characterized by a clinicopathologically distinct symmetric dermopathy and debilitating joint contractures. The condition affects patients with renal insufficiency and appears to show improvement with prompt res...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0b013e31805d08ee
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this article is to report computed tomography demonstration of medial bowing of the lamina papyracea in 5 patients after internal ethmoidectomy. METHODS:We identified 5 patients who had apparent medial bowing of the lamina papyracea after functional endoscopic sinus surgery (FESS) and who had ...
journal_title:Journal of computer assisted tomography
pub_type: 临床试验,杂志文章
doi:10.1097/RCT.0b013e31816c82da
更新日期:2009-01-01 00:00:00
abstract::The central dot sign on CT in Caroli disease has been described previously. We describe a patient with the central dot sign who had periductal cysts but did not have Caroli disease. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199011000-00034
更新日期:1990-11-01 00:00:00
abstract::This is the fourth of a series of 4 white papers that represent expert consensus documents developed by the Society of Computed Body Tomography and Magnetic Resonance through its task force on dual-energy computed tomography. This article, part 4, discusses DECT for abdominal and pelvic applications and, at the end of...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000546
更新日期:2017-01-01 00:00:00
abstract::Idiopathic retroperitoneal fibrosis (IRF) is a rare condition of unknown etiology. An unusual case of IRF exclusively located at the peripancreatic area without extension below the lower renal poles is reported. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198611000-00038
更新日期:1986-11-01 00:00:00
abstract::Two extradural arachnoid cysts of the thoracic spine were studied with magnetic resonance imaging, myelography, and CT. Magnetic resonance imaging correctly characterized the extradural location of the cysts as well as the cyst contents as CSF, thus establishing the diagnosis. Magnetic resonance is helpful in the asse...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198807000-00023
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:To describe the magnetic resonance imaging spectrum of solid pseudopapillary tumors (SPTs), with an emphasis on solid SPTs. METHODS:Thirty-two patients with proven SPTs with preoperative magnetic resonance were included. The SPTs were classified into 3 types: solid, cystic, and mixed; and 2 radiologists anal...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000445639.26581.65
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Homosexual men are at risk for a variety of infectious and neoplastic diseases of the anus and rectum, many of which have been reported in the radiologic literature. The purpose of this study was to describe the CT findings in homosexual men with squamous cell carcinoma of the anus and rectum, a topic that ha...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199411000-00013
更新日期:1994-11-01 00:00:00
abstract::We studied four patients with adrenocorticotropic hormone (ACTH)-independent hypercortisolism due to bilateral massive enlargement of the adrenal glands. The combined weight of the adrenal glands ranged from 69 to 149 g and the adrenal cortex was replaced in three of four patients by multiple nodules ranging from micr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-199109000-00009
更新日期:1991-09-01 00:00:00
abstract:PURPOSE:The goal of this study was to evaluate a newly developed semiautomated contour detection algorithm for the quantitative analysis of cardiovascular MRI. METHOD:Left ventricular function parameters derived from automatically detected endocardial and epicardial contours were compared with results derived from man...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199709000-00019
更新日期:1997-09-01 00:00:00
abstract::Pneumatosis cystoides coli (PCC) is an uncommon condition in which multiple gas-filled cysts in the walls of the colon. Patients with PCC initially complain of various symptoms including abdominal discomfort, constipation, diarrhea, hematochezia, vomiting, and fever. We recently diagnosed PCC by computed tomography (C...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/rct.0b013e31805d08ca
更新日期:2008-01-01 00:00:00
abstract::The CT findings of multiple lipid-containing dermal cysts in a patient with steatocystoma multiplex are presented. The characteristic locations, shapes, and densities of the cysts in this rare skin disorder are discussed. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198603000-00043
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:The purpose of our study was to quantify peritumoral brain edema (PTE) in vivo using NMR relaxation time imaging, as the longitudinal relaxation time T1 is proportional to tissue water content, and to use the method for monitoring the effects of glucocorticoids (GCCs) on PTE in brain tumor patients as a funct...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199407000-00001
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:This study was designed to compare the sensitivity of T1- and diffusion-weighted images for the assessment of brain maturation in human brains. METHODS:T1- and diffusion-weighted images were obtained in 32 children without neurological abnormalities or growth retardation. The ages at which signal intensity cha...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199701000-00001
更新日期:1997-01-01 00:00:00
abstract::Fallopian tube carcinoma is an unusual gynecologic malignancy that is rarely diagnosed preoperatively. We report a case of fallopian tube carcinoma occurring in a patient who had undergone a hysterectomy many years previously, in whom findings on computed tomography and ultrasound were highly suggestive of the diagnos...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-200305000-00011
更新日期:2003-05-01 00:00:00
abstract::Compressive sensing (CS)-based interior tomography is a state-of-the-art method for accurate image reconstruction from only locally truncated projections. Here, we report our preliminary interior tomography results reconstructed from raw projections of a patient acquired on a GE Discovery CT750 HD scanner. This is the...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318231c578
更新日期:2011-11-01 00:00:00
abstract::Prenatal diagnosis of monoamnionicity is necessary for optimal care of a twin gestation. When the fetuses are discordant for a lethal anomaly, unequivocal confirmation is imperative. Ultrasound evaluation of our patient revealed a twin gestation discordant for anencephaly and with possible monoamnionicity. When sonogr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199401000-00034
更新日期:1994-01-01 00:00:00