Characterization of binding sites for the angiotensin II antagonist 125I-[Sarc1,Ile8]-angiotensin II on murine neuroblastoma N1E-115 cells.

abstract：:Incubation of rat cortical synaptosomes in the presence of 1 mM ATP markedly reduced Ca2+-dependent K+-induced release of preloaded 3H-GABA. This effect is probably dependent on phosphorylation of presynaptic membrane proteins. By contrast, the uptake of 3H-GABA by the nerve endings was not significantly affected by p...

journal_title：Journal of neurochemistry

authors： Brennan MJ,Cantrill RC

更新日期：1980-08-01 00:00:00

abstract：:This Editorial highlights a study by Baglietto-Vargas et al. 2015 published in this issue of J. Neurochem. Stress is one of the environmental factors that can contribute to Alzheimer's disease pathogenesis. However, the role of modern-life stress has not been investigated yet. The authors reveal that modern-life stres...

journal_title：Journal of neurochemistry

authors： Marcello E,Gardoni F,Di Luca M

更新日期：2015-09-01 00:00:00

abstract：:We have identified a novel mouse gene named pancortin that is expressed dominantly in the mature cerebral cortex. This gene produces four different species of proteins, Pancortin-1-4, sharing a common region in the middle of their structure with two variations at the N-terminal (A1 or A2 part) and C-terminal (C1 or C2...

journal_title：Journal of neurochemistry

authors： Nagano T,Nakamura A,Konno D,Kurata M,Yagi H,Sato M

更新日期：2000-07-01 00:00:00

abstract：:The present study aims to investigate the role of extracellular glutamate and NMDA receptor stimulation in the neuronal death induced by a transient exposure to H2O2 of cultured neurons originating from mouse cerebral cortex. Most of the neuronal loss following a transient exposure to H2O2 of cortical neurons results ...

journal_title：Journal of neurochemistry

authors： Mailly F,Marin P,Israël M,Glowinski J,Prémont J

更新日期：1999-09-01 00:00:00

abstract：:Excitotoxicity and defects in neuronal energy metabolism have both been implicated in the pathogenesis of neurodegenerative disease. These two mechanisms may be linked through the NMDA receptor, activation of which is dependent on neuronal membrane potential. Because the ability to maintain membrane potential is depen...

journal_title：Journal of neurochemistry

authors： Greene JG,Porter RH,Eller RV,Greenamyre JT

更新日期：1993-09-01 00:00:00

abstract：:125I-Porcine brain natriuretic peptide (125I-pBNP) bound to mouse astrocytes in primary culture in a time-dependent manner (t1/2 = 4.5 min), similar to 125I-human atrial natriuretic peptide (125I-hANP) (t1/2 = 5 min). Binding was saturable and reached equilibrium after 90 min at 22 degrees C for both radioligands. Sca...

journal_title：Journal of neurochemistry

authors： Yeung VT,Lai CK,Cockram CS,Young JD,Nicholls MG

更新日期：1991-05-01 00:00:00

abstract：:The rapid bidirectional transport of dopamine beta-hydroxylase (DBH) in adrenergic axons provides a means of analyzing the life cycle of adrenergic storage vesicles. We compared the physical characteristics of DBH-containing particles traveling to or returning from the terminal varicosities of ligated rat sciatic nerv...

journal_title：Journal of neurochemistry

authors： Studelska DR,Brimijoin S

更新日期：1989-08-01 00:00:00

abstract：:Nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) play an important role in promoting axonal growth from dorsal root ganglion (DRG) neurons. Adult DRG neurons exhibit neurotrophin-independent survival, providing an excellent system with which to study trophic factor effects on neurite growth in the ab...

journal_title：Journal of neurochemistry

authors： Jones DM,Tucker BA,Rahimtula M,Mearow KM

更新日期：2003-09-01 00:00:00

abstract：:It is now clearly established that the brain has the capability of synthesizing various biologically active steroids including 17-hydroxypregnenolone (17OH-Delta(5)P), 17-hydroxyprogesterone (17OH-P), dehydroepiandrosterone (DHEA) and androstenedione (Delta(4)). However, the presence, distribution and activity of cyto...

journal_title：Journal of neurochemistry

authors： Do Rego JL,Tremblay Y,Luu-The V,Repetto E,Castel H,Vallarino M,Bélanger A,Pelletier G,Vaudry H

更新日期：2007-01-01 00:00:00

abstract：:Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

journal_title：Journal of neurochemistry

authors： Wade JV,Samson FE,Nelson SR,Pazdernik TL

更新日期：1987-08-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) provides neuroprotection, but its neuroprotective mechanism has not been resolved. We investigated the neuroprotective mechanism of GDNF using primary culture of the rat mesencephalon. Bleomycin sulfate (BLM) and L-buthionine-[S,R]-sulfoximine (BSO) caused apoptosis i...

journal_title：Journal of neurochemistry

authors： Sawada H,Ibi M,Kihara T,Urushitani M,Nakanishi M,Akaike A,Shimohama S

更新日期：2000-03-01 00:00:00

abstract：:We previously observed that gangliosides GM2, GM1, and GM3 inhibit Ca2+-uptake via the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in neurons and in brain microsomes. We now systematically examine the effect of various gangliosides and their analogs on Ca2+-uptake via SERCA and demonstrate that an exposed carboxyl...

journal_title：Journal of neurochemistry

authors： Ginzburg L,Li SC,Li YT,Futerman AH

更新日期：2008-01-01 00:00:00

abstract：:To examine whether the mitogen-activated protein kinase (MAPK) cascade and phospholipase A2 (PLA2) are involved in the signal transduction mechanism of the opioid receptor, the delta-, mu-, and kappa-opioid receptors were stably expressed from cDNA in Chinese hamster ovary cells. Activation of the delta-, mu-, and kap...

journal_title：Journal of neurochemistry

authors： Fukuda K,Kato S,Morikawa H,Shoda T,Mori K

更新日期：1996-09-01 00:00:00

abstract：:Cultures of bovine adrenomedullary chromaffin cells accumulated 1-[methyl-3H]methyl-4-phenylpyridinium ([3H]MPP+) in a time- and concentration-dependent manner with an apparent Km of 0.7 microM and a Vmax of 3 pmol/min/10(6) cells. The uptake was sodium dependent and sensitive to inhibitors of the cell-surface catecho...

journal_title：Journal of neurochemistry

authors： Reinhard JF Jr,Diliberto EJ Jr,Daniels AJ

更新日期：1989-04-01 00:00:00

abstract：:The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine-synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the ...

journal_title：Journal of neurochemistry

authors： Sacchetti P,Mitchell TR,Granneman JG,Bannon MJ

更新日期：2001-03-01 00:00:00

abstract：:Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute to patholog...

journal_title：Journal of neurochemistry

authors： Yu CG,Yezierski RP,Joshi A,Raza K,Li Y,Geddes JW

更新日期：2010-04-01 00:00:00

abstract：:It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin-1beta (IL-1beta), has been reported in the aged brain associated with a deficit in long-term potentiation (LTP) in rat hippocampus. The precise age at which changes are i...

journal_title：Journal of neurochemistry

authors： Griffin R,Nally R,Nolan Y,McCartney Y,Linden J,Lynch MA

更新日期：2006-11-01 00:00:00

abstract：:Recent evidence supports the emerging hypothesis that the amyloid-β precursor protein C-terminal fragments (APP-CTFs) and dysregulations in both their qualitative and quantitative productions may actively and directly contribute to the neuronal toxicity in early phases of Alzheimer's disease (AD). These new findings r...

journal_title：Journal of neurochemistry

authors： Mosser S,Gerber H,Fraering PC

更新日期：2020-08-05 00:00:00

abstract：:Neurodegenerative diseases such as Alzheimer's disease (AD) are characterized by an abnormal aggregation of misfolded beta-sheet rich proteins such as β-amyloid (Aβ). Various ubiquitously expressed molecular chaperones control the correct folding of cellular proteins and prevent the accumulation of harmful species. We...

journal_title：Journal of neurochemistry

authors： Hoshino A,Helwig M,Rezaei S,Berridge C,Eriksen JL,Lindberg I

更新日期：2014-02-01 00:00:00

abstract：:In contrast to brain, the sciatic nerve concentration of vitamin E in rats increased rapidly during the postnatal period (approximately fivefold between days 1 and 8), then decreased dramatically (about twofold between days 8 and 30), and further decreased slowly between days 30 and 60 and remained constant up to 2 ye...

journal_title：Journal of neurochemistry

authors： Clément M,Bourre JM

更新日期：1990-06-01 00:00:00

abstract：:The existence of pre-synaptic auto- and hetero receptors which modulate neurotransmitter release is well documented. Emerging evidence show that in some cases these pre-synaptic receptors may also cross-talk with each other. The aim of the present work was to investigate whether acetylcholine receptors (nAChRs) and do...

journal_title：Journal of neurochemistry

authors： Grilli M,Zappettini S,Zoli M,Marchi M

更新日期：2009-03-01 00:00:00

abstract：:Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel disease mechanisms, or to be used as a source of biomarkers, is being explored, in particularly in the field of neurodegenerative diseases. Alzheimer's disease (AD...

journal_title：Journal of neurochemistry

authors： Soares Martins T,Trindade D,Vaz M,Campelo I,Almeida M,Trigo G,da Cruz E Silva OAB,Henriques AG

更新日期：2020-07-03 00:00:00

abstract：:The ubiquitous second messenger cyclic GMP (cGMP) is synthesized by soluble guanylate cyclases in response to nitric oxide (NO) and degraded by phosphodiesterases (PDE). We studied the homeostasis of cGMP in living thalamic neurons by using the genetically encoded fluorescence resonance energy transfer sensor Cygnet, ...

journal_title：Journal of neurochemistry

authors： Hepp R,Tricoire L,Hu E,Gervasi N,Paupardin-Tritsch D,Lambolez B,Vincent P

更新日期：2007-09-01 00:00:00

abstract：:The effect of the neuropeptide substance P on the binding of the cholinergic ligands to the nicotinic acetylcholine receptor of Torpedo electroplaque membranes was examined at a physiological concentration of NaCl (150 mM). Substance P had no effect on the initial rate of 125I-alpha-bungarotoxin binding at concentrati...

journal_title：Journal of neurochemistry

authors： Min CK,Weiland GA

更新日期：1993-06-01 00:00:00

abstract：:Subcortical ischemic vascular cognitive impairment (SIVCI) is the most preventable form of cognitive dysfunction. There is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI. Currently, there are no curative pharmaceutical treatments for vascular dementia; how...

journal_title：Journal of neurochemistry

authors： Dao E,Hsiung GR,Liu-Ambrose T

更新日期：2018-03-01 00:00:00

abstract：:Ras-GAP SH3-domain-binding protein, G3BP, is an important component in the assembly of stress granules (SGs), which are cytoplasmic aggregates assembled following translational stress. To assess the physiological function of G3BP, we generated viable G3bp1-knockout (KO) mice, which demonstrated behavioral defects link...

journal_title：Journal of neurochemistry

authors： Martin S,Zekri L,Metz A,Maurice T,Chebli K,Vignes M,Tazi J

更新日期：2013-04-01 00:00:00

abstract：:Exposure to cocaine-associated conditioned stimuli elicits craving and increases the probability of cocaine relapse in cocaine users even after extended periods of abstinence. Recent evidence indicates that cocaine seeking can be inhibited by disrupting the reconsolidation of the cocaine cue memories and that basolate...

journal_title：Journal of neurochemistry

authors： Wu P,Xue YX,Ding ZB,Xue LF,Xu CM,Lu L

更新日期：2011-07-01 00:00:00

abstract：:After intraperitoneal injection of rats with 6-fluorotryptophan (6-FT), brain 5-hydroxytryptamine (5-HT) levels decreased exponentially over 1 h. Depletion was dose-dependent and maximum depletion was observed at 200 mg/kg. 6-FT (200 mg/kg) did not significantly alter the content of 5-hydroxyindoleacetic acid. Turnove...

journal_title：Journal of neurochemistry

authors： Miwa S,Fujiwara M,Lee K,Fujiwara M

更新日期：1987-05-01 00:00:00

abstract：:The postsynaptic density (PSD) is an electron-dense structure located at the synaptic contacts between neurons. Its considerable complexity includes cytoskeletal and scaffold proteins, receptors, ion channels and signaling molecules, in line with the role of PSDs in signal transduction and processing. The phosphorylat...

journal_title：Journal of neurochemistry

authors： Trinidad JC,Thalhammer A,Specht CG,Schoepfer R,Burlingame AL

更新日期：2005-03-01 00:00:00

abstract：:Malignant gliomas are common and aggressive brain tumours associated with significant morbidity and mortality. We showed in this report that substratum adherence and migration by human U87MG glioma cells in culture were significantly attenuated by the extracellular domains of Nogo-A (Nogo-66) and the myelin-associated...

journal_title：Journal of neurochemistry

authors： Liao H,Duka T,Teng FY,Sun L,Bu WY,Ahmed S,Tang BL,Xiao ZC

更新日期：2004-09-01 00:00:00