Alzheimer's disease and modern lifestyle: what is the role of stress?

abstract：:Reactive oxygen species (ROS) have been suggested to act as cellular messengers that mediate signal transduction cascades in various cell types. However, little is known about their role in this capacity in the nervous system. We have begun to investigate the role of ROS, and that of nitric oxide (NO), in mediating mi...

journal_title：Journal of neurochemistry

authors： Kanterewicz BI,Knapp LT,Klann E

更新日期：1998-03-01 00:00:00

abstract：:The protein kinases and protein phosphatases that act on tyrosine hydroxylase in vivo have not been established. Bovine adrenal chromaffin cells were permeabilized with digitonin and incubated with [gamma-32P]ATP, in the presence or absence of 10 microM Ca2+, 1 microM cyclic AMP, 1 microM phorbol dibutyrate, or variou...

journal_title：Journal of neurochemistry

authors： Gonçalves CA,Hall A,Sim AT,Bunn SJ,Marley PD,Cheah TB,Dunkley PR

更新日期：1997-12-01 00:00:00

abstract：:Evidence based on the ability to accumulate [3H]noradrenaline by a mechanism sensitive to desmethylimipramine suggests that there is a period of hyperinnervation of the cerebellum by noradrenergic fibres around the beginning of the second postnatal week. Different developmental profiles for specific noradrenaline upta...

journal_title：Journal of neurochemistry

authors： Waddington G,Banks P

更新日期：1981-09-01 00:00:00

abstract：:Certain non-steroidal anti-inflammatory drugs (NSAIDs) preferentially inhibit production of the amyloidogenic Abeta42 peptide, presumably by direct modulation of gamma-secretase activity. A recent report indicated that NSAIDs could reduce Abeta42 by inhibition of the small GTPase Rho, and a single inhibitor of Rho kin...

journal_title：Journal of neurochemistry

authors： Leuchtenberger S,Kummer MP,Kukar T,Czirr E,Teusch N,Sagi SA,Berdeaux R,Pietrzik CU,Ladd TB,Golde TE,Koo EH,Weggen S

更新日期：2006-01-01 00:00:00

abstract：:It is well established that chronic nicotine treatment produces a dose-dependent increase in high-affinity L-[3H]nicotine binding. This increase may be due to chronic desensitization of the receptor. Sophisticated kinetic analyses of high-affinity nicotine binding to rat brain have demonstrated that the association ra...

journal_title：Journal of neurochemistry

authors： Bhat RV,Marks MJ,Collins AC

更新日期：1994-02-01 00:00:00

abstract：:The effects of the protein kinase inhibitor H-7 on early and delayed responses to nerve growth factor (NGF) were investigated in PC12 cells. H-7 reduced the NGF-induced expression of c-Fos in a dose-dependent manner without affecting the time course of c-Fos appearance. Conversely, H-7 potentiated delayed NGF effects,...

journal_title：Journal of neurochemistry

authors： Kahle P,Mangold M,Kuwahara T,Schubenel R,Hertel C

更新日期：1994-02-01 00:00:00

abstract：:High-affinity binding sites for [3H]PK 11195 and [3H]Ro 5-4864 with the properties of the peripheral-type benzodiazepine receptor were detected in primary cultures of both mouse neocortical and cerebellar astrocytes. The binding sites were enriched in mitochondrial fractions on differential centrifugation. An 18-kDa p...

journal_title：Journal of neurochemistry

authors： Moynagh PN,Schousboe A,Williams DC

更新日期：1994-02-01 00:00:00

abstract：:Iron deficiency (ID) anemia during infancy results in long-term neurological consequences, yet the mediating mechanisms remain unclear. Infant monkeys often become naturally anemic during the first 6 months of life, presenting an opportunity to determine the effect of developmental iron deficiency. After weaning, anim...

journal_title：Journal of neurochemistry

authors： Geguchadze RN,Coe CL,Lubach GR,Clardy TW,Beard JL,Connor JR

更新日期：2008-04-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) activity was measured in microvessels prepared from cerebral cortices of 4-week-old spontaneously hypertensive rats (SHR). The Vmax value of the ACE activity in the cerebral microvessels of SHR was lower than that of Wistar Kyoto controls of the same age by 25% without difference in...

journal_title：Journal of neurochemistry

authors： Kobayashi H,Wada A,Izumi F,Take K,Magnoni MS

更新日期：1985-04-01 00:00:00

abstract：:The Na+ and K+ concentrations in isolated Torpedo marmorata synaptosomes were determined. Synaptosomes made according to the method of Israël et al. have high internal Na+ (290 mM) and low internal K+ (30 mM) concentrations. Modification of the homogenisation media permitted the isolation of synaptosomes which could m...

journal_title：Journal of neurochemistry

authors： Richardson PJ,Whittaker VP

更新日期：1981-04-01 00:00:00

abstract：:Tau, a microtubule-associated protein, is encoded by a single gene, whose expression is primarily neuronal. In this work, we defined an 80-bp region of the tau promoter that confers tau protein with neuronal expression. This fragment works in conjunction with an endogenous initiation region to activate neuronal precur...

journal_title：Journal of neurochemistry

authors： Heicklen-Klein A,Ginzburg I

更新日期：2000-10-01 00:00:00

abstract：:Regional distribution of endogenous gamma-aminobutyric acid (GABA), its synthesizing enzyme, glutamic acid decarboxylase (GAD), and metabolic enzyme, GABA transaminase (GABA-T), were determined in the intestinal tract of guinea pigs and cats and the findings compared with the number of ganglion cells in Auerbach's ple...

journal_title：Journal of neurochemistry

authors： Miki Y,Taniyama K,Tanaka C,Tobe T

更新日期：1983-03-01 00:00:00

abstract：:We have examined some of the characteristics of phorbol ester- and agonist-induced down-regulation of astrocyte receptors coupled to phosphoinositide metabolism. Our results show that preincubation of [3H]inositol-labelled astrocyte cultures with phorbol 12-myristate 13-acetate (PMA) resulted in a time- (t 1/2, 1-2 mi...

journal_title：Journal of neurochemistry

authors： Pearce B,Morrow C,Murphy S

更新日期：1988-03-01 00:00:00

abstract：:The postsynaptic density (PSD) is an electron-dense structure located at the synaptic contacts between neurons. Its considerable complexity includes cytoskeletal and scaffold proteins, receptors, ion channels and signaling molecules, in line with the role of PSDs in signal transduction and processing. The phosphorylat...

journal_title：Journal of neurochemistry

authors： Trinidad JC,Thalhammer A,Specht CG,Schoepfer R,Burlingame AL

更新日期：2005-03-01 00:00:00

abstract：:Oligodendroglial cell death in the myelin proteolipid protein (PLP) mutants can be partially rescued by the environment factor(s) supplied by the wild-type cells in vivo and in vitro. It is possible that the presence of PLP or DM-20 results in secretion of a factor or factors in the CNS influencing oligodendrocyte dev...

journal_title：Journal of neurochemistry

authors： Nakao J,Yamada M,Kagawa T,Kim SU,Miyao Y,Shimizu K,Mikoshiba K,Ikenaka K

更新日期：1995-06-01 00:00:00

abstract：:The existence of pre-synaptic auto- and hetero receptors which modulate neurotransmitter release is well documented. Emerging evidence show that in some cases these pre-synaptic receptors may also cross-talk with each other. The aim of the present work was to investigate whether acetylcholine receptors (nAChRs) and do...

journal_title：Journal of neurochemistry

authors： Grilli M,Zappettini S,Zoli M,Marchi M

更新日期：2009-03-01 00:00:00

abstract：:Apolipoprotein (apo) A-I is the major protein component of high-density lipoproteins (HDLs), which are responsible for reverse cholesterol transport from peripheral tissues to the liver. A low level of plasma HDL is correlated with susceptibility to atherosclerosis and coronary heart disease. Mammalian apo A-I synthes...

journal_title：Journal of neurochemistry

authors： Möckel B,Zinke H,Flach R,Weiss B,Weiler-Güttler H,Gassen HG

更新日期：1994-02-01 00:00:00

abstract：:We have previously reported that the intrinsic ability of motor axons to sprout can vary considerably from nerve to nerve with an inverse correlation to axonal length. In this study we asked whether this variation might be associated with differences in one axonal component, neurofilaments, near the site of outgrowth....

journal_title：Journal of neurochemistry

authors： Pestronk A,Watson DF,Yuan CM

更新日期：1990-03-01 00:00:00

abstract：:The presence of gamma-hydroxybutyric acid (GHB) in synaptosome-enriched fractions of rat brain was ascertained using a GLC technique. The stability of GHB in synaptosomes was evaluated by addition of various gamma-aminobutyric acid (GABA) transaminase (GABA-T) inhibitors, GHB, or ethosuximide to the homogenizing mediu...

journal_title：Journal of neurochemistry

authors： Snead OC 3rd

更新日期：1987-01-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is a peptide neurotransmitter that has been implicated in drug reward and reinforcement. CART mRNA and peptide expression are highly concentrated in several compartments of the mesolimbic reward pathway. Several lines of evidence suggest that CART peptides may contr...

journal_title：Journal of neurochemistry

authors： Salinas A,Wilde JD,Maldve RE

更新日期：2006-04-01 00:00:00

abstract：:The neuronal nitric oxide (NO) synthase generates NO from arginine. NO mediates its physiological effects mainly by stimulating the synthesis of cyclic GMP. We have investigated the role of the arginine availability on the NMDA-induced cyclic GMP accumulation in immature rat brain slices. The effect of NMDA was blocke...

journal_title：Journal of neurochemistry

authors： Grima G,Cuénod M,Pfeiffer S,Mayer B,Do KQ

更新日期：1998-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized pathologically by motor neuron degeneration and associated with aggregation of RNA-binding proteins. TATA-binding protein-associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, and clearance of these...

journal_title：Journal of neurochemistry

authors： Choi HJ,Joo Cha S,Do HA,Kim HJ,Lee JW,Kim K

更新日期：2020-09-11 00:00:00

abstract：:Lead poisoning can cause a wide range of symptoms with particularly severe clinical effects on the CNS. Lead can increase spontaneous neurotransmitter release but decrease evoked neurotransmitter release. These effects may be caused by an interaction of lead with specific molecular targets involved in neurotransmitter...

journal_title：Journal of neurochemistry

authors： Bouton CM,Frelin LP,Forde CE,Arnold Godwin H,Pevsner J

更新日期：2001-03-01 00:00:00

abstract：:Neuroleptics are thought to exert their anti-psychotic effects by counteracting a hyper-dopaminergic transmission. Here, we have examined the dopaminergic status of STOP (stable tubule only polypeptide) null mice, which lack a microtubule-stabilizing protein and which display neuroleptic-sensitive behavioural disorder...

journal_title：Journal of neurochemistry

authors： Brun P,Bégou M,Andrieux A,Mouly-Badina L,Clerget M,Schweitzer A,Scarna H,Renaud B,Job D,Suaud-Chagny MF

更新日期：2005-07-01 00:00:00

abstract：:Local cerebral glucose utilization (LCGU) was measured, using the quantitative autoradiographic [14C]2-deoxy-D-glucose method, in 56 brain regions of 3-month-old, awake Fischer-344 rats, after intraperitoneal administration of sulpiride (SULP) 100 mg/kg. SULP, an "atypical" neuroleptic, is a selective antagonist of D2...

journal_title：Journal of neurochemistry

authors： Pizzolato G,Soncrant TT,Larson DM,Rapoport SI

更新日期：1987-08-01 00:00:00

abstract：:(-)-[3H]Nicotine was found to bind specifically to membranes of human brains obtained at autopsy. The binding was stereospecific, (-)-nicotine being 40 times more potent than (+)-nicotine in displacing labeled (-)-nicotine. Saturation binding studies revealed the presence of two binding sites with dissociation constan...

journal_title：Journal of neurochemistry

authors： Shimohama S,Taniguchi T,Fujiwara M,Kameyama M

更新日期：1985-08-01 00:00:00

abstract：:We have studied the responsiveness of vascular adenylate cyclase to vasoactive intestinal peptide (VIP) and parathyroid hormone (PTH) using preparations of cerebral microvessels and arteries. Cerebral microvessels obtained from rats, guinea-pigs, cattle, and pigs all responded potently to bovine (b) PTH-(1-34), wherea...

journal_title：Journal of neurochemistry

authors： Huang M,Rorstad OP

更新日期：1984-09-01 00:00:00

abstract：:An enzyme-linked immunoadsorbent assay (ELISA) for neurofilament protein was utilised to quantify the effect of exogenous ganglioside on neurite regeneration in cultures of dorsal root ganglion neurones. In contrast to nerve growth factor (NGF), ganglioside GM1 (100 micrograms/ml) failed to support neuronal survival a...

journal_title：Journal of neurochemistry

authors： Doherty P,Dickson JG,Flanigan TP,Walsh FS

更新日期：1985-04-01 00:00:00

abstract：:The weaver mutant mouse has a genetically determined defect in the nigrostriatal dopaminergic system. The present study was undertaken to test the hypothesis that in the weaver mutant mouse, striatal nerve terminals undergo compensatory changes in response to this deficiency. To test this hypothesis, we studied the ba...

journal_title：Journal of neurochemistry

authors： Simon JR,Yu H,Richter JA,Vasko MR,Ghetti B

更新日期：1991-11-01 00:00:00

abstract：:Sodium-dependent, high-affinity glutamate transport is generally assumed to limit the toxicity of glutamate in vivo and in vitro, but there is very little direct evidence to support this hypothesis. In the present study, the effects of the specific uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate on the toxicity...

journal_title：Journal of neurochemistry

authors： Robinson MB,Djali S,Buchhalter JR

更新日期：1993-12-01 00:00:00