Abstract:
:Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Yoo SS,Hong MJ,Choi JE,Lee JH,Baek SA,Lee WK,Lee SY,Lee SY,Lee J,Cha SI,Kim CH,Cho S,Park JYdoi
10.3346/jkms.2016.31.3.463subject
Has Abstractpub_date
2016-03-01 00:00:00pages
463-6issue
3eissn
1011-8934issn
1598-6357journal_volume
31pub_type
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journal_title:Journal of Korean medical science
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