Abstract:
:Gonadotropin induces masculinization and spermatogenesis in men with congenital hypogonadotropic hypogonadism (CHH). However, large cohort studies for the efficacy and reliable predictors of this therapy need to be conducted. The aim of this study was to investigate the efficacy of gonadotropin treatment in a large cohort of male CHH patients and analyze putative predictors for successful spermatogenesis. This retrospective study included 223 CHH azoospermic patients without puberty development treated between 2005 and 2014. All patients received combined human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) and were followed up for >6 months (5109 person-months). Serum total testosterone level, testicular size, spermatogenesis, and pregnancy outcome were recorded at each visit. After gonadotropin therapy, testicular size was enlarged from 2.1 ± 1.6 to 8.1 ± 4.6 mL (P < 0.001) and serum total testosterone was elevated from 0.9 ± 0.5 to 15.1 ± 8.2 nmol/L (P < 0.001). Spermatogenesis (>0/mL) occurred at a median period of 15 months (95% confidence interval 13.5-16.5). Larger basal testicular volume (P = 0.012) and noncryptorchidism history (P = 0.028) are independent predictors for earlier sperm appearance. Sixty four percent (143/223) of patients succeeded in producing sperms and the average time for initial sperm detection was 14 ± 8 months. However, their sperm concentrations (11.7 [2.1, 24.4] million/mL) and sperm progressive motility (A + B 36.9% ± 20.2%) are significantly lower than World Health Organization standards. Of the 34 patients who desired for fathering children, 19 patients impregnanted their partners during the treatment. Gonadotropin therapy induces spermatogenesis in male CHH patients. A larger basal testicular size and noncryptorchidism history are favorable indicators for earlier spermatogenesis.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Liu Z,Mao J,Wu X,Xu H,Wang X,Huang B,Zheng J,Nie M,Zhang Hdoi
10.1097/MD.0000000000002867subject
Has Abstractpub_date
2016-03-01 00:00:00pages
e2867issue
9eissn
0025-7974issn
1536-5964pii
00005792-201603010-00024journal_volume
95pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Pediatric sepsis is a burdensome public health problem. Assessing the mortality risk of pediatric sepsis patients, offering effective treatment guidance, and improving prognosis to reduce mortality rates, are crucial.We extracted data derived from electronic medical records of pediatric sepsis patients that were colle...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006923
更新日期:2017-05-01 00:00:00
abstract::There is relatively little data on the etiology of bacterial infections in patients with sickle cell anemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and Haemophilus influenzae type b (Hib).We conducted a retrospective analysis of SC...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005512
更新日期:2016-12-01 00:00:00
abstract::Mutation analysis as the gold standard is particularly important in diagnosis of osteogenesis imperfecta (OI) and it may be preventable upon early diagnosis. In this study, we aimed to analyze the clinical and genetic materials of an OI pedigree as well as to confirm the deleterious property of the mutation.A pedigree...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007783
更新日期:2017-09-01 00:00:00
abstract:RATIONALE:Scedosporium species is rare pathogen of ocular infection. The accurate diagnosis is delaying in many cases and the clinical prognosis is poor due to its resistance to antifungal agents. This report describes a patient with infectious scleritis and corneal ulcer caused by Scedosporium auranticum infection who...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016063
更新日期:2019-07-01 00:00:00
abstract::The aim of this paper was to evaluate the activity and tolerability of oral vinorelbine in patients with advanced castration resistant prostate cancer (CRPC) who progressed after a minimum of three lines including: abiraterone acetate, docetaxel, cabazitaxel, and enzalutamide.Treatment consisted of weekly oral vinorel...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016249
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is the leading cause of health complications and death among human with immunodeficiency virus (HIV) infection. When TB develops during pregnancy or the early postpartum period, it is associated with negative maternal, pregnancy, and fetus and infant outcome, including premature birth, low ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023089
更新日期:2020-11-20 00:00:00
abstract:INTRODUCTION:Acrometastasis is infrequent and generally indicates a wider spread of metastasis with poor prognosis. The diagnosis is challenging, as it might mimic an infectious, inflammatory, or metabolic disease. Acrometastasis are most commonly found in patients with lung, gastrointestinal, kidney, and breast cancer...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020897
更新日期:2020-07-02 00:00:00
abstract:RATIONALE:Multiple primary malignancies can occur in the same organ or in multiple organs or systems. Likewise, they can occur simultaneously or successively. Based on the timing of the diagnosis, they are classified as multiple synchronous (i.e., concurrent) or metachronous (i.e., successive) primary malignancies. The...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011107
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:We conducted a Pooled analysis to investigate the efficacy and safety of ureteral stent removal using an extraction string. METHODS:A systematic review was performed by using the Preferred Reporting Items for Systematic Reviews and Pooled analyses. The sources including EMBASE, MEDLINE, and the Cochrane Cont...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017169
更新日期:2019-09-01 00:00:00
abstract:ABSTRACT:To date research investigating the associations between handgrip strength and multimorbidity when stratifying by age and sex is limited. Furthermore, this is the first study in a Korean population, and the first to include adults ≥ 19 years of age. Here we investigated the associations between handgrip strengt...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023994
更新日期:2021-01-08 00:00:00
abstract:PURPOSE:To evaluate the incidence risk of programmed cell death-1/programmed cell death ligand 1 (PD-1/PD-L1) inhibitor-related alopecia for cancer patients, the meta-analysis was put into practice. METHOD:The meta-analysis was designed and put into practice according to the preferred reporting items for systematic re...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022555
更新日期:2020-10-16 00:00:00
abstract::High-dose cyclophosphamide has long been used as an anticancer agent, a conditioning regimen for hematopoietic stem cell transplantation, and a potent immunosuppressive agent in autoimmune diseases including aplastic anemia. High-dose cyclophosphamide is highly toxic to lymphocytes but spares hematopoietic stem cells ...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0b013e318210e685
更新日期:2011-03-01 00:00:00
abstract::Calcium channel blockers (CCBs) are widely used for reducing blood pressure of hypertensive patients. Recent reports document the beneficial effects of CCB for preventing dementia; however, the results are controversial. We aim to evaluate the risk of developing dementia among elderly hypertensive patients treated wit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004593
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Epithelial ovarian cancer (EOC) has been classified into four molecular subtypes, of which the mesenchymal subtype has the poorest survival. Our goal is to develop an immune-based prognostic signature by incorporating molecular subtypes for EOC patients. METHODS:The gene expression profiles of EOC samples w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022549
更新日期:2020-10-09 00:00:00
abstract:INTRODUCTION:Congenital cystic adenomatoid malformation (CCAM) is a rare developmental lung abnormality, that typically manifests in neonates and infants but rarely in adults. Ultrasound is an important method of diagnosing CCAM in neonates and infants; however, few articles have reported the value of transthoracic lun...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023505
更新日期:2020-12-04 00:00:00
abstract::Guidelines for patients with subarachnoid hemorrhage (SAH) management and several grading systems or prognostic indices have been used not only to improve the quality of care but to predict also the outcome of these patients. Among them, the gold standards Fisher radiological grading scale, Hunt-Hess and the World Fed...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012769
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:To systematically evaluate efficacy of traditional Chinese medicine (TCM) in treating chronic gastritis (CG). METHODS:Data sources from PubMed, Embase, Springer Link, China National Knowledge Infrastructure, Chinese Scientific Journals Database, Chinese Biomedicine Database, and Wan-fang database were searc...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015710
更新日期:2019-05-01 00:00:00
abstract::Red blood cell distribution width (RDW) is associated with several diseases. However, the diagnostic value of RDW and its related factors remain unclear in colorectal cancer (CRC).This single-center retrospective study evaluated 211 Chinese CRC patients and 103 healthy controls. The association of RDW with the clinica...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015560
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Knee osteoarthritis (KOA) is a common chronic disorder of knee and the leading cause of pain in the elderly with an overall prevalence of 50% in people over 60 years of age. This disease is an important factor affecting the quality of life of middle-aged and elderly people, and its main symptom is knee joint...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020666
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the outcomes of patients with pathologic T0 esophageal carcinoma after neoadjuvant therapy and surgery. METHODS:We searched PubMed, Embase, Cochrane Library, and Medline databases from inception up to November 12, 2016. The meta-analysis was performed to compare odds ra...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007342
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Pain in glossodynia may be severe; it may prevent patients from working, interfere with daily life activities, and necessitate a patient's visit to a medical institution for consultation and treatment. The pain may be described as persistent and burning (tingling, tingling) or stinging. Patients may complain...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021536
更新日期:2020-08-14 00:00:00
abstract:BACKGROUND:Intubation using direct laryngoscopy is a risky and painful procedure that is associated with undesirable hemodynamic changes such as tachycardia, hypertension, and arrhythmia. Recently, intravenous oxycodone was introduced and used for the control of acute postoperative pain and to attenuate intubation-rela...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000015509
更新日期:2019-05-01 00:00:00
abstract::Purpose of this study was to evaluate the outcomes of patients underwent hemiarthroplasty for proximal femoral fracture converted to total hip arthroplasty (THA).A total of 138 patients from October 2009 till October 2014 had conversion of their failed hemiarthroplasties following a proximal femoral fracture to total ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008235
更新日期:2017-10-01 00:00:00
abstract::The vascular endothelial growth factor (VEGF) level in human circulation may reflect the severity of endothelial dysfunction in patients with diabetes mellitus, which leads to diabetic microvascular complications.We determined plasma VEGF levels as well as metabolic control and inflammatory factors in 26 healthy subje...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010415
更新日期:2018-04-01 00:00:00
abstract::Idiopathic pulmonary fibrosis is a chronic and irreversible respiratory disease with a high incidence worldwide and no specific treatment. Currently, the etiology and pathogenesis of this disease remain largely unknown. In main purpose of this study, bioinformatics analysis was used to uncover key genes and pathways r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022099
更新日期:2020-09-04 00:00:00
abstract::The enterococci, members of the group D streptococci and the predominant aerobic streptococci of the gastrointestinal and female genital tracts, have long been recognized as significant pathogens in infective endocarditis. Over the past 2 decades, enterococci have become increasingly important nosocomial pathogens, re...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Coronary heart disease angina pectoris is a common clinical symptom in patients with coronary heart disease, due to coronary atherosclerotic stenosis or sputum leading to coronary insufficiency, myocardial transient ischemia, hypoxia caused by precordial pain as the main clinical manifestations Group syndrom...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018548
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:To investigate the efficacy and safety of acupoint injection of Bacillus Calmette-Guerin polysaccharide nucleic acid (BCG-PSN) in the treatment of chronic urticaria (CU). METHODS:The following databases will be searched from their inception: Medline, Embase, Pubmed, Web of Science, Cochrane Central Register...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019924
更新日期:2020-05-01 00:00:00
abstract::In view of the forthcoming long-acting antiretrovirals, measures should be taken to prevent the selection of HIV drug resistance mutations. All subjects who had been switched to boosted protease inhibitors plus maraviroc (bPIs/MVC) with baseline HIV-1 RNA >50 copies/mL between June, 2014, and April, 2015, were retrosp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005728
更新日期:2017-02-01 00:00:00
abstract:RATIONALE:Prepubertal unilateral gynecomastia is extremely rare, whose etiology and management strategy are not familiar. We would like to present a case and a literature review of unilateral prepubertal gynecomastia. PATIENT CONCERNS:A 11-year old male patient with complaints of unilateral enlargement of breast tissu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017374
更新日期:2019-10-01 00:00:00