A randomized controlled study for Yuanhu Zhitong dropping pills in the treatment of knee osteoarthritis.

Abstract:

BACKGROUND:Knee osteoarthritis (KOA) is a common chronic disorder of knee and the leading cause of pain in the elderly with an overall prevalence of 50% in people over 60 years of age. This disease is an important factor affecting the quality of life of middle-aged and elderly people, and its main symptom is knee joint pain. Due to the pain, the knee joint activity function is limited, bringing great pain to patients, affecting their quality of life, effective prevention, and treatment of KOA is a modern medical problem. METHODS:The 60 patients who met the inclusion criteria were randomly divided into the treatment group and the control group. In this study, single center, randomized control and equivalent clinical trial were used for treatment. The treatment group received Yuanhu Zhitong dropping pills within 4 weeks, and the control group received diclofenac sodium sustained-release capsule treatment within 4 weeks. The main measures were visual analogue scale (VAS), WOMAC osteoarthritis index score and gastrointestinal symptoms rating scale (GSRS).Secondary measures included biochemical markers and adverse reactions during treatment. RESULT:The results of this trial will be published on the website of China Clinical Trial Registration Center (http://www.chictr.org.cn/searchprojen.aspx) and in peer-reviewed journals or academic conferences. CONCLUSIONS:This study is to assess the efficacy and safety of Yuanhu Zhitong dropping pills for knee osteoarthritis (KOA). REGISTRATION:PROSPERO (registration number ChiCTR1900024712).

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Gu Y,Huang J,Guo H,Song X,Li J,Shi Y,Xie X

doi

10.1097/MD.0000000000020666

subject

Has Abstract

pub_date

2020-06-12 00:00:00

pages

e20666

issue

24

eissn

0025-7974

issn

1536-5964

pii

00005792-202006120-00066

journal_volume

99

pub_type

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