Abstract:
BACKGROUND:Knee osteoarthritis (KOA) is a common chronic disorder of knee and the leading cause of pain in the elderly with an overall prevalence of 50% in people over 60 years of age. This disease is an important factor affecting the quality of life of middle-aged and elderly people, and its main symptom is knee joint pain. Due to the pain, the knee joint activity function is limited, bringing great pain to patients, affecting their quality of life, effective prevention, and treatment of KOA is a modern medical problem. METHODS:The 60 patients who met the inclusion criteria were randomly divided into the treatment group and the control group. In this study, single center, randomized control and equivalent clinical trial were used for treatment. The treatment group received Yuanhu Zhitong dropping pills within 4 weeks, and the control group received diclofenac sodium sustained-release capsule treatment within 4 weeks. The main measures were visual analogue scale (VAS), WOMAC osteoarthritis index score and gastrointestinal symptoms rating scale (GSRS).Secondary measures included biochemical markers and adverse reactions during treatment. RESULT:The results of this trial will be published on the website of China Clinical Trial Registration Center (http://www.chictr.org.cn/searchprojen.aspx) and in peer-reviewed journals or academic conferences. CONCLUSIONS:This study is to assess the efficacy and safety of Yuanhu Zhitong dropping pills for knee osteoarthritis (KOA). REGISTRATION:PROSPERO (registration number ChiCTR1900024712).
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Gu Y,Huang J,Guo H,Song X,Li J,Shi Y,Xie Xdoi
10.1097/MD.0000000000020666subject
Has Abstractpub_date
2020-06-12 00:00:00pages
e20666issue
24eissn
0025-7974issn
1536-5964pii
00005792-202006120-00066journal_volume
99pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:The critically ill and surgical patients are at significant risk of delirium, which is associated with a high morbidity and mortality. The association between statin use and the incidence of delirium is still controversial. In this article, we will perform a systematic review and meta-analysis of published s...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013679
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is the leading cause of health complications and death among human with immunodeficiency virus (HIV) infection. When TB develops during pregnancy or the early postpartum period, it is associated with negative maternal, pregnancy, and fetus and infant outcome, including premature birth, low ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023089
更新日期:2020-11-20 00:00:00
abstract::Melanoma, which is usually induced by ultraviolet light exposure and the following DNA damage, is the most dangerous skin cancer. The purpose of the present study was to screen key molecules involved in melanoma.Microarray data of E-MTAB-1862 were downloaded from the ArrayExpress database, which included 21 primary me...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007497
更新日期:2017-07-01 00:00:00
abstract::This article compares the clinical characteristics and prognosis of young patients in different age groups with liver cancer (LC). In this retrospective study, we searched the Surveillance, Epidemiology, and End Results population-based database and identified 2641 patients who had been diagnosed with LC between 1988 ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000684
更新日期:2015-03-01 00:00:00
abstract::Modifiable cardiovascular risk factors such as obesity, hypertension, dyslipidemia, smoking, diabetes mellitus, and metabolic syndrome can easily give rise to coronary heart disease (CHD). However, due to the existence of the so-called "obesity paradox" and "smoking paradox," the impact of these modifiable cardiovascu...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000002313
更新日期:2015-12-01 00:00:00
abstract::We aim to screen the mutations of 3 hearing loss (HL) genes (GJB2, SLC26A4, and 12S rRNA) in 71 cases with nonsyndromic hearing loss (NSHL) using microarray and SNPscan, and identify the roles of nonhotspot mutation of these genes in the screening of NSHL. Seventy-one cases with moderate or severe neurosensory deafnes...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007149
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:Insignifificant, asymmetrical or lack of labial tubercle often occurs after cleft lip surgery due to improper treatment of vermilion tissue. Especially in the cases of bilateral cleft lip, because of short front lip and insuffificient vermilion tissue, the median vermilion depression often occurs after surger...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016161
更新日期:2019-07-01 00:00:00
abstract::The acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 and DGAT2 catalyze the final step in triglycerides biosynthesis. This study examined the relationships of baseline phenotypes and the common polymorphisms in DGAT1 and DGAT2 with the lipid responses to niacin.Lipid responses in Chinese patients with dysl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000881
更新日期:2015-05-01 00:00:00
abstract::To evaluate the impact of visceral obesity on laparoscopic total mesorectal excision (TME) and decide the best index to reflect completion of mesorectum and perioperative outcomes.Patients with rectal cancer who underwent laparoscopic TME were enrolled. The data including body mass index (BMI), visceral fat area (VFA)...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004462
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:To explore the correlation between recurrent risk and CYP2C19 gene polymorphisms in patients with ischemic stroke (IS) treated with clopidogrel for prevention. METHODS:A total of 289 patients with IS treated with clopidogrel regularly were enrolled in this study, and stroke recurrence of all patients were r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019143
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:This study will assess the efficacy and safety of Shenmai injection (SMI) for the treatment of chronic heart failure (CHF). METHODS:The following electronic bibliographic databases will be searched from inception to the March 25, 2020 without language and publication time limitations: MEDLINE, PUBMED, Cochr...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020663
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Implementation of dispatcher-assisted cardiopulmonary resuscitation (DACPR) has increased the likelihood of bystander CPR upon cardiac arrest. However, the quality of CPR has been found to be very low. In this study, we aimed to compare CPR quality between the current DACPR practices and the interventional i...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000022728
更新日期:2020-10-16 00:00:00
abstract::A profound number of prophylactic antibiotics are used after radical cystectomy with an ileal orthotopic neobladder (RCIONB) despite a negative effect of infection control. We investigated the impact of short-term prophylactic antibiotic use on infectious complications after RCIONB.We retrospectively reviewed data fro...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013196
更新日期:2018-11-01 00:00:00
abstract::To evaluate the timing, feasibility, and necessity of early laparoscopic cholecystectomy (LC) in the management of patients with acute calculous cholecystitis complicated with hepatic dysfunction.The clinical data of 60 patients with acute calculous cholecystitis complicated with hepatic dysfunction treated from Janua...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020239
更新日期:2020-06-12 00:00:00
abstract::This study was conducted to estimate the 25-hydroxyvitamin D (25 (OH)D) levels and explore factors related to vitamin D deficiency/insufficiency. This was a multicenter, hospital-based, cross-sectional observational study. Children admitted to hospitals for health examination were included for vitamin D measurement an...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000022463
更新日期:2020-10-30 00:00:00
abstract::Alveolar echinococcosis is a chronically progressive and potentially fatal disease. Patients with multiple giant alveolar echinococcosis have a poor prognosis when radical resection cannot be achieved, but curative resection can be limited by low future remnant liver volumes. In these cases, 2-stage liver resection ma...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007819
更新日期:2017-08-01 00:00:00
abstract:RATIONALE:Hemophagocytic lymphohistiocytosis (HLH) secondary to methicillin-resistant Staphylococcus epidermidis (MRSE)-related left-sided infectious endocarditis had never been reported before. In the last decade, daptomycin, a novel lipopeptide antibiotic, showed its excellent role in anti-Gram-positive bacteria, inc...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000009451
更新日期:2017-12-01 00:00:00
abstract:UNLABELLED:Prevalence estimates of adjacent segment degeneration (ASD) following cervical spine surgery varied greatly in current studies. We conducted a systematic review and meta-analysis to summarize the point prevalence of ASD after cervical spine surgery. METHODS:Comprehensive electronic searches of PubMed, Embas...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004171
更新日期:2016-07-01 00:00:00
abstract::Abnormal liver function tests (LFTs) are often observed in patients with Graves' disease (GD). To date, there are limited data demonstrating the factors or biochemical indexes contributing to LFT abnormalities in this patient population. The aim of this study was to explore factors predicting abnormal LFTs induced by ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000839
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:National Comprehensive Cancer Network (NCCN) guidelines recommend surgery, chemotherapy, and radiation therapy for gastric cancer patients. Neoadjuvant treatments as the administration of therapeutic agents before a main treatment gained in more and more attention. However, the role of neoadjuvant treatments...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010392
更新日期:2018-04-01 00:00:00
abstract::This study is to investigate the relationship of P-selectin (Ps) gene rs1800807 and rs1800808 polymorphisms with plasma soluble P-selectin (sPs) in Han, Uygur, and Kazakh people with atrial fibrillation (AF) and thromboembolism (TE) in Xinjiang, China.A total of 778 Han patients (including 131 patients with AF and TE,...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018937
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Previous studies have reported that rehabilitation training combined acupuncture (RTA) can be used for the treatment of limb hemiplegia (LH) caused by cerebral infarction (CI). However, its effectiveness is still unclear. In this systematic review study, we aim to evaluate the effectiveness and safety of RTA...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023474
更新日期:2021-01-08 00:00:00
abstract::Acute cellular rejection after liver transplantation (LT) can be treated with steroid pulse therapy, but there is no ideal treatment for steroid-resistant acute rejection (SRAR). We aimed to determine the feasibility and potential complications of rabbit anti-thymocyte globulin (rATG) application to treat SRAR in live...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003711
更新日期:2016-06-01 00:00:00
abstract::Aberrant expression of SRY-box 8 (SOX8) is closely correlated with the development and progression of many types of cancers in human. Limited studies report the relationship between SOX8 expression and overall survival in colorectal cancer (CRC). This study aimed to collect the pathological tissues and clinical data i...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016237
更新日期:2019-07-01 00:00:00
abstract::Brachfeld and Gorlin's revised concept of subaortic stenosis derived from their recognition that the large magnitudes of the pressure gradients were incompatible with the relatively mild anatomic lesions found at surgery in 3 of their patients, and the rapidity of their arterial pulse upstroke. They proposed that a gr...
journal_title:Medicine
pub_type: 传,评论,历史文章,杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::Inflammation associated with low 25-hydroxyvitamin D (25(OH)D) is associated with increased morbidity and mortality among HIV-infected patients with vitamin D deficiency. We investigated the association between 25(OH)D and soluble biomarkers among HIV-infected patients on stable antiretroviral therapy. This is a cross...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005270
更新日期:2016-10-01 00:00:00
abstract::The neoadjuvant chemotherapy (NAC) is the gold standard initial treatment of the locally advanced breast cancer (LABC). However, the reliability of methods that used to assess response the NAC is still controversial. In this study, patients with LABC who underwent NAC were evaluated retrospectively. The assessment of ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023538
更新日期:2020-12-04 00:00:00
abstract:INTRODUCTION:Early postoperative complications graded according to the Clavien-Dindo classification system have not previously been correlated with long-term quality of life outcomes in patients who have had restorative proctocolectomy with ileal pouch-anal anastomosis. This study aimed to assess the severity of early ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003966
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:As the general population continues to age, there is an increase need for surgical management of elderly patients. Compared to open hepatectomy (OH), laparoscopic hepatectomy (LH) offers earlier mobilization, less blood loss, and shorter postoperative hospital stay. However, whether these advantages of LH ov...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000011703
更新日期:2018-07-01 00:00:00
abstract:RATIONALE:In patients with pituitary thyroid hormone resistance, the ability of the pituitary gland to detect (and down-regulate) the increase of triiodothyronine is selectively impaired, while the periphery remains sensitive to triiodothyronine levels, producing symptoms of peripheral thyrotoxicity. Subsequently, ther...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010544
更新日期:2018-05-01 00:00:00