Abstract:
:The aim of this paper was to evaluate the activity and tolerability of oral vinorelbine in patients with advanced castration resistant prostate cancer (CRPC) who progressed after a minimum of three lines including: abiraterone acetate, docetaxel, cabazitaxel, and enzalutamide.Treatment consisted of weekly oral vinorelbine 60 mg/m. Chemotherapy was administered until disease progression or unacceptable toxicity.Twenty-six patients received vinorelbine: their median age was 74 years (range 58-84 years). Twenty-four (92.3%) patients had bone metastases. A decrease in PSA levels ≥50% was observed in 2 patients (7.7%). Among the subjects who were symptomatic at baseline, pain was reduced in 3 patients (13.6%) with a significant decrease in analgesic use. Median progression-free survival was 9 weeks (95% CI: 7 to 11) and median overall survival was 17 weeks (95% CI: 12 to 22). Treatment was well tolerated, and no grade 4 toxicities were observed.Our findings do not suggest the use of oral vinorelbine on a weekly schedule, in CRPC heavily pre-treated.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Roviello G,Corona SP,Conca R,Petrioli R,Rosellini P,Bonetta A,Aieta Mdoi
10.1097/MD.0000000000016249subject
Has Abstractpub_date
2019-06-01 00:00:00pages
e16249issue
26eissn
0025-7974issn
1536-5964pii
00005792-201906280-00101journal_volume
98pub_type
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