Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

abstract：:Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior? Using Caenorhabditis elegans, we map a novel sensory neuron circuit motif that encodes odor concentration. Primary neurons, AWC(ON) and AWA, directly detect the foo...

journal_title：eLife

authors： Leinwand SG,Yang CJ,Bazopoulou D,Chronis N,Srinivasan J,Chalasani SH

更新日期：2015-09-22 00:00:00

abstract：:Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge this covalently closed macromolecule during growth, but how these autolytic enzymes are regulated remains poorly understood. Bacillus s...

journal_title：eLife

authors： Dobihal GS,Brunet YR,Flores-Kim J,Rudner DZ

更新日期：2019-12-06 00:00:00

abstract：:Autoinducers are small signaling molecules that mediate intercellular communication in microbial populations and trigger coordinated gene expression via 'quorum sensing'. Elucidating the mechanisms that control autoinducer production is, thus, pertinent to understanding collective microbial behavior, such as virulence...

journal_title：eLife

authors： Bauer M,Knebel J,Lechner M,Pickl P,Frey E

更新日期：2017-07-25 00:00:00

abstract：:In bacteria, multicellular behaviors are regulated by cell-cell signaling through the exchange of both diffusible and contact-dependent signals. In a multicellular context, Myxococcus cells can share outer membrane (OM) materials by an unknown mechanism involving the traAB genes and gliding motility. Using live imagin...

journal_title：eLife

authors： Ducret A,Fleuchot B,Bergam P,Mignot T

更新日期：2013-07-23 00:00:00

abstract：:Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in both model organisms. ...

journal_title：eLife

authors： Brandt T,Mourier A,Tain LS,Partridge L,Larsson NG,Kühlbrandt W

更新日期：2017-07-12 00:00:00

abstract：:Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recogniti...

journal_title：eLife

authors： Morici JF,Miranda M,Gallo FT,Zanoni B,Bekinschtein P,Weisstaub NV

更新日期：2018-05-02 00:00:00

abstract：:Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use two complementary approaches to directly map the specificities of the n...

journal_title：eLife

authors： Dingens AS,Pratap P,Malone KD,Hilton SK,Ketas T,Cottrell CA,Overbaugh JM,Moore JP,Klasse PJ,Ward AB,Bloom JD

更新日期：2021-01-13 00:00:00

abstract：:The >800 human G protein-coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets. Their myriad structural conformations and various modes of signaling make it challenging to understand their structure and function. Here, we devel...

journal_title：eLife

authors： Jones EM,Lubock NB,Venkatakrishnan AJ,Wang J,Tseng AM,Paggi JM,Latorraca NR,Cancilla D,Satyadi M,Davis JE,Babu MM,Dror RO,Kosuri S

更新日期：2020-10-21 00:00:00

abstract：:The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developing vertebrate brain. ...

journal_title：eLife

authors： Agrawal T,Hasan G

更新日期：2015-05-08 00:00:00

abstract：:β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We found that new propellers evolve continuously by amplification from single...

journal_title：eLife

authors： Afanasieva E,Chaudhuri I,Martin J,Hertle E,Ursinus A,Alva V,Hartmann MD,Lupas AN

更新日期：2019-10-15 00:00:00

abstract：:While traditional microbiological freshwater tests focus on the detection of specific bacterial indicator species, including pathogens, direct tracing of all aquatic DNA through metagenomics poses a profound alternative. Yet, in situ metagenomic water surveys face substantial challenges in cost and logistics. Here, we...

journal_title：eLife

authors： Urban L,Holzer A,Baronas JJ,Hall MB,Braeuninger-Weimer P,Scherm MJ,Kunz DJ,Perera SN,Martin-Herranz DE,Tipper ET,Salter SJ,Stammnitz MR

更新日期：2021-01-19 00:00:00

abstract：:Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has in part been limit...

journal_title：eLife

authors： Steinman JB,Santarossa CC,Miller RM,Yu LS,Serpinskaya AS,Furukawa H,Morimoto S,Tanaka Y,Nishitani M,Asano M,Zalyte R,Ondrus AE,Johnson AG,Ye F,Nachury MV,Fukase Y,Aso K,Foley MA,Gelfand VI,Chen JK,Carter AP,Kapo

更新日期：2017-05-19 00:00:00

abstract：:During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Ra...

journal_title：eLife

authors： Chen X,Shibata AC,Hendi A,Kurashina M,Fortes E,Weilinger NL,MacVicar BA,Murakoshi H,Mizumoto K

更新日期：2018-07-31 00:00:00

abstract：:Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections. Late-onset diseases (LOD) occur between 7 and 89 days of life and are largely due to the CC17 GBS hypervirulent clone. We studied the impact of estradiol (E2) and progesterone (P4), which impregnate the fetus during pregnancy, ...

journal_title：eLife

authors： Hays C,Touak G,Bouaboud A,Fouet A,Guignot J,Poyart C,Tazi A

更新日期：2019-11-11 00:00:00

abstract：:Why does a first pregnancy after age 35 increase the risk of breast cancer, and what can be done to combat this? ...

journal_title：eLife

authors： Chakravarthi BV,Varambally S

更新日期：2013-12-31 00:00:00

abstract：:Voltage-gated potassium (Kv) channels enable potassium efflux and membrane repolarization in excitable tissues. Many Kv channels undergo a progressive loss of ion conductance in the presence of a prolonged voltage stimulus, termed slow inactivation, but the atomic determinants that regulate the kinetics of this proces...

journal_title：eLife

authors： Pless SA,Galpin JD,Niciforovic AP,Kurata HT,Ahern CA

更新日期：2013-12-10 00:00:00

abstract：:Strong kinetochore-microtubule attachments are essential for faithful segregation of sister chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule binding components of the Saccharomyces cerevisiae kinetochore. Cooperation between these two complexes enhances kinetochore-microtubule coupling ...

journal_title：eLife

authors： Kim JO,Zelter A,Umbreit NT,Bollozos A,Riffle M,Johnson R,MacCoss MJ,Asbury CL,Davis TN

更新日期：2017-02-13 00:00:00

abstract：:The incubation period for typhoid, polio, measles, leukemia and many other diseases follows a right-skewed, approximately lognormal distribution. Although this pattern was discovered more than sixty years ago, it remains an open question to explain its ubiquity. Here, we propose an explanation based on evolutionary dy...

journal_title：eLife

authors： Ottino-Loffler B,Scott JG,Strogatz SH

更新日期：2017-12-21 00:00:00

abstract：:Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is a critical component of cognitive control that is orchestrated by frontal cortex. The relative roles of distinct subregions within frontal cortex are poorly understood. To examine the dynamics underlying cognitive contro...

journal_title：eLife

authors： Tang H,Yu HY,Chou CC,Crone NE,Madsen JR,Anderson WS,Kreiman G

更新日期：2016-02-18 00:00:00

abstract：:TFIID-a complex of TATA-binding protein (TBP) and TBP-associated factors (TAFs)-is a central component of the Pol II promoter recognition apparatus. Recent studies have revealed significant downregulation of TFIID subunits in terminally differentiated myocytes, hepatocytes and adipocytes. Here, we report that TBP prot...

journal_title：eLife

authors： Li L,Martinez SS,Hu W,Liu Z,Tjian R

更新日期：2015-09-22 00:00:00

abstract：:Muscles organise pseudo-crystalline arrays of actin, myosin and titin filaments to build force-producing sarcomeres. To study sarcomerogenesis, we have generated a transcriptomics resource of developing Drosophila flight muscles and identified 40 distinct expression profile clusters. Strikingly, most sarcomeric compon...

journal_title：eLife

authors： Spletter ML,Barz C,Yeroslaviz A,Zhang X,Lemke SB,Bonnard A,Brunner E,Cardone G,Basler K,Habermann BH,Schnorrer F

更新日期：2018-05-30 00:00:00

abstract：:Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast number of essential physiological functions. Precise control of GPCR signaling requires action of regulators of G protein signaling (RGS) proteins that deactivate heterotrimeric G proteins. RGS proteins are elaborately regulated and ...

journal_title：eLife

authors： Patil DN,Rangarajan ES,Novick SJ,Pascal BD,Kojetin DJ,Griffin PR,Izard T,Martemyanov KA

更新日期：2018-12-12 00:00:00

abstract：:Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of intracellular lipid-sorting to enable mucosal absorption of the incret...

journal_title：eLife

authors： Garcia-Castillo MD,Chinnapen DJ,Te Welscher YM,Gonzalez RJ,Softic S,Pacheco M,Mrsny RJ,Kahn CR,von Andrian UH,Lau J,Pentelute BL,Lencer WI

更新日期：2018-05-31 00:00:00

abstract：:A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarde...

journal_title：eLife

authors： Jagannathan M,Cummings R,Yamashita YM

更新日期：2018-03-26 00:00:00

abstract：:Cells can avoid the effects of so-called 'nonsense' mutations by several methods, including a newly discovered mechanism driven by microRNA molecules. ...

journal_title：eLife

authors： Jopling CL

更新日期：2014-09-09 00:00:00

abstract：:Hair follicle (HF) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells. In humans this process only occurs during embryogenesis and viable strategies to induce new HFs in adult skin are lacking. Here, we reveal that activation of Hedgehog (Hh) signaling in adjacent epithel...

journal_title：eLife

authors： Sun X,Are A,Annusver K,Sivan U,Jacob T,Dalessandri T,Joost S,Füllgrabe A,Gerling M,Kasper M

更新日期：2020-03-17 00:00:00

abstract：:Struggling to get her research project up and running in a new country, a mother gets inspiration from her young daughter. ...

journal_title：eLife

authors： Sadanandappa MK

更新日期：2020-06-10 00:00:00

abstract：:Extracellular vesicles (EVs) encompass a variety of vesicles secreted into the extracellular space. EVs have been implicated in promoting tumor metastasis, but the molecular composition of tumor-derived EV sub-types and the mechanisms by which molecules are sorted into EVs remain mostly unknown. We report the separati...

journal_title：eLife

authors： Temoche-Diaz MM,Shurtleff MJ,Nottingham RM,Yao J,Fadadu RP,Lambowitz AM,Schekman R

更新日期：2019-08-22 00:00:00

abstract：:Behavior relies on the ability of sensory systems to infer properties of the environment from incoming stimuli. The accuracy of inference depends on the fidelity with which behaviorally relevant properties of stimuli are encoded in neural responses. High-fidelity encodings can be metabolically costly, but low-fidelity...

journal_title：eLife

authors： Młynarski WF,Hermundstad AM

更新日期：2018-07-10 00:00:00

abstract：:The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response. ...

journal_title：eLife

authors： Okabe Y,Medzhitov R

更新日期：2014-09-24 00:00:00