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Protective effects of Se-containing protein hydrolysates from Se-enriched rice against Pb(2+)-induced cytotoxicity in PC12 and RAW264.7 cells.

Abstract：

:The protective capacity of Se-containing protein hydrolysates with molecular weight below 1kDa (SPHs-3), against Pb(2+)-induced damage in PC12 and RAW264.7 cells, was investigated in this study. The cell viability, levels of reactive oxygen species (ROS), lactate dehydrogenase (LDH), superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) in cell were analyzed. Results showed that 100μg/ml of SPHs-3 pretreatment could significantly increase cell viability by 24.9% and 23.0% in Pb(2+)-treated PC12 and RAW264.7 cells, respectively (P<0.01). The levels of ROS, NO, LDH and MDA were reduced by 32.2%, 68.2%, 79.7% and 73.7% in 100μg/ml SPHs-3 pretreated PC12 cells, respectively (P<0.01). SPHs-3 pretreatment was also associated with increases of SOD activity and GSH content in cells. In conclusion, SPHs-3 could protect cells against Pb(2+)-induced cytotoxicity, suggesting that Se-enriched rice may be a feasible candidate to improve health standard of the Pb(2+)-pollution population.

journal_name

Food Chem

journal_title

Food chemistry

authors

Xu Z,Fang Y,Chen Y,Yang W,Ma N,Pei F,Kimatu BM,Hu Q,Qiu W

doi

10.1016/j.foodchem.2016.02.021

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

396-403

eissn

0308-8146

issn

1873-7072

pii

S0308-8146(16)30169-8

journal_volume

202

pub_type

杂志文章

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