Abstract:
:Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chelating iron, copper and zinc; scavenging reactive oxygen species; and suppressing the fibrillation of amyloid-beta peptide (Aβ). In this study, nine different food constituents (l-ascorbic acid, caffeic acid, caffeine, curcumin, (-)-epigallocatechin gallate (EGCG), gallic acid, propyl gallate, resveratrol, and α-tocopherol) were investigated for their effects on the above factors, using metal chelation assays, antioxidant assays, and assays of Aβ42 fibrillation. An assay method was developed using 5-Br-PAPS to examine the complexation of Zn(II) and Cu(II). EGCG, gallic acid, and curcumin were identified as a multifunctional compounds, however their poor brain uptake might limit their therapeutic effects. The antioxidants l-ascorbic acid and α-tocopherol, with better brain uptake, deserve further investigation for specifically addressing oxidative stress within the AD brain.
journal_name
Food Chemjournal_title
Food chemistryauthors
Chan S,Kantham S,Rao VM,Palanivelu MK,Pham HL,Shaw PN,McGeary RP,Ross BPdoi
10.1016/j.foodchem.2015.11.118subject
Has Abstractpub_date
2016-05-15 00:00:00pages
185-94eissn
0308-8146issn
1873-7072pii
S0308-8146(15)30263-6journal_volume
199pub_type
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