The Malleable Nature of the Budding Yeast Nuclear Envelope: Flares, Fusion, and Fenestrations.

abstract：:The urokinase system is involved in a variety of physiological processes, such as fibrinolysis, matrix remodeling, wound healing, and regeneration. Upon binding to its cognate receptor urokinase-type plasminogen activator receptor (uPAR), urokinase-type plasminogen activator (uPA) catalyzes the conversion of plasminog...

journal_title：Journal of cellular physiology

authors： Semina EV,Rubina KA,Shmakova AA,Rysenkova KD,Klimovich PS,Aleksanrushkina NA,Sysoeva VY,Karagyaur MN,Tkachuk VA

更新日期：2020-09-01 00:00:00

abstract：:Both the Na+-dependent glucose cotransporter (SGLT1) and the cystic fibrosis transmembrane conductance regulator (CFTR) modulate Na+ and fluid movement, although in opposite directions. Yet few studies have investigated a possible interrelationship between these two transporters. By using the Caco-2 human colon carcin...

journal_title：Journal of cellular physiology

authors： Mailleau C,Capeau J,Brahimi-Horn MC

更新日期：1998-09-01 00:00:00

abstract：:The vagina provides a characteristic low-Na+ and low-pH fluid microenvironment that is considered generally protective. Previous studies have shown that various types of epithelial cells harbor the capacity of intracellular pH (pHi) regulation. However, it remains elusive whether vaginal epithelium could actively regu...

journal_title：Journal of cellular physiology

authors： Zhang YL,Feng JC,Ke LJ,Xu JW,Huang ZX,Huang J,Zhu YX,Zhou WL

更新日期：2019-01-29 00:00:00

abstract：:In a recent publication, Heubusch et al. (J Cell. Physiol, 122:266-272, 1985) reported changes of erythrocyte volume measured by the Coulter counter technique over a wide range of osmolalities (160 to 3000 m0sm). Their results showed a partially hindered, nonlinear response, in contrast to classical observations made ...

journal_title：Journal of cellular physiology

authors： Massaldi HA,Richieri GV,Mel HC

更新日期：1986-06-01 00:00:00

abstract：:Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and immune cells in tumor microenvironment to suppress anti-tumor responses. Two cell surface expressed ...

journal_title：Journal of cellular physiology

authors： Kazemi MH,Raoofi Mohseni S,Hojjat-Farsangi M,Anvari E,Ghalamfarsa G,Mohammadi H,Jadidi-Niaragh F

更新日期：2018-03-01 00:00:00

abstract：:Ion channels are pivotal to many aspects of sperm physiology and function. We have used the patch clamp technique to investigate the distribution of ion channels in the plasma membrane of the head of human spermatozoa. We report that three types of activity are common in the equatorial and acrosomal regions of the spe...

journal_title：Journal of cellular physiology

authors： Jiménez-González MC,Gu Y,Kirkman-Brown J,Barratt CL,Publicover S

更新日期：2007-12-01 00:00:00

abstract：:Sepsis, a complex and dynamic syndrome resulting from microbial invasion and immune system dysregulation, is associated with an increased mortality, reaching up to 35% worldwide. Cholesterol metabolism is often disturbed during sepsis, with low plasma cholesterol levels being associated with poor prognosis. Proprotein...

journal_title：Journal of cellular physiology

authors： Paciullo F,Fallarino F,Bianconi V,Mannarino MR,Sahebkar A,Pirro M

更新日期：2017-09-01 00:00:00

abstract：:In this study, we focused on ERβ regulation in the adenohypophysis under different estrogenic milieu, by analyzing whether ER modulates the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression and its subcellular localization on anterior pituitary glands from Wistar rats and GH3 lactosomatotroph c...

journal_title：Journal of cellular physiology

authors： Perez PA,Petiti JP,Picech F,Guido CB,dV Sosa L,Grondona E,Mukdsi JH,De Paul AL,Torres AI,Gutierrez S

更新日期：2018-02-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) and its receptor (LIFR) are "twins" of Oncostatin M (OSM) and OSMR, respectively, likely having arisen through gene duplications. We compared their effects in a bone nodule-forming model of in vitro osteogenesis, rat calvaria (RC) cell cultures. Using a dominant-negative LIF mutant (hL...

journal_title：Journal of cellular physiology

authors： Malaval L,Liu F,Vernallis AB,Aubin JE

更新日期：2005-08-01 00:00:00

abstract：:Several papers report a hypoxia-induced upregulation of the endothelial nitric oxide synthase (eNOS) mRNA expression. Since there is no known hypoxia-sensitive element binding site in the eNOS promoter, we reasoned that the effect of hypoxia could be simulated by a metabolically elicited alteration of the redox state....

journal_title：Journal of cellular physiology

authors： Hoffmann A,Gloe T,Pohl U

更新日期：2001-07-01 00:00:00

abstract：:Activation of hepatic progenitor cells (HPCs) is commonly observed in chronic liver disease and Wnt/β-catenin signaling plays a crucial role in the expansion of HPCs. However, the molecular mechanisms that regulate the activation of Wnt/β-catenin signaling in the liver, especially in HPCs, remain largely elusive. Here...

journal_title：Journal of cellular physiology

authors： Ding ZY,Liang HF,Jin GN,Chen WX,Wang W,Datta PK,Zhang MZ,Zhang B,Chen XP

更新日期：2014-05-01 00:00:00

abstract：:Osteoblasts are the main functional cells of bone formation, and they are responsible for the synthesis, secretion, and mineralization of the bone matrix. Phosphatidylinositol-3-kinase/Akt is an important signaling pathway involved in the regulation of cell proliferation, death, and survival. Some studies have shown t...

journal_title：Journal of cellular physiology

authors： Bai Y,Zhang Q,Chen Q,Zhou Q,Zhang Y,Shi Z,Nong H,Liu M,Zeng G,Zong S

更新日期：2020-12-30 00:00:00

abstract：:Detailed information regarding the synthesis rates of individual protein components is important in understanding the assembly and dynamics of the cytoskeletal matrix of eukaryotic cells. As an approach to this topic, the dual isotope technique of Clark and Zak (J. Biol. Chem., 256:4863-4870, 1981), was employed to me...

journal_title：Journal of cellular physiology

authors： Mitchell JJ,Low RB,Woodcock-Mitchell JL

更新日期：1990-06-01 00:00:00

abstract：:The relationship between replication and the synthesis of matrix sulfated proteoglycans was investigated with fetal rat chondrocytes grown in monolayer culture. The effect of N6 O2' dibutyryl adenosine 3', 5' cyclic monophosphate (DBcAMP), adenosine 3', 5' cyclic monophosphate (cAMP), 8 Bromo adenosine 3', 5' cyclic m...

journal_title：Journal of cellular physiology

authors： Miller RP,Husain M,Lohin S

更新日期：1979-07-01 00:00:00

abstract：:Our study examines the effect of apoptosis on prothymosin alpha, an abundant, nuclear protein intimately involved with proliferation of all mammalian cells. When HeLa cells were treated with actinomycin D, with etoposide, or with staurosporine following synchronization with hydroxyurea, they underwent apoptosis based ...

journal_title：Journal of cellular physiology

authors： Enkemann SA,Wang RH,Trumbore MW,Berger SL

更新日期：2000-02-01 00:00:00

abstract：:Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine. In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis by suppressing nuclear factor-k...

journal_title：Journal of cellular physiology

authors： Yang Z,Li C,Wang X,Zhai C,Yi Z,Wang L,Liu B,Du B,Wu H,Guo X,Liu M,Li D,Luo J

更新日期：2010-10-01 00:00:00

abstract：:Phospholipase C-ε (PLCε) is frequently overexpressed in tumors and plays an important role in the regulation of tumorigenesis. Although great progress has been made in understanding biological roles of PLCε, the relevant molecular mechanisms underlying its pro-tumor activity remain largely unclear. Here, we demonstrat...

journal_title：Journal of cellular physiology

authors： Fan Y,Ou L,Fan J,Li L,Wang X,Niu L,Wu X,Luo C

更新日期：2020-11-01 00:00:00

abstract：:The purpose of this study was to delineate the traffic patterns of EGF and EGF receptors (EGFR) in primary cultured acinar epithelial cells from rabbit lacrimal glands. Uptake of [(125)I]-EGF exhibited saturable and non-saturable, temperature-dependent components, suggesting both receptor-mediated and fluid phase endo...

journal_title：Journal of cellular physiology

authors： Xie J,Qian L,Wang Y,Rose CM,Yang T,Nakamura T,Hamm-Alvarez SF,Mircheff AK

更新日期：2004-04-01 00:00:00

abstract：:The interaction between dietary lectins, especially wheat germ agglutinin (WGA), and intestinal cells has been implicated in the pathogenesis of celiac disease. The present study was undertaken to investigate the immediate effects following such an interaction. Direct WGA-stimulation of Intestine 407 cells leads to an...

journal_title：Journal of cellular physiology

authors： Sjölander A

更新日期：1988-03-01 00:00:00

abstract：:The basis of the well-known decline in cell proliferation with increasing passage number of human diploid fibroblast-like cell cultures is not known. It has been found that DNA synthesis was deficient in the remaining but still proliferating cells, but when appropriate corrections reflecting the remaining dividing cel...

journal_title：Journal of cellular physiology

authors： Collins JM,Chu AK

更新日期：1990-04-01 00:00:00

abstract：:Aberrant glycosylation changes on many glycoproteins are often related to cancer progression and metastasis. sp2 -Iminosugar-type castanospermine analogues, inhibitors of α-glucosidases, have been reported to exhibit antitumor activity. However, their effects on cell migration and the underlying molecular mechanism ar...

journal_title：Journal of cellular physiology

authors： Gueder N,Allan G,Telliez MS,Hague F,Fernandez JM,Sanchez-Fernandez EM,Ortiz-Mellet C,Ahidouch A,Ouadid-Ahidouch H

更新日期：2017-12-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) promotes bone formation by stimulating proliferation and differentiation of osteoblasts. Bone sialoprotein (BSP), is thought to function in the initial mineralization of bone, is selectively expressed by differentiated osteoblast. To determine the molecular mechanism of IGF-I regul...

journal_title：Journal of cellular physiology

authors： Nakayama Y,Nakajima Y,Kato N,Takai H,Kim DS,Arai M,Mezawa M,Araki S,Sodek J,Ogata Y

更新日期：2006-08-01 00:00:00

abstract：:The role of individual supplements necessary for the long-term self-renewal of embryonic stem (ES) cells is poorly characterized in feeder/serum-free culture systems. This study sought to characterize the relationship between the effects of glucose on ES cell proliferation and fibronectin (FN) synthesis, and to assess...

journal_title：Journal of cellular physiology

authors： Kim YH,Ryu JM,Lee YJ,Han HJ

更新日期：2010-05-01 00:00:00

abstract：:The human polyomavirus, JC virus (JCV), provides an excellent model system to investigate the reciprocal interaction of the immune and nervous systems. Infection with JCV occurs during childhood and the virus remains in the latent state with no apparent clinical symptoms. However, under immunosuppressed conditions, th...

journal_title：Journal of cellular physiology

authors： Sweet TM,Del Valle L,Khalili K

更新日期：2002-06-01 00:00:00

abstract：:Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways are triggered by receptor ac...

journal_title：Journal of cellular physiology

authors： Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H

更新日期：2019-07-01 00:00:00

abstract：:Sirtuin 3 (SIRT3) a mitochondrial enzyme that plays an important role in energy homeostasis, cardiac remodeling, and heart failure (HF). The expression of SIRT3 declines with advanced age, cardiovascular, and metabolic diseases. Accumulating evidence suggests that SIRT3 plays a critical role in protecting the heart fr...

journal_title：Journal of cellular physiology

authors： He X,Zeng H,Chen JX

更新日期：2019-03-01 00:00:00

abstract：:Cover: The cover image, by Michaela R. Reagan et al., is based on the Perspective A Perspective on Malignancy in the Marrow, DOI 10.1002/jcp.25860. ...

journal_title：Journal of cellular physiology

authors： Reagan MR,Lian JB,Rosen CJ,Stein GS

更新日期：2017-12-01 00:00:00

abstract：:Long suspected, recently recognized, and increasingly studied, non protein-coding RNAs (ncRNAs) are emerging as key drivers of biological control and pathology. Since their discovery in 1993, microRNAs (miRNAs) have been the subject of intense research focus and investigations have revealed striking findings, establis...

journal_title：Journal of cellular physiology

authors： Tye CE,Gordon JA,Martin-Buley LA,Stein JL,Lian JB,Stein GS

更新日期：2015-03-01 00:00:00

abstract：:PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA). However, its potential modulatory role in early OA progression has not been investigated yet. Here, a mouse destabilization OA model in the tibia was used to investigate roles of PI3K/AKT signaling in the early subchondral bone chang...

journal_title：Journal of cellular physiology

authors： Lin C,Shao Y,Zeng C,Zhao C,Fang H,Wang L,Pan J,Liu L,Qi W,Feng X,Qiu H,Zhang H,Chen Y,Wang H,Cai D,Xian CJ

更新日期：2018-08-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type-9 (PCSK9), a member of the proprotein convertase family, is an important drug target because of its crucial role in lipid metabolism. Emerging evidence suggests a direct role of localized PCSK9 in the pathogenesis of vascular diseases. With this in our consideration, we revi...

journal_title：Journal of cellular physiology

authors： Guo Y,Yan B,Gui Y,Tang Z,Tai S,Zhou S,Zheng XL

更新日期：2020-09-01 00:00:00