Effect of endothelin as a coronary vasoconstrictor in the Langendorff-perfused rat heart.

abstract：:FACS analysis and [14C]-taurine efflux were used to determine whether activation of the volume-sensitive organic osmolyte/anion channel plays a role in cell cycle progression. This was achieved by examining the effects of a collection of (i) H(1) antagonists and tricyclic antidepressants with a known inhibitory effect...

journal_title：European journal of pharmacology

authors： Belsey MJ,Culliford SJ,Morley RM,Witchel HJ,Kozlowski RZ

更新日期：2003-08-08 00:00:00

abstract：:R-isovaline is a non-proteinogenic amino acid which produces analgesia in a range of nociceptive assays. Mediation of this effect by metabotropic receptors for γ-aminobutyric acid (GABA) and glutamate, demonstrated by previous work, may depend on the type of tissue or receptor system. The objective of this study was t...

journal_title：European journal of pharmacology

authors： Fung T,Asseri KA,Asiri YI,Wall RA,Schwarz SKW,Puil E,MacLeod BA

更新日期：2016-11-15 00:00:00

abstract：:CPP has a potent anticonvulsant effect against sound-induced seizures in audiogenic DBA/2 mice. Pretreatment with CPP (0.01-10 nmol i.c.v., 45 min) protects against successive phases of sound-induced seizures in a dose-dependent fashion (ED50, tonic phase, 0.023 nmol; clonic phase, 0.039 nmol; wild running, 0.17 nmol)...

journal_title：European journal of pharmacology

authors： Chapman AG,Meldrum BS,Nanji N,Watkins JC

更新日期：1987-07-02 00:00:00

abstract：:In cases of severe human scorpion envenoming, lung injury is a common finding and frequently the cause of death. In the rat, two distinct mechanisms account for oedema following the intravenous injection of the venom -- acute left ventricular failure resulting from a massive release of catecholamines and an increase i...

journal_title：European journal of pharmacology

authors： Matos IM,Souza DG,Seabra DG,Freire-Maia L,Teixeira MM

更新日期：1999-07-09 00:00:00

abstract：:Administration of ovalbumin by aerosol to sensitised rats produced a rapid (15 min) protein exudation in different airway tissues, as determined by Evans blue staining. This was associated with marked mast cell degranulation determined by histological examination, with there being no difference between mucosal and con...

journal_title：European journal of pharmacology

authors： Damazo AS,Tavares de Lima W,Perretti M,Oliani SM

更新日期：2001-08-24 00:00:00

abstract：:Fructose-2,6-bisphosphate is a potent activator of 6-phosphofructo-1-kinase, a key enzyme in glycolysis. We previously revealed that sulfonylureas stimulate fructose-2,6-bisphosphate production in the rat liver by activating 6-phosphofructo-2-kinase. In the present study, we show that CS-045, a new antidiabetic agent,...

journal_title：European journal of pharmacology

authors： Murano K,Inoue Y,Emoto M,Kaku K,Kaneko T

更新日期：1994-03-21 00:00:00

abstract：:We have investigated the effect of 2(4-((2-carboxymethyl)phenyl)ethylamino)-5'-N-ethylcarboxamidoadenosine (CGS 21680), a potent and selective agonist at adenosine A2A receptors, on pulmonary inflammation induced by allergen challenge in the ovalbumin-sensitised, Brown Norway rat. Aerosol administration of ovalbumin (...

journal_title：European journal of pharmacology

authors： Fozard JR,Ellis KM,Villela Dantas MF,Tigani B,Mazzoni L

更新日期：2002-03-08 00:00:00

abstract：:Alterations in iron homeostasis are well described in obese patients. The effects of iron chelators on adipose tissue and other organs affected by obesity have been the interest of experimental studies, both in vivo and in vitro. The aim of this review was to update the available information indicating the potential o...

journal_title：European journal of pharmacology

authors： Rodrigues de Morais T,Gambero A

更新日期：2019-10-15 00:00:00

abstract：:Zolpidem has abuse potential, particularly among individuals with histories of drug abuse. This double-blind, placebo-controlled, cross over pilot study investigated the subjective effects of zolpidem (10 mg) in drug-naïve females. Over the course of a 5-h period vital signs were monitored and a series of computerized...

journal_title：European journal of pharmacology

authors： Licata SC,Penetar DM,Dunlap S,Lukas SE

更新日期：2008-11-19 00:00:00

abstract：:A specific protein kinase C inhibitor, calphostin C, which injected alone had no effect on the antinociception induced by intrathecal (i.t.) administration of a selective mu-opioid receptor agonist, [D-Ala2,NMePhe4,Gly(ol)5]enkephalin (DAMGO), dose-dependently attenuated the development of acute tolerance to the i.t. ...

journal_title：European journal of pharmacology

authors： Narita M,Narita M,Mizoguchi H,Tseng LF

更新日期：1995-07-04 00:00:00

abstract：:Peripheral nerve injury, which gives rise to persistent chronic pain, has become an area of intense research activity, largely because it represents a disorder with a high unmet medical need. In this study, serum biomarkers of the spinal nerve ligation model were successfully investigated with the metabolomic method. ...

journal_title：European journal of pharmacology

authors： Mao YF,Liu XR,Liao XZ,Lv YH,Xu H,Deng XM,Yan SK,Xiong YC,Zhang WD

更新日期：2009-08-01 00:00:00

abstract：:The anticonvulsant activity of riluzole against sound-induced seizures was studied in the DBA/2 mouse model. Riluzole (0.1-4 mg kg(-1), intraperitoneal (i.p.)) produced dose-dependent effects with ED(50) values for the suppression of tonic, clonic and wild running phases of 0.72, 1.38 and 2.71 mg kg(-1), respectively....

journal_title：European journal of pharmacology

authors： De Sarro G,Siniscalchi A,Ferreri G,Gallelli L,De Sarro A

更新日期：2000-11-10 00:00:00

abstract：:The role of leukotriene synthesis in the gastrointestinal damage induced by platelet-activating factor (PAF) was examined in the rat. The effects of a 20-min infusion of PAF (100 ng/kg per min) on leukotriene B4 (LTB4) and leukotriene C4 (LTC4) synthesis were examined in samples of the stomach, duodenum, jejunum, ileu...

journal_title：European journal of pharmacology

authors： Wallace JL,MacNaughton WK

更新日期：1988-06-22 00:00:00

abstract：:The general anaesthetic ketamine affects the central cholinergic system in several manners, but its effect on spinal acetylcholine release, which may be an important transmitter in spinal antinociception, is unknown. This study aimed to investigate the effect of ketamine on spinal acetylcholine release. Microdialysis ...

journal_title：European journal of pharmacology

authors： Abelson KS,Goldkuhl RR,Nylund A,Höglund AU

更新日期：2006-03-18 00:00:00

abstract：:The influence of the membrane environment on the alpha 1-adrenoceptor has been investigated by examining the effect of phospholipase digestion on the binding of [3H]prazosin to aortic and hepatic membranes. Membrane digestion by phospholipase A2 and phospholipase C was found to markedly reduce prazosin binding to the ...

journal_title：European journal of pharmacology

authors： Shreeve SM,Valliere JE

更新日期：1992-05-12 00:00:00

abstract：:After spinal cord injury (SCI), there is an acute phase of alternatively activated (M2) macrophage infiltration, followed by a long-lasting phase of classically activated (M1) macrophage accumulation in the wound, which is believed to derail healing and compromize organ functions. Thus, agents which are able to modula...

journal_title：European journal of pharmacology

authors： Yang R,He J,Wang Y

更新日期：2016-11-15 00:00:00

abstract：:The pharmacological profile of a new CCKA receptor antagonist, T-0632 [sodium (S)-1-(2-fluorophenyl)-2,3-dihydro-3-[(3-isoquinolinylcarbonyl) amino]-6-methoxy-2-oxo-1H-indole-3-propanoate], was examined in in vivo studies and compared with those of L-364, 718 [3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1, 4-benzo...

journal_title：European journal of pharmacology

authors： Taniguchi H,Yazaki N,Yomota E,Shikano T,Endo T,Nagasaki M

更新日期：1996-09-26 00:00:00

abstract：:Intracellular recording was used to study the effect of uncouplers of oxidative phosphorylation on miniature endplate potentials (m.e.p.p.s) in skeletal muscles from dystrophic mice and their clinically normal littermates. Control m.e.p.p. frequency in muscles from dystrophic mice was not significantly different from ...

journal_title：European journal of pharmacology

authors： Kelly S,Morgan G,Smith J

更新日期：1988-02-16 00:00:00

abstract：:The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery...

journal_title：European journal of pharmacology

authors： Shimazawa M,Takiguchi Y,Umemura K,Kondo K,Nakashima M

更新日期：1997-06-11 00:00:00

abstract：:In the spinal cord of the pentobarbitone-anaesthetised cat, microelectrophoretic pitrazepin reduced the inhibitory effects on neuronal firing of both glycine and GABA. ...

journal_title：European journal of pharmacology

authors： Curtis DR,Gynther BD

更新日期：1986-11-19 00:00:00

abstract：:Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect ...

journal_title：European journal of pharmacology

authors： Kennes D,Odberg FO,Bouquet Y,De Rycke PH

更新日期：1988-08-09 00:00:00

abstract：:The cerebrovascular actions of bosentan, a novel endothelin antagonist with effects at endothelin ETA and ETB receptors, have been examined in individual pial arterioles on the cortical surface of chloralose-anaesthetised cats. Subarachnoid perivascular microapplication of bosentan (0.3-300 microM) had minimal effect ...

journal_title：European journal of pharmacology

authors： Patel TR,McAuley MA,McCulloch J

更新日期：1994-07-21 00:00:00

abstract：:Activated microglia that produce reactive nitrogen species (RNS), inflammatory factors, reactive oxygen species (ROS), and other neurovirulent factors may lead to the development of neurodegenerative diseases. Certain compounds can inhibit the activation of microglia. However, these mechanisms remain unclear. In the p...

journal_title：European journal of pharmacology

authors： Pflüger P,Viau CM,Coelho VR,Berwig NA,Staub RB,Pereira P,Saffi J

更新日期：2016-06-05 00:00:00

abstract：:The effects of the long-term administration of diazepam on the potential difference and short-circuit current of the isolated skin of the toad Pleurodema thaul (P. thaul) were investigated. Diazepam applied in a concentration range of 4.6 x 10(-6) to 5.2 x 10(-5) M decreased both electrical parameters. This response w...

journal_title：European journal of pharmacology

authors： Norris B,Contreras E,Nunez G,Contreras G

更新日期：1995-07-04 00:00:00

abstract：:CP-96,345, a non-peptide, selective tachykinin NK1 receptor blocker and its inactive enantiomer, CP-96,344, inhibit ligand binding of phenylalkylamine but not dihydropyridine Ca2+ channel antagonists. Whether these Ca2+ channel antagonist properties of CP-96,345 and CP-96,344 can be expressed as cardiovascular effects...

journal_title：European journal of pharmacology

authors： Constantine JW,Lebel WS,Woody HA,Benoit PA,Wolfgang EA,Knight DR

更新日期：1994-02-11 00:00:00

abstract：:The effects of some alpha 1-adrenoceptor antagonists (prazosin, nonselective for the alpha 1A- and alpha 1B-adrenoceptor subtypes; 5-methyl-urapidil, selective for the alpha 1A-adrenoceptor subtype; chloroethylclonidine, selective for the alpha 1B-adrenoceptor subtype) and nifedipine were compared on contractile respo...

journal_title：European journal of pharmacology

authors： Teng CM,Guh JH,Ko FN

更新日期：1994-11-14 00:00:00

abstract：:Activation of P2X7 receptors by endogenous ATP contributes to the development of inflammatory hyperalgesia. Given the clinical importance of mechanical hyperalgesia in inflammatory states, we hypothesized that the activation of the P2X7 receptor by endogenous ATP contributes to carrageenan-induced mechanical hyperalge...

journal_title：European journal of pharmacology

authors： Teixeira JM,Oliveira MC,Parada CA,Tambeli CH

更新日期：2010-10-10 00:00:00

abstract：:Geniposide (GE) can effectively inhibit diabetic nephropathy (DN), but its mechanism is unclear. The objective of this study was to explore the antidiabetic nephropathy effects of GE both in high fat diet/streptozotocin-induced DN mice and in high glucose-induced podocyte model. Renal function in DN mice was evaluated...

journal_title：European journal of pharmacology

authors： Li F,Chen Y,Li Y,Huang M,Zhao W

更新日期：2020-11-05 00:00:00

abstract：:The relation of the structure of 31 quaternary ammonium compounds (28 inhibitors; 3 substrate analogues) with their effects on the activity of acetylcholinesterase (EC 3.1.1.7; AChE) was studied. The compounds were structurally related to the natural substrate acetylcholine (ACh). All bear a trimethylammonium moiety a...

journal_title：European journal of pharmacology

authors： Thanei-Wyss P,Waser PG

更新日期：1989-05-11 00:00:00

abstract：:Agomelatine is an antidepressant with a novel mechanism of action. It is a melatonergic agonist for MT1 and MT2 receptors and a serotonin (5-HT2C) receptor antagonist. Agomelatine has been suggested not to have adverse effects on sexual functions. However, the effects of chronic agomelatine administration on reproduct...

journal_title：European journal of pharmacology

authors： Canpolat S,Ulker N,Yardimci A,Bulmus O,Ozdemir G,Sahin Z,Ercan Z,Serhatlioglu I,Kacar E,Ozcan M,Turk G,Ozkan Y,Atmaca M,Yilmaz B,Kelestimur H

更新日期：2016-01-05 00:00:00