Connexin43 knockdown in bone marrow‑derived dendritic cells by small interfering RNA leads to a diminished T-cell stimulation.

abstract：:Diabetic infected foot is the outcome of progressive vascular and neurological damage caused by persistent chronic hyperglycemia. Due to acute hypoxia and infection, the tissues develop extensive necrosis and gangrene, which often require amputation. The decision regarding the level of amputation relies mainly on the ...

journal_title：Molecular medicine reports

authors： Bekker-Méndez C,Guzmán-Aguilar RM,Hernández-Cueto MA,Huerta-Yepez S,Jarillo-Luna RA,González-Veyrand E,González-Bonilla CR

更新日期：2012-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a type of movement disorder caused by loss of dopamine‑producing neurons in the midbrain. In order to identify the synergistic microRNA (miRNA) pattern in PD, miRNA and mRNA double expression profiles of PD were downloaded. Differentially expressed miRNA and mRNA were identified [P<0.01, fo...

journal_title：Molecular medicine reports

authors： Hao B,Chen X,Dai D,Zou C,Wu X,Chen J

更新日期：2015-02-01 00:00:00

abstract：:De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and fa...

journal_title：Molecular medicine reports

authors： Wayhelova M,Oppelt J,Smetana J,Hladilkova E,Filkova H,Makaturova E,Nikolova P,Beharka R,Gaillyova R,Kuglik P

更新日期：2019-07-01 00:00:00

abstract：:Platanus acerifolia is one of the major sources of outdoor allergens to humans, and can induce allergic asthma, rhinitis, dermatitis and other allergic diseases. Pla a 2 is a polygalacturonase and represents the major allergen identified in P. acerifolia pollen. The aim of the present study was to express and purify P...

journal_title：Molecular medicine reports

authors： Wang DW,Ni WW,Zhou YJ,Huang W,Cao MD,Meng L,Wei JF

更新日期：2018-01-01 00:00:00

abstract：:Ezrin is involved in maintaining cell structure and cell motility. Expression levels of the ezrin gene correlate with numerous human malignancies. The aim of this study was to explore the role of ezrin in tumor progression and the prognostic evaluation of colorectal adenocarcinoma (CRA). The levels of ezrin protein in...

journal_title：Molecular medicine reports

authors： Lin LJ,Chen LT

更新日期：2013-07-01 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is considered to be the main reason for chemoresistance, metastasis and the ultimate failure of treatment in hepatocellular carcinoma (HCC). However, there are a few chemical agents that may inhibit CSCs. The present study identified that 4,4'‑bond secalonic acid D (4,4'‑SAD),...

journal_title：Molecular medicine reports

authors： Chen L,Cheng MM,Li YP,Lin SF,Zheng QH,Liu QY

更新日期：2020-06-01 00:00:00

abstract：:Dietary n‑3 polyunsaturated fatty acid (PUFA) exerts anti‑inflammatory and immunoregulatory effects via downregulation of the innate and adaptive immune responses. However, the effect of dietary n‑3 PUFA on experimental Crohn's Disease (CD) in rats and the underlying mechanisms are unclear. The present study aimed to ...

journal_title：Molecular medicine reports

authors： Yao J,Lu Y,Zhi M,Hu P,Wu W,Gao X

更新日期：2017-12-01 00:00:00

abstract：:Postmenopausal osteoporosis is a common systemic skeletal disease that is associated with estrogen‑deficiency. Bone loss associated with bisphosphonates therapy can increase the risk of developing oral osteonecrosis. Recent studies have indicated that enoxacin may inhibit osteoclast formation and bone resorption via a...

journal_title：Molecular medicine reports

authors： Zhang X,Xu X,Liu X,Mao C,Qin A,Lu E

更新日期：2018-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:Retroviral vectors have been considered the most promising vehicles for the transfer of therapeutic genes into cells of the hematopoietic system. In clinical studies, however, cases of leukemoid clonogenic expansion of the transduced cells in vivo caused by semirandom integration of the foreign DNA in the genome have ...

journal_title：Molecular medicine reports

authors： Zehnpfennig D,Deissler H,Polack A,Herr D,Bornkamm GW,Kurzeder C

更新日期：2010-07-01 00:00:00

abstract：:Cancer survivors after radiotherapy may suffer a variety of bone‑related adverse side effects, including radioactive osteoporosis and fractures. Localized irradiation is a common treatment modality for malignancies. Recently, a series of reactions and injuries called indirect effects (remote changes in bone when other...

journal_title：Molecular medicine reports

authors： Sun R,Zhu G,Wang J,Tong L,Zhai J

更新日期：2017-06-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway. Male albino Wistar rats were injected subcutaneously with isoproterenol (100 ...

journal_title：Molecular medicine reports

authors： Jia G,Zao M,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. However, the effect of PKE as a cancer drug ...

journal_title：Molecular medicine reports

authors： Park BH,Jung KH,Son MK,Seo JH,Lee HS,Lee JH,Hong SS

更新日期：2013-01-01 00:00:00

abstract：:Macrophage cholesterol efflux is important in maintaining cellular lipid homeostasis and preventing the formation of lipid‑laden foam cells. Although radioactive [3H]‑cholesterol is widely used as a tracer in cholesterol efflux assays, the lengthy and labor‑intensive assay procedure, and the radioactivity disposal pro...

journal_title：Molecular medicine reports

authors： Song W,Wang W,Wang Y,Dou L,Chen L,Yan X

更新日期：2015-10-01 00:00:00

abstract：:Krüppel-like factors (KLFs) regulate a wide variety of cellular functions and modulate pathological processes. In the present study, a post‑translational mechanism of microRNAs (miRs) was investigated in H2O2-induced human cardiomyocyte (HCM) injury. In H2O2‑cultured HCM cells, reactive oxygen species and apoptotic ce...

journal_title：Molecular medicine reports

authors： Zhang X,Liu F,Wang Q,Geng Y

更新日期：2017-10-01 00:00:00

abstract：:Several studies have noted benign thecoma‑fibroma tumors with positive F‑18 fluorodeoxyglucose (FDG) accumulation mimicking malignant ovarian tumors following F‑18 FDG positron emission tomography (PET). The present study analyzed four cases with false‑positive F‑18 FDG PET/computed tomography (CT) diagnoses of thecom...

journal_title：Molecular medicine reports

authors： Seino H,Ono S,Miura H,Morohashi S,Wu Y,Tsushima F,Takai Y,Kijima H

更新日期：2016-05-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning of Japan and is available throughout the world. The two main raw ingredients of soy sauce are soybean and wheat, both of which are established food allergens. The present study examined the degradation and removal of soybean allergens in soy sauce by immunoblotting with a...

journal_title：Molecular medicine reports

authors： Magishi N,Yuikawa N,Kobayashi M,Taniuchi S

更新日期：2017-08-01 00:00:00

abstract：:Centromere protein M (CENPM), a protein required for chromosome separation, is involved in in mitosis. However, little has been reported about the roles of CENPM in various types of cancer. The present study identified that the mRNA expression levels of CENPM were significantly upregulated in 14 types of human cancer ...

journal_title：Molecular medicine reports

authors： Liu Y,Yu W,Ren P,Zhang T

更新日期：2020-11-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a type of epidermal growth factor‑like protein primarily distributed in the nervous and cardiovascular systems. When sepsis occurs, the incidence of cardiac dysfunction in myocardial injury is high and the mechanism is complicated. It directly causes myocardial cell damage, whilst also causing ...

journal_title：Molecular medicine reports

authors： Kang W,Cheng Y,Wang X,Zhou F,Zhou C,Wang L,Zhong L

更新日期：2020-06-01 00:00:00

abstract：:Infantile hemangioma (IH) is one of the most common vascular tumors that occurs during childhood, but its pathogenesis is currently not completely understood. Even though lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays vital roles in tumorigenesis of malignant tumors, its roles in IH remain unclear. The...

journal_title：Molecular medicine reports

authors： Yu L,Shu H,Xing L,Lv MX,Li L,Xie YC,Zhang Z,Zhang L,Xie YY

更新日期：2020-10-01 00:00:00

abstract：:The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

journal_title：Molecular medicine reports

authors： Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

更新日期：2015-11-01 00:00:00

abstract：:The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 w...

journal_title：Molecular medicine reports

authors： Cao Z,Ye BD,Shen ZW,Cheng XF,Yang ZX,Liu YY,Wu RH,Geng K,Xiao YY

更新日期：2015-06-01 00:00:00

abstract：:Subsequently to the publication of this article, the authors have realized that Fig. 4 contained some incorrectly incorporated data panels; specifically, the A‑d, B‑b and B‑c panels did not display the correct data. The revised version of Fig. 4 featuring the correct data for the A‑d, B‑b and B‑c panels is shown on th...

journal_title：Molecular medicine reports

authors： Cheng L,Song J,Li G,Liu Y,Wang Y,Meng X,Sun G,Sun X

更新日期：2019-11-01 00:00:00

abstract：:Abnormal expression of matrix metalloproteinase 9 (MMP9) is correlated with podocyte epithelial-to---mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the mechanisms underlying this process are not well defined. Site‑specific demethylation may sustain high expression levels of target genes. In the pr...

journal_title：Molecular medicine reports

authors： Ling L,Chen L,Zhang C,Gui S,Zhao H,Li Z

更新日期：2018-04-01 00:00:00

abstract：:Previous studies have demonstrated that calcium channel blockers have protective effects on damaged brains. In the present study, the protective effect of the calcium channel blocker nicardipine against rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells was investigated...

journal_title：Molecular medicine reports

authors： Park HJ,Kim HJ

更新日期：2013-03-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) analogues are likely to exert cardioprotective effects via balancing the energy metabolism in cardiomyocytes following ischemic or hypoxic insults. The present study aimed to explore the protective effects and mechanism of exendin-4, a GLP-1 analogue, on cardiomyocyte glucose uptake usi...

journal_title：Molecular medicine reports

authors： Lu K,Chang G,Ye L,Zhang P,Li Y,Zhang D

更新日期：2015-08-01 00:00:00

abstract：:Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC‑803 and SGC‑7901) in vitro, and to determine whether the apoptosis‑relat...

journal_title：Molecular medicine reports

authors： Liu H,Zhou Y,Tang L

更新日期：2017-09-01 00:00:00

abstract：:Cancer stem cells (CSCs) are proposed to be responsible for tumor recurrence, metastasis and the high mortality rate of cancer patients. Isolation and identification of CSCs is crucial for basic and preclinical studies. However, as there are currently no universal markers for the isolation and identification of CSCs i...

journal_title：Molecular medicine reports

authors： Wang L,Guo H,Lin C,Yang L,Wang X

更新日期：2014-06-01 00:00:00

abstract：:As well-known regulators of gene expression, microRNAs (miRNAs) are important not only in cell proliferation and differentiation, but also in tumorigenesis and organ development. It has been estimated that miRNAs may be responsible for regulating the expression of almost one third of the human genome. Simultaneously, ...

journal_title：Molecular medicine reports

authors： Kan Q,Ding S,Yang Y,Zhou X

更新日期：2015-08-01 00:00:00