Low dose cyclophosphamide: Mechanisms of T cell modulation.

Abstract:

:Cyclophosphamide is considered one of the most successful chemotherapy drugs and is listed on the World Health Organisations List of Essential Medicines. Since its initial synthesis in 1958, it has been widely used to treat a range of cancers but its use has been declining due to the advent of platinum based and other chemotherapy agents. However, cyclophosphamide is still used either as a single agent or as adjuvant therapy to treat lymphomas, and breast and ovarian cancers at much lower doses. The efficacy of low dose cyclophosphamide is primarily due to its ability to promote anti-tumour immunity, by selectively depleting regulatory T cells and enhancing effector T cell function. Compared to effecter T cells, regulatory T cells have metabolic adaptations that make them more susceptible to cyclophosphamide-mediated cytotoxicity. In this review, we highlight the potential for improving the efficacy of low dose cyclophosphamide by combining insights on the mechanisms of cyclophosphamide-mediated cytotoxicity, and how these cytotoxic effects of cyclophosphamide influence T cell function, thereby contributing to anti-tumour immunity.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Madondo MT,Quinn M,Plebanski M

doi

10.1016/j.ctrv.2015.11.005

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

3-9

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(15)00203-0

journal_volume

42

pub_type

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