Abstract:
BACKGROUND:Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed to evaluate drug resistance profiles of TBM isolates in adult patients in nine European countries involving 32 centers to provide insight into the empiric treatment of TBM. METHODS:Mycobacterium tuberculosis was cultured from the cerebrospinal fluid (CSF) of 142 patients and was tested for susceptibility to first-line antituberculosis drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) and ethambutol (EMB). RESULTS:Twenty of 142 isolates (14.1 %) were resistant to at least one antituberculosis drug, and five (3.5 %) were resistant to at least INH and RIF, [multidrug resistant (MDR)]. The resistance rate was 12, 4.9, 4.2 and 3.5 % for INH, SM, EMB and RIF, respectively. The monoresistance rate was 6.3, 1.4 and 0.7 % for INH, SM and EMB respectively. There was no monoresistance to RIF. The mortality rate was 23.8 % in fully susceptible cases while it was 33.3 % for those exhibiting monoresistance to INH, and 40 % in cases with MDR-TBM. In compared to patients without resistance to any first-line drug, the relative risk of death for INH-monoresistance and MDR-TBM was 1.60 (95 % CI, 0.38-6.82) and 2.14 (95 % CI, 0:34-13:42), respectively. CONCLUSION:INH-resistance and MDR rates seemed not to be worrisome in our study. However, considering their adverse effects on treatment, rapid detection of resistance to at least INH and RIF would be most beneficial for designing anti-TB therapy. Still, empiric TBM treatment should be started immediately without waiting the drug susceptibility testing.
journal_name
Ann Clin Microbiol Antimicrobjournal_title
Annals of clinical microbiology and antimicrobialsauthors
Senbayrak S,Ozkutuk N,Erdem H,Johansen IS,Civljak R,Inal AS,Kayabas U,Kursun E,Elaldi N,Savic B,Simeon S,Yilmaz E,Dulovic O,Ozturk-Engin D,Ceran N,Lakatos B,Sipahi OR,Sunbul M,Yemisen M,Alabay S,Beovic B,Ulu-Kildoi
10.1186/s12941-015-0107-zsubject
Has Abstractpub_date
2015-11-04 00:00:00pages
47issn
1476-0711pii
10.1186/s12941-015-0107-zjournal_volume
14pub_type
杂志文章,多中心研究abstract:BACKGROUND:Miscarriage and preterm delivery are the most important challenges of pregnancy. Different bacterial and viral infection may cause miscarriage and preterm delivery. Among bacterial factors, Mycoplasma genitalium and Chlamydia trachomatis have the most important role and human papilloma virus (HPV) is the lea...
journal_title:Annals of clinical microbiology and antimicrobials
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abstract:BACKGROUND:Cationic antimicrobial peptides (CAMPs) are well recognized to be promising as novel antimicrobial and antitumor agents. To obtain novel skeletons of CAMPs, we propose a simple strategy using acid-amide substitution (i.e. Glu→Gln, Asp→Asn) to confer net positive charge to natural non-antimicrobial sequences ...
journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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更新日期:2016-09-29 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,多中心研究
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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doi:10.1186/1476-0711-11-6
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-13-25
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-018-0253-1
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1186/1476-0711-10-38
更新日期:2011-12-16 00:00:00