Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study.


BACKGROUND:Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed to evaluate drug resistance profiles of TBM isolates in adult patients in nine European countries involving 32 centers to provide insight into the empiric treatment of TBM. METHODS:Mycobacterium tuberculosis was cultured from the cerebrospinal fluid (CSF) of 142 patients and was tested for susceptibility to first-line antituberculosis drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) and ethambutol (EMB). RESULTS:Twenty of 142 isolates (14.1 %) were resistant to at least one antituberculosis drug, and five (3.5 %) were resistant to at least INH and RIF, [multidrug resistant (MDR)]. The resistance rate was 12, 4.9, 4.2 and 3.5 % for INH, SM, EMB and RIF, respectively. The monoresistance rate was 6.3, 1.4 and 0.7 % for INH, SM and EMB respectively. There was no monoresistance to RIF. The mortality rate was 23.8 % in fully susceptible cases while it was 33.3 % for those exhibiting monoresistance to INH, and 40 % in cases with MDR-TBM. In compared to patients without resistance to any first-line drug, the relative risk of death for INH-monoresistance and MDR-TBM was 1.60 (95 % CI, 0.38-6.82) and 2.14 (95 % CI, 0:34-13:42), respectively. CONCLUSION:INH-resistance and MDR rates seemed not to be worrisome in our study. However, considering their adverse effects on treatment, rapid detection of resistance to at least INH and RIF would be most beneficial for designing anti-TB therapy. Still, empiric TBM treatment should be started immediately without waiting the drug susceptibility testing.


Senbayrak S,Ozkutuk N,Erdem H,Johansen IS,Civljak R,Inal AS,Kayabas U,Kursun E,Elaldi N,Savic B,Simeon S,Yilmaz E,Dulovic O,Ozturk-Engin D,Ceran N,Lakatos B,Sipahi OR,Sunbul M,Yemisen M,Alabay S,Beovic B,Ulu-Kil




Has Abstract


2015-11-04 00:00:00










  • Miliary tuberculosis with no pulmonary involvement in myelodysplastic syndromes: a curable, yet rarely diagnosed, disease: case report and review of the literature.

    abstract:BACKGROUND:Although tuberculosis is not uncommon among patients with myelodysplastic syndrome (MDS), only a few reports of such patients suffering from miliary tuberculosis (MT) exist. MT often presents as a fever of unknown origin and it is a curable disease, yet fatal if left untreated. CASE PRESENTATION:We report a...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,评审


    authors: Neonakis IK,Alexandrakis MG,Gitti Z,Tsirakis G,Krambovitis E,Spandidos DA

    更新日期:2008-03-13 00:00:00

  • The prevalence of malaria among HIV seropositive individuals and the impact of the co- infection on their hemoglobin levels.

    abstract:BACKGROUND:Malaria and HIV/AIDS are the two most common infections in sub-Sahara Africa. There are hypotheses and study reports on the possible association between these two infections, hence the prevalence and outcome of their co-infection in an endemic population will be important in defining healthcare strategies. A...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Tay SC,Badu K,Mensah AA,Gbedema SY

    更新日期:2015-03-07 00:00:00

  • Two or more enteropathogens are associated with diarrhoea in Mexican children.

    abstract:BACKGROUND:Diarrhoeal diseases constitute a major public health problem, particularly in the developing world, where the rate of mortality and morbidity is very high. The purpose of this study was to conduct a 2 years and 3 months study in order to determine the prevalence of five enteropathogen diarrheogenic agents in...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Paniagua GL,Monroy E,García-González O,Alonso J,Negrete E,Vaca S

    更新日期:2007-12-28 00:00:00

  • Hepatic adverse events during highly active antiretroviral therapy containing nevirapine: a case report.

    abstract:BACKGROUND:Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV infected patient on HAART including nevirapine and taking antidepressive agents, with acute toxic hepatitis. CASE PRESENTATION:A 39 year old patient diagnosed ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Gökengin D,Yamazhan T

    更新日期:2002-09-16 00:00:00

  • Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: an increasing problem.

    abstract::Stenotrophomonas maltophilia (S. maltophilia) has recently emerged as an important nosocomial pathogen. Treatment of invasive infections caused by this organism is difficult as the bacterium is frequently resistant to a wide range of commonly used antimicrobials. Trimethoprim-sulfamethoxazole (TMP - SXT) is recommende...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Al-Jasser AM

    更新日期:2006-09-18 00:00:00

  • 3,4-DHPEA-EA from Olea Europaea L. is effective against standard and clinical isolates of Staphylococcus sp.

    abstract:BACKGROUND:The aim of the present work was to evaluate the antibacterial effect of 3,4-DHPEA-EA (methyl-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-formyl-2-methyl-3,4-dihydro-2H-pyran-5-carboxylate), a derivate of oleuropein, against a range of Gram-positive bacteria, including ATCC strains, food and clinical isolate...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Bisignano C,Filocamo A,Ginestra G,Giofre' SV,Navarra M,Romeo R,Mandalari G

    更新日期:2014-07-01 00:00:00

  • Analysis of integrons and associated gene cassettes in clinical isolates of multidrug resistant Pseudomonas aeruginosa from Southwest Nigeria.

    abstract:BACKGROUND:Multidrug resistant Pseudomonas aeruginosa harbours integrons and other mobile genetic elements such as plasmids and transposons, which easily disseminate antibiotic resistance genes among clinical strains of P. aeruginosa. METHODOLOGY:Plasmid extraction of 54 clinical isolates of P. aeruginosa was carried ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Odumosu BT,Adeniyi BA,Chandra R

    更新日期:2013-10-21 00:00:00

  • Antibacterial activity of Aquilaria crassna leaf extract against Staphylococcus epidermidis by disruption of cell wall.

    abstract:BACKGROUND:Aquilaria crassna Pierre ex Lecomte has been traditionally used in Thailand for treatment of infectious diseases such as diarrhoea and skin diseases for a long time. The main objectives of this study were to examine antibacterial activity of the Aquilaria crassna leaf extract against Staphylococcus epidermid...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Kamonwannasit S,Nantapong N,Kumkrai P,Luecha P,Kupittayanant S,Chudapongse N

    更新日期:2013-08-20 00:00:00

  • Complications of peritonsillar abscess.

    abstract:BACKGROUND:The vast majority of patients with peritonsillar abscess (PTA) recover uneventfully on abscess drainage and antibiotic therapy. However, occasionally patient´s condition deteriorates as the infection spread in the upper airway mucosa, through cervical tissues, or hematogenously. The bacterial etiology of PTA...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,评审


    authors: Klug TE,Greve T,Hentze M

    更新日期:2020-07-30 00:00:00

  • The carbapenem-resistant Enterobacteriaceae threat is growing: NDM-1 epidemic at a training hospital in Turkey.

    abstract:BACKGROUND:Recently, new carbapenemases in Enterobacteriaceae strains and non-fermentative gram-negative bacilli have been reported. The New Delhi metallo-β-lactamase-1 (NDM-1) is a major problem around the world. The purpose of this article is to address the NDM-1 Klebsiella pneumoniae epidemic detected in eight cases...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Karabay O,Altindis M,Koroglu M,Karatuna O,Aydemir ÖA,Erdem AF

    更新日期:2016-02-09 00:00:00

  • Impact of a multidimensional infection control approach on central line-associated bloodstream infections rates in adult intensive care units of 8 cities of Turkey: findings of the International Nosocomial Infection Control Consortium (INICC).

    abstract:BACKGROUND:Central line-associated bloodstream infections (CLABs) have long been associated with excess lengths of stay, increased hospital costs and mortality attributable to them. Different studies from developed countries have shown that practice bundles reduce the incidence of CLAB in intensive care units. However,...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,多中心研究


    authors: Leblebicioglu H,Öztürk R,Rosenthal VD,Akan ÖA,Sirmatel F,Ozdemir D,Uzun C,Turgut H,Ersoz G,Koksal I,Özgültekin A,Esen S,Ulger F,Dilek A,Yilmaz H,Dikmen Y,Aygún G,Tulunay M,Oral M,Ünal N,Cengiz M,Yilmaz L,Geyik

    更新日期:2013-05-04 00:00:00

  • Molecular identification of clinical "difficult-to-identify" microbes from sequencing 16S ribosomal DNA and internal transcribed spacer 2.

    abstract:BACKGROUND:Clinical microbiology laboratories have to accurately identify clinical microbes. However, some isolates are difficult to identify by the automated biochemical text platforms, which are called "difficult-to-identify" microbes in this study. Therefore, the ability of 16S ribosomal DNA (16S rDNA) and internal ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Cheng C,Sun J,Zheng F,Wu K,Rui Y

    更新日期:2014-01-03 00:00:00

  • Short-term treatment outcomes in human immunodeficiency virus type-1 and hepatitis B virus co-infections.

    abstract:BACKGROUND:Co-infection of HIV with HBV is common in West Africa but little information is available on the effects of HBV on short-term therapy for HIV patients. A 28 day longitudinal study was conducted to examine short-term antiretroviral therapy (ART) outcomes in HIV infected individuals with HBV co-infection. MET...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Sagoe KW,Duedu KO,Ziga F,Agyei AA,Adiku TK,Lartey M,Mingle JA,Arens M

    更新日期:2016-06-02 00:00:00

  • Clonal dissemination of KPC-2 producing Klebsiella pneumoniae ST11 clone with high prevalence of oqxAB and rmtB in a tertiary hospital in China: results from a 3-year period.

    abstract:BACKGROUND:Carbapenemase-producing Klebsiella pneumoniae (CPKP) strains have emerged as a major problem for healthcare systems. The aim of this study was to determine the circulating clones and analyze the clinical and molecular characteristics of CPKP in our hospital. METHODS:A total of 74 carbapenemase producers col...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Cheng L,Cao XL,Zhang ZF,Ning MZ,Xu XJ,Zhou W,Chen JH,Zhang JH,Shen H,Zhang K

    更新日期:2016-01-19 00:00:00

  • Antimicrobial susceptibility among Gram-positive and Gram-negative organisms collected from the Latin American region between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial.

    abstract:BACKGROUND:The in vitro activity of tigecycline and comparator agents was evaluated against Gram-positive and Gram-negative isolates collected in Latin American centers between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) global surveillance study. METHODS:Minimum inhibitory co...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Vega S,Dowzicky MJ

    更新日期:2017-07-12 00:00:00

  • COVID-19 vaccine development: What lessons can we learn from TB?

    abstract::At the time of writing, the SARS-CoV-2 virus has infected more than 49 million people causing more than 1.2 million deaths worldwide since its emergence from Wuhan, China in December 2019. Vaccine development against SARS-CoV-2 has drawn the global attention in order to stop the spread of the virus, with more than 10 ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,评审


    authors: Safar HA,Mustafa AS,McHugh TD

    更新日期:2020-11-30 00:00:00

  • Molecular characterization of selected multidrug resistant Pseudomonas from water distribution systems in southwestern Nigeria.

    abstract:BACKGROUND:Persistence of antibiotic resistant bacteria, including multidrug resistant (MDR) pseudomonads, is an important environmental health problem associated with drinking water distribution systems (DWDS) worldwide. There is paucity of data on the molecular characteristics of antibiotic resistance genes and their...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Adesoji AT,Ogunjobi AA,Olatoye IO

    更新日期:2015-09-02 00:00:00

  • Detection of urinary Chlamydia trachomatis, Mycoplasma genitalium and human papilloma virus in the first trimester of pregnancy by PCR method.

    abstract:BACKGROUND:Miscarriage and preterm delivery are the most important challenges of pregnancy. Different bacterial and viral infection may cause miscarriage and preterm delivery. Among bacterial factors, Mycoplasma genitalium and Chlamydia trachomatis have the most important role and human papilloma virus (HPV) is the lea...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Rahimkhani M,Mordadi A,Gilanpour M

    更新日期:2018-06-04 00:00:00

  • Ginger (Zingiber officinale) phytochemicals-gingerenone-A and shogaol inhibit SaHPPK: molecular docking, molecular dynamics simulations and in vitro approaches.

    abstract:BACKGROUND:Antibiotic resistance is a defense mechanism, harbored by pathogens to survive under unfavorable conditions. Among several antibiotic resistant microbial consortium, Staphylococcus aureus is one of the most havoc microorganisms. Staphylococcus aureus encodes a unique enzyme 6-hydroxymethyl-7,8-dihydropterin ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Rampogu S,Baek A,Gajula RG,Zeb A,Bavi RS,Kumar R,Kim Y,Kwon YJ,Lee KW

    更新日期:2018-04-02 00:00:00

  • Epidemiology of urinary tract infections and antibiotics sensitivity among pregnant women at Khartoum North Hospital.

    abstract:BACKGROUND:Urinary tract infections (UTI) can lead to poor maternal and perinatal outcomes. Investigating epidemiology of UTI and antibiotics sensitivity among pregnant women is fundamental for care-givers and health planners. METHODS:A cross sectional study has been conducted at Khartoum north teaching hospital Anten...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Hamdan HZ,Ziad AH,Ali SK,Adam I

    更新日期:2011-01-18 00:00:00

  • Generation of novel cationic antimicrobial peptides from natural non-antimicrobial sequences by acid-amide substitution.

    abstract:BACKGROUND:Cationic antimicrobial peptides (CAMPs) are well recognized to be promising as novel antimicrobial and antitumor agents. To obtain novel skeletons of CAMPs, we propose a simple strategy using acid-amide substitution (i.e. Glu→Gln, Asp→Asn) to confer net positive charge to natural non-antimicrobial sequences ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Ueno S,Minaba M,Nishiuchi Y,Taichi M,Tamada Y,Yamazaki T,Kato Y

    更新日期:2011-03-22 00:00:00

  • Should we use closed or open infusion containers for prevention of bloodstream infections?

    abstract:BACKGROUND:Hospitalized patients in critical care settings are at risk for bloodstream infections (BSI). Most BSIs originate from a central line (CL), and they increase length of stay, cost, and mortality. Open infusion containers may increase the risk of contamination and administration-related (CLAB) because they all...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Rangel-Frausto MS,Higuera-Ramirez F,Martinez-Soto J,Rosenthal VD

    更新日期:2010-02-02 00:00:00

  • Pseudomonas aeruginosa contamination of mouth swabs during production causing a major outbreak.

    abstract:BACKGROUND:In 2002 we investigated an outbreak comprising 231 patients in Norway, caused by Pseudomonas aeruginosa and linked to the use of contaminated mouth swabs called Dent-O-Sept. Here we describe the extent of contamination of the swabs, and identify critical points in the production process that made the contami...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Iversen BG,Eriksen HM,Bø G,Hagestad K,Jacobsen T,Engeset E,Lassen J,Aavitsland P

    更新日期:2007-03-13 00:00:00

  • Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial.

    abstract:INTRODUCTION:Antibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments. AIMS&METHODS: Whether 7 days moxifloxacin with lansoprasole and amoxycillin can be compared with 10 days moxifloxa...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,随机对照试验


    authors: Bago J,Majstorović K,Belosić-Halle Z,Kućisec N,Bakula V,Tomić M,Bago P,Troskot R

    更新日期:2010-04-15 00:00:00

  • Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites.

    abstract:BACKGROUND:Leishmaniasis and malaria are the two most common parasitic diseases and responsible for large number of deaths per year particularly in developing countries like Pakistan. Majority of Pakistan population rely on medicinal plants due to their low socio-economic status. The present review was designed to gath...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,评审


    authors: Tariq A,Adnan M,Amber R,Pan K,Mussarat S,Shinwari ZK

    更新日期:2016-09-20 00:00:00

  • Performance evaluation of a rapid whole-blood immunoassay for the detection of IgG antibodies against Helicobacter pylori in daily clinical practice.

    abstract:BACKGROUND:A growing number of rapid Helicobacter pylori antibody tests are commercially available now, however, some of these tests are often used without sufficient evaluation. The aim of this study was to evaluate the performance of a commercially available rapid whole-blood immunoassay (gabControl(®) H. pylori; gab...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Enko D,Halwachs-Baumann G,Stolba R,Rössler O,Kriegshäuser G

    更新日期:2016-08-08 00:00:00

  • Aetiological agents of cerebrospinal meningitis: a retrospective study from a teaching hospital in Ghana.

    abstract:BACKGROUND:Meningitis is an important cause of morbidity and mortality in low-resource settings. In sub-Saharan Africa, the meningitis belt has been characterized by particularly high and seasonal incidences of bacterial meningitis extending throughout life. Despite the progress being made in treating the condition, th...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Owusu M,Nguah SB,Boaitey YA,Badu-Boateng E,Abubakr AR,Lartey RA,Adu-Sarkodie Y

    更新日期:2012-10-04 00:00:00

  • Intestinal invasion and disseminated disease associated with Penicillium chrysogenum.

    abstract:BACKGROUND:Penicillium sp., other than P. marneffei, is an unusual cause of invasive disease. These organisms are often identified in immunosuppressed patients, either due to human immunodeficiency virus or from immunosuppressant medications post-transplantation. They are a rarely identified cause of infection in immun...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Barcus AL,Burdette SD,Herchline TE

    更新日期:2005-12-21 00:00:00

  • Variable antibiotic susceptibility patterns among Streptomyces species causing actinomycetoma in man and animals.

    abstract:BACKGROUND:Drug therapy is recommended in conjunction with surgery in treatment of actinomycetoma. The specific prescription depends on the type of bacteria (actinomycetoma) or fungi (eumycetoma) causing the disease and their in vitro antimicrobial susceptibility. OBJECTIVES:To investigate the antimicrobial susceptibi...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Hamid ME

    更新日期:2011-06-06 00:00:00

  • Raoultella planticola bacteremia-induced fatal septic shock following burn injury.

    abstract:BACKGROUND:Raoultella planticola, a Gram-negative, aerobic bacillus commonly isolated from soil and water, rarely causes invasive infections in humans. Septic shock from R. planticola after burn injury has not been previously reported. CASE PRESENTATION:A 79-year-old male was admitted to the emergency intensive care u...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章


    authors: Yumoto T,Naito H,Ihoriya H,Tsukahara K,Ota T,Watanabe T,Nakao A

    更新日期:2018-05-04 00:00:00