Abstract:
BACKGROUND:Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed to evaluate drug resistance profiles of TBM isolates in adult patients in nine European countries involving 32 centers to provide insight into the empiric treatment of TBM. METHODS:Mycobacterium tuberculosis was cultured from the cerebrospinal fluid (CSF) of 142 patients and was tested for susceptibility to first-line antituberculosis drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) and ethambutol (EMB). RESULTS:Twenty of 142 isolates (14.1 %) were resistant to at least one antituberculosis drug, and five (3.5 %) were resistant to at least INH and RIF, [multidrug resistant (MDR)]. The resistance rate was 12, 4.9, 4.2 and 3.5 % for INH, SM, EMB and RIF, respectively. The monoresistance rate was 6.3, 1.4 and 0.7 % for INH, SM and EMB respectively. There was no monoresistance to RIF. The mortality rate was 23.8 % in fully susceptible cases while it was 33.3 % for those exhibiting monoresistance to INH, and 40 % in cases with MDR-TBM. In compared to patients without resistance to any first-line drug, the relative risk of death for INH-monoresistance and MDR-TBM was 1.60 (95 % CI, 0.38-6.82) and 2.14 (95 % CI, 0:34-13:42), respectively. CONCLUSION:INH-resistance and MDR rates seemed not to be worrisome in our study. However, considering their adverse effects on treatment, rapid detection of resistance to at least INH and RIF would be most beneficial for designing anti-TB therapy. Still, empiric TBM treatment should be started immediately without waiting the drug susceptibility testing.
journal_name
Ann Clin Microbiol Antimicrobjournal_title
Annals of clinical microbiology and antimicrobialsauthors
Senbayrak S,Ozkutuk N,Erdem H,Johansen IS,Civljak R,Inal AS,Kayabas U,Kursun E,Elaldi N,Savic B,Simeon S,Yilmaz E,Dulovic O,Ozturk-Engin D,Ceran N,Lakatos B,Sipahi OR,Sunbul M,Yemisen M,Alabay S,Beovic B,Ulu-Kildoi
10.1186/s12941-015-0107-zsubject
Has Abstractpub_date
2015-11-04 00:00:00pages
47issn
1476-0711pii
10.1186/s12941-015-0107-zjournal_volume
14pub_type
杂志文章,多中心研究abstract:INTRODUCTION:During clinical use, gastrointestinal endoscopes are grossly contaminated with patient's native flora. These endoscopes undergo reprocessing to prevent infectious transmission upon future use. Endoscopy-associated infections and outbreaks have been reported, with a recent focus on the transmission of multi...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
doi:10.1186/s12941-018-0289-2
更新日期:2018-10-10 00:00:00
abstract:BACKGROUND:Klebsiella pneumoniae is a public health concern because of its ability to develop multidrug resistance and hypervirulent genotypes, of those capsular types K1 and K2 cause community and nosocomial life-threatening infections. This study aimed to determine the antibiotic susceptibility patterns and genotypic...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-020-00349-z
更新日期:2020-03-31 00:00:00
abstract:BACKGROUND:Vaginitis is among the most common conditions women are seeking medical care for. Although these infections can easily be treated, the relapse rate is high. This may be due to inadequate use of the diagnostic potential. METHODS:We evaluated the misjudgement rate of the aetiology of vaginal complaints. A tot...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-5-4
更新日期:2006-02-17 00:00:00
abstract:BACKGROUND:Drug therapy is recommended in conjunction with surgery in treatment of actinomycetoma. The specific prescription depends on the type of bacteria (actinomycetoma) or fungi (eumycetoma) causing the disease and their in vitro antimicrobial susceptibility. OBJECTIVES:To investigate the antimicrobial susceptibi...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-10-24
更新日期:2011-06-06 00:00:00
abstract:BACKGROUND:Clinical microbiology laboratories have to accurately identify clinical microbes. However, some isolates are difficult to identify by the automated biochemical text platforms, which are called "difficult-to-identify" microbes in this study. Therefore, the ability of 16S ribosomal DNA (16S rDNA) and internal ...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-13-1
更新日期:2014-01-03 00:00:00
abstract:BACKGROUND:Mycetoma is a chronic mutilating disease of the skin and the underlying tissues caused by fungi or bacteria. Although recently included in the list of neglected tropical diseases by the World Health Organization, strategic control and preventive measures are yet to be outlined. Thus, it continues to pose hug...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
doi:10.1186/s12941-018-0287-4
更新日期:2018-08-10 00:00:00
abstract::At the time of writing, the SARS-CoV-2 virus has infected more than 49 million people causing more than 1.2 million deaths worldwide since its emergence from Wuhan, China in December 2019. Vaccine development against SARS-CoV-2 has drawn the global attention in order to stop the spread of the virus, with more than 10 ...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
doi:10.1186/s12941-020-00402-x
更新日期:2020-11-30 00:00:00
abstract::Stenotrophomonas maltophilia (S. maltophilia) has recently emerged as an important nosocomial pathogen. Treatment of invasive infections caused by this organism is difficult as the bacterium is frequently resistant to a wide range of commonly used antimicrobials. Trimethoprim-sulfamethoxazole (TMP - SXT) is recommende...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-5-23
更新日期:2006-09-18 00:00:00
abstract:BACKGROUND:Miscarriage and preterm delivery are the most important challenges of pregnancy. Different bacterial and viral infection may cause miscarriage and preterm delivery. Among bacterial factors, Mycoplasma genitalium and Chlamydia trachomatis have the most important role and human papilloma virus (HPV) is the lea...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-018-0276-7
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:Tuberculous spondylitis (Pott's disease) is an ancient human disease. Because it is rare in high-income, tuberculosis (TB) low incidence countries, misdiagnoses occur as sufficient clinical experience is lacking. CASE PRESENTATION:We describe a fatal case of a patient with spinal TB, who was mistakenly irra...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-8-32
更新日期:2009-11-20 00:00:00
abstract:BACKGROUND:Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV infected patient on HAART including nevirapine and taking antidepressive agents, with acute toxic hepatitis. CASE PRESENTATION:A 39 year old patient diagnosed ...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-1-1
更新日期:2002-09-16 00:00:00
abstract:BACKGROUND:In 2002 we investigated an outbreak comprising 231 patients in Norway, caused by Pseudomonas aeruginosa and linked to the use of contaminated mouth swabs called Dent-O-Sept. Here we describe the extent of contamination of the swabs, and identify critical points in the production process that made the contami...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-6-3
更新日期:2007-03-13 00:00:00
abstract::Ebola virus disease (EVD) is a potentially fatal haemorrhagic disease of humans. The last and most serious outbreak of Ebola virus (EBOV) started in December 2013 in West Africa and also affected other continents. Animals such as fruit bats and non-human primates are potential sources of EBOV. This review highlights t...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
doi:10.1186/s12941-015-0089-x
更新日期:2015-05-28 00:00:00
abstract:BACKGROUND:Co-infection of HIV with HBV is common in West Africa but little information is available on the effects of HBV on short-term therapy for HIV patients. A 28 day longitudinal study was conducted to examine short-term antiretroviral therapy (ART) outcomes in HIV infected individuals with HBV co-infection. MET...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-016-0152-2
更新日期:2016-06-02 00:00:00
abstract:BACKGROUND:Four medicinal plants (Chrozophora hierosolymitana Spreng, Chrysanthemum leucanthemum L., Ephedra gerardiana Wall. ex Stapf, and Quercus dilatata L.) used by indigenous healers to treat various infectious diseases were selected for the present study. The major objective of the present study was isolation and...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-11-11
更新日期:2012-05-03 00:00:00
abstract:BACKGROUND:Recently, new carbapenemases in Enterobacteriaceae strains and non-fermentative gram-negative bacilli have been reported. The New Delhi metallo-β-lactamase-1 (NDM-1) is a major problem around the world. The purpose of this article is to address the NDM-1 Klebsiella pneumoniae epidemic detected in eight cases...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-016-0118-4
更新日期:2016-02-09 00:00:00
abstract::A panel of national experts was convened by the Brazilian Infectious Diseases Society in order to organize the national recommendations for the management of zika virus infection. The focus of this document is the diagnosis, both clinical and laboratorial, and appropriate treatment of the diverse manifestations of thi...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
doi:10.1186/s12941-016-0172-y
更新日期:2016-09-29 00:00:00
abstract:BACKGROUND:Farnesol is a sesquiterpene alcohol produced by many organisms, and also found in several essential oils. Its role as a quorum sensing molecule and as a virulence factor of Candida albicans has been well described. Studies revealed that farnesol affect the growth of a number of bacteria and fungi, pointing t...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-8-13
更新日期:2009-04-29 00:00:00
abstract:BACKGROUND:Escherichia coli isolates of equine faecal origin were investigated for antibiotic resistance, resistance genes and their ability to perform horizontal transfer. METHODS:In total, 264 faecal samples were collected from 138 horses in hospital and community livery premises in northwest England, yielding 296 r...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-9-12
更新日期:2010-04-07 00:00:00
abstract:BACKGROUND:Klebsiella pneumoniae is a frequent nosocomial pathogen, with the multidrug-resistant (MDR) K. pneumoniae being a major public health concern, frequently causing difficult-to-treat infections worldwide. The aim of this study was to investigate the molecular characterization of clinical MDR Klebsiella pneumon...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-13-16
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to show the emergence of the qnrD gene among fluoroquinolone-resistant Morganella morganii isolate. The occurrence of mutations in DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC,parE) genes was also investigated in this strain. METHODOLOGY:95 clinical Enterobacteria were s...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-014-0034-4
更新日期:2014-08-09 00:00:00
abstract:BACKGROUND:The in vitro activity of tigecycline and comparator agents was evaluated against Gram-positive and Gram-negative isolates collected in Latin American centers between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) global surveillance study. METHODS:Minimum inhibitory co...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-017-0222-0
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Leishmaniasis and malaria are the two most common parasitic diseases and responsible for large number of deaths per year particularly in developing countries like Pakistan. Majority of Pakistan population rely on medicinal plants due to their low socio-economic status. The present review was designed to gath...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
doi:10.1186/s12941-016-0170-0
更新日期:2016-09-20 00:00:00
abstract:BACKGROUND:Persistent bacteremia occurs in at least 30% of patients with Staphylococcus aureus bloodstream infection (SAB) and may be attributable to a dysregulated host immune response. Neutrophils interact with a variety of S. aureus microbial factors, including lipoteichoic acid (LTA), to activate phagocytic functio...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-020-00392-w
更新日期:2020-11-03 00:00:00
abstract::Resistance to beta-lactam antibiotics in enteric Gram-negative bacilli may be difficult to detect using standard methods of either Kirby-Bauer disc diffusion (KBDD) or broth dilution for minimal inhibitory concentration (MIC). This difficulty is due to genetic differences in resistance determinants, differences in lev...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-3-13
更新日期:2004-07-15 00:00:00
abstract:BACKGROUND:The vast majority of patients with peritonsillar abscess (PTA) recover uneventfully on abscess drainage and antibiotic therapy. However, occasionally patient´s condition deteriorates as the infection spread in the upper airway mucosa, through cervical tissues, or hematogenously. The bacterial etiology of PTA...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
doi:10.1186/s12941-020-00375-x
更新日期:2020-07-30 00:00:00
abstract:BACKGROUND:Hospitalized patients in critical care settings are at risk for bloodstream infections (BSI). Most BSIs originate from a central line (CL), and they increase length of stay, cost, and mortality. Open infusion containers may increase the risk of contamination and administration-related (CLAB) because they all...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-9-6
更新日期:2010-02-02 00:00:00
abstract:BACKGROUND:This study aimed to evaluate in vitro susceptibility to ceftobiprole of clinical strains identified from prosthetic joint infections (PJIs) compared to that of the associations currently recommended for post-operative empirical antibiotic therapy (PEAT) (vancomycin with either cefepime, third-generation ceph...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-020-00351-5
更新日期:2020-03-21 00:00:00
abstract:BACKGROUND:Chenopodium ambrosioides and Kielmeyera neglecta are plants traditionally used in Brazil to treat various infectious diseases. The study of the biological activities of these plants is of great importance for the detection of biologically active compounds. METHODS:Extracts from these plants were extracted w...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-11-20
更新日期:2012-07-28 00:00:00
abstract:BACKGROUND:Multidrug resistant strains of Acinetobacter baumannii (MDR-AB) have emerged as alarming nosocomial pathogens among patients admitted to Intensive Care Unit and burned patients. The aim of this study was to determine the susceptibility of A. baumannii isolates, the carbapenems resistance patterns bla(OXA-23)...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-014-0038-0
更新日期:2014-09-25 00:00:00