Abstract:
BACKGROUND:Recently, new carbapenemases in Enterobacteriaceae strains and non-fermentative gram-negative bacilli have been reported. The New Delhi metallo-β-lactamase-1 (NDM-1) is a major problem around the world. The purpose of this article is to address the NDM-1 Klebsiella pneumoniae epidemic detected in eight cases in our hospital. METHODS:Bacteria identified in this epidemic were from patients already admitted to the intensive care unit of the Sakarya University Training and Research Hospital during efforts toward establishment of infection surveillance and control program. Antimicrobial susceptibility testing of strains was performed using the VITEK 2 system (bioMérieux, France), E-test gradient strips (bioMérieux, France), and the disc diffusion test. For the metallo-beta-lactamase activity, the combined disc diffusion test and modified Hodge test as phenotypic tests were performed. To identify the resistance gene, the Xpert Carba-R kit (Cepheid Inc., USA) and an in-house multiplex polymerase chain reaction (PCR) method designed for five common carbapenemase genes (IMP, VIM, KPC, NDM-1, and OXA-48) were employed. The clonal relationship of these strains was explored by the repetitive PCR (rep-PCR, DiversiLab System, bioMérieux, France) method. RESULTS:During the December 2014 to March 2015 period, NDM-1 positive K. pneumoniae strains were detected in eight patients. All of these strains were found to produce NDM-1, while two of them also revealed the presence of OXA-48. The rep-PCR results reveal a clonal proximity of 95 % for six of the eight strains. CONCLUSIONS:Our findings suggest the tendency of NDM-1-producing strains to spread in our country as well. A carbapenem-resistant K. pneumoniae threat may pose a great risk to our country. It is clear that more comprehensive infection control precautions should be implemented in our hospitals.
journal_name
Ann Clin Microbiol Antimicrobjournal_title
Annals of clinical microbiology and antimicrobialsauthors
Karabay O,Altindis M,Koroglu M,Karatuna O,Aydemir ÖA,Erdem AFdoi
10.1186/s12941-016-0118-4subject
Has Abstractpub_date
2016-02-09 00:00:00pages
6issn
1476-0711pii
10.1186/s12941-016-0118-4journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Vaginitis is among the most common conditions women are seeking medical care for. Although these infections can easily be treated, the relapse rate is high. This may be due to inadequate use of the diagnostic potential. METHODS:We evaluated the misjudgement rate of the aetiology of vaginal complaints. A tot...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-5-4
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abstract:BACKGROUND:Malaria and HIV/AIDS are the two most common infections in sub-Sahara Africa. There are hypotheses and study reports on the possible association between these two infections, hence the prevalence and outcome of their co-infection in an endemic population will be important in defining healthcare strategies. A...
journal_title:Annals of clinical microbiology and antimicrobials
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doi:10.1186/s12941-015-0064-6
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abstract:BACKGROUND:Miscarriage and preterm delivery are the most important challenges of pregnancy. Different bacterial and viral infection may cause miscarriage and preterm delivery. Among bacterial factors, Mycoplasma genitalium and Chlamydia trachomatis have the most important role and human papilloma virus (HPV) is the lea...
journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-018-0276-7
更新日期:2018-06-04 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-7-13
更新日期:2008-06-18 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,多中心研究
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更新日期:2010-03-19 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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doi:10.1186/1476-0711-5-17
更新日期:2006-07-27 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,随机对照试验
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更新日期:2010-04-15 00:00:00
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pub_type: 杂志文章
doi:10.1186/1476-0711-6-3
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-6-4
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-8-32
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pub_type: 杂志文章
doi:10.1186/1476-0711-8-15
更新日期:2009-05-18 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-4-21
更新日期:2005-12-21 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
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更新日期:2016-09-20 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-016-0152-2
更新日期:2016-06-02 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-13-25
更新日期:2014-07-02 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章,评审
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/s12941-018-0292-7
更新日期:2018-11-16 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
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更新日期:2011-03-22 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
doi:10.1186/1476-0711-13-7
更新日期:2014-01-09 00:00:00
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journal_title:Annals of clinical microbiology and antimicrobials
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-03-31 00:00:00