Antimicrobial susceptibility among Gram-positive and Gram-negative organisms collected from the Latin American region between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial.

Abstract:

BACKGROUND:The in vitro activity of tigecycline and comparator agents was evaluated against Gram-positive and Gram-negative isolates collected in Latin American centers between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) global surveillance study. METHODS:Minimum inhibitory concentrations (MICs) were determined using the broth microdilution methodology according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Antimicrobial susceptibility was determined using CLSI breakpoints, except for tigecycline for which the US Food and Drugs Administration breakpoints were used. RESULTS:A total of 48.3% (2202/4563) of Staphylococcus aureus isolates were methicillin-resistant S. aureus (MRSA). All MRSA isolates were susceptible to linezolid and vancomycin, and 99.9% (2199/2202) were susceptible to tigecycline. Among Streptococcus pneumoniae isolates, 13.8% (198/1436) were penicillin-resistant; all were susceptible to linezolid and vancomycin, and 98.0% (194/198) were susceptible to tigecycline. Susceptibility was >99.0% for linezolid and tigecycline against Enterococcus faecium and Enterococcus faecalis isolates. A total of 40.8% (235/576) E. faecium and 1.6% (33/2004) E. faecalis isolates were vancomycin-resistant. Among the Enterobacteriaceae, 36.3% (1465/4032) of Klebsiella pneumoniae isolates, 16.4% (67/409) of Klebsiella oxytoca isolates and 25.4% (1246/4912) of Escherichia coli isolates were extended-spectrum β-lactamase (ESBL) producers. Of the ESBL-producing K. pneumoniae and E. coli isolates, susceptibility was highest to tigecycline [93.4% (1369/1465) and 99.8% (1244/1246), respectively] and meropenem [86.9% (1103/1270) and 97.0% (1070/1103), respectively]. A total of 26.7% (966/3613) of Pseudomonas aeruginosa isolates were multidrug-resistant (MDR). Among all P. aeruginosa isolates, susceptibility was highest to amikacin [72.8% (2632/3613)]. A total of 70.3% (1654/2354) of Acinetobacter baumannii isolates were MDR, and susceptibility was highest to minocycline [88.3% (2079/2354) for all isolates, 86.2% (1426/1654) for MDR isolates]. Tigecycline had the lowest MIC90 (2 mg/L) among A. baumannii isolates, including MDR isolates. CONCLUSIONS:This study of isolates from Latin America shows that linezolid, vancomycin and tigecycline continue to be active in vitro against important Gram-positive organisms such as MRSA, and that susceptibility rates to meropenem and tigecycline against members of the Enterobacteriaceae, including ESBL-producers, were high. However, we report that Latin America has high rates of MRSA, MDR A. baumannii and ESBL-producing Enterobacteriaceae which require continued monitoring.

authors

Vega S,Dowzicky MJ

doi

10.1186/s12941-017-0222-0

subject

Has Abstract

pub_date

2017-07-12 00:00:00

pages

50

issue

1

issn

1476-0711

pii

10.1186/s12941-017-0222-0

journal_volume

16

pub_type

杂志文章
  • Aetiological agents of cerebrospinal meningitis: a retrospective study from a teaching hospital in Ghana.

    abstract:BACKGROUND:Meningitis is an important cause of morbidity and mortality in low-resource settings. In sub-Saharan Africa, the meningitis belt has been characterized by particularly high and seasonal incidences of bacterial meningitis extending throughout life. Despite the progress being made in treating the condition, th...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-11-28

    authors: Owusu M,Nguah SB,Boaitey YA,Badu-Boateng E,Abubakr AR,Lartey RA,Adu-Sarkodie Y

    更新日期:2012-10-04 00:00:00

  • Hepatic adverse events during highly active antiretroviral therapy containing nevirapine: a case report.

    abstract:BACKGROUND:Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV infected patient on HAART including nevirapine and taking antidepressive agents, with acute toxic hepatitis. CASE PRESENTATION:A 39 year old patient diagnosed ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-1-1

    authors: Gökengin D,Yamazhan T

    更新日期:2002-09-16 00:00:00

  • Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation.

    abstract:BACKGROUND:Drug resistance in Mycobacterium tuberculosis (MTB) is a major health issue worldwide. Recently, next-generation sequencing (NGS) technology has begun to be used to detect resistance genes of MTB. We aimed to assess the clinical usefulness of Ion S5 NGS TB research panel for detecting MTB resistance in Korea...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-018-0300-y

    authors: Ko DH,Lee EJ,Lee SK,Kim HS,Shin SY,Hyun J,Kim JS,Song W,Kim HS

    更新日期:2019-01-03 00:00:00

  • Molecular characterization of clinical multidrug-resistant Klebsiella pneumoniae isolates.

    abstract:BACKGROUND:Klebsiella pneumoniae is a frequent nosocomial pathogen, with the multidrug-resistant (MDR) K. pneumoniae being a major public health concern, frequently causing difficult-to-treat infections worldwide. The aim of this study was to investigate the molecular characterization of clinical MDR Klebsiella pneumon...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-13-16

    authors: Cao X,Xu X,Zhang Z,Shen H,Chen J,Zhang K

    更新日期:2014-05-01 00:00:00

  • Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant Staphylococcus aureus in a renal transplant recipient with Fabry-Anderson disease.

    abstract::Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-11-6

    authors: Polilli E,Ursini T,Mazzotta E,Sozio F,Savini V,D'Antonio D,Barbato M,Consorte A,Parruti G

    更新日期:2012-03-11 00:00:00

  • Mycetoma: a clinical dilemma in resource limited settings.

    abstract:BACKGROUND:Mycetoma is a chronic mutilating disease of the skin and the underlying tissues caused by fungi or bacteria. Although recently included in the list of neglected tropical diseases by the World Health Organization, strategic control and preventive measures are yet to be outlined. Thus, it continues to pose hug...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,评审

    doi:10.1186/s12941-018-0287-4

    authors: Emmanuel P,Dumre SP,John S,Karbwang J,Hirayama K

    更新日期:2018-08-10 00:00:00

  • Two or more enteropathogens are associated with diarrhoea in Mexican children.

    abstract:BACKGROUND:Diarrhoeal diseases constitute a major public health problem, particularly in the developing world, where the rate of mortality and morbidity is very high. The purpose of this study was to conduct a 2 years and 3 months study in order to determine the prevalence of five enteropathogen diarrheogenic agents in...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-6-17

    authors: Paniagua GL,Monroy E,García-González O,Alonso J,Negrete E,Vaca S

    更新日期:2007-12-28 00:00:00

  • Epidemiology of urinary tract infections and antibiotics sensitivity among pregnant women at Khartoum North Hospital.

    abstract:BACKGROUND:Urinary tract infections (UTI) can lead to poor maternal and perinatal outcomes. Investigating epidemiology of UTI and antibiotics sensitivity among pregnant women is fundamental for care-givers and health planners. METHODS:A cross sectional study has been conducted at Khartoum north teaching hospital Anten...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-10-2

    authors: Hamdan HZ,Ziad AH,Ali SK,Adam I

    更新日期:2011-01-18 00:00:00

  • Clonal dissemination of KPC-2 producing Klebsiella pneumoniae ST11 clone with high prevalence of oqxAB and rmtB in a tertiary hospital in China: results from a 3-year period.

    abstract:BACKGROUND:Carbapenemase-producing Klebsiella pneumoniae (CPKP) strains have emerged as a major problem for healthcare systems. The aim of this study was to determine the circulating clones and analyze the clinical and molecular characteristics of CPKP in our hospital. METHODS:A total of 74 carbapenemase producers col...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-015-0109-x

    authors: Cheng L,Cao XL,Zhang ZF,Ning MZ,Xu XJ,Zhou W,Chen JH,Zhang JH,Shen H,Zhang K

    更新日期:2016-01-19 00:00:00

  • The carbapenem-resistant Enterobacteriaceae threat is growing: NDM-1 epidemic at a training hospital in Turkey.

    abstract:BACKGROUND:Recently, new carbapenemases in Enterobacteriaceae strains and non-fermentative gram-negative bacilli have been reported. The New Delhi metallo-β-lactamase-1 (NDM-1) is a major problem around the world. The purpose of this article is to address the NDM-1 Klebsiella pneumoniae epidemic detected in eight cases...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-016-0118-4

    authors: Karabay O,Altindis M,Koroglu M,Karatuna O,Aydemir ÖA,Erdem AF

    更新日期:2016-02-09 00:00:00

  • 3,4-DHPEA-EA from Olea Europaea L. is effective against standard and clinical isolates of Staphylococcus sp.

    abstract:BACKGROUND:The aim of the present work was to evaluate the antibacterial effect of 3,4-DHPEA-EA (methyl-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-formyl-2-methyl-3,4-dihydro-2H-pyran-5-carboxylate), a derivate of oleuropein, against a range of Gram-positive bacteria, including ATCC strains, food and clinical isolate...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-13-24

    authors: Bisignano C,Filocamo A,Ginestra G,Giofre' SV,Navarra M,Romeo R,Mandalari G

    更新日期:2014-07-01 00:00:00

  • Non-typhoidal Salmonella bacteraemia: epidemiology, clinical characteristics and its' association with severe immunosuppression.

    abstract:BACKGROUND:Non-typhoidal Salmonella (NTS) is increasingly recognized as an important pathogen associated with bacteraemia especially in immunosuppressed patients. However, there is limited data specifically describing the clinical characteristics and outcome amongst the immunosuppressed patients. METHODS:A total of 56...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-8-15

    authors: Dhanoa A,Fatt QK

    更新日期:2009-05-18 00:00:00

  • Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis.

    abstract:BACKGROUND:The emergence of Mycobacterium tuberculosis strains resistant to antituberculosis agents has recently received increased attention owing largely to the dramatic outbreaks of multi drug resistance tuberculosis (MDR-TB). METHODS:Patients residing in Zonguldak and Kayseri provinces of Turkey with, pulmonary tu...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-1-6

    authors: Kart L,Altin R,Tor M,Gulmez I,Oymak SF,Atmaca HM,Erdem F

    更新日期:2002-12-16 00:00:00

  • Complications of peritonsillar abscess.

    abstract:BACKGROUND:The vast majority of patients with peritonsillar abscess (PTA) recover uneventfully on abscess drainage and antibiotic therapy. However, occasionally patient´s condition deteriorates as the infection spread in the upper airway mucosa, through cervical tissues, or hematogenously. The bacterial etiology of PTA...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,评审

    doi:10.1186/s12941-020-00375-x

    authors: Klug TE,Greve T,Hentze M

    更新日期:2020-07-30 00:00:00

  • Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis.

    abstract:BACKGROUND:Farnesol is a sesquiterpene alcohol produced by many organisms, and also found in several essential oils. Its role as a quorum sensing molecule and as a virulence factor of Candida albicans has been well described. Studies revealed that farnesol affect the growth of a number of bacteria and fungi, pointing t...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-8-13

    authors: Derengowski LS,De-Souza-Silva C,Braz SV,Mello-De-Sousa TM,Báo SN,Kyaw CM,Silva-Pereira I

    更新日期:2009-04-29 00:00:00

  • Pseudomonas aeruginosa contamination of mouth swabs during production causing a major outbreak.

    abstract:BACKGROUND:In 2002 we investigated an outbreak comprising 231 patients in Norway, caused by Pseudomonas aeruginosa and linked to the use of contaminated mouth swabs called Dent-O-Sept. Here we describe the extent of contamination of the swabs, and identify critical points in the production process that made the contami...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-6-3

    authors: Iversen BG,Eriksen HM,Bø G,Hagestad K,Jacobsen T,Engeset E,Lassen J,Aavitsland P

    更新日期:2007-03-13 00:00:00

  • Type II and type IV topoisomerase mutations in clinical isolates of Morganella morganii harbouring the qnrD gene.

    abstract:INTRODUCTION:The aim of this study was to show the emergence of the qnrD gene among fluoroquinolone-resistant Morganella morganii isolate. The occurrence of mutations in DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC,parE) genes was also investigated in this strain. METHODOLOGY:95 clinical Enterobacteria were s...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-014-0034-4

    authors: Nasri Yaiche M,Denden Rafraf I,Guo Q,Mastouri M,Aouni M,Wang M

    更新日期:2014-08-09 00:00:00

  • Comparison of fungal and bacterial keratitis between tropical and subtropical Taiwan: a prospective cohort study.

    abstract:BACKGROUND:Fungal keratitis (FK) has been shown to be a climate-sensitive disease. The differentiation between FK from bacterial keratitis (BK) was difficult. The purpose of this study was to compare the bacteriology and mycology between tropical and subtropical Taiwan and to investigate the independent risk factors fo...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-020-00353-3

    authors: Chen CA,Hsu SL,Hsiao CH,Ma DH,Sun CC,Yu HJ,Fang PC,Kuo MT

    更新日期:2020-03-30 00:00:00

  • The prevalence of malaria among HIV seropositive individuals and the impact of the co- infection on their hemoglobin levels.

    abstract:BACKGROUND:Malaria and HIV/AIDS are the two most common infections in sub-Sahara Africa. There are hypotheses and study reports on the possible association between these two infections, hence the prevalence and outcome of their co-infection in an endemic population will be important in defining healthcare strategies. A...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-015-0064-6

    authors: Tay SC,Badu K,Mensah AA,Gbedema SY

    更新日期:2015-03-07 00:00:00

  • Variable antibiotic susceptibility patterns among Streptomyces species causing actinomycetoma in man and animals.

    abstract:BACKGROUND:Drug therapy is recommended in conjunction with surgery in treatment of actinomycetoma. The specific prescription depends on the type of bacteria (actinomycetoma) or fungi (eumycetoma) causing the disease and their in vitro antimicrobial susceptibility. OBJECTIVES:To investigate the antimicrobial susceptibi...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-10-24

    authors: Hamid ME

    更新日期:2011-06-06 00:00:00

  • Short-term treatment outcomes in human immunodeficiency virus type-1 and hepatitis B virus co-infections.

    abstract:BACKGROUND:Co-infection of HIV with HBV is common in West Africa but little information is available on the effects of HBV on short-term therapy for HIV patients. A 28 day longitudinal study was conducted to examine short-term antiretroviral therapy (ART) outcomes in HIV infected individuals with HBV co-infection. MET...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-016-0152-2

    authors: Sagoe KW,Duedu KO,Ziga F,Agyei AA,Adiku TK,Lartey M,Mingle JA,Arens M

    更新日期:2016-06-02 00:00:00

  • Assessment of the requisites of microbiology based infectious disease training under the pressure of consultation needs.

    abstract:BACKGROUND:Training of infectious disease (ID) specialists is structured on classical clinical microbiology training in Turkey and ID specialists work as clinical microbiologists at the same time. Hence, this study aimed to determine the clinical skills and knowledge required by clinical microbiologists. METHODS:A cro...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-10-38

    authors: Erdem H,Tekin-Koruk S,Koruk I,Tozlu-Keten D,Ulu-Kilic A,Oncul O,Guner R,Birengel S,Mert G,Nayman-Alpat S,Eren-Tulek N,Demirdal T,Elaldi N,Ataman-Hatipoglu C,Yilmaz E,Mete B,Kurtaran B,Ceran N,Karabay O,Inan D,Ceng

    更新日期:2011-12-16 00:00:00

  • Prevalence of Helicobacter pylori vacA, cagA, iceA and oipA genotypes in Tunisian patients.

    abstract:BACKGROUND:Distinct virulence factors of H. pylori have been described: the vaculating cytotoxin (vacA), the cytotoxin associated gene (cagA), the induced by contact with epithelium factor Antigen (iceA gene) and the outer membrane protein oipA. In Tunisia, there are no data regarding the pattern of H. pylori genotypes...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1476-0711-9-10

    authors: Ben Mansour K,Fendri C,Zribi M,Masmoudi A,Labbene M,Fillali A,Ben Mami N,Najjar T,Meherzi A,Sfar T,Burucoa C

    更新日期:2010-03-19 00:00:00

  • Biofilm formation and adherence characteristics of an Elizabethkingia meningoseptica isolate from Oreochromis mossambicus.

    abstract:BACKGROUND:Elizabethkingia spp. are opportunistic pathogens often found associated with intravascular device-related bacteraemias and ventilator-associated pneumonia. Their ability to exist as biofilm structures has been alluded to but not extensively investigated. METHODS:The ability of Elizabethkingia meningoseptica...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-10-16

    authors: Jacobs A,Chenia HY

    更新日期:2011-05-05 00:00:00

  • Should we use closed or open infusion containers for prevention of bloodstream infections?

    abstract:BACKGROUND:Hospitalized patients in critical care settings are at risk for bloodstream infections (BSI). Most BSIs originate from a central line (CL), and they increase length of stay, cost, and mortality. Open infusion containers may increase the risk of contamination and administration-related (CLAB) because they all...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-9-6

    authors: Rangel-Frausto MS,Higuera-Ramirez F,Martinez-Soto J,Rosenthal VD

    更新日期:2010-02-02 00:00:00

  • Antimicrobial susceptibility pattern, and associated factors of Salmonella and Shigella infections among under five children in Arba Minch, South Ethiopia.

    abstract:BACKGROUND:Diarrheal diseases continue to be the major cause of morbidity and mortality among children under 5 years. Salmonella and Shigella specious are the major enteric pathogen causing diarrhea among children worldwide. Examination of stool sample is the most sensitive method to diagnose diarrheal disease in child...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-018-0253-1

    authors: Ameya G,Tsalla T,Getu F,Getu E

    更新日期:2018-02-01 00:00:00

  • Differential effects of antibiotics on neutrophils exposed to lipoteichoic acid derived from Staphylococcus aureus.

    abstract:BACKGROUND:Persistent bacteremia occurs in at least 30% of patients with Staphylococcus aureus bloodstream infection (SAB) and may be attributable to a dysregulated host immune response. Neutrophils interact with a variety of S. aureus microbial factors, including lipoteichoic acid (LTA), to activate phagocytic functio...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-020-00392-w

    authors: Algorri M,Wong-Beringer A

    更新日期:2020-11-03 00:00:00

  • The emergence of the hypervirulent Klebsiella pneumoniae (hvKp) strains among circulating clonal complex 147 (CC147) harbouring blaNDM/OXA-48 carbapenemases in a tertiary care center of Iran.

    abstract:BACKGROUND:Klebsiella pneumoniae is a public health concern because of its ability to develop multidrug resistance and hypervirulent genotypes, of those capsular types K1 and K2 cause community and nosocomial life-threatening infections. This study aimed to determine the antibiotic susceptibility patterns and genotypic...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/s12941-020-00349-z

    authors: Pajand O,Darabi N,Arab M,Ghorbani R,Bameri Z,Ebrahimi A,Hojabri Z

    更新日期:2020-03-31 00:00:00

  • Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyllum.

    abstract::For centuries, plants have been used in traditional medicines and there has been recent interest in the chemopreventive properties of compounds derived from plants. In the present study, we investigated the antibutyrylcholinestrasic (anti-BuChE) and antioxidant (against some free radicals) activities of extracts from ...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-10-32

    authors: Ben Mansour H,Yatouji S,Mbarek S,Houas I,Delai A,Dridi D

    更新日期:2011-08-31 00:00:00

  • Antimicrobial resistance in community and nosocomial Escherichia coli urinary tract isolates, London 2005-2006.

    abstract:BACKGROUND:Escherichia coli is the commonest cause of community and nosocomial urinary tract infection (UTI). Antibiotic treatment is usually empirical relying on susceptibility data from local surveillance studies. We therefore set out to determine levels of resistance to 8 commonly used antimicrobial agents amongst a...

    journal_title:Annals of clinical microbiology and antimicrobials

    pub_type: 杂志文章

    doi:10.1186/1476-0711-7-13

    authors: Bean DC,Krahe D,Wareham DW

    更新日期:2008-06-18 00:00:00