Abstract:
OBJECTIVE:Synovitis associated with osteoarthritis (OA) is directly responsible for several clinical symptoms and reflects OA's structural progression. This study sought to analyze the expression of proinflammatory mediations, including Interleukin (IL)-17 and IL-22, which play key roles in regulating inflammatory processes, in inflamed and non-inflamed areas of osteoarthritic synovium. METHODS:Synovium from knees of 32 OA patients were collected at surgery. Macroscopic evaluation of inflammation enabled inflamed and non-inflamed areas to be separated. Samples were incubated to obtain tissue-conditioned media. Quantitative mRNA expression of proinflammatory mediators was analyzed by RT-PCR and protein levels by ELISA and gelatin zymography. Immunohistochemistry and histology were performed. RESULTS:Inflamed synovium were characterized by increased leukocyte infiltration and a higher vessel-to-tissue area ratio than non-inflamed tissues. Macrophages, T and B lymphocytes, and some neutrophils were found only in the inflamed tissue, and only in the subintimal layer. Levels of proinflammatory cytokines and MMP-9 were significantly higher in tissue-conditioned media from inflamed than non-inflamed tissues. Inflamed areas were associated with higher expression of IL-17 and IL-22, both correlated with the combined release of IL-6, IL-23, and TGFβ1. CONCLUSION:Our results showed that inflammatory cytokines, including IL-17 and IL-22, are expressed at higher levels by inflamed OA synovium and suggest IL-22 involvement in OA pathophysiology. This study will help identify new therapeutic strategies for OA, especially the targeting of IL-22 to decrease inflammation.
journal_name
Osteoarthritis Cartilagejournal_title
Osteoarthritis and cartilageauthors
Deligne C,Casulli S,Pigenet A,Bougault C,Campillo-Gimenez L,Nourissat G,Berenbaum F,Elbim C,Houard Xdoi
10.1016/j.joca.2014.12.007subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1843-52issue
11eissn
1063-4584issn
1522-9653pii
S1063-4584(14)01379-Xjournal_volume
23pub_type
杂志文章abstract:OBJECTIVE:To compare measurement properties of the P4 pain scale, Western Ontario and McMaster Universities Arthritis Index pain subscale (WOMAC-pain), and Intermittent and Constant Osteoarthritis Pain (ICOAP) measure in patients with knee osteoarthritis (OA). DESIGN:A secondary analysis from a randomized controlled t...
journal_title:Osteoarthritis and cartilage
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,随机对照试验
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joca.2009.12.001
更新日期:2010-04-01 00:00:00
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doi:10.1016/j.joca.2020.12.005
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2010-02-01 00:00:00
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doi:10.1016/s1063-4584(05)80070-6
更新日期:1994-09-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1016/j.joca.2005.04.014
更新日期:2005-09-01 00:00:00
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更新日期:2016-04-01 00:00:00
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doi:10.1053/joca.2002.0837
更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joca.2008.05.016
更新日期:2009-01-01 00:00:00
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1053/joca.2002.0800
更新日期:2002-08-01 00:00:00
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更新日期:2000-03-01 00:00:00
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更新日期:2011-07-01 00:00:00
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更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joca.2006.03.015
更新日期:2006-10-01 00:00:00
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更新日期:2007-05-01 00:00:00
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更新日期:2004-02-01 00:00:00
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-07-01 00:00:00
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更新日期:2019-07-01 00:00:00
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