T1rho relaxation time of the meniscus and its relationship with T1rho of adjacent cartilage in knees with acute ACL injuries at 3 T.

Abstract:

OBJECTIVE:The aim of this study was to assess the reproducibility of meniscus T1rho measurements, and to study T1rho relaxation time in the lateral meniscus (LM) and its relationship with adjacent cartilage T1rho in knees with acute anterior cruciate ligament (ACL) injuries at 3T magnetic resonance imaging. METHOD:Quantitative assessment of the meniscus and cartilage was performed in 15 healthy controls and 16 ACL-injured patients using a T1rho mapping technique. All ACL-injured patients were imaged prior to surgery within 1-3 months of injury. The anterior and posterior horns of LM and medial meniscus (MM) were associated with partitioned weight-bearing cartilage sub-compartments (anterior, central, and posterior). RESULTS:T1rho measurements in the meniscus showed excellent reproducibility (coefficient of variation (CV)<5%). Significantly elevated T1rho values were found in the LM in patients compared with controls (P<0.01). No differences were found in the MM. Significantly higher T1rho values were found at the posterior horn compared with the anterior horn of patients' meniscus (P=0.005). At the posterior sub-compartment of lateral tibia (LT), significantly increased cartilage T1rho values were found in patients compared with controls (P=0.002). A significant correlation (R(2)=0.47, P=0.007) was found between T1rho values of posterior horn of LM and T1rho values of posterior sub-compartment of LT cartilage in patients. CONCLUSION:A strong injury-related relationship was demonstrated between meniscus and cartilage biochemical changes. T1rho mapping techniques provide tools to quantitatively evaluate meniscus and cartilage matrix in patients with ACL injuries.

authors

Bolbos RI,Link TM,Ma CB,Majumdar S,Li X

doi

10.1016/j.joca.2008.05.016

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

12-8

issue

1

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(08)00176-3

journal_volume

17

pub_type

杂志文章
  • Reliability of the Ahlbäck classification of knee osteoarthritis.

    abstract:OBJECTIVE:The aim of the study was to assess the inter-observer reliability and intra-observer reproducibility of the Ahlbäck radiographic classification for knee osteoarthritis (OA). DESIGN:Ninety-six knee radiographs of patients with clinical signs of arthritis were evaluated and classified into five grades of Ahlbä...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/s1063-4584(03)00095-5

    authors: Galli M,De Santis V,Tafuro L

    更新日期:2003-08-01 00:00:00

  • Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis.

    abstract:OBJECTIVE:To examine whether urine concentrations of type II collagen neoepitope (uTIINE) distinguish subjects with progressive radiographic and/or symptomatic knee osteoarthritis (OA) from those with stable disease. METHODS:Subjects were 120 obese middle-aged women with unilateral knee OA who participated in a 30-mon...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.joca.2006.04.009

    authors: Hellio Le Graverand MP,Brandt KD,Mazzuca SA,Katz BP,Buck R,Lane KA,Pickering E,Nemirovskiy OV,Sunyer T,Welsch DJ

    更新日期:2006-11-01 00:00:00

  • Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients.

    abstract:OBJECTIVE:To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS:Body mass index (BMI) was calculated in 45 patients (16 women),...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2008.10.009

    authors: Ericsson YB,Tjörnstrand J,Tiderius CJ,Dahlberg LE

    更新日期:2009-05-01 00:00:00

  • Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects.

    abstract:OBJECTIVE:Currently, the surgical treatment of localized cartilage defects has limitations. Alternatively, localized cartilage defects may be treated with small biocompatible metal cartilage tacks. Our purpose was to investigate the applicability of defect-size femoral implants. Different bearing materials, cobalt-chro...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2007.02.007

    authors: Custers RJ,Dhert WJ,van Rijen MH,Verbout AJ,Creemers LB,Saris DB

    更新日期:2007-08-01 00:00:00

  • A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.

    abstract:OBJECTIVE:Scottish fold cats, named for their unique ear shape, have a dominantly inherited osteochondrodysplasia involving malformation in the distal forelimbs, distal hindlimbs and tail, and progressive joint destruction. This study aimed to identify the gene and the underlying variant responsible for the osteochondr...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2016.03.019

    authors: Gandolfi B,Alamri S,Darby WG,Adhikari B,Lattimer JC,Malik R,Wade CM,Lyons LA,Cheng J,Bateman JF,McIntyre P,Lamandé SR,Haase B

    更新日期:2016-08-01 00:00:00

  • FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.

    abstract:OBJECTIVE:To characterize a novel secreted frizzled-related protein (SFRP) and determine its tissue distribution at the mRNA and protein level. METHODS:The FrzB-2 gene was identified by expressed sequence tag (EST) analysis of human tissue-derived libraries. Tissue distribution of FrzB-2 mRNA was determined by Norther...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1053/joca.1999.0321

    authors: James IE,Kumar S,Barnes MR,Gress CJ,Hand AT,Dodds RA,Connor JR,Bradley BR,Campbell DA,Grabill SE,Williams K,Blake SM,Gowen M,Lark MW

    更新日期:2000-11-01 00:00:00

  • The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study.

    abstract:OBJECTIVE:In this population-based cohort study, we examined the association between the presence of symptomatic osteoarthritis (OA) and risk for cardiovascular (CV) events. METHOD:A cohort aged ≥55 years recruited from 1996 to 98 was followed through provincial health administrative data to 2014. Demographics, joint ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2017.07.024

    authors: Kendzerska T,Jüni P,King LK,Croxford R,Stanaitis I,Hawker GA

    更新日期:2017-11-01 00:00:00

  • Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection.

    abstract:OBJECTIVE:The aim of this study was to investigate the site-dependent changes in the structure and function of articular cartilage in the lapine knee joint at a very early stage of osteoarthritis (OA), created experimentally by anterior cruciate ligament transection (ACLT). METHODS:Unilateral ACLT was performed in eig...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2014.04.010

    authors: Mäkelä JT,Rezaeian ZS,Mikkonen S,Madden R,Han SK,Jurvelin JS,Herzog W,Korhonen RK

    更新日期:2014-06-01 00:00:00

  • Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis.

    abstract:OBJECTIVE:Obesity is a highly cited risk factor for knee osteoarthritis (OA), but its role in knee OA pathogenesis and progression is not as clear. Excess weight may contribute to an increased mechanical burden and altered dynamic movement and loading patterns at the knee. The objective of this study was to examine the...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2012.08.004

    authors: Harding GT,Hubley-Kozey CL,Dunbar MJ,Stanish WD,Astephen Wilson JL

    更新日期:2012-11-01 00:00:00

  • Systematic review of non-surgical therapies for osteoarthritis of the hand: an update.

    abstract:OBJECTIVE:To update our earlier systematic review which evaluated all published randomized controlled trials (RCTs) evaluating pharmacological and non-pharmacological therapies in patients with hand osteoarthritis (OA). Surgical therapies were not evaluated. METHOD:RCTs published between August 2004 and February 2008 ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2009.04.006

    authors: Mahendira D,Towheed TE

    更新日期:2009-10-01 00:00:00

  • Reinforcement of articular cartilage with a tissue-interpenetrating polymer network reduces friction and modulates interstitial fluid load support.

    abstract:OBJECTIVE:Osteoarthritis (OA) is associated with increased articular cartilage hydraulic permeability and decreased maintenance of high interstitial fluid load support (IFLS) during articulation, resulting in increased friction on the cartilage solid matrix. This study assesses frictional response following in situ syn...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2017.03.001

    authors: Cooper BG,Lawson TB,Snyder BD,Grinstaff MW

    更新日期:2017-07-01 00:00:00

  • Dynamic knee loading is related to cartilage defects and tibial plateau bone area in medial knee osteoarthritis.

    abstract:OBJECTIVE:To evaluate the relationship between dynamic mechanical loading, as indicated by external knee adduction moment (KAM) measures during walking, and measures of articular cartilage morphology and subchondral bone size in people with medial knee osteoarthritis (OA). DESIGN:180 individuals with radiographic medi...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2010.08.013

    authors: Creaby MW,Wang Y,Bennell KL,Hinman RS,Metcalf BR,Bowles KA,Cicuttini FM

    更新日期:2010-11-01 00:00:00

  • Joint distraction in treatment of osteoarthritis: a two-year follow-up of the ankle.

    abstract:OBJECTIVE:Osteoarthritis (OA) is a degenerative joint disease with an incidence exceeding 10% of the adult population. In end stages, OA can result in severe restriction of activity and consequent disability. For these severe cases of OA, no effective remedy is available yet. Joint distraction is a new experimental app...

    journal_title:Osteoarthritis and cartilage

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1053/joca.1998.0242

    authors: van Valburg AA,van Roermund PM,Marijnissen AC,van Melkebeek J,Lammens J,Verbout AJ,Lafeber FP,Bijlsma JW

    更新日期:1999-09-01 00:00:00

  • The contribution of hip geometry to the prediction of hip osteoarthritis.

    abstract:OBJECTIVE:To determine how well measures of hip geometry can predict radiological incident hip osteoarthritis (HOA) compared to well known clinical risk factors. DESIGN:The study population is part of the Rotterdam Study, a prospective population-based cohort. Baseline pelvic radiographs were used to measure hip geome...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2013.06.012

    authors: Castaño-Betancourt MC,Van Meurs JB,Bierma-Zeinstra S,Rivadeneira F,Hofman A,Weinans H,Uitterlinden AG,Waarsing JH

    更新日期:2013-10-01 00:00:00

  • UTE-T2∗ mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear.

    abstract:OBJECTIVE:Meniscus tear is a known risk factor for osteoarthritis (OA). Quantitative assessment of meniscus degeneration, prior to surface break-down, is important to identification of early disease potentially amenable to therapeutic interventions. This work examines the diagnostic potential of ultrashort echo time-en...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2012.01.009

    authors: Williams A,Qian Y,Golla S,Chu CR

    更新日期:2012-06-01 00:00:00

  • Ropivacaine- and bupivacaine-induced death of rabbit annulus fibrosus cells in vitro: involvement of the mitochondrial apoptotic pathway.

    abstract:OBJECTIVE:The purposes of this study were to assess whether local anesthetics (LAs), such as ropivacaine and bupivacaine, could induce apoptosis of rabbit annulus fibrosus (AF) cells in vitro and further to explore the possible underlying mechanism. METHODS:Rabbit AF cells at second passage were treated with saline so...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2015.05.013

    authors: Cai XY,Xia Y,Yang SH,Liu XZ,Shao ZW,Liu YL,Yang W,Xiong LM

    更新日期:2015-10-01 00:00:00

  • Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?

    abstract:OBJECTIVE:Adipose tissue-derived mesenchymal stem cells (ATMSCs) have been shown to differentiate into bone, cartilage, fat or muscle. However, it is not certain that ATMSCs are equal to bone marrow-derived mesenchymal stem cells (BMMSC) for their bone and cartilage forming potential. The purpose of this study was to a...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2005.05.005

    authors: Im GI,Shin YW,Lee KB

    更新日期:2005-10-01 00:00:00

  • The validity of in vivo ultrasonographic grading of osteoarthritic femoral condylar cartilage: a comparison with in vitro ultrasonographic and histologic gradings.

    abstract:OBJECTIVES:To establish an ultrasonographic (US) grading for semiquantitative evaluation of the femoral condylar cartilage of knee osteoarthritis (OA), in vivo, and compare the in vivo US grading with the in vitro US and histologic gradings. DESIGN:Ninety-five patients going to receive total knee arthroplasty because ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2007.07.013

    authors: Lee CL,Huang MH,Chai CY,Chen CH,Su JY,Tien YC

    更新日期:2008-03-01 00:00:00

  • A positive association of smoking and articular knee joint cartilage in healthy people.

    abstract:OBJECTIVE:To determine whether smoking affects knee cartilage in healthy adults by examining the association of tobacco use with tibial cartilage volume and tibiofemoral cartilage defects. METHODS:Two hundred and ninety-seven healthy adult subjects were recruited from an existing cohort examining healthy aging, the Me...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2006.12.005

    authors: Racunica TL,Szramka M,Wluka AE,Wang Y,English DR,Giles GG,O'Sullivan R,Cicuttini FM

    更新日期:2007-05-01 00:00:00

  • Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state.

    abstract:OBJECTIVE:Mesenchymal stem cells (MSCs) are a promising cell type for the repair of damaged cartilage in osteoarthritis (OA). However, OA synovial fluid and factors secreted by synovium impede chondrogenic differentiation of MSCs, and the mechanism responsible for this effect remains unclear. In this study, we sought t...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2014.05.021

    authors: Fahy N,de Vries-van Melle ML,Lehmann J,Wei W,Grotenhuis N,Farrell E,van der Kraan PM,Murphy JM,Bastiaansen-Jenniskens YM,van Osch GJ

    更新日期:2014-08-01 00:00:00

  • The chondrogenic potential of carbon fiber and carbon fiber periosteum implants: an ultrastructural study in the rabbit.

    abstract::The articular tissue generated on carbon fiber rods in rabbit knee joints after 75 days of intermittent active motion was compared with tissue generated on carbon fiber rods whose articular surfaces were covered with a free reversed periosteal graft. Both methods were effective in generating articular tissue; however,...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/s1063-4584(05)80077-9

    authors: Curtin W,Reville W,Heapes M,Lyons J,Muckle D

    更新日期:1994-12-01 00:00:00

  • Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury.

    abstract:OBJECTIVE:To examine the correlation between synovial fluid cartilage markers and degree of cartilage damage determined by arthroscopic evaluation in subjects with acute knee injury. DESIGN:Chondral damage was quantified using a validated arthroscopic scoring system in 20 subjects with effusive acute knee injuries of ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/s1063-4584(97)80046-5

    authors: Bello AE,Garrett WE Jr,Wang H,Lohnes J,DeLong E,Caterson B,Kraus VB

    更新日期:1997-11-01 00:00:00

  • Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis.

    abstract::A major objective of this article is to examine the research implications of recently available genome-wide expression profiles of cartilage from human osteoarthritis (OA) joints. We propose that, when viewed in the light of extensive earlier work, this novel data provides a unique opportunity to reorient the design o...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2015.03.027

    authors: Sandy JD,Chan DD,Trevino RL,Wimmer MA,Plaas A

    更新日期:2015-11-01 00:00:00

  • Persisting CAM deformity is associated with early cartilage degeneration after Slipped Capital Femoral Epiphysis: 11-year follow-up including dGEMRIC.

    abstract:OBJECTIVE:Slipped capital femoral epiphysis (SCFE) in adolescence is associated with increased risk of future osteoarthritis (OA). The purpose of this study was to study clinical and radiographic risk factors for early cartilage degeneration after SCFE. DESIGN:22 patients (44 hips) (mean age 24 years, range 18-27) tre...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2018.01.013

    authors: Örtegren J,Peterson P,Svensson J,Tiderius CJ

    更新日期:2018-04-01 00:00:00

  • Cartilage loss in radiographically normal knees depends on radiographic status of the contralateral knee - data from the Osteoarthritis Initiative.

    abstract:OBJECTIVE:To test whether radiographically normal knees with contralateral radiographic knee osteoarthritis (OA), but without contralateral trauma history, display greater cartilage thickness loss than knees from subjects with bilaterally radiographically normal knees. METHODS:828 radiographically normal knees (Kellgr...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2018.10.006

    authors: Eckstein F,Maschek S,Roemer FW,Duda GN,Sharma L,Wirth W

    更新日期:2019-02-01 00:00:00

  • Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.

    abstract:OBJECTIVE:To investigate the mechanism of aggrecanolysis in interleukin-1 (IL-1)-treated cartilage tissue by examining the time course of aggrecan cleavages and the tissue and medium content of membrane type 4-matrix metalloproteinases (MT4-MMP) and a disintegrin and metalloproteinase with thrombospondin type I motifs ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2004.10.023

    authors: Patwari P,Gao G,Lee JH,Grodzinsky AJ,Sandy JD

    更新日期:2005-04-01 00:00:00

  • Distinct expression pattern of early- and late-response genes in normal and osteoarthritic human synovial membranes.

    abstract::The significance of activating proteins (AP-1), c-fos, c-jun and jun B relative to the AP-1 responsive metallothionein, collagenase and stromelysin gene expression in the pathophysiology of osteoarthritis (OA) was investigated. The 'early' c-fos, c-jun and jun-B mRNAs were ubiquitously expressed in normal and OA human...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/s1063-4584(05)80085-8

    authors: Zafarullah M,Martel-Pelletier J,Cloutier JM,Gedamu L,Pelletier JP

    更新日期:1993-07-01 00:00:00

  • The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

    abstract:OBJECTIVE:Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms contributing to the a...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2016.05.015

    authors: Xu L,Nwosu LN,Burston JJ,Millns PJ,Sagar DR,Mapp PI,Meesawatsom P,Li L,Bennett AJ,Walsh DA,Chapman V

    更新日期:2016-09-01 00:00:00

  • The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis.

    abstract:OBJECTIVE:A significant risk factor for anterior cruciate ligament (ACL) tears in young athletes is a reduced femoral Notch Width Index (NWI). The purpose of this study was to test if persons with knee osteoarthritis (OA) and ACL tears have smaller NWI independent of prior joint injury and osteophyte volume. METHODS:W...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.joca.2009.09.006

    authors: Stein V,Li L,Guermazi A,Zhang Y,Kent Kwoh C,Eaton CB,Hunter DJ,OAI Investigators.

    更新日期:2010-02-01 00:00:00

  • Risk factors for osteoarthritis: genetics.

    abstract::Although the multifactorial nature of osteoarthritis (OA) is well recognized, genetic factors have been found to be strong determinants of the disease. Evidence of a genetic influence of OA comes from a number of sources, including epidemiological studies of family history and family clustering, twin studies, and expl...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2003.09.005

    authors: Spector TD,MacGregor AJ

    更新日期:2004-01-01 00:00:00