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The original Beckman Coulter Generation II assay significantly underestimates AMH levels compared with the revised protocol.

Abstract：

PURPOSE:Anti-Müllerian hormone (AMH) is used as a marker for ovarian reserve. Since 2011, the standard test for AMH has been the Beckman Coulter Generation (Gen) II assay. However, in July 2013, the protocol was revised due to falsely low readings. The aim of this study was to compare AMH levels measured with the original and revised Gen II assay and to establish a fertile female reference range for the revised protocol. METHODS:Serum AMH levels were measured for 492 natural conception first trimester pregnant women using the original and revised Gen II assay. RESULTS:The original protocol significantly underestimated AMH levels compared with the revised protocol (p < 0.001), the median being 8.4 and 14.2 pmol/L, respectively. In all samples with detectable AMH levels, the revised protocol yielded a higher concentration compared with the original protocol, the magnitude shift ranging from 3.4 to 283.3 % (median 68.0 %). AMH levels measured with the revised protocol were collated to generate an age-specific reference range, with median levels peaking at 27 years then declining with advancing age. The median AMH concentration for ages 20-24 was 17.3 pmol/L, ages 25-29 was 20.5 pmol/L, ages 30-34 was 17.8 pmol/L, ages 35-39 was 10.8 pmol/L, and ages 40-44 was 6.1 pmol/L. CONCLUSIONS:Our study demonstrated that the original Gen II assay significantly underestimated AMH levels, suggesting caution is required when interpreting literature and testing results achieved with this assay. We also established the revised Gen II assay reference range for AMH in women with unassisted proven fertility.

journal_name

J Assist Reprod Genet

journal_title

Journal of assisted reproduction and genetics

authors

Bonifacio M,Bradley CK,Karia S,Livingstone M,Bowman MC,McArthur SJ

doi

10.1007/s10815-015-0579-y

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1691-6

issue

11

eissn

1058-0468

issn

1573-7330

pii

10.1007/s10815-015-0579-y

journal_volume

32

pub_type

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