当前位置： SCI文献检索 > JOURNAL OF ASSISTED REPRODUCTION AND GENETICS期刊下所有文献 > Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review.

Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review.

Abstract：

:Benign hydatidiform mole, complete or partial, is the most common type of gestational trophoblastic disease (GTD) characterised by excessive trophoblastic proliferation and abnormal embryonic development. Although most complete hydatidiform moles (CHMs) are diploid androgenetic, a few cases of CHMs are biparental, characterised by recurrence and familial clustering. In these rare cases, mutations in NLRP7 or KHDC3L genes, associated with maternal imprinting defects, have been implicated. Current data regarding future pregnancy options in hydatidiform moles are discussed and our opinion is presented based on an incidence that took place in our hospital with a woman with consecutive molar pregnancies. In recurrent hydatidiform moles, DNA testing should be performed and when NLRP7 or KHDC3L mutation are detected, oocyte donation should be proposed as an option to maximise woman's chances of having a normal pregnancy.

journal_name

J Assist Reprod Genet

journal_title

Journal of assisted reproduction and genetics

authors

Kalogiannidis I,Kalinderi K,Kalinderis M,Miliaras D,Tarlatzis B,Athanasiadis A

doi

10.1007/s10815-018-1202-9

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

967-973

issue

6

eissn

1058-0468

issn

1573-7330

pii

10.1007/s10815-018-1202-9

journal_volume

35

pub_type

杂志文章,评审

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