Complete response of adult-onset CNS Langerhans cell histiocytosis documented on 18F-FDG PET/CT.

Abstract:

:We report a case of a 49-year-old woman with biopsy-proven multisystemic Langerhans cell histiocytosis (LCH) with hypothalamic involvement documented on F-FDG PET/CT. Chemotherapy with a combination of vinblastine, prednisolone, methotrexate, and 6-mercaptopurine was carried out. Two months later, a 90% reduction of the hypothalamic tumor mass was noted on magnetic resonance imaging, but with no signs of pathological F-FDG accumulation. The patient died 4 months later, and we found no signs of LCH on autopsy. Our case highlights the need for further studies regarding the role of F-FDG PET/CT in the assessment of treatment response in patients with LCH.

journal_name

Clin Nucl Med

authors

Kruljac I,Balenović A,Gaćina P,Imashuku S,Vrkljan M

doi

10.1097/RLU.0000000000000994

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

981-2

issue

12

eissn

0363-9762

issn

1536-0229

journal_volume

40

pub_type

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