Abstract：
:There is a growing body of evidence that the insulin-like growth factor-1 (IGF-1) is dynamically involved in the regulation of body homeostasis and glucose regulation. Traumatic brain injury (TBI) is considered to be a risk factor for Alzheimer's disease (AD). As alterations of IGF-1 have been implicated in both TBI and AD and the IGF-1 signaling also mediates the neuronal excitability and synaptic plasticity in both diseases, we propose that IGF-1 may act as the endogenous connection between TBI and AD. Growing evidence suggests that dysfunction of this pathway contributes to the progressive loss of neurons in Alzheimer's disease (AD), one of the most frequent neurodegenerative disorders. These findings have led to numerous studies in preclinical models of neurodegenerative disorders targeting IGF-1 signaling with currently available antidiabetics. These studies have shown that exogenous administration of IGF-1 reverses signaling abnormalities and has neuroprotective effects. In the first part of this review, we discuss physiological functions of IGF-1 signaling pathway including its distribution within the brain and its relationship with TBI and AD. In the second part, we undertake a comprehensive overview of IGF-1 signaling in TBI and AD, respectively. We then detail targeted IGF-1 in preclinical models of neurodegeneration and the design of clinical trials that have used anti-diabetics for treating AD patients. We close with future considerations that treat relevant issues for successful translation of these encouraging preclinical results into clinical sessions.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Zheng P,Tong Wdoi
10.23736/S0390-5616.16.03431-7subject
Has Abstractpub_date
2017-08-01 00:00:00pages
416-421issue
4eissn
0390-5616issn
1827-1855pii
R38Y9999N00A150075journal_volume
61pub_type
杂志文章,评审abstract：:Craniobasal tumors affecting the middle cranial fossa are rarely treated radically; the main problem to solve is the presence of important nervous and vascular structures in this region. The Authors report a case of complete removal of a malignant tumor involving the temporal bone and the middle cranial fossa. Surgery...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：BACKGROUND:This study aimed to compare the accuracy of screw placement between open pedicle screw fixation and percutaneous pedicle screw fixation (MIS) for the treatment of thoracolumbar spine fractures (TSF). METHODS:forty-nine patients with acute TSF who were treated with transpedicular screw fixation from January ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04439-9
更新日期：2021-02-01 00:00:00
abstract：:Nine patients out of more than 300 with severe Graves' ophthalmopathy followed in this institution were submitted to orbital decompression carried out on 16 eyes by a three-wall procedure consisting of a transfrontal approach with the removal of the roof, the lateral wall and part of the floor of the orbit. All patien...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Echinococcosis is a potentially fatal parasitic disease that can affect many animals and humans. The disease results from infection by tapeworm larvae of the genus Echinococcus--notably, E. granulosus, E. multilocularis, E. vogeli andE. oligarthrus. Cyst hydatid disease is usually seen in adults, and mainly affects li...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:The Authors describe the case of a patient with facial pain associated with hydrocephalus which had a complete recovery after the placement of a ventriculo-atrial shunt. The possible pathological basis of this symptom are discussed. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Evolution of psychological disorders following head injury including memory disorders and other cognitive ones are common. The best known are psychiatric disturbances of various kind after lesions of frontal lobes. Cognitive, behavioural and emotional disorders are not usually seen in patients with bilateral temporal ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm, notorious for being able to evade and suppress the immune-system. We present a new immunotherapeutic approach that can potentially overcome or circumvent many of the GBM laden obstacles for an efficient antitumor immune response. In thi...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.16.03755-3
更新日期：2017-08-01 00:00:00
abstract：:Reporting two cases of dorsally located cervico-medullary hemangioblastomas the Authors discuss clinico-biological features, diagnosis and therapy of this vascular neoplasms, analyzing the cases reported in detail in the available literature. In this site the tumor has often an exophitic development, adhering more or ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:The case of posttraumatic patient with persistent vegetative state and severe and prolonged hyperthermia (T = 39-40 degrees C for more than 20 days), in absence of infection, is described. Diffuse muscular rigidity, treated with L-dopa, slightly preceded the onset of hyperthermia, which was treated with several antipy...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:The aim of this study is to evaluate the prognostic parameters and treatment modalities of malignant melanoma patients with brain metastases. METHODS: EXPERIMENTAL DESIGN:a retrospective study with a mean follow-up of 46 months. SETTING:specialized Cancer Center. PATIENTS:the charts of 136 patients, trea...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:Precise identification of tumor margins is of the utmost importance in neuro-oncology. Confocal microscopy is capable of rapid imaging of fresh tissues at cellular resolution and has been miniaturized into handheld probe-based systems suitable for use in the operating room. We aimed to perform a literature review to p...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.18.04553-8
更新日期：2018-12-01 00:00:00
abstract：AIM:The challenge in large cranial base meningiomas is total resection of the tumor with the least possible mortality and morbidity. During the last two decades the technical approaches for anterior skull base tumors have shown a considerable progress, providing a wide exposure with minimal brain retraction. The purpos...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:This article aims to describe the roles, operative strategies and outcomes of neuroablative procedures in treatment of movement disorders related to cerebral palsy (CP). The authors reviewed relevant medical literatures concerning ablative neurosurgical procedures for CP. Neurosurgery is an appropriate option for trea...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：:The brainstem is an uncommon site for a brain abscess. It accounts for less than 4% of all posterior cranial fossa abscesses, and less than 1% of all intracranial abscesses. The pons is the most common site for these abscesses. The aim of the present report was to describe the case of a Brazilian Amazon man with a bra...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:The filum terminale is an exceptional location for isolated hemangioblastoma. Only five cases are reported in literature, prior to the magnetic resonance imaging era. A 57-year-old man was referred to our Department with a prolonged history of progressive back pain, particularly severe when recumbent, and recurrent un...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：: ...
journal_title：Journal of neurosurgical sciences
pub_type： 信件
doi：10.23736/S0390-5616.17.04156-X
更新日期：2019-04-01 00:00:00
abstract：:We present three cases of pituitary adenoma with adjacent carotid artery aneurysm. The three adenomas are HGH-producing, prolactinoma and non-functioning tumors. Two of these 3 patients showed signs and symptoms of adenoma, while the other one showed a subarachnoid hemorrhage (SAH). The presence of the aneurysm adjace...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Stereotactic biopsy, together with CT and MRI, plays a very important role in the diagnosis of intracranial neoplasms and in their subsequent treatment. Serial neuroimaging-driven biopsies are considered the method of choice when dealing with gliomas, due to their well know morphological dishomogeneity; peritumoral ti...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：AIM:Mesenchymal stem cells (MSCs) migrate in response to chemokines and possess extensive tropism for experimental glioma. Antitumor effects have been reported following intracranial and intravenous administration of gene-modified MSCs. Among the different routes for cell transplant, the intraventricular (IV) approach ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:During the last seven years (1985-91) 28 primary tumours in the cauda among 104 intraspinal tumors were observed. The largest group (71%) comprised ependymomas and neurinomas. The rest included 5 lipomas, 2 astrocytomas and 1 epidermoid. Low-back pain without or with sciatic or crural irradiation was the most common i...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:Malignant exophthalmos is often not resolvable using only medical or radiation therapy. The pressure on the optic nerve which is generally associated with it evolves rapidly in many cases towards optic atrophy and subsequently loss of vision. Only surgical treatment offers any guarantee of success and of the various t...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:The authors tried to assess neurotic traits of 19 consecutive patients having micro-lumbar discectomy and to verify the relation between psychic distress and surgical outcome. All subjects had unequivocal clinical and myelographic evidence of lumbar disc herniation. Neurotic distress was measured by Middlesex Hospital...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:The case of a 53-year-old woman with adult-onset neurological dysfunction secondary to spinal dysraphia and lumbosacral lipoma is presented. This condition not only affects children, but may produce neurological troubles also in adult age. This observation confirms that lumbosacral lipomas do not represent a static co...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Two cases of Hodgkin's disease are described; one was intracerebrally located and the other one extended to bone, dura mater and cerebral parenchyma. The classification of the different types of intracranial Hodgkin's disease is reviewed, and the role of Computed Tomography and surgery in the management of this pathol...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:A case of cerebral gumma is reported. The appearance of this kind of lesion is exceptional at the present time. Gummas are the expression of localized meningovascular forms of neurosyphilis and their clinical symptoms and signs are similar to those of any other space-occupying intracranial lesion. Computed tomography ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：AIM:Fractionated stereotactic radiotherapy is an alternative to radiosurgery or conformal radiotherapy when meningiomas are surgically inaccessible, incompletely removed, or recurrent. The authors report preliminary results of a feasible trial on hypofractionated stereotactic radiotherapy (hFSRT) in patients (pts) with...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:Traumatic brain injury (TBI) is a common cause of permanent disability for which clinical management remains suboptimal. Elevated intracranial pressure (ICP) is a common sequela following TBI leading to death and permanent disability if not properly managed. While clinicians often employ stepwise acute care algorithms...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.17.04133-9
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:A radical surgery of spine metastases is not possible in many cases, especially by elder multi morbid patients. The modern CAVITY/coblation method offers a very good therapeutic alternative for such patients. The goal of this paper was to evaluate and present the method as well as the results of the treatmen...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：10.23736/S0390-5616.16.03690-0
更新日期：2017-12-01 00:00:00
abstract：:It has been recently observed that arachidonic acid (AA) metabolites may modulate many of the mechanisms involved in tumor growth and metastasis. In order to clarify the role played in human brain tumors, authors have determined AA metabolic profiles in 63 surgical specimen of human intracranial tumors (mostly neuroep...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：:A 68-year-old woman with a subarachnoid hemorrhage was operated on for an anterior communicating artery aneurysm demonstrated by angiography. A month later she developed intestinal hemorrhage and a selective angiography showed multiple aneurysmatic dilatations, which were compatible with angiodysplasia, to be the caus...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
