Abstract：
:Precise identification of tumor margins is of the utmost importance in neuro-oncology. Confocal microscopy is capable of rapid imaging of fresh tissues at cellular resolution and has been miniaturized into handheld probe-based systems suitable for use in the operating room. We aimed to perform a literature review to provide an update on the current status of confocal laser endomicroscopy (CLE) technology for brain tumor surgery. Aside from benchtop confocal microscopes used in ex vivo fashion, there are four CLE systems that have been investigated for potential application in the workflow of brain tumor surgery. Preclinical studies on animal tumor models and clinical studies on human brain tumors have assessed in vivo and ex vivo imaging approaches, suggesting that confocal microscopy holds promise for rapid identification of the characteristic (diagnostic) histological features of tumor and normal brain tissues. However, there are few studies assessing diagnostic accuracy sufficient to provide a definitive determination of the clinical and economical value of CLE in brain tumor surgery. Intraoperative real-time, high-resolution tissue imaging has significant clinical potential in the field of neuro-oncology. CLE is an emerging imaging technology that shows promise for improving brain tumor surgery workflow in in vivo and ex vivo studies. Future clinical studies are necessary to demonstrate clinical and economic benefit of CLE.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Belykh E,Cavallo C,Gandhi S,Zhao X,Veljanoski D,Izady Yazdanabadi M,Martirosyan NL,Byvaltsev VA,Eschbacher J,Preul MC,Nakaji Pdoi
10.23736/S0390-5616.18.04553-8subject
Has Abstractpub_date
2018-12-01 00:00:00pages
704-717issue
6eissn
0390-5616issn
1827-1855pii
S0390-5616.18.04553-8journal_volume
62pub_type
杂志文章,评审abstract：:Two cases are reported in which a cerebral glioma developed after radiation therapy for a different primary tumor. The first case was a boy, who presented a right thalamic anaplastic astrocytoma 7 years after irradiation for a left temporal polymorphic cell sarcoma. The second case was a woman, with a right temporal a...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1989-07-01 00:00:00
abstract：: ...
journal_title：Journal of neurosurgical sciences
pub_type： 信件
doi：10.23736/S0390-5616.17.04043-7
更新日期：2019-02-01 00:00:00
abstract：:The case of posttraumatic patient with persistent vegetative state and severe and prolonged hyperthermia (T = 39-40 degrees C for more than 20 days), in absence of infection, is described. Diffuse muscular rigidity, treated with L-dopa, slightly preceded the onset of hyperthermia, which was treated with several antipy...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Spinal cord injury (SCI) inevitably extends beyond neurologic consequences. The relationship between the spinal cord and its control of other organ systems make SCI management complex, requiring treatment on a multisystem approach. Patients frequently have hemodynamic instability and respiratory insufficiency secondar...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2013-12-01 00:00:00
abstract：:The authors' experience in the routine use of temporary clipping procedures in the surgery of endocranial aneurysms is reported. To analyse the validity of such a method we compared the outcome in a series of 153 aneurysms operated according to the traditional procedure (temporary clipping of the afferent vessel only ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:A small group of patients with carpal tunnel syndrome (CTS) can present recurrences and persistent symptoms of CTS after its surgical release. If recurrence is due to scarring between median nerve and surrounding tissue (true recurrence of CTS, transverse carpal ligament [TCL] reconstruction with transposition flap te...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:A radical surgery of spine metastases is not possible in many cases, especially by elder multi morbid patients. The modern CAVITY/coblation method offers a very good therapeutic alternative for such patients. The goal of this paper was to evaluate and present the method as well as the results of the treatmen...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：10.23736/S0390-5616.16.03690-0
更新日期：2017-12-01 00:00:00
abstract：:Traumatic brain injury (TBI) is a common cause of permanent disability for which clinical management remains suboptimal. Elevated intracranial pressure (ICP) is a common sequela following TBI leading to death and permanent disability if not properly managed. While clinicians often employ stepwise acute care algorithms...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.17.04133-9
更新日期：2019-08-01 00:00:00
abstract：:Hyponatremia is a frequent occurrence after pituitary surgery, having been described in 9% to 35% of the patients. It is produced by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) or, more frequently, by the cerebral salt-wasting syndrome (CSWS). The clinical presentation of both syndromes is ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:First advocated by Santoni et al. in 2009, the cortical bone trajectory pedicle screw technique is an alternative to the traditional, convergent technique that shows comparable biomechanical features and potentially requires less aggressive tissue retraction. Aim of this therapy note is to describe this new ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.03230-6
更新日期：2017-06-01 00:00:00
abstract：:A preliminary report on the immunological monitoring of primary intracranial neoplasms is presented. The most important findings concerning B-cells and T-cells mediated immunity and delayed hypersensitivity reactions in this kind of patients, are discussed. Among the fairly significant immunobiological pictures, the A...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：:The filum terminale is an exceptional location for isolated hemangioblastoma. Only five cases are reported in literature, prior to the magnetic resonance imaging era. A 57-year-old man was referred to our Department with a prolonged history of progressive back pain, particularly severe when recumbent, and recurrent un...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:Echinococcosis is a potentially fatal parasitic disease that can affect many animals and humans. The disease results from infection by tapeworm larvae of the genus Echinococcus--notably, E. granulosus, E. multilocularis, E. vogeli andE. oligarthrus. Cyst hydatid disease is usually seen in adults, and mainly affects li...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:Brain metastases are a common problem in solid malignancies and still represent a major cause of morbidity and mortality. With the ongoing improvement in systemic therapies, the expectations on the efficacy of brain metastases directed treatment options are growing. As local therapies against brain metastases continue...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2016-09-01 00:00:00
abstract：:Metastatic involvement of brachial plexopathy is a rare condition that is often associated with advanced systemic breast cancer and the role of surgeon appears to be restricted because radio-chemotherapy is better recommended in this setting. We report a case of a 64-year-old woman that presented a very delayed breast...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Cardiac complications are frequent in patients with subarachnoid hemorrhage (SAH). They include ECG abnormalities, cardiac arrhythmias, myocardial damage, and neurogenic pulmonary edema. The pathophysiology of these abnormalities is related to an imbalance of the autonomic cardiovascular control and to increased circu...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Adjacent-level disease after anterior cervical discectomy and fusion (ACDF) occurs in a significant proportion of patients and frequently requires revision operation. Methods using traditional plates typically require removal of the plate with anecdotally increased operative-time and morbidity. We review our...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04172-3
更新日期：2020-10-01 00:00:00
abstract：AIM:Ossification of the posterior longitudinal ligament (OPLL) is a pathological ossification of the ligament that causes slowly progressive myelo-radiculopathy in adults. Because of long-standing compression of the spinal cord by OPLL, functional prognosis may not always be favorable. Efforts have been made in recent ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
abstract：AIM:The challenge in large cranial base meningiomas is total resection of the tumor with the least possible mortality and morbidity. During the last two decades the technical approaches for anterior skull base tumors have shown a considerable progress, providing a wide exposure with minimal brain retraction. The purpos...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:Free fat in the ventricular space is a rare but well recognized complication of ruptured tumour of dermal origin. However, only 1 patient of spontaneous rupture of spinal dermoid tumour with disseminated fat in the central canal and ventricles has been described in the literature. The authors report an extremely rare ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Peripheral nerve lesions in the upper limbs occur predominantly in reproductive-age men and are often caused by sharp objects. Microsurgery is the choice treatment for these injuries, and regeneration after surgery typically is evaluated with clinical and electrophysiological examinations. The aim of this st...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：:A short review of polyamines and their possible clinical interest and applications in the field of brain neoplasms is presented. Dosage of CSF polyamines was proved to be useful in monitoring patients with medulloblastomas and others malignancies with meningeal involvement. Polyamines and their enzymes in neoplastic t...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1982-07-01 00:00:00
abstract：:It is reported a case that required transoral exposure of C2-C3 intervertebral space in order to remove a huge osteophyte spur projecting into the spinal canal and producing a severe myelopathy. This unusual surgical route was used because the relevant interspace was inaccessible via the standard anterior approach due...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Patients undergoing elective spinal fusion have an alarming rate of vitamin D deficiency, but its impact on bone fusion and patient outcomes is unclear. We investigated the association of perioperative vitamin D levels, fusion rates, and patient-reported outcome in patients undergoing spinal fusion for cervi...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.03846-7
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Meningiomas have been found to have receptors for several hormones, such as oestrogen, progesterone, somatostatin, dopamine and recently also for prolactin. METHODS:To investigate any possible role of prolactin in the growth of those tumours we detected the presence of prolactin-receptors (PRL-R) in 22 meni...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:Tumor related fractures of the spine frequently dictate surgical management. The most critical factors influencing the need and type of surgery are degree of epidural cord compression, radiosensitivity of the tumor, presence of spinal instability and patient medical status/ estimated survivorship. There is a wide spec...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：AIM:Mesenchymal stem cells (MSCs) migrate in response to chemokines and possess extensive tropism for experimental glioma. Antitumor effects have been reported following intracranial and intravenous administration of gene-modified MSCs. Among the different routes for cell transplant, the intraventricular (IV) approach ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:Spontaneous infarction of the ligamentum flavum is a very rare cause of mielo-radicular compression. In the literature only four cases are reported, all characterized by a clinical history of slowly progressive mielo-radiculopathy and good outcome after surgical treatment. A 70 year-old female patient presented with a...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2006-06-01 00:00:00
abstract：:Cavernous malformations are vascular lesions that occur in all parts of the central nervous system but most commonly in the cerebral hemispheres; unusually they may be found along the midline (basal ganglia, pineal region or brain stem), into the ventricle possibly encroaching upon the fourth and third ventricle. We r...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Primary cerebellar glioblastoma multiforme (GBM) is a rare tumor in adults that accounts for just 1% of all cases of GBM. Cerebellar GBMs are not yet completely understood also as far as the prognosis. We report a case of cerebellar GBM in a 27-year-old woman. Magnetic resonance imaging (MRI) showed a 3x3.6 cm-sized, ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
