Abstract：
AIM:Mesenchymal stem cells (MSCs) migrate in response to chemokines and possess extensive tropism for experimental glioma. Antitumor effects have been reported following intracranial and intravenous administration of gene-modified MSCs. Among the different routes for cell transplant, the intraventricular (IV) approach found very little employment in comparison with intraparenchymal, intratumoral and intravenous administration protocols. Nevertheless, IV transplantation offers advantages in terms of cells viability and distribution toward target sites, opening interesting opportunities for its clinical application. METHODS:Using a rat glioma model, we investigated migratory capacity, tumor tropism, distribution and differentiation of MSCs following IV administration. RESULTS:Transplanted MSCs create niches of viable cells in the subventricular zone and can be stimulated to migrate to sites of tumor infiltration. MSCs seemed not to be involved in tumor growth and angiogenesis. CONCLUSION:We speculate that the IV route can be used to achieve a kind of reservoir of self-renewal cells, potentially active against the spread of cancer cells. Further studies are needed to shed light on MSCs distribution close to the ventricular wall, in order to define their lifespan and their capacity to migrate towards new-enhancing foci time after implantation.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Panciani PP,Fontanella M,Tamagno I,Battaglia L,Garbossa D,Inghirami G,Fagioli F,Pagano M,Ducati A,Lanotte Msubject
Has Abstractpub_date
2012-09-01 00:00:00pages
221-9issue
3eissn
0390-5616issn
1827-1855pii
R38122333journal_volume
56pub_type
杂志文章abstract：:Long-term ICP monitoring was carried out in 53 children and adolescents with severe head injuries. 36 of them exhibited bilateral decerebrate posturing and 13 bilateral pupil unresponsiveness. The highest ICP levels never exceeded 10 mmHg in 3 patients, ranged between 11 and 20 mmHg in 12 and between 21 and 50 in 16. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：AIM:The authors report the results of anterior submuscular transposition, on a clinical series of selected patients with severe cubital tunnel syndrome. In these patients, the degree of ulnar nerve compression was valued using a grading system that includes measurements of motor and sensitive function. In this series, ...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:Reporting two cases of dorsally located cervico-medullary hemangioblastomas the Authors discuss clinico-biological features, diagnosis and therapy of this vascular neoplasms, analyzing the cases reported in detail in the available literature. In this site the tumor has often an exophitic development, adhering more or ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:The authors describe 2 patients with solitary cerebral metastasis occurring 13 years after treatment for a renal tumor in one and 17 in the other. Both patients are alive 30 and 36 months after surgery respectively. The pathogenetic and therapeutic features typical of this type of solitary metastasis with late-onset a...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The brainstem is an uncommon site for a brain abscess. It accounts for less than 4% of all posterior cranial fossa abscesses, and less than 1% of all intracranial abscesses. The pons is the most common site for these abscesses. The aim of the present report was to describe the case of a Brazilian Amazon man with a bra...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:The authors report two clinical trials concerning chemotherapy and immunotherapy combined in the treatment of primary and metastatic brain tumors. In the first study bacillus Calmette-Guerin (BCG) and in the second Levamisole (LMS) were utilized as immunostimulating agents. Chemotherapy was performed with BCNU or CCNU...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Despite decades of therapeutic and molecular refinements, the prognosis of patients with glioblastoma (GBM) still remains unfavorable. Integrative clinical studies allow a better understanding of the natural evolution of GBM. To assess independent predictors of overall survival (OS) and progression free surv...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.20.04850-X
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:Spinal arteriovenous malformations (AVMs) are rare disease entities with significant morbidity if untreated. Risk factors of complications, hospitalization and costs-of-care remain in need of characterization. METHODS:Using the National Inpatient Sample years 2002-2014, adult subjects with spinal AVMs who u...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04552-6
更新日期：2021-02-01 00:00:00
abstract：:A case of a 52-year-old male presented with an unusual penetrating brain injury with nasal entry. At admission he had erythema of periorbital soft tissue in the left eye and epistaxis. His neurological condition was lethargic (Glasgow Coma Scale of 13) with nonfluent aphasia. Computed tomography scan revealed intracra...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Multiple approaches are available to measure global and regional cerebral blood flow. The inert gas method of Kety-Schmidt provides the mathematical basis for essentially all of these methods with the exception of microspheres. The preferred method depends largely upon the type of information to be obtained. The prefe...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:A 68-year-old woman with a subarachnoid hemorrhage was operated on for an anterior communicating artery aneurysm demonstrated by angiography. A month later she developed intestinal hemorrhage and a selective angiography showed multiple aneurysmatic dilatations, which were compatible with angiodysplasia, to be the caus...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Interferon-beta (IFN-B) plus thymostimulin (Th) were administered for eight weeks, intravenously and by intramuscular route to eight patients with metastatic brain tumors. No patient had a complete response. One had a stable disease and seven a progressive disease during that time. The mechanisms of the action of IFN-...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:If pragmatic recommendations for treatment of severely head-injured patients could really be applied, they would probably have a considerable impact in terms of reduction in mortality and disability. Since 1995 a Group of Italian Neurointensivists and Neurosurgeons belonging to the Italian Societies of Neurosurgery (S...
journal_title：Journal of neurosurgical sciences
pub_type： 指南,杂志文章,实务指引
doi：
更新日期：2000-03-01 00:00:00
abstract：AIM:Deep brain stimulation (DBS) is the treatment of choice for advanced Parkinson's disease. The target co-ordinates are traditionally calculated in relation to the intercommissural distance. Anterior (AC) and posterior commissures (PC) may be visualised by the means of ventriculography, CT or MRI. METHODS:We have st...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:The case of posttraumatic patient with persistent vegetative state and severe and prolonged hyperthermia (T = 39-40 degrees C for more than 20 days), in absence of infection, is described. Diffuse muscular rigidity, treated with L-dopa, slightly preceded the onset of hyperthermia, which was treated with several antipy...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Fournier's gangrene is a rare, multi-organism infection of the perineum. The disease is most often confined to the groin area with distant spread being extremely unusual. A ase of spinal epidural abscess as a complication of Fournier's gangrene is presented. The infection appears to have spread by the hematogenous rou...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Neuropsychological changes following corpus callosotomy depend on the degree of the callosal section, the portion sectioned and the patient's age at the time of the surgery. Anterior section frequently results in transient hemiparesis of the non-dominant leg and temporary difficulties in initiating speech. Posterior s...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1997-03-01 00:00:00
abstract：:A 22-year-old male with unilateral facial, cochlear and glossopharyngeal cranial nerve dysfunction and ataxia that was slowly progressive over one year is described. Although clinically it was considered he probably had an acoustic neuroma, surgery revealed a pontine glioblastoma exophytic into the cerebellopontine an...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:The Authors report three cases of pseudotumor cerebri with noteworthy visual defect. Lumboperitoneal shunt enables good recovery where there was no atrophy of the optic nerve and demonstrated its usefulness also in serious situations. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Primary cerebellar glioblastoma multiforme (GBM) is a rare tumor in adults that accounts for just 1% of all cases of GBM. Cerebellar GBMs are not yet completely understood also as far as the prognosis. We report a case of cerebellar GBM in a 27-year-old woman. Magnetic resonance imaging (MRI) showed a 3x3.6 cm-sized, ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:The authors' experience in the routine use of temporary clipping procedures in the surgery of endocranial aneurysms is reported. To analyse the validity of such a method we compared the outcome in a series of 153 aneurysms operated according to the traditional procedure (temporary clipping of the afferent vessel only ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:The Authors report their case material concerning some basic items of the dysraphic pathology of the Posterior Fossa: 22 cases of Dandy Walker syndromes (DWS) and "Arachnoid Cysts" (PFC). The mean clinical findings (predominant involvement of the vestibular structures of the brain stem in the DWS, frequent epileptic s...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:The traditional approach to patients suffering from cervical spondylotic myelopathy (CSM) consists of mere assessment of radiological standard magnetic resonance (MR) images and evaluation of surgical indication, depending on clinical symptoms and degree of radiological stenosis. Identification of prognostic...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.03724-3
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The short pars and the narrowed surgical corridor for far lateral L5S1 herniation make the transpars approach challenging. The aim of this study is to determine the feasibility, efficacy and safety of the transpars microscopic approach for the treatment of L5-S1 foraminal and extraforaminal lumbar disc herni...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.20.05165-6
更新日期：2020-12-09 00:00:00
abstract：INTRODUCTION:The choice of heterologous materials for cranioplasty after decompressive craniectomy is still difficult. The aim of this study is to examine the association between material of choice and related complications to suggest the best treatment option. EVIDENCE ACQUISITION:A systematic review was performed fo...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.19.04779-9
更新日期：2019-12-01 00:00:00
abstract：AIM:Ossification of the posterior longitudinal ligament (OPLL) is a pathological ossification of the ligament that causes slowly progressive myelo-radiculopathy in adults. Because of long-standing compression of the spinal cord by OPLL, functional prognosis may not always be favorable. Efforts have been made in recent ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
abstract：:(1) In a total of 100 patients with traumatic coma who were admitted to the intensive care unit of our Department of Neurosurgery we examined the effect of Encephabol after intravenous administration. (2) Compared to patients with the same clinico-neurological conditions who were, however, not treated with Encephabol,...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:We present three cases of pituitary adenoma with adjacent carotid artery aneurysm. The three adenomas are HGH-producing, prolactinoma and non-functioning tumors. Two of these 3 patients showed signs and symptoms of adenoma, while the other one showed a subarachnoid hemorrhage (SAH). The presence of the aneurysm adjace...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:The transcallosal route has been propagated as a safe approach to midline tumors. The present study was performed in order to elucidate the neurobehavioral late sequelae in patients after transcallosal microsurgery on near-midline tumors. EXPERIMENTAL DESIGN:The present study was performed retrospectively wi...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Computed tomography was performed in a patient with a median nerve tumor at the arm, histologically confirmed as neurilemmoma. Neurilemmoma was a slightly hypodense, solid tumor with no vascular contrast enhancement. To our knowledge this is the first CT description of a median nerve neurilemmoma at the arm. According...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1993-03-01 00:00:00
