Abstract：
BACKGROUND:The aim of this study is to evaluate the prognostic parameters and treatment modalities of malignant melanoma patients with brain metastases. METHODS: EXPERIMENTAL DESIGN:a retrospective study with a mean follow-up of 46 months. SETTING:specialized Cancer Center. PATIENTS:the charts of 136 patients, treated in Roswell Park Cancer Institute, for melanoma brain metastases, were analyzed. INTERVENTIONS:all patients were treated surgically and in the majority adjuvant therapy was applied. MEASURES:survival and time of recurrence of patients and possible prognostic factors. RESULTS:PATIENTS who were treated surgically had a better one-year survival rate (28.3%), than patients who received radiotherapy and/or chemotherapy (6.67%) or patients who refused any kind of treatment (3.45%), (p=0.006). Prolonged survival after surgical treatment was found in patients with single metastatic lesions and in patients with multiple metastatic lesions. CONCLUSIONS:Melanoma patients with single metastatic lesions to the brain seem to do better after surgical treatment. The role of surgical intervention in patients with multiple brain metastases needs re-evaluation from a big multicenter, prospective trial.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Konstadoulakis MM,Messaris E,Zografos G,Androulakis G,Karakousis Ckeywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
211-8; discussion 219issue
4eissn
0390-5616issn
1827-1855journal_volume
44pub_type
杂志文章abstract：:Fournier's gangrene is a rare, multi-organism infection of the perineum. The disease is most often confined to the groin area with distant spread being extremely unusual. A ase of spinal epidural abscess as a complication of Fournier's gangrene is presented. The infection appears to have spread by the hematogenous rou...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：INTRODUCTION:There is uncertainty as to the best management of arteriovenous malformations of the brain (bAVM). However, the Spetzler-Martin grade (SMG) has been validated as an effective determinant of surgical risks. We performed a systematic review for the best evidence regarding the management of bAVM for series th...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.18.04370-9
更新日期：2018-08-01 00:00:00
abstract：:Lumbar stenosis patients typically present with neurogenic claudication or radiculopathy. Studies have shown the benefit of surgical management of lumbar stenosis for patients who fail medical management. Surgical management traditionally involved an open laminectomy and foramenotomies. The emergence of minimally inva...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:This study aimed to compare the accuracy of screw placement between open pedicle screw fixation and percutaneous pedicle screw fixation (MIS) for the treatment of thoracolumbar spine fractures (TSF). METHODS:forty-nine patients with acute TSF who were treated with transpedicular screw fixation from January ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04439-9
更新日期：2021-02-01 00:00:00
abstract：:The authors present the results of a long-term follow up of 52 juvenile head-injured patients who showed early epileptic seizures. The purpose of this study is to stress the role of long-term prognosis in the early seizures and to determine in which cases a treatment preventing late seizures is eligible. They consider...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：:The 8 Italian centers participating in the International Cooperative Study on Timing of Aneurysm Surgery operated upon 68% of their patients eligible for the study. This low operative rate is mainly explained by the prevailing use of a delayed surgical policy. Only 28% of cases were operated on within 3 days of hemorr...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:The transcallosal route has been propagated as a safe approach to midline tumors. The present study was performed in order to elucidate the neurobehavioral late sequelae in patients after transcallosal microsurgery on near-midline tumors. EXPERIMENTAL DESIGN:The present study was performed retrospectively wi...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:It is reported a case that required transoral exposure of C2-C3 intervertebral space in order to remove a huge osteophyte spur projecting into the spinal canal and producing a severe myelopathy. This unusual surgical route was used because the relevant interspace was inaccessible via the standard anterior approach due...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:We reviewed the neuroimaging studies of 150 patients with cavernous sinus tumors operated on during an 8-year period. Meningiomas (66 cases), chordomas (18 cases), trigeminal neurolemmomas (12 cases), and chondrosarcomas (11 cases) were the most common diagnosed neoplasms. Neuroradiological findings are briefly descri...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:(1) In a total of 100 patients with traumatic coma who were admitted to the intensive care unit of our Department of Neurosurgery we examined the effect of Encephabol after intravenous administration. (2) Compared to patients with the same clinico-neurological conditions who were, however, not treated with Encephabol,...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The Authors report their results on the treatment of 10 cases of primary spinal epidural lymphoma. All patients underwent surgery followed by radiotherapy and 60% of them improved after treatment. The Authors stress the importance the preoperative neurological status and early diagnosis play on the prognosis. They con...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：BACKGROUND:Impairments in cognitive function are difficult to evaluate and measure. In most cases, subjects do not perceive any alteration in their own status, particularly in case of mild cognitive impairment. In case of minimal alterations of cognitive function, no real treatment exists at the moment. Functional and/...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04382-5
更新日期：2018-06-01 00:00:00
abstract：:Cavernous malformations are vascular lesions that occur in all parts of the central nervous system but most commonly in the cerebral hemispheres; unusually they may be found along the midline (basal ganglia, pineal region or brain stem), into the ventricle possibly encroaching upon the fourth and third ventricle. We r...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Long-term ICP monitoring was carried out in 53 children and adolescents with severe head injuries. 36 of them exhibited bilateral decerebrate posturing and 13 bilateral pupil unresponsiveness. The highest ICP levels never exceeded 10 mmHg in 3 patients, ranged between 11 and 20 mmHg in 12 and between 21 and 50 in 16. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：BACKGROUND:Accurately locating small subcortical brain lesions is very important for maximal surgical resection with minimal neurological damage. Intraoperative MRI has proved to be more precise than ultrasound, it is relatively expensive and is not available in all centers. Herein we describe a new, simple, safe and e...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.03336-1
更新日期：2019-06-01 00:00:00
abstract：: ...
journal_title：Journal of neurosurgical sciences
pub_type： 信件
doi：10.23736/S0390-5616.17.04270-9
更新日期：2019-10-01 00:00:00
abstract：:The brainstem is an uncommon site for a brain abscess. It accounts for less than 4% of all posterior cranial fossa abscesses, and less than 1% of all intracranial abscesses. The pons is the most common site for these abscesses. The aim of the present report was to describe the case of a Brazilian Amazon man with a bra...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:The present study reports the results of the stereotactic treatment via endocavitary irradiation (Talaraich's method) of 50 gliomatous cysts (volume: 5-242 cm3; av.: 73 cm3) in 45 patients (M: 24; F: 21; age 3.5-57 yrs; av.: 22 yrs) in the period January 1973-January 1987. Twenty-four patients (27 cysts) were affected...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：:The traditional dilemma making surgery for diffuse low-grade gliomas (DLGGs) challenging is underlain by the need to optimize tumor resection in order to significantly increase survival versus the risk of permanent neurological morbidity. Development of neuroimaging led neurosurgeons to achieve tumorectomy according t...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：:The authors describe 2 patients with solitary cerebral metastasis occurring 13 years after treatment for a renal tumor in one and 17 in the other. Both patients are alive 30 and 36 months after surgery respectively. The pathogenetic and therapeutic features typical of this type of solitary metastasis with late-onset a...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:A case of acromegaly associated to a giant osteoma of the cranial vault and hydrocephalus in a young woman is reported. It can be suggested that acromegaly favoured the marked growth of the osteoma. Hydrocephalus resulted consequent to both the compression of the superior longitudinal sinus by the tumor and alteration...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：:In the routine practice of neurosurgery, the attainment of appropriate hemostasis during and after surgery is of the utmost importance. In the last few years, we have noticed that in several cases the standard coagulation methods (bipolar, Tabotamp, Spongostan) were not sufficient; in particular, patients with intrapa...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.03362-2
更新日期：2019-12-01 00:00:00
abstract：:The authors tried to assess neurotic traits of 19 consecutive patients having micro-lumbar discectomy and to verify the relation between psychic distress and surgical outcome. All subjects had unequivocal clinical and myelographic evidence of lumbar disc herniation. Neurotic distress was measured by Middlesex Hospital...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive electrophysiological method to modulate cortical excitability. As such, rTMS can be used in conjunction with conventional physiotherapy or occupational therapy to facilitate rehabilitation of motor function in patients with focal brain lesions. This...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2012-12-01 00:00:00
abstract：:Recent data from phase II trials have shown that lonidamine (LND) is effective in the treatment of tumors of various histogenesis, including gliomas. In the present work, we tested the antiproliferative effect of LND on a human glioblastoma cell line (LI) in different culture conditions. When LI are cultured in their ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Minimally invasive spine surgery is a rapidly developing field that has the potential to decrease surgical morbidity and improve recovery compared to traditional spinal approaches. Minimally invasive approaches have been developed for all regions of the spine, but have been best documented for degenerative conditions ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2012-03-01 00:00:00
abstract：: ...
journal_title：Journal of neurosurgical sciences
pub_type： 信件
doi：10.23736/S0390-5616.17.04156-X
更新日期：2019-04-01 00:00:00
abstract：:The paper reports two cases of supratentorial neuroepithelial cysts, also called ependymal cysts. One of them was extracerebral and the other intracerebral. The preoperative diagnosis was made by determination of attenuation values of consecutive sections of cyst on computed tomography. The ultrastructure of the cyst ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:An isolated oculomotor nerve palsy is very rarely the presenting sign of a pituitary adenoma. It may occur slowly due to mechanical compression or rapidly, secondary to pituitary apoplexy. Magnetic resonance imaging (MRI) with and without gadolinium DTPA enhancement provides excellent anatomical detail and is useful i...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:The authors present two cases of non-traumatic subdural haematomas associated with a meningioma. Relevant literature is reviewed and the pathogenesis of this rare condition is discussed. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
