Abstract：
:Recent data from phase II trials have shown that lonidamine (LND) is effective in the treatment of tumors of various histogenesis, including gliomas. In the present work, we tested the antiproliferative effect of LND on a human glioblastoma cell line (LI) in different culture conditions. When LI are cultured in their standard conditions, a reduction of cell growth is seen after 3 days of treatment with 10(-4) M LND. It reaches 70% with respect to control after 6 days and is statistically significant. LND is ineffective at the other concentrations tested. In more stringent culture conditions, 10(-4) M LND determines a higher inhibition of cell proliferation both after 3 and 6 days of exposure, while other doses of LND are unable to affect cell growth.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Iacopino F,Sica G,Macrì P,Paggi MG,Scerrati M,Roselli R,Marchetti P,Della Cuna GR,Marini Lsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
193-7issue
3-4eissn
0390-5616issn
1827-1855journal_volume
34pub_type
杂志文章abstract：BACKGROUND:Adjacent-level disease after anterior cervical discectomy and fusion (ACDF) occurs in a significant proportion of patients and frequently requires revision operation. Methods using traditional plates typically require removal of the plate with anecdotally increased operative-time and morbidity. We review our...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04172-3
更新日期：2020-10-01 00:00:00
abstract：: ...
journal_title：Journal of neurosurgical sciences
pub_type： 信件
doi：10.23736/S0390-5616.17.04285-0
更新日期：2018-12-01 00:00:00
abstract：:Substantia nigra (SN) hyperechogenicity has been proved to be a characteristic finding for idiopathic Parkinson's disease (PD), occurring in more than 90% of the patients. This echofeature is owed to increased amounts of iron in the SN region and reflects a functional impairment of the nigrostriatal dopaminergic syste...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.19.04696-4
更新日期：2019-08-01 00:00:00
abstract：:The authors report the case of an encapsulated intradiploic hematoma observed in a 2 year old patient who, 6 months prior to their observation, underwent an internal CSF drainage for hydrocephalus. The surgical findings are described and the possible etiopathological causes discussed. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
abstract：:A 49-year-old male, with a relatively uncommon multiple neurilemmoma, exhibited symptoms of cauda equina compression. Following a diagnosis of multiple tumor of the cauda equina and extradural cyst, based on myelography and CTM, the tumors at L1-L2, the left S1 nerve root, and left hip were resected. Three years after...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:A 68-year-old woman with a subarachnoid hemorrhage was operated on for an anterior communicating artery aneurysm demonstrated by angiography. A month later she developed intestinal hemorrhage and a selective angiography showed multiple aneurysmatic dilatations, which were compatible with angiodysplasia, to be the caus...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND:This study aimed to compare the accuracy of screw placement between open pedicle screw fixation and percutaneous pedicle screw fixation (MIS) for the treatment of thoracolumbar spine fractures (TSF). METHODS:forty-nine patients with acute TSF who were treated with transpedicular screw fixation from January ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04439-9
更新日期：2021-02-01 00:00:00
abstract：:Two cases are reported in which a cerebral glioma developed after radiation therapy for a different primary tumor. The first case was a boy, who presented a right thalamic anaplastic astrocytoma 7 years after irradiation for a left temporal polymorphic cell sarcoma. The second case was a woman, with a right temporal a...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:Coronavirus Disease 2019 (COVID-19) has greatly disturbed healthcare and the practice of neurosurgery. As healthcare systems evolve in the face of COVID-19, the use of telehealth platforms has expanded. We present the results of a large survey of patient perspectives on the role of telehealth in the care of ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.20.05220-0
更新日期：2021-01-04 00:00:00
abstract：:Starting from January 2008, we systematically irrigated the surgical wounds of patients undergoing spine surgery with a solution of povidone-iodine and hydrogen peroxide. We prospectively recorded the clinical data of patients who underwent spine surgery during 2008 and we compared the results with retrospectively rev...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,收录出版
doi：
更新日期：2011-06-01 00:00:00
abstract：:Evolution of psychological disorders following head injury including memory disorders and other cognitive ones are common. The best known are psychiatric disturbances of various kind after lesions of frontal lobes. Cognitive, behavioural and emotional disorders are not usually seen in patients with bilateral temporal ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive electrophysiological method to modulate cortical excitability. As such, rTMS can be used in conjunction with conventional physiotherapy or occupational therapy to facilitate rehabilitation of motor function in patients with focal brain lesions. This...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2012-12-01 00:00:00
abstract：AIM:Mesenchymal stem cells (MSCs) migrate in response to chemokines and possess extensive tropism for experimental glioma. Antitumor effects have been reported following intracranial and intravenous administration of gene-modified MSCs. Among the different routes for cell transplant, the intraventricular (IV) approach ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:During the last seven years (1985-91) 28 primary tumours in the cauda among 104 intraspinal tumors were observed. The largest group (71%) comprised ependymomas and neurinomas. The rest included 5 lipomas, 2 astrocytomas and 1 epidermoid. Low-back pain without or with sciatic or crural irradiation was the most common i...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm, notorious for being able to evade and suppress the immune-system. We present a new immunotherapeutic approach that can potentially overcome or circumvent many of the GBM laden obstacles for an efficient antitumor immune response. In thi...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.16.03755-3
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:The transcallosal route has been propagated as a safe approach to midline tumors. The present study was performed in order to elucidate the neurobehavioral late sequelae in patients after transcallosal microsurgery on near-midline tumors. EXPERIMENTAL DESIGN:The present study was performed retrospectively wi...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND:The availability of Flow Diverters and new endovascular techniques has greatly reduced the need and indications for bypass surgery. Nevertheless, there are situations where a bypass is the best option for a complex cerebrovascular problem. METHODS:Generally typical indications are giant aneurysms with a wid...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2016-01-20 00:00:00
abstract：:A short review of polyamines and their possible clinical interest and applications in the field of brain neoplasms is presented. Dosage of CSF polyamines was proved to be useful in monitoring patients with medulloblastomas and others malignancies with meningeal involvement. Polyamines and their enzymes in neoplastic t...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1982-07-01 00:00:00
abstract：AIM:The novel YL-1 hollow needle aspiration drainage system is an effective minimally invasive treatment in chronic subdural hematoma (CSDH). In order to find the risk prognosis factors of chronic subdural hematoma (CSDH) performed by the novel YL-1 hollow needle aspiration drainage system, a logistic analysis of posto...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:The Authors report a rare case of spontaneous intraparenchymal and intraventricular pneumocephalus, caused by the external rupture of an otogenous temporal abscess. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1974-07-01 00:00:00
abstract：: ...
journal_title：Journal of neurosurgical sciences
pub_type： 信件
doi：10.23736/S0390-5616.17.04156-X
更新日期：2019-04-01 00:00:00
abstract：:Isolated abducens nerve palsy following lumbar puncture is a very rare condition. In this case we discussed the probable causes of abducens nerve palsy and review the mechanism of action in anatomical relevant literature. A 53-year old hypertensive female patient with a saccular aneursym on the left middle cerebral ar...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Spinal surgery has to address the challenge of a dramatic increase of the growing number of older persons. The purpose of the present study was to project the numbers of surgically treated degenerative spine disease (DSD) in Austria from 2017 until 2080 to provide potential future scenarios that the Austrian...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.21.05178-X
更新日期：2021-01-22 00:00:00
abstract：:Long-term ICP monitoring was carried out in 53 children and adolescents with severe head injuries. 36 of them exhibited bilateral decerebrate posturing and 13 bilateral pupil unresponsiveness. The highest ICP levels never exceeded 10 mmHg in 3 patients, ranged between 11 and 20 mmHg in 12 and between 21 and 50 in 16. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：BACKGROUND:Spinal arteriovenous malformations (AVMs) are rare disease entities with significant morbidity if untreated. Risk factors of complications, hospitalization and costs-of-care remain in need of characterization. METHODS:Using the National Inpatient Sample years 2002-2014, adult subjects with spinal AVMs who u...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04552-6
更新日期：2021-02-01 00:00:00
abstract：:A case of acromegaly associated to a giant osteoma of the cranial vault and hydrocephalus in a young woman is reported. It can be suggested that acromegaly favoured the marked growth of the osteoma. Hydrocephalus resulted consequent to both the compression of the superior longitudinal sinus by the tumor and alteration...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：:The Authors report three cases of pseudotumor cerebri with noteworthy visual defect. Lumboperitoneal shunt enables good recovery where there was no atrophy of the optic nerve and demonstrated its usefulness also in serious situations. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:The authors report their personal series of 100 consecutive surgically treated single brain metastases between 1981 and 1988. Patients selection was decided with respect to general and neurological conditions and to primary cancer development. Resection was mostly radical, postoperative mortality rate was 6% and neuro...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:It has been recently observed that arachidonic acid (AA) metabolites may modulate many of the mechanisms involved in tumor growth and metastasis. In order to clarify the role played in human brain tumors, authors have determined AA metabolic profiles in 63 surgical specimen of human intracranial tumors (mostly neuroep...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Many neurosurgeons advocate subpial technique as the best technique to remove supratentorial gliomas. However, few authors clearly defined advantages and features of this technique. The aim of our study is to describe microsurgical subpial technique related to glioma surgery, with regard to its safety and co...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.20.05046-8
更新日期：2020-09-28 00:00:00
