Abstract：
:Substantia nigra (SN) hyperechogenicity has been proved to be a characteristic finding for idiopathic Parkinson's disease (PD), occurring in more than 90% of the patients. This echofeature is owed to increased amounts of iron in the SN region and reflects a functional impairment of the nigrostriatal dopaminergic system. In a prospective blinded study in which a group of patients with early mild signs and symptoms of unclear Parkinsonism were followed until a definite clinical diagnosis of PD, the hyperechogenicity of the SN was demonstrated to be highly predictive of a final diagnosis of PD. For the diagnosis of PD in individuals with early motor symptoms, both the sensitivity and positive predictive value of SN hyperechogenicity were higher than 90% and both the specificity and negative predictive value were higher than 80%. For early differential diagnosis between PD and atypical Parkinsonian syndromes, the sensitivity and positive predictive value of SN hyperechogenicity were higher than 90%, and both the specificity and negative predictive value were higher than 80%. The diagnostic specificity is increased if combining the TCS findings of SN, lenticular nucleus and third ventricle. In asymptomatic adult subjects, SN hyperechogenicity, at least unilaterally, indicates a subclinical functional insufficiency of the nigrostriatal dopaminergic system. Recent papers revealed that SN hyperechogenicity might suggest preclinical PD. Reduced echogenicity of midbrain raphe indicates increased risk of depression in PD patients. Caudate nucleus hyperechogenicity has been associated with drug-induced psychosis, and frontal horn dilatation >20 mm with dementia. Transcranial brain sonography can be a valuable tool for managing patients with Parkinsonian signs and symptoms.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Bor-Seng-Shu E,Paschoal FM,Almeida KJ,De Lima Oliveira M,Nogueira RC,Teixeira MJ,Walter Udoi
10.23736/S0390-5616.19.04696-4subject
Has Abstractpub_date
2019-08-01 00:00:00pages
441-449issue
4eissn
0390-5616issn
1827-1855pii
S0390-5616.19.04696-4journal_volume
63pub_type
杂志文章,评审abstract：BACKGROUND:Recent clinical trials demonstrated the efficacy of thrombectomy for ischemic stroke against acute large vessel occlusion (LVO). To overcome the problem with excessive examination time for diagnosis of cerebral perfusion and/or the use of contrast agent to determine penumbra, we adopted a new magnetic resona...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04607-6
更新日期：2018-11-21 00:00:00
abstract：:Metastatic involvement of brachial plexopathy is a rare condition that is often associated with advanced systemic breast cancer and the role of surgeon appears to be restricted because radio-chemotherapy is better recommended in this setting. We report a case of a 64-year-old woman that presented a very delayed breast...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Ependymoma can arise throughout all compartments of the central nervous system with prevalence for intracranial and spinal location in children and adults, respectively. The current histopathology based WHO grading system distinguishes grade I, II 'classic', and III 'anaplastic' ependymoma. However, analysis of multip...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.17.04152-2
更新日期：2018-02-01 00:00:00
abstract：AIM:Fractionated stereotactic radiotherapy is an alternative to radiosurgery or conformal radiotherapy when meningiomas are surgically inaccessible, incompletely removed, or recurrent. The authors report preliminary results of a feasible trial on hypofractionated stereotactic radiotherapy (hFSRT) in patients (pts) with...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Spinal arteriovenous malformations (AVMs) are rare disease entities with significant morbidity if untreated. Risk factors of complications, hospitalization and costs-of-care remain in need of characterization. METHODS:Using the National Inpatient Sample years 2002-2014, adult subjects with spinal AVMs who u...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04552-6
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:The traditional approach to patients suffering from cervical spondylotic myelopathy (CSM) consists of mere assessment of radiological standard magnetic resonance (MR) images and evaluation of surgical indication, depending on clinical symptoms and degree of radiological stenosis. Identification of prognostic...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.03724-3
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Many neurosurgeons advocate subpial technique as the best technique to remove supratentorial gliomas. However, few authors clearly defined advantages and features of this technique. The aim of our study is to describe microsurgical subpial technique related to glioma surgery, with regard to its safety and co...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.20.05046-8
更新日期：2020-09-28 00:00:00
abstract：BACKGROUND:Impairments in cognitive function are difficult to evaluate and measure. In most cases, subjects do not perceive any alteration in their own status, particularly in case of mild cognitive impairment. In case of minimal alterations of cognitive function, no real treatment exists at the moment. Functional and/...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04382-5
更新日期：2018-06-01 00:00:00
abstract：:Stereotactic biopsy, together with CT and MRI, plays a very important role in the diagnosis of intracranial neoplasms and in their subsequent treatment. Serial neuroimaging-driven biopsies are considered the method of choice when dealing with gliomas, due to their well know morphological dishomogeneity; peritumoral ti...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Recurrent radicular pain after lumbar micro-discectomy may lead to reduced quality of life of the patient. Lumbar epidural fibrosis is believed to be one of the mechanisms involved in the genesis of the pain. The use of absorbable gel temporarily separating disc remnants, muscle or bone structures from the nerve roots...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：:The authors describe 2 patients with solitary cerebral metastasis occurring 13 years after treatment for a renal tumor in one and 17 in the other. Both patients are alive 30 and 36 months after surgery respectively. The pathogenetic and therapeutic features typical of this type of solitary metastasis with late-onset a...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Brain metastases are a common problem in solid malignancies and still represent a major cause of morbidity and mortality. With the ongoing improvement in systemic therapies, the expectations on the efficacy of brain metastases directed treatment options are growing. As local therapies against brain metastases continue...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2016-09-01 00:00:00
abstract：:Precise identification of tumor margins is of the utmost importance in neuro-oncology. Confocal microscopy is capable of rapid imaging of fresh tissues at cellular resolution and has been miniaturized into handheld probe-based systems suitable for use in the operating room. We aimed to perform a literature review to p...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.18.04553-8
更新日期：2018-12-01 00:00:00
abstract：:Reporting two cases of dorsally located cervico-medullary hemangioblastomas the Authors discuss clinico-biological features, diagnosis and therapy of this vascular neoplasms, analyzing the cases reported in detail in the available literature. In this site the tumor has often an exophitic development, adhering more or ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:The Authors report their case material concerning some basic items of the dysraphic pathology of the Posterior Fossa: 22 cases of Dandy Walker syndromes (DWS) and "Arachnoid Cysts" (PFC). The mean clinical findings (predominant involvement of the vestibular structures of the brain stem in the DWS, frequent epileptic s...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:A preliminary report on the immunological monitoring of primary intracranial neoplasms is presented. The most important findings concerning B-cells and T-cells mediated immunity and delayed hypersensitivity reactions in this kind of patients, are discussed. Among the fairly significant immunobiological pictures, the A...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：BACKGROUND:The aim of this prospective comparative study is to assess the functional outcome in two groups of patients suffering from spinal lumbar instability and treated by decompression and stabilization with posterior lumbar interbody fusion using percutaneous pedicle screws (PCT) or a novel technique of divergent ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.20.04893-6
更新日期：2020-02-25 00:00:00
abstract：:The change of cerebral blood flow (CBF) with aging was analyzed in 9 cases of moyamoya disease whose age ranged from 16 years old to 58 years old. CBF decreased more prominently in the various lobes with aging than control subjects and the decrement was more rapid in the affected side than in the non-affected side. CB...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:A 22-year-old male with unilateral facial, cochlear and glossopharyngeal cranial nerve dysfunction and ataxia that was slowly progressive over one year is described. Although clinically it was considered he probably had an acoustic neuroma, surgery revealed a pontine glioblastoma exophytic into the cerebellopontine an...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Coronavirus Disease 2019 (COVID-19) has greatly disturbed healthcare and the practice of neurosurgery. As healthcare systems evolve in the face of COVID-19, the use of telehealth platforms has expanded. We present the results of a large survey of patient perspectives on the role of telehealth in the care of ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.20.05220-0
更新日期：2021-01-04 00:00:00
abstract：:An isolated oculomotor nerve palsy is very rarely the presenting sign of a pituitary adenoma. It may occur slowly due to mechanical compression or rapidly, secondary to pituitary apoplexy. Magnetic resonance imaging (MRI) with and without gadolinium DTPA enhancement provides excellent anatomical detail and is useful i...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Two cases of Hodgkin's disease are described; one was intracerebrally located and the other one extended to bone, dura mater and cerebral parenchyma. The classification of the different types of intracranial Hodgkin's disease is reviewed, and the role of Computed Tomography and surgery in the management of this pathol...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:The traditional dilemma making surgery for diffuse low-grade gliomas (DLGGs) challenging is underlain by the need to optimize tumor resection in order to significantly increase survival versus the risk of permanent neurological morbidity. Development of neuroimaging led neurosurgeons to achieve tumorectomy according t...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：:The filum terminale is an exceptional location for isolated hemangioblastoma. Only five cases are reported in literature, prior to the magnetic resonance imaging era. A 57-year-old man was referred to our Department with a prolonged history of progressive back pain, particularly severe when recumbent, and recurrent un...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to develop a strategy to determine a sound methodology for decision-making in lumbar spinal canal stenosis (LSCS). METHODS:This was a retrospective study of patients with LSCS to determine the rationale for those who underwent surgery and those who received conservative treatment. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.02901-5
更新日期：2017-08-01 00:00:00
abstract：:The Authors report their results on the treatment of 10 cases of primary spinal epidural lymphoma. All patients underwent surgery followed by radiotherapy and 60% of them improved after treatment. The Authors stress the importance the preoperative neurological status and early diagnosis play on the prognosis. They con...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:The Authors report a case of intracranial meningioma in two sisters, with no evidence of neurofibromatosis. A study of the karyotype has been performed; in one patient we have found a pericentric inversion of one chromosome 9. The possible role of the genetical factors in the develop of familial meningiomas is discuss...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1987-07-01 00:00:00
abstract：BACKGROUND:Nitric oxide (NO) is synthesized by the conversion of Arginine (Arg) into the NO and Citrulline (Cit). Although the NO is involved into the pathogenesis of several physiological and pathological processes, the role of NO in pituitary adenomas (PA) progression is not determined. Our purpose was to evaluate th...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.17.04083-8
更新日期：2020-10-01 00:00:00
abstract：:Cavernous malformations are vascular lesions that occur in all parts of the central nervous system but most commonly in the cerebral hemispheres; unusually they may be found along the midline (basal ganglia, pineal region or brain stem), into the ventricle possibly encroaching upon the fourth and third ventricle. We r...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:A selected panel of monoclonal antibodies (MoAbs) directed to distinct tumor associated antigens (TAA) has been tested to define the capability of these reagents to differentiate among metastatic carcinoma, lymphoma and primary brain tumor on cytologic specimens obtained with stereotactic techniques. Results obtained ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
