Abstract：
:Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm, notorious for being able to evade and suppress the immune-system. We present a new immunotherapeutic approach that can potentially overcome or circumvent many of the GBM laden obstacles for an efficient antitumor immune response. In this molecular construct, a soluble major-histocompatibility complex (MHC), presenting an immunogenic peptide is directed towards GBM cells. This soluble complex is known to be able to activate relevant cytotoxic T-lymphocyte (CTL's) populations, mounting an effective local immune response. The chimeric protein consists of a targeting domain, a function that can be fulfilled by an antibody or other small molecule that binds tumor associated antigens, and an effector domain. A single chain MHC directly linked to an immunogenic Cytomegalovirus derived peptide (phosphoprotein 65) can be used as such an effector domain. Targeting MHC complexes to the tumor enables to recruit different lymphocyte populations using MHC-molecules bearing a single, highly antigenic peptide derived from immunogenic T cell epitopes. Moreover, the recruited potent memory CTL's at the tumor's milieu may prove resistant to the previously described local immunosuppressive environment, and may enable the shift to TH1 cytokine profile resulting in specific massive tumor destruction.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Cohen-Inbar O,Reiter Y,Zaaroor Mdoi
10.23736/S0390-5616.16.03755-3subject
Has Abstractpub_date
2017-08-01 00:00:00pages
422-428issue
4eissn
0390-5616issn
1827-1855pii
R38Y9999N00A16061502journal_volume
61pub_type
杂志文章,评审abstract：BACKGROUND:Peripheral nerve lesions in the upper limbs occur predominantly in reproductive-age men and are often caused by sharp objects. Microsurgery is the choice treatment for these injuries, and regeneration after surgery typically is evaluated with clinical and electrophysiological examinations. The aim of this st...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：:Between 1985 and 1993, we treated seven cases of optic nerve sheath meningiomas. The median age at onset of their symptoms was 42.14 years. All of the patients were aged between 27 and 60 females with a slowly progressive lesion. Computed tomography and/or magnetic resonance imaging were used as diagnostic procedure i...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:The results of a retrospective study of 24 adult patients with occult dysraphism are described. There were 15 males and 9 females, with an average age of 31.1 years. Specific circumstances precipitated symptomatic onset in 67% of patients. Pain, often referred to the anorectal region, was the most common presenting sy...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：AIM:Mesenchymal stem cells (MSCs) migrate in response to chemokines and possess extensive tropism for experimental glioma. Antitumor effects have been reported following intracranial and intravenous administration of gene-modified MSCs. Among the different routes for cell transplant, the intraventricular (IV) approach ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Numerous implants for posterior stabilisation of cervical spine have been described so far. The aims of all these implants and techniques are rigid spinal stabilisation without neurologic damage, restoration of neuroanatomy and excellent radiological studies in postoperative period. The objective of this stu...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:The aim of this study was to develop a strategy to determine a sound methodology for decision-making in lumbar spinal canal stenosis (LSCS). METHODS:This was a retrospective study of patients with LSCS to determine the rationale for those who underwent surgery and those who received conservative treatment. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.16.02901-5
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:A radical surgery of spine metastases is not possible in many cases, especially by elder multi morbid patients. The modern CAVITY/coblation method offers a very good therapeutic alternative for such patients. The goal of this paper was to evaluate and present the method as well as the results of the treatmen...
journal_title：Journal of neurosurgical sciences
pub_type： 临床试验,杂志文章
doi：10.23736/S0390-5616.16.03690-0
更新日期：2017-12-01 00:00:00
abstract：:Multiple meningiomas in different neuraxial compartments are quite rare. The authors report two new cases of association between cranial and spinal meningiomas, one of them in a patient operated upon for multiple intracranial meningiomas. The first case was a 60-year-old woman with progressive paraparesis who had been...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:The use of Halifax interlaminar clamps in posterior arthrodesis for atlanto-axial instabilities has recently been reported. The four Anderson II fractures submitted were surgically treated by posterior arthrodesis with Halifax clamps and bilateral "H" shaped bone-grafts obtained from the iliac crest. Only in the first...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：: ...
journal_title：Journal of neurosurgical sciences
pub_type： 信件
doi：10.23736/S0390-5616.17.04270-9
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Spinal arteriovenous malformations (AVMs) are rare disease entities with significant morbidity if untreated. Risk factors of complications, hospitalization and costs-of-care remain in need of characterization. METHODS:Using the National Inpatient Sample years 2002-2014, adult subjects with spinal AVMs who u...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.18.04552-6
更新日期：2021-02-01 00:00:00
abstract：:Embolization is commonly used for the treatment of brain arteriovenous malformations (AVMs) prior to stereotactic radiosurgery (SRS). Due to mixed outcomes, however, its use remains controversial. This article is a review of recent studies assessing the efficacy of pre-radiosurgical embolization for brain AVMs. Articl...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：10.23736/S0390-5616.18.04425-9
更新日期：2018-08-01 00:00:00
abstract：:The authors propose a new experimental model of nervous anastomosis between intercostal and lumbar nerves in rabbit with the purpose of providing a technique to by-pass a spinal lesion. Before carrying out the surgical experiments, an histological study has been performed on the donor and receiver nerves which demonst...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:The aim of this study is to evaluate the prognostic parameters and treatment modalities of malignant melanoma patients with brain metastases. METHODS: EXPERIMENTAL DESIGN:a retrospective study with a mean follow-up of 46 months. SETTING:specialized Cancer Center. PATIENTS:the charts of 136 patients, trea...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:The diffusion of the surgical technique of cardiac valve replacement with metallic prostheses, as well as bypass graft in the arterial occlusive disease of the lower extremities, both requiring permanent oral anticoagulation, has increased the number of patients affected by chronic subdural hematoma that can...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：AIM:Ossification of the posterior longitudinal ligament (OPLL) is a pathological ossification of the ligament that causes slowly progressive myelo-radiculopathy in adults. Because of long-standing compression of the spinal cord by OPLL, functional prognosis may not always be favorable. Efforts have been made in recent ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
abstract：:The authors present two cases of non-traumatic subdural haematomas associated with a meningioma. Relevant literature is reviewed and the pathogenesis of this rare condition is discussed. ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
abstract：:The Authors report 4 cases of spinal lipomas: 2 intradural, 2 completely intrarachidian extradural. The intradural lipomas observed were 2 cases in the lumbo-sacral area, both operated on by the partial removal of the lesion with very good clinical results; histologically they were found to be 2 fibrolipomas. The 2 ca...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1974-04-01 00:00:00
abstract：:Lumbar stenosis patients typically present with neurogenic claudication or radiculopathy. Studies have shown the benefit of surgical management of lumbar stenosis for patients who fail medical management. Surgical management traditionally involved an open laminectomy and foramenotomies. The emergence of minimally inva...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2015-03-01 00:00:00
abstract：:Arteriovenous malformations (AVM) can occur in the entire central nervous system with a predilection of the supratentorial intracranial compartment. Intracerebral hemorrhage is the most common clinical presentation of AVM and associated with a high morbidity and mortality rate. Correct management of these lesions is t...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2011-03-01 00:00:00
abstract：:The improved knowledge of clinical and emodynamical aspects of extracranial arteriovenous malformations in the 18 th century provided a foundation for the understanding and treatment of cerebrovascular pathology. It was not until the late 19 th century that detailed clinicopathological reports of intracranial arteriov...
journal_title：Journal of neurosurgical sciences
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：AIM:The challenge in large cranial base meningiomas is total resection of the tumor with the least possible mortality and morbidity. During the last two decades the technical approaches for anterior skull base tumors have shown a considerable progress, providing a wide exposure with minimal brain retraction. The purpos...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:The authors describe 2 patients with solitary cerebral metastasis occurring 13 years after treatment for a renal tumor in one and 17 in the other. Both patients are alive 30 and 36 months after surgery respectively. The pathogenetic and therapeutic features typical of this type of solitary metastasis with late-onset a...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:A 22-year-old male with unilateral facial, cochlear and glossopharyngeal cranial nerve dysfunction and ataxia that was slowly progressive over one year is described. Although clinically it was considered he probably had an acoustic neuroma, surgery revealed a pontine glioblastoma exophytic into the cerebellopontine an...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:Recurrent radicular pain after lumbar micro-discectomy may lead to reduced quality of life of the patient. Lumbar epidural fibrosis is believed to be one of the mechanisms involved in the genesis of the pain. The use of absorbable gel temporarily separating disc remnants, muscle or bone structures from the nerve roots...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：INTRODUCTION:The choice of heterologous materials for cranioplasty after decompressive craniectomy is still difficult. The aim of this study is to examine the association between material of choice and related complications to suggest the best treatment option. EVIDENCE ACQUISITION:A systematic review was performed fo...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：10.23736/S0390-5616.19.04779-9
更新日期：2019-12-01 00:00:00
abstract：:The paper reports two cases of supratentorial neuroepithelial cysts, also called ependymal cysts. One of them was extracerebral and the other intracerebral. The preoperative diagnosis was made by determination of attenuation values of consecutive sections of cyst on computed tomography. The ultrastructure of the cyst ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:Free fat in the ventricular space is a rare but well recognized complication of ruptured tumour of dermal origin. However, only 1 patient of spontaneous rupture of spinal dermoid tumour with disseminated fat in the central canal and ventricles has been described in the literature. The authors report an extremely rare ...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2004-06-01 00:00:00
abstract：:The case of posttraumatic patient with persistent vegetative state and severe and prolonged hyperthermia (T = 39-40 degrees C for more than 20 days), in absence of infection, is described. Diffuse muscular rigidity, treated with L-dopa, slightly preceded the onset of hyperthermia, which was treated with several antipy...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Malignant exophthalmos is often not resolvable using only medical or radiation therapy. The pressure on the optic nerve which is generally associated with it evolves rapidly in many cases towards optic atrophy and subsequently loss of vision. Only surgical treatment offers any guarantee of success and of the various t...
journal_title：Journal of neurosurgical sciences
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
