Meta-analysis of Functional Neuroimaging of Major Depressive Disorder in Youth.

Abstract:

IMPORTANCE:Despite its high prevalence and morbidity, the underlying neural basis of major depressive disorder (MDD) in youth is not well understood. OBJECTIVES:To identify in youth diagnosed as having MDD the most reliable neural abnormalities reported in existing functional neuroimaging studies and characterize their relations with specific psychological dysfunctions. DATA SOURCES:Searches were conducted in PubMed and Web of Science to identify relevant studies published from November 2006 through February 2015. The current analysis took place from August 21, 2014, to March 28, 2015. STUDY SELECTION:We retained articles that conducted a comparison of youth aged 4 to 24 years diagnosed as having MDD and age-matched healthy controls using task-based functional magnetic resonance imaging and a voxelwise whole-brain approach. DATA EXTRACTION AND SYNTHESIS:We extracted coordinates of brain regions exhibiting differential activity in youth with MDD compared with healthy control participants. Multilevel kernel density analysis was used to examine voxelwise between-group differences throughout the whole brain. Correction for multiple comparisons was performed by computing null hypothesis distributions from 10 000 Monte Carlo simulations and calculating the cluster size necessary to obtain the familywise error rate control at P < .05. MAIN OUTCOMES AND MEASURES:Abnormal levels of activation in youth diagnosed as having MDD compared with control participants during a variety of affective processing and executive functioning tasks. RESULTS:Compared with age-matched healthy control participants (n = 274), youth with MDD (n = 246) showed reliable patterns of abnormal activation, including the following task-general and task-specific effects: hyperactivation in subgenual anterior cingulate cortex (P < .05) and ventrolateral prefrontal cortex (P < .05) and hypoactivation in caudate (P < .01) across aggregated tasks; hyperactivation in thalamus (P < .03) and parahippocampal gyrus (P < .003) during affective processing tasks; hypoactivation in cuneus (P < .001), dorsal cingulate cortex (P < .05), and dorsal anterior insula (P < .05) during executive functioning tasks; hypoactivity in posterior insula (P < .005) during positive valence tasks; and hyperactivity in dorsolateral prefrontal cortex (P < .001) and superior temporal cortex (P < .003) during negative valence tasks. CONCLUSIONS AND RELEVANCE:Altered activations in several distributed brain networks may help explain the following seemingly disparate symptoms of MDD in youth: hypervigilance toward emotional stimuli from the overactivation of central hubs in the subgenual anterior cingulate cortex and thalamus that lead to a cascade of other symptoms; ineffective emotion regulation despite increased activation of the dorsolateral prefrontal cortex and ventrolateral prefrontal cortex during affective processing, which may reverse across development or the clinical course; maladaptive rumination and poor executive control from difficulties shifting from default mode network activity to task-positive network activity during cognitively demanding tasks; and anhedonia from hypoactivation of the cuneus and posterior insula during reward processing.

journal_name

JAMA Psychiatry

journal_title

JAMA psychiatry

authors

Miller CH,Hamilton JP,Sacchet MD,Gotlib IH

doi

10.1001/jamapsychiatry.2015.1376

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1045-53

issue

10

eissn

2168-622X

issn

2168-6238

pii

2431084

journal_volume

72

pub_type

杂志文章,meta分析
  • Latent Trajectories of Common Mental Health Disorder Risk Across 3 Decades of Adulthood in a Population-Based Cohort.

    abstract:Importance:Epidemiologic evidence indicates that most of the general population will experience a mental health disorder at some point in their lives. However, few prospective population-based studies have estimated trajectories of risk for mental disorders from young through middle adulthood to estimate the proportion...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2016.1921

    authors: Paksarian D,Cui L,Angst J,Ajdacic-Gross V,Rössler W,Merikangas KR

    更新日期:2016-10-01 00:00:00

  • Association of Symptom Network Structure With the Course of [corrected] Depression.

    abstract:IMPORTANCE:Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.2079

    authors: van Borkulo C,Boschloo L,Borsboom D,Penninx BW,Waldorp LJ,Schoevers RA

    更新日期:2015-12-01 00:00:00

  • Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder.

    abstract:IMPORTANCE:Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it is unclear whether these areas are also characterized by altered brain network properties. OBJECTIVES:To determine regions of abnormal degree...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.173

    authors: Beucke JC,Sepulcre J,Talukdar T,Linnman C,Zschenderlein K,Endrass T,Kaufmann C,Kathmann N

    更新日期:2013-06-01 00:00:00

  • Establishment of Best Practices for Evidence for Prediction: A Review.

    abstract:Importance:Great interest exists in identifying methods to predict neuropsychiatric disease states and treatment outcomes from high-dimensional data, including neuroimaging and genomics data. The goal of this review is to highlight several potential problems that can arise in studies that aim to establish prediction. ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.3671

    authors: Poldrack RA,Huckins G,Varoquaux G

    更新日期:2020-05-01 00:00:00

  • Functional magnetic resonance imaging of impaired sensory prediction in schizophrenia.

    abstract:IMPORTANCE:Forward models predict the sensory consequences of planned actions and permit discrimination of self- and non-self-elicited sensation; their impairment in schizophrenia is implied by an abnormality in behavioral force-matching and the flawed agency judgments characteristic of positive symptoms, including aud...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.2974

    authors: Shergill SS,White TP,Joyce DW,Bays PM,Wolpert DM,Frith CD

    更新日期:2014-01-01 00:00:00

  • Interventions to Reduce Compulsory Psychiatric Admissions: A Systematic Review and Meta-analysis.

    abstract:IMPORTANCE:Compulsory admissions, defined as admissions against the will of the patient (according to local judicial procedures), have a strong effect on psychiatric patients. In several Western countries, the rate of such admissions is tending to rise. Its reduction is urgently needed. OBJECTIVE:To establish which in...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1001/jamapsychiatry.2016.0501

    authors: de Jong MH,Kamperman AM,Oorschot M,Priebe S,Bramer W,van de Sande R,Van Gool AR,Mulder CL

    更新日期:2016-07-01 00:00:00

  • The Origin of Spousal Resemblance for Alcohol Use Disorder.

    abstract:Importance:Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. Objectives:To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.4457

    authors: Kendler KS,Lönn SL,Salvatore J,Sundquist J,Sundquist K

    更新日期:2018-03-01 00:00:00

  • Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users.

    abstract:IMPORTANCE:After major policy changes in the United States, policymakers, health care professionals, and the general public seek information about whether recreational cannabis use is associated with physical health problems later in life. OBJECTIVE:To test associations between cannabis use over 20 years and a variety...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2016.0637

    authors: Meier MH,Caspi A,Cerdá M,Hancox RJ,Harrington H,Houts R,Poulton R,Ramrakha S,Thomson WM,Moffitt TE

    更新日期:2016-07-01 00:00:00

  • Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving.

    abstract:Importance:A relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (CS). Preclinical studies suggest that drug reward memories can undergo memory reconsolida...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2016.3907

    authors: Xue YX,Deng JH,Chen YY,Zhang LB,Wu P,Huang GD,Luo YX,Bao YP,Wang YM,Shaham Y,Shi J,Lu L

    更新日期:2017-03-01 00:00:00

  • Thirty-day prevalence of DSM-IV mental disorders among nondeployed soldiers in the US Army: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS).

    abstract:IMPORTANCE:Although high rates of current mental disorder are known to exist in the US Army, little is known about the proportions of these disorders that had onsets prior to enlistment. OBJECTIVE:To estimate the proportions of 30-day DSM-IV mental disorders among nondeployed US Army personnel with first onsets prior ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2014.28

    authors: Kessler RC,Heeringa SG,Stein MB,Colpe LJ,Fullerton CS,Hwang I,Naifeh JA,Nock MK,Petukhova M,Sampson NA,Schoenbaum M,Zaslavsky AM,Ursano RJ,Army STARRS Collaborators.

    更新日期:2014-05-01 00:00:00

  • Reward signals, attempted suicide, and impulsivity in late-life depression.

    abstract::IMPORTANCE—Suicide can be viewed as an escape from unendurable punishment at the cost of any future rewards. Could faulty estimation of these outcomes predispose to suicidal behavior? In behavioral studies, many of those who have attempted suicide misestimate expected rewards on gambling and probabilistic learning tas...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.75

    authors: Dombrovski AY,Szanto K,Clark L,Reynolds CF,Siegle GJ

    更新日期:2013-10-01 00:00:00

  • Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus.

    abstract:IMPORTANCE:Animal data suggest that chronic stress is associated with a reduction in norepinephrine transporter (NET) availability in the locus coeruleus. However, it is unclear whether such models are relevant to posttraumatic stress disorder (PTSD), which has been linked to noradrenergic dysfunction in humans. OBJEC...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,收录出版

    doi:10.1001/jamapsychiatry.2013.399

    authors: Pietrzak RH,Gallezot JD,Ding YS,Henry S,Potenza MN,Southwick SM,Krystal JH,Carson RE,Neumeister A

    更新日期:2013-11-01 00:00:00

  • The relationship between delusions and violence: findings from the East London first episode psychosis study.

    abstract:IMPORTANCE:Psychotic persons who are violent often explain their violence as being due to delusions. However, research has failed to confirm associations between delusions and violent behavior. OBJECTIVES:To investigate which delusional beliefs and characteristics are associated with violent behavior during a first ep...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.12

    authors: Coid JW,Ullrich S,Kallis C,Keers R,Barker D,Cowden F,Stamps R

    更新日期:2013-05-01 00:00:00

  • Neurocognitive growth charting in psychosis spectrum youths.

    abstract:IMPORTANCE:Psychosis-risk studies have examined help-seeking adolescents and young adults. Population-based studies evaluating psychotic symptoms and neurocognitive performance across childhood are needed for "growth charting" cognitive development. We hypothesized that psychosis spectrum youths have delayed neurocogni...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.4190

    authors: Gur RC,Calkins ME,Satterthwaite TD,Ruparel K,Bilker WB,Moore TM,Savitt AP,Hakonarson H,Gur RE

    更新日期:2014-04-01 00:00:00

  • Activation, self-management, engagement, and retention in behavioral health care: a randomized clinical trial of the DECIDE intervention.

    abstract:IMPORTANCE:Given minority patients' unequal access to quality care, patient activation and self-management strategies have been suggested as a promising approach to improving mental health care. OBJECTIVE:To determine whether the DECIDE (Decide the problem; Explore the questions; Closed or open-ended questions; Identi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamapsychiatry.2013.4519

    authors: Alegría M,Carson N,Flores M,Li X,Shi P,Lessios AS,Polo A,Allen M,Fierro M,Interian A,Jimenez A,La Roche M,Lee C,Lewis-Fernández R,Livas-Stein G,Safar L,Schuman C,Storey J,Shrout PE

    更新日期:2014-05-01 00:00:00

  • Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis.

    abstract:Importance:Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding, making causal inference and determining the direction of these associations difficult. Objective:To investigate the potential bidirectional associations...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.3554

    authors: Rosoff DB,Smith GD,Lohoff FW

    更新日期:2020-11-11 00:00:00

  • Self-injury Mortality in the United States in the Early 21st Century: A Comparison With Proximally Ranked Diseases.

    abstract:Importance:Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective:To compare national trends and patterns of self-injur...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2016.1870

    authors: Rockett IR,Lilly CL,Jia H,Larkin GL,Miller TR,Nelson LS,Nolte KB,Putnam SL,Smith GS,Caine ED

    更新日期:2016-10-01 00:00:00

  • Cross-sectional Comparison of the Epidemiology of DSM-5 Generalized Anxiety Disorder Across the Globe.

    abstract:Importance:Generalized anxiety disorder (GAD) is poorly understood compared with other anxiety disorders, and debates persist about the seriousness of this disorder. Few data exist on GAD outside a small number of affluent, industrialized nations. No population-based data exist on GAD as it is currently defined in DSM-...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0056

    authors: Ruscio AM,Hallion LS,Lim CCW,Aguilar-Gaxiola S,Al-Hamzawi A,Alonso J,Andrade LH,Borges G,Bromet EJ,Bunting B,Caldas de Almeida JM,Demyttenaere K,Florescu S,de Girolamo G,Gureje O,Haro JM,He Y,Hinkov H,Hu C,de Jonge

    更新日期:2017-05-01 00:00:00

  • Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial.

    abstract:Importance:More effective, tolerable interventions for bipolar depression treatment are needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with few severe adverse events that showed promising results for unipolar depression. Objective:To determine the efficacy and safety of tDCS as ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2017.4040

    authors: Sampaio-Junior B,Tortella G,Borrione L,Moffa AH,Machado-Vieira R,Cretaz E,Fernandes da Silva A,Fraguas R,Aparício LV,Klein I,Lafer B,Goerigk S,Benseñor IM,Lotufo PA,Gattaz WF,Brunoni AR

    更新日期:2018-02-01 00:00:00

  • Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.

    abstract:Importance:Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Ob...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0669

    authors: Sheffield JM,Kandala S,Tamminga CA,Pearlson GD,Keshavan MS,Sweeney JA,Clementz BA,Lerman-Sinkoff DB,Hill SK,Barch DM

    更新日期:2017-06-01 00:00:00

  • Structural and Functional Brain Abnormalities in Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder: A Comparative Meta-analysis.

    abstract:IMPORTANCE:Patients with attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) share impaired inhibitory control. However, it is unknown whether impairments are mediated by shared or disorder-specific neurostructural and neurofunctional abnormalities. OBJECTIVE:To establish shared and...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamapsychiatry.2016.0700

    authors: Norman LJ,Carlisi C,Lukito S,Hart H,Mataix-Cols D,Radua J,Rubia K

    更新日期:2016-08-01 00:00:00

  • Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.

    abstract:Importance:Several recent population-based studies have linked exposure to maternal smoking during pregnancy to increased risk of severe mental illness in offspring (eg, bipolar disorder, schizophrenia). It is not yet clear, however, whether this association results from causal teratogenic effects or from confounding i...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0456

    authors: Quinn PD,Rickert ME,Weibull CE,Johansson ALV,Lichtenstein P,Almqvist C,Larsson H,Iliadou AN,D'Onofrio BM

    更新日期:2017-06-01 00:00:00

  • Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III.

    abstract:IMPORTANCE:National epidemiologic information from recently collected data on the new DSM-5 classification of alcohol use disorder (AUD) using a reliable, valid, and uniform data source is needed. OBJECTIVE:To present nationally representative findings on the prevalence, correlates, psychiatric comorbidity, associated...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.0584

    authors: Grant BF,Goldstein RB,Saha TD,Chou SP,Jung J,Zhang H,Pickering RP,Ruan WJ,Smith SM,Huang B,Hasin DS

    更新日期:2015-08-01 00:00:00

  • Developmental Trajectories of Impaired Community Functioning in Schizophrenia.

    abstract:IMPORTANCE:Community functioning is a core component of the functional deficits in schizophrenia, yet little systematic research on the origins of these functional deficits has been performed. OBJECTIVES:To examine 3 key domains of community functioning--social activity, independent behavior, and functioning in school...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.2253

    authors: Velthorst E,Reichenberg A,Kapra O,Goldberg S,Fromer M,Fruchter E,Ginat K,de Haan L,Davidson M,Weiser M

    更新日期:2016-01-01 00:00:00

  • Disparities in adverse childhood experiences among individuals with a history of military service.

    abstract:IMPORTANCE:Adverse childhood experiences (ACEs) are associated with several adulthood health problems, such as self-directed violence. For some individuals, enlistment in the military may be an instrumental act to escape adverse household environments; however, to our knowledge prevalence of ACEs among persons with a h...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2014.724

    authors: Blosnich JR,Dichter ME,Cerulli C,Batten SV,Bossarte RM

    更新日期:2014-09-01 00:00:00

  • Reporting Bias in Clinical Trials Investigating the Efficacy of Second-Generation Antidepressants in the Treatment of Anxiety Disorders: A Report of 2 Meta-analyses.

    abstract:IMPORTANCE:Studies have shown that the scientific literature has overestimated the efficacy of antidepressants for depression, but other indications for these drugs have not been considered. OBJECTIVE:To examine reporting biases in double-blind, placebo-controlled trials on the pharmacologic treatment of anxiety disor...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamapsychiatry.2015.15

    authors: Roest AM,de Jonge P,Williams CD,de Vries YA,Schoevers RA,Turner EH

    更新日期:2015-05-01 00:00:00

  • Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities.

    abstract:IMPORTANCE:The 16p11.2 BP4-BP5 duplication is the copy number variant most frequently associated with autism spectrum disorder (ASD), schizophrenia, and comorbidities such as decreased body mass index (BMI). OBJECTIVES:To characterize the effects of the 16p11.2 duplication on cognitive, behavioral, medical, and anthro...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.2123

    authors: D'Angelo D,Lebon S,Chen Q,Martin-Brevet S,Snyder LG,Hippolyte L,Hanson E,Maillard AM,Faucett WA,Macé A,Pain A,Bernier R,Chawner SJ,David A,Andrieux J,Aylward E,Baujat G,Caldeira I,Conus P,Ferrari C,Forzano F,Gér

    更新日期:2016-01-01 00:00:00

  • Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.

    abstract:Importance:Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics for the treatmen...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.1807

    authors: Yu L,Tasaki S,Schneider JA,Arfanakis K,Duong DM,Wingo AP,Wingo TS,Kearns N,Thatcher GRJ,Seyfried NT,Levey AI,De Jager PL,Bennett DA

    更新日期:2020-07-01 00:00:00

  • Prediction of Sex-Specific Suicide Risk Using Machine Learning and Single-Payer Health Care Registry Data From Denmark.

    abstract:Importance:Suicide is a public health problem, with multiple causes that are poorly understood. The increased focus on combining health care data with machine-learning approaches in psychiatry may help advance the understanding of suicide risk. Objective:To examine sex-specific risk profiles for death from suicide usi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.2905

    authors: Gradus JL,Rosellini AJ,Horváth-Puhó E,Street AE,Galatzer-Levy I,Jiang T,Lash TL,Sørensen HT

    更新日期:2020-01-01 00:00:00

  • Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences.

    abstract:Importance:There is concern about potentially causal effects of tobacco use on psychosis, but epidemiological studies have been less robust in attempts to minimize effects of confounding than studies of cannabis use have been. Objectives:To examine the association of patterns of cigarette and cannabis use with precedi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.4271

    authors: Jones HJ,Gage SH,Heron J,Hickman M,Lewis G,Munafò MR,Zammit S

    更新日期:2018-03-01 00:00:00