The Emerging Clinical Neuroscience of Autism Spectrum Disorder: A Review.

abstract：IMPORTANCE:Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders. OBJECTIVE:To identify biological pathways that contribute to risk for bipolar disorder (BP) using genes with consistent evidence for association in multiple genome-wide association studies (GWAS). ...

journal_title：JAMA psychiatry

authors： Nurnberger JI Jr,Koller DL,Jung J,Edenberg HJ,Foroud T,Guella I,Vawter MP,Kelsoe JR,Psychiatric Genomics Consortium Bipolar Group.

更新日期：2014-06-01 00:00:00

abstract：Importance:Generalized anxiety disorder (GAD) is poorly understood compared with other anxiety disorders, and debates persist about the seriousness of this disorder. Few data exist on GAD outside a small number of affluent, industrialized nations. No population-based data exist on GAD as it is currently defined in DSM-...

journal_title：JAMA psychiatry

authors： Ruscio AM,Hallion LS,Lim CCW,Aguilar-Gaxiola S,Al-Hamzawi A,Alonso J,Andrade LH,Borges G,Bromet EJ,Bunting B,Caldas de Almeida JM,Demyttenaere K,Florescu S,de Girolamo G,Gureje O,Haro JM,He Y,Hinkov H,Hu C,de Jonge

更新日期：2017-05-01 00:00:00

abstract：Importance:This article briefly reports the experience of mental health services and the lessons learned during the coronavirus disease 2019 (COVID-19) crisis. In particular, this report offers opportunities to build on experience gained in managing the COVID-19 emergency in the Departments of Mental Health and Addicti...

journal_title：JAMA psychiatry

authors： de Girolamo G,Cerveri G,Clerici M,Monzani E,Spinogatti F,Starace F,Tura G,Vita A

更新日期：2020-09-01 00:00:00

abstract：Importance:Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective:To identify genetic variants associated with adolescent brain structure and explo...

journal_title：JAMA psychiatry

authors： Luo Q,Chen Q,Wang W,Desrivières S,Quinlan EB,Jia T,Macare C,Robert GH,Cui J,Guedj M,Palaniyappan L,Kherif F,Banaschewski T,Bokde ALW,Büchel C,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,

更新日期：2019-04-01 00:00:00

abstract：Importance:Publicly funded mental health services play an important role in addressing co-occurring mental health problems in children with autism spectrum disorder (ASD); however, therapists report lacking training to effectively serve this complex population. Objective:To test the effectiveness of training community...

journal_title：JAMA psychiatry

authors： Brookman-Frazee L,Roesch S,Chlebowski C,Baker-Ericzen M,Ganger W

更新日期：2019-06-01 00:00:00

abstract：Importance:More effective, tolerable interventions for bipolar depression treatment are needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with few severe adverse events that showed promising results for unipolar depression. Objective:To determine the efficacy and safety of tDCS as ...

journal_title：JAMA psychiatry

authors： Sampaio-Junior B,Tortella G,Borrione L,Moffa AH,Machado-Vieira R,Cretaz E,Fernandes da Silva A,Fraguas R,Aparício LV,Klein I,Lafer B,Goerigk S,Benseñor IM,Lotufo PA,Gattaz WF,Brunoni AR

更新日期：2018-02-01 00:00:00

abstract：Importance:Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective:To compare national trends and patterns of self-injur...

journal_title：JAMA psychiatry

authors： Rockett IR,Lilly CL,Jia H,Larkin GL,Miller TR,Nelson LS,Nolte KB,Putnam SL,Smith GS,Caine ED

更新日期：2016-10-01 00:00:00

abstract：Importance:The US Army suicide attempt rate increased sharply during the wars in Afghanistan and Iraq. Although soldiers with a prior mental health diagnosis (MH-Dx) are known to be at risk, little is known about risk among those with no history of diagnosis. Objective:To examine risk factors for suicide attempt among...

journal_title：JAMA psychiatry

authors： Ursano RJ,Kessler RC,Naifeh JA,Herberman Mash HB,Nock MK,Aliaga PA,Fullerton CS,Wynn GH,Ng THH,Dinh HM,Sampson NA,Kao TC,Heeringa SG,Stein MB

更新日期：2018-10-01 00:00:00

abstract：Importance:Because more than one-third of people making nonfatal suicide attempts do not receive mental health treatment, it is essential to extend suicide attempt risk factors beyond high-risk clinical populations to the general adult population. Objective:To identify future suicide attempt risk factors in the genera...

journal_title：JAMA psychiatry

authors： García de la Garza Á,Blanco C,Olfson M,Wall MM

更新日期：2021-01-06 00:00:00

abstract：:IMPORTANCE—Suicide can be viewed as an escape from unendurable punishment at the cost of any future rewards. Could faulty estimation of these outcomes predispose to suicidal behavior? In behavioral studies, many of those who have attempted suicide misestimate expected rewards on gambling and probabilistic learning tas...

journal_title：JAMA psychiatry

authors： Dombrovski AY,Szanto K,Clark L,Reynolds CF,Siegle GJ

更新日期：2013-10-01 00:00:00

abstract：Importance:Since the release of the DSM-5 diagnosis of attenuated psychosis syndrome (DSM-5-APS) in 2013, several research studies have investigated its clinical validity. Although critical and narrative reviews have reviewed these progresses, no systematic review has comprehensively summarized the available evidence r...

journal_title：JAMA psychiatry

authors： Salazar de Pablo G,Catalan A,Fusar-Poli P

更新日期：2020-03-01 00:00:00

abstract：Importance:Suicide deaths are a leading cause of maternal mortality in the US, yet the prevalence and trends in suicidality (suicidal ideation and/or intentional self-harm) among childbearing individuals remain poorly described. Objective:To characterize trends in suicidality among childbearing individuals. Design, S...

journal_title：JAMA psychiatry

authors： Admon LK,Dalton VK,Kolenic GE,Ettner SL,Tilea A,Haffajee RL,Brownlee RM,Zochowski MK,Tabb KM,Muzik M,Zivin K

更新日期：2020-11-18 00:00:00

abstract：IMPORTANCE:Psychosis-risk studies have examined help-seeking adolescents and young adults. Population-based studies evaluating psychotic symptoms and neurocognitive performance across childhood are needed for "growth charting" cognitive development. We hypothesized that psychosis spectrum youths have delayed neurocogni...

journal_title：JAMA psychiatry

authors： Gur RC,Calkins ME,Satterthwaite TD,Ruparel K,Bilker WB,Moore TM,Savitt AP,Hakonarson H,Gur RE

更新日期：2014-04-01 00:00:00

abstract：IMPORTANCE:The requirement of a childhood onset has always been a key criterion for the diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults, but recently this requirement has become surrounded by controversy. OBJECTIVE:To investigate whether impaired young adults with ADHD symptoms always have a chi...

journal_title：JAMA psychiatry

authors： Caye A,Rocha TB,Anselmi L,Murray J,Menezes AM,Barros FC,Gonçalves H,Wehrmeister F,Jensen CM,Steinhausen HC,Swanson JM,Kieling C,Rohde LA

更新日期：2016-07-01 00:00:00

abstract：Importance:Major depressive disorder (MDD) might involve dopamine (DA) reductions. The DA transporter (DAT) regulates DA clearance and neurotransmission and is sensitive to DA levels, with preclinical studies (including those involving inescapable stressors) showing that DAT density decreases when DA signaling is reduc...

journal_title：JAMA psychiatry

authors： Pizzagalli DA,Berretta S,Wooten D,Goer F,Pilobello KT,Kumar P,Murray L,Beltzer M,Boyer-Boiteau A,Alpert N,El Fakhri G,Mechawar N,Vitaliano G,Turecki G,Normandin M

更新日期：2019-08-01 00:00:00

abstract：Importance:Altered neurodevelopmental trajectories are thought to reflect heterogeneity in the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these trajectories are associated with future psychosis is unclear. Objective:To investigate distinct neuroanatomical markers that can diffe...

journal_title：JAMA psychiatry

authors： Chung Y,Addington J,Bearden CE,Cadenhead K,Cornblatt B,Mathalon DH,McGlashan T,Perkins D,Seidman LJ,Tsuang M,Walker E,Woods SW,McEwen S,van Erp TGM,Cannon TD,North American Prodrome Longitudinal Study (NAPLS) Consortium and

更新日期：2018-09-01 00:00:00

abstract：Importance:Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There cur...

journal_title：JAMA psychiatry

authors： Berk M,Woods RL,Nelson MR,Shah RC,Reid CM,Storey E,Fitzgerald S,Lockery JE,Wolfe R,Mohebbi M,Dodd S,Murray AM,Stocks N,Fitzgerald PB,Mazza C,Agustini B,McNeil JJ

更新日期：2020-10-01 00:00:00

abstract：Importance:Dysfunctional reward processing is a leading candidate mechanism for the development of certain depressive symptoms, such as anhedonia. However, to our knowledge, there has not yet been a systematic assessment of whether and to what extent depression is associated with impairments on behavioral reward-proces...

journal_title：JAMA psychiatry

authors： Halahakoon DC,Kieslich K,O'Driscoll C,Nair A,Lewis G,Roiser JP

更新日期：2020-07-29 00:00:00

abstract：IMPORTANCE:Twin-family studies have shown that parent-child resemblance on substance use disorders and antisocial behavior can be accounted for by the transmission of a general liability to a spectrum of externalizing disorders. Most studies, however, include only biological parents and offspring, which confound geneti...

journal_title：JAMA psychiatry

authors： Hicks BM,Foster KT,Iacono WG,McGue M

更新日期：2013-10-01 00:00:00

abstract：Importance:A relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (CS). Preclinical studies suggest that drug reward memories can undergo memory reconsolida...

journal_title：JAMA psychiatry

authors： Xue YX,Deng JH,Chen YY,Zhang LB,Wu P,Huang GD,Luo YX,Bao YP,Wang YM,Shaham Y,Shi J,Lu L

更新日期：2017-03-01 00:00:00

abstract：IMPORTANCE:Posttraumatic stress disorder (PTSD) is a common, debilitating mental disorder that has been associated with type 2 diabetes mellitus (T2D) and its risk factors, including obesity, in cross-sectional studies. If PTSD increases risk of incident T2D, enhanced surveillance in high-risk populations may be warran...

journal_title：JAMA psychiatry

authors： Roberts AL,Agnew-Blais JC,Spiegelman D,Kubzansky LD,Mason SM,Galea S,Hu FB,Rich-Edwards JW,Koenen KC

更新日期：2015-03-01 00:00:00

abstract：IMPORTANCE:Community functioning is a core component of the functional deficits in schizophrenia, yet little systematic research on the origins of these functional deficits has been performed. OBJECTIVES:To examine 3 key domains of community functioning--social activity, independent behavior, and functioning in school...

journal_title：JAMA psychiatry

authors： Velthorst E,Reichenberg A,Kapra O,Goldberg S,Fromer M,Fruchter E,Ginat K,de Haan L,Davidson M,Weiser M

更新日期：2016-01-01 00:00:00

abstract：IMPORTANCE:Forward models predict the sensory consequences of planned actions and permit discrimination of self- and non-self-elicited sensation; their impairment in schizophrenia is implied by an abnormality in behavioral force-matching and the flawed agency judgments characteristic of positive symptoms, including aud...

journal_title：JAMA psychiatry

authors： Shergill SS,White TP,Joyce DW,Bays PM,Wolpert DM,Frith CD

更新日期：2014-01-01 00:00:00

abstract：IMPORTANCE:The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. OBJECTIVES:To characterize ZNF804A expression in human br...

journal_title：JAMA psychiatry

authors： Tao R,Cousijn H,Jaffe AE,Burnet PW,Edwards F,Eastwood SL,Shin JH,Lane TA,Walker MA,Maher BJ,Weinberger DR,Harrison PJ,Hyde TM,Kleinman JE

更新日期：2014-10-01 00:00:00

abstract：IMPORTANCE:Freud argued that in conversion disorder (CD) the affect attached to stressful memories is "repressed" and "converted" into physical symptoms, although this has never been subject to scientific study to our knowledge. OBJECTIVE:To examine the neural correlates of recall of life events judged to be of causal...

journal_title：JAMA psychiatry

authors： Aybek S,Nicholson TR,Zelaya F,O'Daly OG,Craig TJ,David AS,Kanaan RA

更新日期：2014-01-01 00:00:00

abstract：IMPORTANCE:Motivational and cognitive deficits are core features of schizophrenia, both closely linked with functional outcomes. Although poor effort and decreased motivation are known to affect performance on cognitive tests, the extent of this relationship is unclear in patients with schizophrenia. OBJECTIVE:To eval...

journal_title：JAMA psychiatry

authors： Fervaha G,Zakzanis KK,Foussias G,Graff-Guerrero A,Agid O,Remington G

更新日期：2014-09-01 00:00:00

abstract：Importance:Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. Objectives:To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner ...

journal_title：JAMA psychiatry

authors： Kendler KS,Lönn SL,Salvatore J,Sundquist J,Sundquist K

更新日期：2018-03-01 00:00:00

abstract：Importance:Posttraumatic stress disorder (PTSD) is associated with an increased risk of type 2 diabetes mellitus (T2DM). Existing literature has adjusted for obesity in combination with other confounders, which does not allow estimating the contribution of obesity alone on the association of PTSD with incident T2DM. O...

journal_title：JAMA psychiatry

authors： Scherrer JF,Salas J,Lustman PJ,van den Berk-Clark C,Schnurr PP,Tuerk P,Cohen BE,Friedman MJ,Norman SB,Schneider FD,Chard KM

更新日期：2018-11-01 00:00:00

abstract：IMPORTANCE:The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. OBJECTIVES:First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to diff...

journal_title：JAMA psychiatry

authors： Redlich R,Almeida JJ,Grotegerd D,Opel N,Kugel H,Heindel W,Arolt V,Phillips ML,Dannlowski U

更新日期：2014-11-01 00:00:00

abstract：IMPORTANCE:Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it is unclear whether these areas are also characterized by altered brain network properties. OBJECTIVES:To determine regions of abnormal degree...

journal_title：JAMA psychiatry

authors： Beucke JC,Sepulcre J,Talukdar T,Linnman C,Zschenderlein K,Endrass T,Kaufmann C,Kathmann N

更新日期：2013-06-01 00:00:00