Functional magnetic resonance imaging of impaired sensory prediction in schizophrenia.

abstract：IMPORTANCE:Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conducted in Mexico. OBJECTIVE:To evaluate the safety a...

journal_title：JAMA psychiatry

authors： Somoza EC,Winship D,Gorodetzky CW,Lewis D,Ciraulo DA,Galloway GP,Segal SD,Sheehan M,Roache JD,Bickel WK,Jasinski D,Watson DW,Miller SR,Somoza P,Winhusen T

更新日期：2013-06-01 00:00:00

abstract：IMPORTANCE:Cocaine addiction is associated with altered resting-state functional connectivity among regions of the mesocorticolimbic dopamine pathways. Methylphenidate hydrochloride, an indirect dopamine agonist, normalizes task-related regional brain activity and associated behavior in cocaine users; however, the neur...

journal_title：JAMA psychiatry

authors： Konova AB,Moeller SJ,Tomasi D,Volkow ND,Goldstein RZ

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:Psychosis-risk studies have examined help-seeking adolescents and young adults. Population-based studies evaluating psychotic symptoms and neurocognitive performance across childhood are needed for "growth charting" cognitive development. We hypothesized that psychosis spectrum youths have delayed neurocogni...

journal_title：JAMA psychiatry

authors： Gur RC,Calkins ME,Satterthwaite TD,Ruparel K,Bilker WB,Moore TM,Savitt AP,Hakonarson H,Gur RE

更新日期：2014-04-01 00:00:00

abstract：Importance:Suicide deaths are a leading cause of maternal mortality in the US, yet the prevalence and trends in suicidality (suicidal ideation and/or intentional self-harm) among childbearing individuals remain poorly described. Objective:To characterize trends in suicidality among childbearing individuals. Design, S...

journal_title：JAMA psychiatry

authors： Admon LK,Dalton VK,Kolenic GE,Ettner SL,Tilea A,Haffajee RL,Brownlee RM,Zochowski MK,Tabb KM,Muzik M,Zivin K

更新日期：2020-11-18 00:00:00

abstract：IMPORTANCE:Community functioning is a core component of the functional deficits in schizophrenia, yet little systematic research on the origins of these functional deficits has been performed. OBJECTIVES:To examine 3 key domains of community functioning--social activity, independent behavior, and functioning in school...

journal_title：JAMA psychiatry

authors： Velthorst E,Reichenberg A,Kapra O,Goldberg S,Fromer M,Fruchter E,Ginat K,de Haan L,Davidson M,Weiser M

更新日期：2016-01-01 00:00:00

abstract：Importance:Epidemiologic evidence indicates that most of the general population will experience a mental health disorder at some point in their lives. However, few prospective population-based studies have estimated trajectories of risk for mental disorders from young through middle adulthood to estimate the proportion...

journal_title：JAMA psychiatry

authors： Paksarian D,Cui L,Angst J,Ajdacic-Gross V,Rössler W,Merikangas KR

更新日期：2016-10-01 00:00:00

abstract：IMPORTANCE:Fragile X syndrome (FXS) is an X-linked neurogenetic disorder characterized by a cognitive and behavioral phenotype resembling features of autism spectrum disorder. Until now, research has focused largely on identifying regional differences in brain structure and function between individuals with FXS and var...

journal_title：JAMA psychiatry

authors： Hall SS,Jiang H,Reiss AL,Greicius MD

更新日期：2013-11-01 00:00:00

abstract：Importance:Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There cur...

journal_title：JAMA psychiatry

authors： Berk M,Woods RL,Nelson MR,Shah RC,Reid CM,Storey E,Fitzgerald S,Lockery JE,Wolfe R,Mohebbi M,Dodd S,Murray AM,Stocks N,Fitzgerald PB,Mazza C,Agustini B,McNeil JJ

更新日期：2020-10-01 00:00:00

abstract：IMPORTANCE:Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems ...

journal_title：JAMA psychiatry

authors： van Borkulo C,Boschloo L,Borsboom D,Penninx BW,Waldorp LJ,Schoevers RA

更新日期：2015-12-01 00:00:00

abstract：Importance:Suicide is a leading cause of deaths in the United States. Although the emergency department (ED) is an opportune setting for initiating suicide prevention efforts, ED-initiated suicide prevention interventions remain underdeveloped. Objective:To determine whether an ED-initiated intervention reduces subseq...

journal_title：JAMA psychiatry

authors： Miller IW,Camargo CA Jr,Arias SA,Sullivan AF,Allen MH,Goldstein AB,Manton AP,Espinola JA,Jones R,Hasegawa K,Boudreaux ED,ED-SAFE Investigators.

更新日期：2017-06-01 00:00:00

abstract：Importance:The US Army suicide attempt rate increased sharply during the wars in Afghanistan and Iraq. Although soldiers with a prior mental health diagnosis (MH-Dx) are known to be at risk, little is known about risk among those with no history of diagnosis. Objective:To examine risk factors for suicide attempt among...

journal_title：JAMA psychiatry

authors： Ursano RJ,Kessler RC,Naifeh JA,Herberman Mash HB,Nock MK,Aliaga PA,Fullerton CS,Wynn GH,Ng THH,Dinh HM,Sampson NA,Kao TC,Heeringa SG,Stein MB

更新日期：2018-10-01 00:00:00

abstract：Importance:Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Ob...

journal_title：JAMA psychiatry

authors： Sheffield JM,Kandala S,Tamminga CA,Pearlson GD,Keshavan MS,Sweeney JA,Clementz BA,Lerman-Sinkoff DB,Hill SK,Barch DM

更新日期：2017-06-01 00:00:00

abstract：IMPORTANCE:At least 11 rare copy number variants (CNVs) have been shown to be major risk factors for schizophrenia (SZ). These CNVs also increase the risk for other neurodevelopmental disorders, such as intellectual disability. It is possible that additional intellectual disability-associated CNVs increase the risk for...

journal_title：JAMA psychiatry

authors： Rees E,Kendall K,Pardiñas AF,Legge SE,Pocklington A,Escott-Price V,MacCabe JH,Collier DA,Holmans P,O'Donovan MC,Owen MJ,Walters JTR,Kirov G

更新日期：2016-09-01 00:00:00

abstract：Importance:Great interest exists in identifying methods to predict neuropsychiatric disease states and treatment outcomes from high-dimensional data, including neuroimaging and genomics data. The goal of this review is to highlight several potential problems that can arise in studies that aim to establish prediction. ...

journal_title：JAMA psychiatry

authors： Poldrack RA,Huckins G,Varoquaux G

更新日期：2020-05-01 00:00:00

abstract：Importance:Depressive severity is typically measured according to total scores on questionnaires that include a diverse range of symptoms despite convincing evidence that depression is not a unitary construct. When evaluated according to aggregate measurements, treatment efficacy is generally modest and differences in ...

journal_title：JAMA psychiatry

authors： Chekroud AM,Gueorguieva R,Krumholz HM,Trivedi MH,Krystal JH,McCarthy G

更新日期：2017-04-01 00:00:00

abstract：Importance:Generalized anxiety disorder (GAD) is poorly understood compared with other anxiety disorders, and debates persist about the seriousness of this disorder. Few data exist on GAD outside a small number of affluent, industrialized nations. No population-based data exist on GAD as it is currently defined in DSM-...

journal_title：JAMA psychiatry

authors： Ruscio AM,Hallion LS,Lim CCW,Aguilar-Gaxiola S,Al-Hamzawi A,Alonso J,Andrade LH,Borges G,Bromet EJ,Bunting B,Caldas de Almeida JM,Demyttenaere K,Florescu S,de Girolamo G,Gureje O,Haro JM,He Y,Hinkov H,Hu C,de Jonge

更新日期：2017-05-01 00:00:00

abstract：Importance:Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding, making causal inference and determining the direction of these associations difficult. Objective:To investigate the potential bidirectional associations...

journal_title：JAMA psychiatry

authors： Rosoff DB,Smith GD,Lohoff FW

更新日期：2020-11-11 00:00:00

abstract：IMPORTANCE:Despite the prevalence of antenatal depression and the fact that only one-third of pregnant women with depression consider it acceptable to take antidepressants, the effect of untreated depression on neonatal outcomes remains to be addressed thoroughly. OBJECTIVE:To undertake a systematic review and meta-an...

journal_title：JAMA psychiatry

authors： Jarde A,Morais M,Kingston D,Giallo R,MacQueen GM,Giglia L,Beyene J,Wang Y,McDonald SD

更新日期：2016-08-01 00:00:00

abstract：Importance:Antipsychotic medications are commonly used to treat nonpsychotic disruptive behavioral disorders in youths. Objective:To characterize the metabolic effects of first exposure to antipsychotics in youths using criterion standard assessments of body composition and insulin sensitivity. Design, Setting, and P...

journal_title：JAMA psychiatry

authors： Nicol GE,Yingling MD,Flavin KS,Schweiger JA,Patterson BW,Schechtman KB,Newcomer JW

更新日期：2018-08-01 00:00:00

abstract：:Suicide rates have continued to rise in the United States. Speculations for this rise proliferate but the causes for the increase remain unknown. While research focuses on identifying causes, the health care system is an important site for identification of patients at risk. Forty percent of individuals who die by sui...

journal_title：JAMA psychiatry

authors： Stanley B,Mann JJ

更新日期：2020-01-01 00:00:00

abstract：:In 1893 and 1896, in his fourth and fifth textbook editions, Emil Kraepelin brought together 3 syndromes to form the first and second of his 2 prequels to dementia praecox (DP), a definitive version of which he would propose in his 1899 sixth textbook edition. These syndromes, which would become hebephrenic DP, catato...

journal_title：JAMA psychiatry

authors： Kendler KS

更新日期：2020-06-10 00:00:00

abstract：IMPORTANCE:Some, but not all, previous magnetic resonance imaging studies have indicated smaller cortical and local gray matter volumes (GMVs) in men with schizotypal personality disorder (SPD) compared with healthy control (HC) subjects. Thus, there is need for a whole-brain comparison to resolve inconsistencies and p...

journal_title：JAMA psychiatry

authors： Asami T,Whitford TJ,Bouix S,Dickey CC,Niznikiewicz M,Shenton ME,Voglmaier MM,McCarley RW

更新日期：2013-04-01 00:00:00

abstract：Importance:Posttraumatic stress disorder (PTSD) is associated with an increased risk of type 2 diabetes mellitus (T2DM). Existing literature has adjusted for obesity in combination with other confounders, which does not allow estimating the contribution of obesity alone on the association of PTSD with incident T2DM. O...

journal_title：JAMA psychiatry

authors： Scherrer JF,Salas J,Lustman PJ,van den Berk-Clark C,Schnurr PP,Tuerk P,Cohen BE,Friedman MJ,Norman SB,Schneider FD,Chard KM

更新日期：2018-11-01 00:00:00

abstract：IMPORTANCE:In 1939, English mathematician, geneticist, and psychiatrist Lionel Sharples Penrose hypothesized that the numbers of psychiatric hospital beds and the sizes of prison populations were inversely related; 75 years later, the question arises as to whether the hypothesis applies to recent developments in South ...

journal_title：JAMA psychiatry

authors： Mundt AP,Chow WS,Arduino M,Barrionuevo H,Fritsch R,Girala N,Minoletti A,Mitkiewicz F,Rivera G,Tavares M,Priebe S

更新日期：2015-02-01 00:00:00

abstract：IMPORTANCE:Depression and obesity are 2 prevalent disorders that have been repeatedly shown to be associated. However, the mechanisms and temporal sequence underlying this association are poorly understood. OBJECTIVE:To determine whether the subtypes of major depressive disorder (MDD; melancholic, atypical, combined, ...

journal_title：JAMA psychiatry

authors： Lasserre AM,Glaus J,Vandeleur CL,Marques-Vidal P,Vaucher J,Bastardot F,Waeber G,Vollenweider P,Preisig M

更新日期：2014-08-01 00:00:00

abstract：IMPORTANCE:Freud argued that in conversion disorder (CD) the affect attached to stressful memories is "repressed" and "converted" into physical symptoms, although this has never been subject to scientific study to our knowledge. OBJECTIVE:To examine the neural correlates of recall of life events judged to be of causal...

journal_title：JAMA psychiatry

authors： Aybek S,Nicholson TR,Zelaya F,O'Daly OG,Craig TJ,David AS,Kanaan RA

更新日期：2014-01-01 00:00:00

abstract：Importance:Understanding the neurodevelopmental trajectory of psychiatric symptoms is important for improving early identification, intervention, and prevention of mental disorders. Objective:To test whether the strength of the coupling of activation between specific brain regions, as measured by resting-state functio...

journal_title：JAMA psychiatry

authors： Whitfield-Gabrieli S,Wendelken C,Nieto-Castañón A,Bailey SK,Anteraper SA,Lee YJ,Chai XQ,Hirshfeld-Becker DR,Biederman J,Cutting LE,Bunge SA

更新日期：2020-04-01 00:00:00

abstract：IMPORTANCE:The continuum view of the psychosis spectrum (PS) implies that, in population-based samples, PS symptoms should be associated with neural abnormalities similar to those found in help-seeking clinical risk individuals and in schizophrenia. To our knowledge, functional neuroimaging has not previously been appl...

journal_title：JAMA psychiatry

authors： Wolf DH,Satterthwaite TD,Calkins ME,Ruparel K,Elliott MA,Hopson RD,Jackson CT,Prabhakaran K,Bilker WB,Hakonarson H,Gur RC,Gur RE

更新日期：2015-05-01 00:00:00

abstract：IMPORTANCE:Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia. OBJECTIVE:To evaluate hippocampal volumetric measures and neurometabolites in unmedicated patients with schizophrenia and the correlations between these markers. Our a priori hypothes...

journal_title：JAMA psychiatry

authors： Kraguljac NV,White DM,Reid MA,Lahti AC

更新日期：2013-12-01 00:00:00

abstract：:CONTEXT Clinical experience and factor analytic studies suggest that some psychiatric disorders may be more closely related to one another, as indicated by the frequency of their co-occurrence, which may have etiologic and treatment implications. OBJECTIVE To construct a virtual space of common psychiatric disorders, ...

journal_title：JAMA psychiatry

authors： Blanco C,Krueger RF,Hasin DS,Liu SM,Wang S,Kerridge BT,Saha T,Olfson M

更新日期：2013-02-01 00:00:00