Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia.

abstract：Importance:Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective:To compare national trends and patterns of self-injur...

journal_title：JAMA psychiatry

authors： Rockett IR,Lilly CL,Jia H,Larkin GL,Miller TR,Nelson LS,Nolte KB,Putnam SL,Smith GS,Caine ED

更新日期：2016-10-01 00:00:00

abstract：IMPORTANCE:Although high rates of current mental disorder are known to exist in the US Army, little is known about the proportions of these disorders that had onsets prior to enlistment. OBJECTIVE:To estimate the proportions of 30-day DSM-IV mental disorders among nondeployed US Army personnel with first onsets prior ...

journal_title：JAMA psychiatry

authors： Kessler RC,Heeringa SG,Stein MB,Colpe LJ,Fullerton CS,Hwang I,Naifeh JA,Nock MK,Petukhova M,Sampson NA,Schoenbaum M,Zaslavsky AM,Ursano RJ,Army STARRS Collaborators.

更新日期：2014-05-01 00:00:00

abstract：IMPORTANCE:The inverse social gradient in mental disorders is a well-established research finding with important implications for causal models and policy. This research has used traditional objective social status (OSS) measures, such as educational level, income, and occupation. Recently, subjective social status (SS...

journal_title：JAMA psychiatry

authors： Scott KM,Al-Hamzawi AO,Andrade LH,Borges G,Caldas-de-Almeida JM,Fiestas F,Gureje O,Hu C,Karam EG,Kawakami N,Lee S,Levinson D,Lim CC,Navarro-Mateu F,Okoliyski M,Posada-Villa J,Torres Y,Williams DR,Zakhozha V,Kessler

更新日期：2014-12-01 00:00:00

abstract：IMPORTANCE:The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. OBJECTIVES:First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to diff...

journal_title：JAMA psychiatry

authors： Redlich R,Almeida JJ,Grotegerd D,Opel N,Kugel H,Heindel W,Arolt V,Phillips ML,Dannlowski U

更新日期：2014-11-01 00:00:00

abstract：IMPORTANCE:Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it is unclear whether these areas are also characterized by altered brain network properties. OBJECTIVES:To determine regions of abnormal degree...

journal_title：JAMA psychiatry

authors： Beucke JC,Sepulcre J,Talukdar T,Linnman C,Zschenderlein K,Endrass T,Kaufmann C,Kathmann N

更新日期：2013-06-01 00:00:00

abstract：Importance:Great interest exists in identifying methods to predict neuropsychiatric disease states and treatment outcomes from high-dimensional data, including neuroimaging and genomics data. The goal of this review is to highlight several potential problems that can arise in studies that aim to establish prediction. ...

journal_title：JAMA psychiatry

authors： Poldrack RA,Huckins G,Varoquaux G

更新日期：2020-05-01 00:00:00

abstract：Importance:More than 30 million people live with a stroke diagnosis worldwide. Depression after stroke is frequent, and greater knowledge of associated risk factors and outcomes is needed to understand the etiology and implications of this disabling complication. Objectives:To examine whether the incidence of and risk...

journal_title：JAMA psychiatry

authors： Jørgensen TS,Wium-Andersen IK,Wium-Andersen MK,Jørgensen MB,Prescott E,Maartensson S,Kragh-Andersen P,Osler M

更新日期：2016-10-01 00:00:00

abstract：Importance:Depressive severity is typically measured according to total scores on questionnaires that include a diverse range of symptoms despite convincing evidence that depression is not a unitary construct. When evaluated according to aggregate measurements, treatment efficacy is generally modest and differences in ...

journal_title：JAMA psychiatry

authors： Chekroud AM,Gueorguieva R,Krumholz HM,Trivedi MH,Krystal JH,McCarthy G

更新日期：2017-04-01 00:00:00

abstract：IMPORTANCE:Whether traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD) has been difficult to determine because of the prevalence of comorbid conditions, overlapping symptoms, and cross-sectional samples. OBJECTIVE:To examine the extent to which self-reported predeployment and deploym...

journal_title：JAMA psychiatry

authors： Yurgil KA,Barkauskas DA,Vasterling JJ,Nievergelt CM,Larson GE,Schork NJ,Litz BT,Nash WP,Baker DG,Marine Resiliency Study Team.

更新日期：2014-02-01 00:00:00

abstract：IMPORTANCE:Sedentary behaviors and physical inactivity are not only increasing worldwide but also are critical risk factors for adverse health outcomes. Yet, few studies have examined the effects of sedentary behavior on cognition or the long-term role of either behavior in early to middle adulthood. OBJECTIVE:To inve...

journal_title：JAMA psychiatry

authors： Hoang TD,Reis J,Zhu N,Jacobs DR Jr,Launer LJ,Whitmer RA,Sidney S,Yaffe K

更新日期：2016-01-01 00:00:00

abstract：Importance:The US Army suicide attempt rate increased sharply during the wars in Afghanistan and Iraq. Although soldiers with a prior mental health diagnosis (MH-Dx) are known to be at risk, little is known about risk among those with no history of diagnosis. Objective:To examine risk factors for suicide attempt among...

journal_title：JAMA psychiatry

authors： Ursano RJ,Kessler RC,Naifeh JA,Herberman Mash HB,Nock MK,Aliaga PA,Fullerton CS,Wynn GH,Ng THH,Dinh HM,Sampson NA,Kao TC,Heeringa SG,Stein MB

更新日期：2018-10-01 00:00:00

abstract：:IMPORTANCE—Suicide can be viewed as an escape from unendurable punishment at the cost of any future rewards. Could faulty estimation of these outcomes predispose to suicidal behavior? In behavioral studies, many of those who have attempted suicide misestimate expected rewards on gambling and probabilistic learning tas...

journal_title：JAMA psychiatry

authors： Dombrovski AY,Szanto K,Clark L,Reynolds CF,Siegle GJ

更新日期：2013-10-01 00:00:00

abstract：IMPORTANCE:The requirement of a childhood onset has always been a key criterion for the diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults, but recently this requirement has become surrounded by controversy. OBJECTIVE:To investigate whether impaired young adults with ADHD symptoms always have a chi...

journal_title：JAMA psychiatry

authors： Caye A,Rocha TB,Anselmi L,Murray J,Menezes AM,Barros FC,Gonçalves H,Wehrmeister F,Jensen CM,Steinhausen HC,Swanson JM,Kieling C,Rohde LA

更新日期：2016-07-01 00:00:00

abstract：IMPORTANCE:Psychosis-risk studies have examined help-seeking adolescents and young adults. Population-based studies evaluating psychotic symptoms and neurocognitive performance across childhood are needed for "growth charting" cognitive development. We hypothesized that psychosis spectrum youths have delayed neurocogni...

journal_title：JAMA psychiatry

authors： Gur RC,Calkins ME,Satterthwaite TD,Ruparel K,Bilker WB,Moore TM,Savitt AP,Hakonarson H,Gur RE

更新日期：2014-04-01 00:00:00

abstract：IMPORTANCE:Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders. OBJECTIVE:To identify biological pathways that contribute to risk for bipolar disorder (BP) using genes with consistent evidence for association in multiple genome-wide association studies (GWAS). ...

journal_title：JAMA psychiatry

authors： Nurnberger JI Jr,Koller DL,Jung J,Edenberg HJ,Foroud T,Guella I,Vawter MP,Kelsoe JR,Psychiatric Genomics Consortium Bipolar Group.

更新日期：2014-06-01 00:00:00

abstract：Importance:Substance abuse preventive interventions frequently target middle school students and demonstrate efficacy to prevent early onset and use of alcohol and illicit drugs. However, evidence of sustained results to prevent later patterns of alcohol misuse and more serious alcohol abuse disorders has been lacking,...

journal_title：JAMA psychiatry

authors： Gonzales NA,Jensen M,Tein JY,Wong JJ,Dumka LE,Mauricio AM

更新日期：2018-05-01 00:00:00

abstract：Importance:Autism spectrum disorder (ASD) is 2 to 5 times more common in male individuals than in female individuals. While the male preponderant prevalence of ASD might partially be explained by sex differences in clinical symptoms, etiological models suggest that the biological male phenotype carries a higher intrins...

journal_title：JAMA psychiatry

authors： Ecker C,Andrews DS,Gudbrandsen CM,Marquand AF,Ginestet CE,Daly EM,Murphy CM,Lai MC,Lombardo MV,Ruigrok AN,Bullmore ET,Suckling J,Williams SC,Baron-Cohen S,Craig MC,Murphy DG,Medical Research Council Autism Imaging Multice

更新日期：2017-04-01 00:00:00

abstract：Importance:Suicide is a leading cause of deaths in the United States. Although the emergency department (ED) is an opportune setting for initiating suicide prevention efforts, ED-initiated suicide prevention interventions remain underdeveloped. Objective:To determine whether an ED-initiated intervention reduces subseq...

journal_title：JAMA psychiatry

authors： Miller IW,Camargo CA Jr,Arias SA,Sullivan AF,Allen MH,Goldstein AB,Manton AP,Espinola JA,Jones R,Hasegawa K,Boudreaux ED,ED-SAFE Investigators.

更新日期：2017-06-01 00:00:00

abstract：Importance:Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There cur...

journal_title：JAMA psychiatry

authors： Berk M,Woods RL,Nelson MR,Shah RC,Reid CM,Storey E,Fitzgerald S,Lockery JE,Wolfe R,Mohebbi M,Dodd S,Murray AM,Stocks N,Fitzgerald PB,Mazza C,Agustini B,McNeil JJ

更新日期：2020-10-01 00:00:00

abstract：Importance:Suicide deaths are a leading cause of maternal mortality in the US, yet the prevalence and trends in suicidality (suicidal ideation and/or intentional self-harm) among childbearing individuals remain poorly described. Objective:To characterize trends in suicidality among childbearing individuals. Design, S...

journal_title：JAMA psychiatry

authors： Admon LK,Dalton VK,Kolenic GE,Ettner SL,Tilea A,Haffajee RL,Brownlee RM,Zochowski MK,Tabb KM,Muzik M,Zivin K

更新日期：2020-11-18 00:00:00

abstract：Importance:The onset of adult psychopathologic disorders can be traced to behavioral or emotional symptoms observed in childhood, which could be targeted in early interventions to prevent future mental disorders. The network perspective is a novel conceptualization of psychopathologic disorders that could help to ident...

journal_title：JAMA psychiatry

authors： Rouquette A,Pingault JB,Fried EI,Orri M,Falissard B,Kossakowski JJ,Vitaro F,Tremblay R,Cote SM,Borsboom D

更新日期：2018-11-01 00:00:00

abstract：IMPORTANCE:Despite the prevalence of antenatal depression and the fact that only one-third of pregnant women with depression consider it acceptable to take antidepressants, the effect of untreated depression on neonatal outcomes remains to be addressed thoroughly. OBJECTIVE:To undertake a systematic review and meta-an...

journal_title：JAMA psychiatry

authors： Jarde A,Morais M,Kingston D,Giallo R,MacQueen GM,Giglia L,Beyene J,Wang Y,McDonald SD

更新日期：2016-08-01 00:00:00

abstract：IMPORTANCE:Brain imaging studies have identified robust changes in brain structure and function during the development of psychosis, but the contribution of abnormal brain connectivity to the onset of psychosis is unclear. Furthermore, antipsychotic treatment can modulate brain activity and functional connectivity duri...

journal_title：JAMA psychiatry

authors： Schmidt A,Smieskova R,Aston J,Simon A,Allen P,Fusar-Poli P,McGuire PK,Riecher-Rössler A,Stephan KE,Borgwardt S

更新日期：2013-09-01 00:00:00

abstract：IMPORTANCE:Freud argued that in conversion disorder (CD) the affect attached to stressful memories is "repressed" and "converted" into physical symptoms, although this has never been subject to scientific study to our knowledge. OBJECTIVE:To examine the neural correlates of recall of life events judged to be of causal...

journal_title：JAMA psychiatry

authors： Aybek S,Nicholson TR,Zelaya F,O'Daly OG,Craig TJ,David AS,Kanaan RA

更新日期：2014-01-01 00:00:00

abstract：Importance:Maturation of white matter fiber systems subserves cognitive, behavioral, emotional, and motor development during adolescence. Hazardous drinking during this active neurodevelopmental period may alter the trajectory of white matter microstructural development, potentially increasing risk for developing alcoh...

journal_title：JAMA psychiatry

authors： Zhao Q,Sullivan EV,Honnorat N,Adeli E,Podhajsky S,De Bellis MD,Voyvodic J,Nooner KB,Baker FC,Colrain IM,Tapert SF,Brown SA,Thompson WK,Nagel BJ,Clark DB,Pfefferbaum A,Pohl KM

更新日期：2020-12-30 00:00:00

abstract：Importance:Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective:To use systematic review and network meta-analysis to compare the association of using manualized psychotherapies and th...

journal_title：JAMA psychiatry

authors： Miklowitz DJ,Efthimiou O,Furukawa TA,Scott J,McLaren R,Geddes JR,Cipriani A

更新日期：2020-10-14 00:00:00

abstract：IMPORTANCE:In 1939, English mathematician, geneticist, and psychiatrist Lionel Sharples Penrose hypothesized that the numbers of psychiatric hospital beds and the sizes of prison populations were inversely related; 75 years later, the question arises as to whether the hypothesis applies to recent developments in South ...

journal_title：JAMA psychiatry

authors： Mundt AP,Chow WS,Arduino M,Barrionuevo H,Fritsch R,Girala N,Minoletti A,Mitkiewicz F,Rivera G,Tavares M,Priebe S

更新日期：2015-02-01 00:00:00

abstract：Importance:Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics for the treatmen...

journal_title：JAMA psychiatry

authors： Yu L,Tasaki S,Schneider JA,Arfanakis K,Duong DM,Wingo AP,Wingo TS,Kearns N,Thatcher GRJ,Seyfried NT,Levey AI,De Jager PL,Bennett DA

更新日期：2020-07-01 00:00:00

abstract：Importance:Little is known about changes in marijuana use and cannabis use disorder (CUD) after recreational marijuana legalization (RML). Objectives:To examine the associations between RML enactment and changes in marijuana use, frequent use, and CUD in the United States from 2008 to 2016. Design, Setting, and Parti...

journal_title：JAMA psychiatry

authors： Cerdá M,Mauro C,Hamilton A,Levy NS,Santaella-Tenorio J,Hasin D,Wall MM,Keyes KM,Martins SS

更新日期：2020-02-01 00:00:00

abstract：Importance:Bipolar disorder (BD) overlaps schizophrenia in its clinical presentation and genetic liability. Alternative approaches to patient stratification beyond current diagnostic categories are needed to understand the underlying disease processes and mechanisms. Objective:To investigate the association between co...

journal_title：JAMA psychiatry

authors： Allardyce J,Leonenko G,Hamshere M,Pardiñas AF,Forty L,Knott S,Gordon-Smith K,Porteous DJ,Haywood C,Di Florio A,Jones L,McIntosh AM,Owen MJ,Holmans P,Walters JTR,Craddock N,Jones I,O'Donovan MC,Escott-Price V

更新日期：2018-01-01 00:00:00