Suicide Prevention in an Emergency Department Population: The ED-SAFE Study.

Abstract:

Importance:Suicide is a leading cause of deaths in the United States. Although the emergency department (ED) is an opportune setting for initiating suicide prevention efforts, ED-initiated suicide prevention interventions remain underdeveloped. Objective:To determine whether an ED-initiated intervention reduces subsequent suicidal behavior. Design, Setting, and Participants:This multicenter study of 8 EDs in the United States enrolled adults with a recent suicide attempt or ideation and was composed of 3 sequential phases: (1) a treatment as usual (TAU) phase from August 2010 to December 2011, (2) a universal screening (screening) phase from September 2011 to December 2012, and (3) a universal screening plus intervention (intervention) phase from July 2012 to November 2013. Interventions:Screening consisted of universal suicide risk screening. The intervention phase consisted of universal screening plus an intervention, which included secondary suicide risk screening by the ED physician, discharge resources, and post-ED telephone calls focused on reducing suicide risk. Main Outcomes and Measures:The primary outcome was suicide attempts (nonfatal and fatal) over the 52-week follow-up period. The proportion and total number of attempts were analyzed. Results:A total of 1376 participants were recruited, including 769 females (55.9%) with a median (interquartile range) age of 37 (26-47) years. A total of 288 participants (20.9%) made at least 1 suicide attempt, and there were 548 total suicide attempts among participants. There were no significant differences in risk reduction between the TAU and screening phases (23% vs 22%, respectively). However, compared with the TAU phase, patients in the intervention phase showed a 5% absolute reduction in suicide attempt risk (23% vs 18%), with a relative risk reduction of 20%. Participants in the intervention phase had 30% fewer total suicide attempts than participants in the TAU phase. Negative binomial regression analysis indicated that the participants in the intervention phase had significantly fewer total suicide attempts than participants in the TAU phase (incidence rate ratio, 0.72; 95% CI, 0.52-1.00; P = .05) but no differences between the TAU and screening phases (incidence rate ratio, 1.00; 95% CI, 0.71-1.41; P = .99). Conclusions and Relevance:Among at-risk patients in the ED, a combination of brief interventions administered both during and after the ED visit decreased post-ED suicidal behavior.

journal_name

JAMA Psychiatry

journal_title

JAMA psychiatry

authors

Miller IW,Camargo CA Jr,Arias SA,Sullivan AF,Allen MH,Goldstein AB,Manton AP,Espinola JA,Jones R,Hasegawa K,Boudreaux ED,ED-SAFE Investigators.

doi

10.1001/jamapsychiatry.2017.0678

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

563-570

issue

6

eissn

2168-622X

issn

2168-6238

pii

2623157

journal_volume

74

pub_type

临床试验,杂志文章,多中心研究
  • A Telephone-Based Program to Provide Symptom Monitoring Alone vs Symptom Monitoring Plus Care Management for Late-Life Depression and Anxiety: A Randomized Clinical Trial.

    abstract:IMPORTANCE:Mental health (MH) conditions are undertreated in late life. It is important to identify treatment strategies that address variability in treatment content and delivery and take individual-specific symptoms into account, particularly among low-income, community-dwelling older adults. OBJECTIVE:To evaluate p...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2015.2157

    authors: Mavandadi S,Benson A,DiFilippo S,Streim JE,Oslin D

    更新日期:2015-12-01 00:00:00

  • Effect of Middle School Interventions on Alcohol Misuse and Abuse in Mexican American High School Adolescents: Five-Year Follow-up of a Randomized Clinical Trial.

    abstract:Importance:Substance abuse preventive interventions frequently target middle school students and demonstrate efficacy to prevent early onset and use of alcohol and illicit drugs. However, evidence of sustained results to prevent later patterns of alcohol misuse and more serious alcohol abuse disorders has been lacking,...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2018.0058

    authors: Gonzales NA,Jensen M,Tein JY,Wong JJ,Dumka LE,Mauricio AM

    更新日期:2018-05-01 00:00:00

  • Identifying large-scale brain networks in fragile X syndrome.

    abstract:IMPORTANCE:Fragile X syndrome (FXS) is an X-linked neurogenetic disorder characterized by a cognitive and behavioral phenotype resembling features of autism spectrum disorder. Until now, research has focused largely on identifying regional differences in brain structure and function between individuals with FXS and var...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.247

    authors: Hall SS,Jiang H,Reiss AL,Greicius MD

    更新日期:2013-11-01 00:00:00

  • Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.

    abstract:Importance:Bipolar disorder (BD) overlaps schizophrenia in its clinical presentation and genetic liability. Alternative approaches to patient stratification beyond current diagnostic categories are needed to understand the underlying disease processes and mechanisms. Objective:To investigate the association between co...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.3485

    authors: Allardyce J,Leonenko G,Hamshere M,Pardiñas AF,Forty L,Knott S,Gordon-Smith K,Porteous DJ,Haywood C,Di Florio A,Jones L,McIntosh AM,Owen MJ,Holmans P,Walters JTR,Craddock N,Jones I,O'Donovan MC,Escott-Price V

    更新日期:2018-01-01 00:00:00

  • Establishment of Best Practices for Evidence for Prediction: A Review.

    abstract:Importance:Great interest exists in identifying methods to predict neuropsychiatric disease states and treatment outcomes from high-dimensional data, including neuroimaging and genomics data. The goal of this review is to highlight several potential problems that can arise in studies that aim to establish prediction. ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.3671

    authors: Poldrack RA,Huckins G,Varoquaux G

    更新日期:2020-05-01 00:00:00

  • Incidence and Determinants of Mental Health Service Use After Bariatric Surgery.

    abstract:Importance:Obesity is associated with an increased prevalence of psychiatric disorders. The association of bariatric surgery with mental health outcomes is poorly understood. Objective:To investigate the association of bariatric surgery with the incidence of outpatient, emergency department (ED), and inpatient mental ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.2741

    authors: Morgan DJR,Ho KM,Platell C

    更新日期:2020-01-01 00:00:00

  • Structural and Functional Brain Abnormalities in Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder: A Comparative Meta-analysis.

    abstract:IMPORTANCE:Patients with attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) share impaired inhibitory control. However, it is unknown whether impairments are mediated by shared or disorder-specific neurostructural and neurofunctional abnormalities. OBJECTIVE:To establish shared and...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamapsychiatry.2016.0700

    authors: Norman LJ,Carlisi C,Lukito S,Hart H,Mataix-Cols D,Radua J,Rubia K

    更新日期:2016-08-01 00:00:00

  • The Origin of Spousal Resemblance for Alcohol Use Disorder.

    abstract:Importance:Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. Objectives:To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.4457

    authors: Kendler KS,Lönn SL,Salvatore J,Sundquist J,Sundquist K

    更新日期:2018-03-01 00:00:00

  • Cross-sectional Comparison of the Epidemiology of DSM-5 Generalized Anxiety Disorder Across the Globe.

    abstract:Importance:Generalized anxiety disorder (GAD) is poorly understood compared with other anxiety disorders, and debates persist about the seriousness of this disorder. Few data exist on GAD outside a small number of affluent, industrialized nations. No population-based data exist on GAD as it is currently defined in DSM-...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0056

    authors: Ruscio AM,Hallion LS,Lim CCW,Aguilar-Gaxiola S,Al-Hamzawi A,Alonso J,Andrade LH,Borges G,Bromet EJ,Bunting B,Caldas de Almeida JM,Demyttenaere K,Florescu S,de Girolamo G,Gureje O,Haro JM,He Y,Hinkov H,Hu C,de Jonge

    更新日期:2017-05-01 00:00:00

  • Parents bereaved by offspring suicide: a population-based longitudinal case-control study.

    abstract::CONTEXT Suicide bereavement remains understudied and poorly understood. OBJECTIVES To examine outcomes of parents bereaved by the suicide death of their offspring and to compare these with both nonbereaved parent controls and parents who had offspring die in a motor vehicle crash (MVC). DESIGN Population-based case-co...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.275

    authors: Bolton JM,Au W,Leslie WD,Martens PJ,Enns MW,Roos LL,Katz LY,Wilcox HC,Erlangsen A,Chateau D,Walld R,Spiwak R,Seguin M,Shear K,Sareen J

    更新日期:2013-02-01 00:00:00

  • Association Between Recreational Marijuana Legalization in the United States and Changes in Marijuana Use and Cannabis Use Disorder From 2008 to 2016.

    abstract:Importance:Little is known about changes in marijuana use and cannabis use disorder (CUD) after recreational marijuana legalization (RML). Objectives:To examine the associations between RML enactment and changes in marijuana use, frequent use, and CUD in the United States from 2008 to 2016. Design, Setting, and Parti...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.3254

    authors: Cerdá M,Mauro C,Hamilton A,Levy NS,Santaella-Tenorio J,Hasin D,Wall MM,Keyes KM,Martins SS

    更新日期:2020-02-01 00:00:00

  • Self-injury Mortality in the United States in the Early 21st Century: A Comparison With Proximally Ranked Diseases.

    abstract:Importance:Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective:To compare national trends and patterns of self-injur...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2016.1870

    authors: Rockett IR,Lilly CL,Jia H,Larkin GL,Miller TR,Nelson LS,Nolte KB,Putnam SL,Smith GS,Caine ED

    更新日期:2016-10-01 00:00:00

  • Disparities in adverse childhood experiences among individuals with a history of military service.

    abstract:IMPORTANCE:Adverse childhood experiences (ACEs) are associated with several adulthood health problems, such as self-directed violence. For some individuals, enlistment in the military may be an instrumental act to escape adverse household environments; however, to our knowledge prevalence of ACEs among persons with a h...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2014.724

    authors: Blosnich JR,Dichter ME,Cerulli C,Batten SV,Bossarte RM

    更新日期:2014-09-01 00:00:00

  • A Cross-Disorder Method to Identify Novel Candidate Genes for Developmental Brain Disorders.

    abstract:IMPORTANCE:Developmental brain disorders are a group of clinically and genetically heterogeneous disorders characterized by high heritability. Specific highly penetrant genetic causes can often be shared by a subset of individuals with different phenotypic features, and recent advances in genome sequencing have allowed...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.2692

    authors: Gonzalez-Mantilla AJ,Moreno-De-Luca A,Ledbetter DH,Martin CL

    更新日期:2016-03-01 00:00:00

  • Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.

    abstract:IMPORTANCE:The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. OBJECTIVES:To characterize ZNF804A expression in human br...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2014.1079

    authors: Tao R,Cousijn H,Jaffe AE,Burnet PW,Edwards F,Eastwood SL,Shin JH,Lane TA,Walker MA,Maher BJ,Weinberger DR,Harrison PJ,Hyde TM,Kleinman JE

    更新日期:2014-10-01 00:00:00

  • Association of Symptom Network Structure With the Course of [corrected] Depression.

    abstract:IMPORTANCE:Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.2079

    authors: van Borkulo C,Boschloo L,Borsboom D,Penninx BW,Waldorp LJ,Schoevers RA

    更新日期:2015-12-01 00:00:00

  • Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study.

    abstract:IMPORTANCE:Posttraumatic stress disorder (PTSD) is a common, debilitating mental disorder that has been associated with type 2 diabetes mellitus (T2D) and its risk factors, including obesity, in cross-sectional studies. If PTSD increases risk of incident T2D, enhanced surveillance in high-risk populations may be warran...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2014.2632

    authors: Roberts AL,Agnew-Blais JC,Spiegelman D,Kubzansky LD,Mason SM,Galea S,Hu FB,Rich-Edwards JW,Koenen KC

    更新日期:2015-03-01 00:00:00

  • Discriminating risk and resilience endophenotypes from lifetime illness effects in familial major depressive disorder.

    abstract:IMPORTANCE:The neural systems that confer risk or vulnerability for developing familial depression, and those that protect against or confer resilience to becoming ill, can be disentangled from the effects of prior illness by comparing brain imaging measures in previously ill and never ill persons who have either a hig...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.4048

    authors: Peterson BS,Wang Z,Horga G,Warner V,Rutherford B,Klahr KW,Graniello B,Wickramaratne P,Garcia F,Yu S,Hao X,Adams PB,Qian M,Liu J,Gerber A,Weissman MM

    更新日期:2014-02-01 00:00:00

  • Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials.

    abstract:Importance:Recent estimates suggest that more than 50% of all deaths worldwide are currently attributable to inflammation-related diseases. Psychosocial interventions may represent a potentially useful strategy for addressing this global public health problem, but which types of interventions reliably improve immune sy...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.0431

    authors: Shields GS,Spahr CM,Slavich GM

    更新日期:2020-10-01 00:00:00

  • Reward-Processing Behavior in Depressed Participants Relative to Healthy Volunteers: A Systematic Review and Meta-analysis.

    abstract:Importance:Dysfunctional reward processing is a leading candidate mechanism for the development of certain depressive symptoms, such as anhedonia. However, to our knowledge, there has not yet been a systematic assessment of whether and to what extent depression is associated with impairments on behavioral reward-proces...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.2139

    authors: Halahakoon DC,Kieslich K,O'Driscoll C,Nair A,Lewis G,Roiser JP

    更新日期:2020-07-29 00:00:00

  • Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.

    abstract:Importance:Several recent population-based studies have linked exposure to maternal smoking during pregnancy to increased risk of severe mental illness in offspring (eg, bipolar disorder, schizophrenia). It is not yet clear, however, whether this association results from causal teratogenic effects or from confounding i...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0456

    authors: Quinn PD,Rickert ME,Weibull CE,Johansson ALV,Lichtenstein P,Almqvist C,Larsson H,Iliadou AN,D'Onofrio BM

    更新日期:2017-06-01 00:00:00

  • Activation, self-management, engagement, and retention in behavioral health care: a randomized clinical trial of the DECIDE intervention.

    abstract:IMPORTANCE:Given minority patients' unequal access to quality care, patient activation and self-management strategies have been suggested as a promising approach to improving mental health care. OBJECTIVE:To determine whether the DECIDE (Decide the problem; Explore the questions; Closed or open-ended questions; Identi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamapsychiatry.2013.4519

    authors: Alegría M,Carson N,Flores M,Li X,Shi P,Lessios AS,Polo A,Allen M,Fierro M,Interian A,Jimenez A,La Roche M,Lee C,Lewis-Fernández R,Livas-Stein G,Safar L,Schuman C,Storey J,Shrout PE

    更新日期:2014-05-01 00:00:00

  • Association of Preeclampsia in Term Births With Neurodevelopmental Disorders in Offspring.

    abstract:Importance:Preeclampsia during pregnancy has been linked to an increased risk of cerebral palsy in offspring. Less is known about the role of preeclampsia in other neurodevelopmental disorders. Objective:To determine the association between preeclampsia and a range of adverse neurodevelopmental outcomes in offspring a...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.0306

    authors: Sun BZ,Moster D,Harmon QE,Wilcox AJ

    更新日期:2020-08-01 00:00:00

  • Adjunctive Psychotherapy for Bipolar Disorder: A Systematic Review and Component Network Meta-analysis.

    abstract:Importance:Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective:To use systematic review and network meta-analysis to compare the association of using manualized psychotherapies and th...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.2993

    authors: Miklowitz DJ,Efthimiou O,Furukawa TA,Scott J,McLaren R,Geddes JR,Cipriani A

    更新日期:2020-10-14 00:00:00

  • Causes of Death After Nonfatal Opioid Overdose.

    abstract:Importance:A recent increase in patients presenting with nonfatal opioid overdoses has focused clinical attention on characterizing their risks of premature mortality. Objective:To describe all-cause mortality rates, selected cause-specific mortality rates, and standardized mortality rate ratios (SMRs) of adults durin...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2018.1471

    authors: Olfson M,Crystal S,Wall M,Wang S,Liu SM,Blanco C

    更新日期:2018-08-01 00:00:00

  • Neonatal Outcomes in Women With Untreated Antenatal Depression Compared With Women Without Depression: A Systematic Review and Meta-analysis.

    abstract:IMPORTANCE:Despite the prevalence of antenatal depression and the fact that only one-third of pregnant women with depression consider it acceptable to take antidepressants, the effect of untreated depression on neonatal outcomes remains to be addressed thoroughly. OBJECTIVE:To undertake a systematic review and meta-an...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1001/jamapsychiatry.2016.0934

    authors: Jarde A,Morais M,Kingston D,Giallo R,MacQueen GM,Giglia L,Beyene J,Wang Y,McDonald SD

    更新日期:2016-08-01 00:00:00

  • Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach.

    abstract:Importance:Depressive severity is typically measured according to total scores on questionnaires that include a diverse range of symptoms despite convincing evidence that depression is not a unitary construct. When evaluated according to aggregate measurements, treatment efficacy is generally modest and differences in ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0025

    authors: Chekroud AM,Gueorguieva R,Krumholz HM,Trivedi MH,Krystal JH,McCarthy G

    更新日期:2017-04-01 00:00:00

  • Clinical Validity of DSM-5 Attenuated Psychosis Syndrome: Advances in Diagnosis, Prognosis, and Treatment.

    abstract:Importance:Since the release of the DSM-5 diagnosis of attenuated psychosis syndrome (DSM-5-APS) in 2013, several research studies have investigated its clinical validity. Although critical and narrative reviews have reviewed these progresses, no systematic review has comprehensively summarized the available evidence r...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.3561

    authors: Salazar de Pablo G,Catalan A,Fusar-Poli P

    更新日期:2020-03-01 00:00:00

  • Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.

    abstract:Importance:Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Ob...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0669

    authors: Sheffield JM,Kandala S,Tamminga CA,Pearlson GD,Keshavan MS,Sweeney JA,Clementz BA,Lerman-Sinkoff DB,Hill SK,Barch DM

    更新日期:2017-06-01 00:00:00

  • Comparison of 2 family therapies for adolescent anorexia nervosa: a randomized parallel trial.

    abstract:IMPORTANCE:Anorexia nervosa (AN) is a serious disorder with high rates of morbidity and mortality. Family-based treatment (FBT) is an evidence-based therapy for adolescent AN, but less than half of those who receive this approach recover. Hence, it is important to identify other approaches to prevent the development of...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamapsychiatry.2014.1025

    authors: Agras WS,Lock J,Brandt H,Bryson SW,Dodge E,Halmi KA,Jo B,Johnson C,Kaye W,Wilfley D,Woodside B

    更新日期:2014-11-01 00:00:00