Suicide Prevention in an Emergency Department Population: The ED-SAFE Study.

Abstract:

Importance:Suicide is a leading cause of deaths in the United States. Although the emergency department (ED) is an opportune setting for initiating suicide prevention efforts, ED-initiated suicide prevention interventions remain underdeveloped. Objective:To determine whether an ED-initiated intervention reduces subsequent suicidal behavior. Design, Setting, and Participants:This multicenter study of 8 EDs in the United States enrolled adults with a recent suicide attempt or ideation and was composed of 3 sequential phases: (1) a treatment as usual (TAU) phase from August 2010 to December 2011, (2) a universal screening (screening) phase from September 2011 to December 2012, and (3) a universal screening plus intervention (intervention) phase from July 2012 to November 2013. Interventions:Screening consisted of universal suicide risk screening. The intervention phase consisted of universal screening plus an intervention, which included secondary suicide risk screening by the ED physician, discharge resources, and post-ED telephone calls focused on reducing suicide risk. Main Outcomes and Measures:The primary outcome was suicide attempts (nonfatal and fatal) over the 52-week follow-up period. The proportion and total number of attempts were analyzed. Results:A total of 1376 participants were recruited, including 769 females (55.9%) with a median (interquartile range) age of 37 (26-47) years. A total of 288 participants (20.9%) made at least 1 suicide attempt, and there were 548 total suicide attempts among participants. There were no significant differences in risk reduction between the TAU and screening phases (23% vs 22%, respectively). However, compared with the TAU phase, patients in the intervention phase showed a 5% absolute reduction in suicide attempt risk (23% vs 18%), with a relative risk reduction of 20%. Participants in the intervention phase had 30% fewer total suicide attempts than participants in the TAU phase. Negative binomial regression analysis indicated that the participants in the intervention phase had significantly fewer total suicide attempts than participants in the TAU phase (incidence rate ratio, 0.72; 95% CI, 0.52-1.00; P = .05) but no differences between the TAU and screening phases (incidence rate ratio, 1.00; 95% CI, 0.71-1.41; P = .99). Conclusions and Relevance:Among at-risk patients in the ED, a combination of brief interventions administered both during and after the ED visit decreased post-ED suicidal behavior.

journal_name

JAMA Psychiatry

journal_title

JAMA psychiatry

authors

Miller IW,Camargo CA Jr,Arias SA,Sullivan AF,Allen MH,Goldstein AB,Manton AP,Espinola JA,Jones R,Hasegawa K,Boudreaux ED,ED-SAFE Investigators.

doi

10.1001/jamapsychiatry.2017.0678

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

563-570

issue

6

eissn

2168-622X

issn

2168-6238

pii

2623157

journal_volume

74

pub_type

临床试验,杂志文章,多中心研究
  • Motivational deficits and cognitive test performance in schizophrenia.

    abstract:IMPORTANCE:Motivational and cognitive deficits are core features of schizophrenia, both closely linked with functional outcomes. Although poor effort and decreased motivation are known to affect performance on cognitive tests, the extent of this relationship is unclear in patients with schizophrenia. OBJECTIVE:To eval...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2014.1105

    authors: Fervaha G,Zakzanis KK,Foussias G,Graff-Guerrero A,Agid O,Remington G

    更新日期:2014-09-01 00:00:00

  • Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis.

    abstract:Importance:Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding, making causal inference and determining the direction of these associations difficult. Objective:To investigate the potential bidirectional associations...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.3554

    authors: Rosoff DB,Smith GD,Lohoff FW

    更新日期:2020-11-11 00:00:00

  • Neural correlates of recall of life events in conversion disorder.

    abstract:IMPORTANCE:Freud argued that in conversion disorder (CD) the affect attached to stressful memories is "repressed" and "converted" into physical symptoms, although this has never been subject to scientific study to our knowledge. OBJECTIVE:To examine the neural correlates of recall of life events judged to be of causal...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.2842

    authors: Aybek S,Nicholson TR,Zelaya F,O'Daly OG,Craig TJ,David AS,Kanaan RA

    更新日期:2014-01-01 00:00:00

  • Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study.

    abstract:IMPORTANCE:Serotonin is involved in negative affect, but whether anxiety syndromes, such as social anxiety disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. Serotonin 1A autoreceptors, which inhibit serotonin synthesis and release, are downregulated in SAD, and...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.0125

    authors: Frick A,Åhs F,Engman J,Jonasson M,Alaie I,Björkstrand J,Frans Ö,Faria V,Linnman C,Appel L,Wahlstedt K,Lubberink M,Fredrikson M,Furmark T

    更新日期:2015-08-01 00:00:00

  • Meta-analysis of Functional Neuroimaging of Major Depressive Disorder in Youth.

    abstract:IMPORTANCE:Despite its high prevalence and morbidity, the underlying neural basis of major depressive disorder (MDD) in youth is not well understood. OBJECTIVES:To identify in youth diagnosed as having MDD the most reliable neural abnormalities reported in existing functional neuroimaging studies and characterize thei...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamapsychiatry.2015.1376

    authors: Miller CH,Hamilton JP,Sacchet MD,Gotlib IH

    更新日期:2015-10-01 00:00:00

  • The Role of Obesity in the Association Between Posttraumatic Stress Disorder and Incident Diabetes.

    abstract:Importance:Posttraumatic stress disorder (PTSD) is associated with an increased risk of type 2 diabetes mellitus (T2DM). Existing literature has adjusted for obesity in combination with other confounders, which does not allow estimating the contribution of obesity alone on the association of PTSD with incident T2DM. O...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2018.2028

    authors: Scherrer JF,Salas J,Lustman PJ,van den Berk-Clark C,Schnurr PP,Tuerk P,Cohen BE,Friedman MJ,Norman SB,Schneider FD,Chard KM

    更新日期:2018-11-01 00:00:00

  • Prediction of Sex-Specific Suicide Risk Using Machine Learning and Single-Payer Health Care Registry Data From Denmark.

    abstract:Importance:Suicide is a public health problem, with multiple causes that are poorly understood. The increased focus on combining health care data with machine-learning approaches in psychiatry may help advance the understanding of suicide risk. Objective:To examine sex-specific risk profiles for death from suicide usi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.2905

    authors: Gradus JL,Rosellini AJ,Horváth-Puhó E,Street AE,Galatzer-Levy I,Jiang T,Lash TL,Sørensen HT

    更新日期:2020-01-01 00:00:00

  • A Telephone-Based Program to Provide Symptom Monitoring Alone vs Symptom Monitoring Plus Care Management for Late-Life Depression and Anxiety: A Randomized Clinical Trial.

    abstract:IMPORTANCE:Mental health (MH) conditions are undertreated in late life. It is important to identify treatment strategies that address variability in treatment content and delivery and take individual-specific symptoms into account, particularly among low-income, community-dwelling older adults. OBJECTIVE:To evaluate p...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2015.2157

    authors: Mavandadi S,Benson A,DiFilippo S,Streim JE,Oslin D

    更新日期:2015-12-01 00:00:00

  • Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users.

    abstract:IMPORTANCE:After major policy changes in the United States, policymakers, health care professionals, and the general public seek information about whether recreational cannabis use is associated with physical health problems later in life. OBJECTIVE:To test associations between cannabis use over 20 years and a variety...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2016.0637

    authors: Meier MH,Caspi A,Cerdá M,Hancox RJ,Harrington H,Houts R,Poulton R,Ramrakha S,Thomson WM,Moffitt TE

    更新日期:2016-07-01 00:00:00

  • Use of Machine Learning to Determine Deviance in Neuroanatomical Maturity Associated With Future Psychosis in Youths at Clinically High Risk.

    abstract:Importance:Altered neurodevelopmental trajectories are thought to reflect heterogeneity in the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these trajectories are associated with future psychosis is unclear. Objective:To investigate distinct neuroanatomical markers that can diffe...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamapsychiatry.2018.1543

    authors: Chung Y,Addington J,Bearden CE,Cadenhead K,Cornblatt B,Mathalon DH,McGlashan T,Perkins D,Seidman LJ,Tsuang M,Walker E,Woods SW,McEwen S,van Erp TGM,Cannon TD,North American Prodrome Longitudinal Study (NAPLS) Consortium and

    更新日期:2018-09-01 00:00:00

  • Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus.

    abstract:IMPORTANCE:Animal data suggest that chronic stress is associated with a reduction in norepinephrine transporter (NET) availability in the locus coeruleus. However, it is unclear whether such models are relevant to posttraumatic stress disorder (PTSD), which has been linked to noradrenergic dysfunction in humans. OBJEC...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,收录出版

    doi:10.1001/jamapsychiatry.2013.399

    authors: Pietrzak RH,Gallezot JD,Ding YS,Henry S,Potenza MN,Southwick SM,Krystal JH,Carson RE,Neumeister A

    更新日期:2013-11-01 00:00:00

  • The Emerging Clinical Neuroscience of Autism Spectrum Disorder: A Review.

    abstract:Importance:Autism spectrum disorder (ASD) is a highly prevalent disorder, and community psychiatrists are likely to treat many individuals with ASD during their clinical practice. This clinical case challenge describes a routine evaluation of irritability and self-injury in a preschool-aged child who meets the criteria...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,评审

    doi:10.1001/jamapsychiatry.2017.4685

    authors: Muhle RA,Reed HE,Stratigos KA,Veenstra-VanderWeele J

    更新日期:2018-05-01 00:00:00

  • Activation, self-management, engagement, and retention in behavioral health care: a randomized clinical trial of the DECIDE intervention.

    abstract:IMPORTANCE:Given minority patients' unequal access to quality care, patient activation and self-management strategies have been suggested as a promising approach to improving mental health care. OBJECTIVE:To determine whether the DECIDE (Decide the problem; Explore the questions; Closed or open-ended questions; Identi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamapsychiatry.2013.4519

    authors: Alegría M,Carson N,Flores M,Li X,Shi P,Lessios AS,Polo A,Allen M,Fierro M,Interian A,Jimenez A,La Roche M,Lee C,Lewis-Fernández R,Livas-Stein G,Safar L,Schuman C,Storey J,Shrout PE

    更新日期:2014-05-01 00:00:00

  • Religious Service Attendance and Deaths Related to Drugs, Alcohol, and Suicide Among US Health Care Professionals.

    abstract:Importance:The increase in deaths related to drugs, alcohol, and suicide (referred to as deaths from despair) has been identified as a public health crisis. The antecedents associated with these deaths have, however, seldom been investigated empirically. Objective:To prospectively examine the association between relig...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.0175

    authors: Chen Y,Koh HK,Kawachi I,Botticelli M,VanderWeele TJ

    更新日期:2020-07-01 00:00:00

  • Reward signals, attempted suicide, and impulsivity in late-life depression.

    abstract::IMPORTANCE—Suicide can be viewed as an escape from unendurable punishment at the cost of any future rewards. Could faulty estimation of these outcomes predispose to suicidal behavior? In behavioral studies, many of those who have attempted suicide misestimate expected rewards on gambling and probabilistic learning tas...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.75

    authors: Dombrovski AY,Szanto K,Clark L,Reynolds CF,Siegle GJ

    更新日期:2013-10-01 00:00:00

  • Parents bereaved by offspring suicide: a population-based longitudinal case-control study.

    abstract::CONTEXT Suicide bereavement remains understudied and poorly understood. OBJECTIVES To examine outcomes of parents bereaved by the suicide death of their offspring and to compare these with both nonbereaved parent controls and parents who had offspring die in a motor vehicle crash (MVC). DESIGN Population-based case-co...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.275

    authors: Bolton JM,Au W,Leslie WD,Martens PJ,Enns MW,Roos LL,Katz LY,Wilcox HC,Erlangsen A,Chateau D,Walld R,Spiwak R,Seguin M,Shear K,Sareen J

    更新日期:2013-02-01 00:00:00

  • Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability.

    abstract:Importance:Tobacco use disorder is associated with dysregulated neurocognitive function in the right inferior frontal gyrus (IFG)-one node in a corticothalamic inhibitory control (IC) network. Objective:To examine associations between IC neural circuitry structure and function and lapse/relapse vulnerability in 2 inde...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0017

    authors: Froeliger B,McConnell PA,Bell S,Sweitzer M,Kozink RV,Eichberg C,Hallyburton M,Kaiser N,Gray KM,McClernon FJ

    更新日期:2017-04-01 00:00:00

  • The Origin of Spousal Resemblance for Alcohol Use Disorder.

    abstract:Importance:Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. Objectives:To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.4457

    authors: Kendler KS,Lönn SL,Salvatore J,Sundquist J,Sundquist K

    更新日期:2018-03-01 00:00:00

  • Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences.

    abstract:Importance:There is concern about potentially causal effects of tobacco use on psychosis, but epidemiological studies have been less robust in attempts to minimize effects of confounding than studies of cannabis use have been. Objectives:To examine the association of patterns of cigarette and cannabis use with precedi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.4271

    authors: Jones HJ,Gage SH,Heron J,Hickman M,Lewis G,Munafò MR,Zammit S

    更新日期:2018-03-01 00:00:00

  • Repetitive Transcranial Magnetic Stimulation for the Acute Treatment of Major Depressive Episodes: A Systematic Review With Network Meta-analysis.

    abstract:Importance:Although several strategies of repetitive transcranial magnetic stimulation (rTMS) have been investigated as treatment of major depressive disorder (MDD), their comparative efficacy and acceptability is unknown. Objective:To establish the relative efficacy and acceptability of the different modalities of rT...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1001/jamapsychiatry.2016.3644

    authors: Brunoni AR,Chaimani A,Moffa AH,Razza LB,Gattaz WF,Daskalakis ZJ,Carvalho AF

    更新日期:2017-02-01 00:00:00

  • The Development of Kraepelin's Concept of Dementia Praecox: A Close Reading of Relevant Texts.

    abstract::In 1893 and 1896, in his fourth and fifth textbook editions, Emil Kraepelin brought together 3 syndromes to form the first and second of his 2 prequels to dementia praecox (DP), a definitive version of which he would propose in his 1899 sixth textbook edition. These syndromes, which would become hebephrenic DP, catato...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.1266

    authors: Kendler KS

    更新日期:2020-06-10 00:00:00

  • Association of Symptom Network Structure With the Course of [corrected] Depression.

    abstract:IMPORTANCE:Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.2079

    authors: van Borkulo C,Boschloo L,Borsboom D,Penninx BW,Waldorp LJ,Schoevers RA

    更新日期:2015-12-01 00:00:00

  • Functional magnetic resonance imaging of impaired sensory prediction in schizophrenia.

    abstract:IMPORTANCE:Forward models predict the sensory consequences of planned actions and permit discrimination of self- and non-self-elicited sensation; their impairment in schizophrenia is implied by an abnormality in behavioral force-matching and the flawed agency judgments characteristic of positive symptoms, including aud...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.2974

    authors: Shergill SS,White TP,Joyce DW,Bays PM,Wolpert DM,Frith CD

    更新日期:2014-01-01 00:00:00

  • Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.

    abstract:IMPORTANCE:Cannabis dependence (CAD) is a serious problem worldwide and is of growing importance in the United States because cannabis is increasingly available legally. Although genetic factors contribute substantially to CAD risk, at present no well-established specific genetic risk factors for CAD have been elucidat...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamapsychiatry.2016.0036

    authors: Sherva R,Wang Q,Kranzler H,Zhao H,Koesterer R,Herman A,Farrer LA,Gelernter J

    更新日期:2016-05-01 00:00:00

  • Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction.

    abstract:IMPORTANCE:Cocaine addiction is associated with altered resting-state functional connectivity among regions of the mesocorticolimbic dopamine pathways. Methylphenidate hydrochloride, an indirect dopamine agonist, normalizes task-related regional brain activity and associated behavior in cocaine users; however, the neur...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2013.1129

    authors: Konova AB,Moeller SJ,Tomasi D,Volkow ND,Goldstein RZ

    更新日期:2013-08-01 00:00:00

  • Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial.

    abstract:Importance:More effective, tolerable interventions for bipolar depression treatment are needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with few severe adverse events that showed promising results for unipolar depression. Objective:To determine the efficacy and safety of tDCS as ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2017.4040

    authors: Sampaio-Junior B,Tortella G,Borrione L,Moffa AH,Machado-Vieira R,Cretaz E,Fernandes da Silva A,Fraguas R,Aparício LV,Klein I,Lafer B,Goerigk S,Benseñor IM,Lotufo PA,Gattaz WF,Brunoni AR

    更新日期:2018-02-01 00:00:00

  • Association of Heavy Drinking With Deviant Fiber Tract Development in Frontal Brain Systems in Adolescents.

    abstract:Importance:Maturation of white matter fiber systems subserves cognitive, behavioral, emotional, and motor development during adolescence. Hazardous drinking during this active neurodevelopmental period may alter the trajectory of white matter microstructural development, potentially increasing risk for developing alcoh...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.4064

    authors: Zhao Q,Sullivan EV,Honnorat N,Adeli E,Podhajsky S,De Bellis MD,Voyvodic J,Nooner KB,Baker FC,Colrain IM,Tapert SF,Brown SA,Thompson WK,Nagel BJ,Clark DB,Pfefferbaum A,Pohl KM

    更新日期:2020-12-30 00:00:00

  • Reward-Processing Behavior in Depressed Participants Relative to Healthy Volunteers: A Systematic Review and Meta-analysis.

    abstract:Importance:Dysfunctional reward processing is a leading candidate mechanism for the development of certain depressive symptoms, such as anhedonia. However, to our knowledge, there has not yet been a systematic assessment of whether and to what extent depression is associated with impairments on behavioral reward-proces...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.2139

    authors: Halahakoon DC,Kieslich K,O'Driscoll C,Nair A,Lewis G,Roiser JP

    更新日期:2020-07-29 00:00:00

  • A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence.

    abstract:IMPORTANCE:Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conducted in Mexico. OBJECTIVE:To evaluate the safety a...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamapsychiatry.2013.872

    authors: Somoza EC,Winship D,Gorodetzky CW,Lewis D,Ciraulo DA,Galloway GP,Segal SD,Sheehan M,Roache JD,Bickel WK,Jasinski D,Watson DW,Miller SR,Somoza P,Winhusen T

    更新日期:2013-06-01 00:00:00

  • Identifying large-scale brain networks in fragile X syndrome.

    abstract:IMPORTANCE:Fragile X syndrome (FXS) is an X-linked neurogenetic disorder characterized by a cognitive and behavioral phenotype resembling features of autism spectrum disorder. Until now, research has focused largely on identifying regional differences in brain structure and function between individuals with FXS and var...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.247

    authors: Hall SS,Jiang H,Reiss AL,Greicius MD

    更新日期:2013-11-01 00:00:00